Fah (fumarylacetoacetate hydrolase) - Rat Genome Database

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Gene: Fah (fumarylacetoacetate hydrolase) Ictidomys tridecemlineatus
Analyze
Symbol: Fah
Name: fumarylacetoacetate hydrolase
RGD ID: 12570989
Description: ENCODES a protein that exhibits catalytic activity (inferred); fumarylacetoacetase activity (inferred); hydrolase activity (inferred); INVOLVED IN arginine catabolic process (ortholog); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); COVID-19 (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fumarylacetoacetase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640120,292,223 - 120,326,410 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647138,140,324 - 38,174,472 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

Genomics

Comparative Map Data
Fah
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640120,292,223 - 120,326,410 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647138,140,324 - 38,174,472 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381580,152,789 - 80,186,949 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1580,152,490 - 80,186,946 (+)EnsemblGRCh38hg38GRCh38
GRCh371580,445,131 - 80,479,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361578,232,396 - 78,265,737 (+)NCBINCBI36Build 36hg18NCBI36
Build 341578,232,395 - 78,265,737NCBI
Celera1557,382,789 - 57,416,130 (+)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1557,208,400 - 57,236,922 (+)NCBIHuRef
CHM1_11580,563,191 - 80,596,880 (+)NCBICHM1_1
T2T-CHM13v2.01578,016,209 - 78,050,378 (+)NCBIT2T-CHM13v2.0
Fah
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39784,234,367 - 84,255,150 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl784,234,367 - 84,255,930 (-)EnsemblGRCm39 Ensembl
GRCm38784,585,159 - 84,605,942 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl784,585,159 - 84,606,722 (-)EnsemblGRCm38mm10GRCm38
MGSCv37791,733,669 - 91,754,452 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36784,461,355 - 84,481,937 (-)NCBIMGSCv36mm8
Celera781,987,620 - 82,008,470 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map748.36NCBI
Fah
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21138,548,830 - 138,571,599 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1138,548,834 - 138,571,505 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1146,501,260 - 146,524,074 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01153,670,263 - 153,693,077 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01146,545,471 - 146,568,281 (-)NCBIRnor_WKY
Rnor_6.01146,713,663 - 146,736,339 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1146,713,676 - 146,736,261 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01147,640,316 - 147,662,920 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41140,851,975 - 140,876,187 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11140,930,382 - 140,954,593 (-)NCBI
Celera1130,566,888 - 130,589,532 (-)NCBICelera
Cytogenetic Map1q31NCBI
Fah
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955533904,295 - 921,730 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955533904,294 - 921,730 (+)NCBIChiLan1.0ChiLan1.0
FAH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11578,081,523 - 78,115,169 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1578,048,571 - 78,115,098 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01559,121,657 - 59,155,229 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FAH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,300,422 - 57,326,546 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl357,300,441 - 57,326,486 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha359,958,877 - 59,985,019 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0357,726,930 - 57,753,060 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl357,702,957 - 57,753,270 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1357,232,805 - 57,258,945 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0357,439,515 - 57,465,634 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0357,786,369 - 57,812,502 (-)NCBIUU_Cfam_GSD_1.0
FAH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl749,047,902 - 49,087,783 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1749,047,833 - 49,087,790 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2754,556,153 - 54,596,338 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1263,223,327 - 3,259,367 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl263,223,079 - 3,258,657 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048138,616,632 - 138,652,526 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fah
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249411,039,429 - 1,056,568 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249411,039,389 - 1,056,568 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005316883   ⟹   XP_005316940
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640120,292,223 - 120,326,410 (+)NCBI
SpeTri2.0NW_00493647138,140,324 - 38,174,472 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040275160   ⟹   XP_040131094
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640120,292,303 - 120,326,410 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005316940 (Get FASTA)   NCBI Sequence Viewer  
  XP_040131094 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3262417 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005316940   ⟸   XM_005316883
- Peptide Label: isoform X1
- UniProtKB: I3M3D4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040131094   ⟸   XM_040275160
- Peptide Label: isoform X2
Protein Domains
FAA_hydrolase   FAA_hydrolase_N


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003980 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000003565 ENTREZGENE
  ENSSTOP00000003565.3 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003977.3 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.230 UniProtKB/TrEMBL
  3.90.850.10 UniProtKB/TrEMBL
InterPro Fumarylacetoacetase UniProtKB/TrEMBL
  Fumarylacetoacetase-like_C UniProtKB/TrEMBL
  Fumarylacetoacetase_C_sf UniProtKB/TrEMBL
  Fumarylacetoacetase_N UniProtKB/TrEMBL
  Fumarylacetoacetase_N_sf UniProtKB/TrEMBL
NCBI Gene Fah ENTREZGENE
PANTHER PTHR43069 UniProtKB/TrEMBL
Pfam FAA_hydrolase UniProtKB/TrEMBL
  FAA_hydrolase_N UniProtKB/TrEMBL
Superfamily-SCOP SSF56529 UniProtKB/TrEMBL
  SSF63433 UniProtKB/TrEMBL
TIGRFAMs fum_ac_acetase UniProtKB/TrEMBL
UniProt I3M3D4 ENTREZGENE, UniProtKB/TrEMBL