Rhag (Rh-associated glycoprotein) - Rat Genome Database

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Gene: Rhag (Rh-associated glycoprotein) Rattus norvegicus
Analyze
Symbol: Rhag
Name: Rh-associated glycoprotein
RGD ID: 61871
Description: Predicted to enable ammonium transmembrane transporter activity; ankyrin binding activity; and leak channel activity. Predicted to be involved in several processes, including ammonium homeostasis; ammonium transmembrane transport; and carbon dioxide transport. Predicted to act upstream of or within erythrocyte development and multicellular organismal iron ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Rh deficiency syndrome; hemolytic anemia; and overhydrated hereditary stomatocytosis. Orthologous to human RHAG (Rh associated glycoprotein); INTERACTS WITH ammonium chloride; bisphenol A; cadmium atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ammonium transporter Rh type A; erythrocyte membrane glycoprotein Rh50; glycoprotein 50kD; LOC100361616; rh family type A glycoprotein; rh type A glycoprotein; Rh50; rhesus blood group family type A glycoprotein; Rhesus blood group-associated A glycoprotein; Rhesus blood group-associated A glycoprotein-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2920,069,800 - 20,097,836 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl920,069,807 - 20,097,836 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx928,641,038 - 28,669,067 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0933,715,588 - 33,743,623 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0932,026,353 - 32,054,431 (-)NCBIRnor_WKY
Rnor_6.0923,465,190 - 23,493,081 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl923,465,197 - 23,493,081 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0922,323,155 - 22,351,046 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4915,940,864 - 15,968,319 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1916,206,790 - 16,234,831 (-)NCBI
Celera917,746,824 - 17,774,869 (-)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cellular_component  (ND)
membrane  (IEA,ISO,ISS)
plasma membrane  (IBA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Molecular basis for Rh(null) syndrome: identification of three new missense mutations in the Rh50 glycoprotein gene. Huang CH, etal., Am J Hematol. 1999 Sep;62(1):25-32.
4. Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene. Kitano T, etal., Biochem Biophys Res Commun 1998 Aug 10;249(1):78-85.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:11062476   PMID:12719424   PMID:15856280   PMID:15929723   PMID:16227429   PMID:16574458   PMID:16580865   PMID:16866382   PMID:17712059   PMID:18931342   PMID:19273840   PMID:19807729  
PMID:22012326  


Genomics

Comparative Map Data
Rhag
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2920,069,800 - 20,097,836 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl920,069,807 - 20,097,836 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx928,641,038 - 28,669,067 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0933,715,588 - 33,743,623 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0932,026,353 - 32,054,431 (-)NCBIRnor_WKY
Rnor_6.0923,465,190 - 23,493,081 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl923,465,197 - 23,493,081 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0922,323,155 - 22,351,046 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4915,940,864 - 15,968,319 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1916,206,790 - 16,234,831 (-)NCBI
Celera917,746,824 - 17,774,869 (-)NCBICelera
Cytogenetic Map9q13NCBI
RHAG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38649,605,175 - 49,636,839 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl649,605,175 - 49,636,839 (-)EnsemblGRCh38hg38GRCh38
GRCh37649,572,888 - 49,604,552 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36649,680,847 - 49,712,546 (-)NCBINCBI36Build 36hg18NCBI36
Build 34649,680,850 - 49,712,511NCBI
Celera651,129,020 - 51,160,725 (-)NCBICelera
Cytogenetic Map6p12.3ENTREZGENE
HuRef649,302,584 - 49,334,437 (-)NCBIHuRef
CHM1_1649,575,821 - 49,607,510 (-)NCBICHM1_1
T2T-CHM13v2.0649,447,195 - 49,478,851 (-)NCBIT2T-CHM13v2.0
Rhag
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391741,121,990 - 41,154,985 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1741,122,017 - 41,151,645 (+)EnsemblGRCm39 Ensembl
GRCm381740,811,099 - 40,844,094 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1740,811,126 - 40,840,754 (+)EnsemblGRCm38mm10GRCm38
MGSCv371740,948,098 - 40,977,703 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361740,274,633 - 40,304,238 (+)NCBIMGSCv36mm8
Celera1744,216,540 - 44,246,099 (+)NCBICelera
Cytogenetic Map17B2NCBI
cM Map1719.54NCBI
Rhag
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554118,335,230 - 8,353,465 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554118,335,223 - 8,354,430 (+)NCBIChiLan1.0ChiLan1.0
RHAG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1650,436,504 - 50,468,203 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl650,436,307 - 50,468,250 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0649,174,973 - 49,206,667 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
RHAG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11217,433,660 - 17,454,323 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1217,433,670 - 17,454,311 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1217,333,447 - 17,354,099 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01217,929,429 - 17,950,114 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1217,929,439 - 17,950,091 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11217,449,489 - 17,469,874 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01217,554,969 - 17,575,628 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01217,684,421 - 17,705,041 (-)NCBIUU_Cfam_GSD_1.0
Rhag
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494652,851,930 - 52,885,730 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647611,081,652 - 11,107,211 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647611,081,631 - 11,106,636 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHAG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl743,703,876 - 43,729,995 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1743,704,152 - 43,730,944 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2750,018,284 - 50,044,481 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHAG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11722,779,382 - 22,809,771 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1722,779,751 - 22,809,192 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604449,565,602 - 49,600,316 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rhag
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479914,446,288 - 14,467,106 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479914,445,270 - 14,467,161 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rhag
261 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:65
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000072144
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat

Markers in Region
RH129212  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2920,069,835 - 20,070,043 (+)MAPPERmRatBN7.2
Rnor_6.0923,465,226 - 23,465,433NCBIRnor6.0
Rnor_5.0922,323,191 - 22,323,398UniSTSRnor5.0
RGSC_v3.4916,209,503 - 16,209,710UniSTSRGSC3.4
RGSC_v3.4915,940,900 - 15,941,107UniSTSRGSC3.4
Celera917,746,860 - 17,747,067UniSTS
Cytogenetic Map9q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 14 24 24 10 24 6 7
Low 6 4 3 2 3 23 12 11 7
Below cutoff 1 20 24 11 6 11 8 8 20 8 14 4 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000072144   ⟹   ENSRNOP00000065437
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl920,069,807 - 20,097,836 (-)Ensembl
Rnor_6.0 Ensembl923,465,197 - 23,493,081 (-)Ensembl
RefSeq Acc Id: NM_023022   ⟹   NP_075411
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2920,069,800 - 20,097,836 (-)NCBI
Rnor_6.0923,465,190 - 23,493,081 (-)NCBI
Rnor_5.0922,323,155 - 22,351,046 (-)NCBI
RGSC_v3.4915,940,864 - 15,968,319 (-)RGD
Celera917,746,824 - 17,774,869 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_075411 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ10014 (Get FASTA)   NCBI Sequence Viewer  
  BAA32443 (Get FASTA)   NCBI Sequence Viewer  
  EDM18672 (Get FASTA)   NCBI Sequence Viewer  
  Q7TNK7 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_075411   ⟸   NM_023022
- Peptide Label: precursor
- UniProtKB: O88300 (UniProtKB/Swiss-Prot),   Q7TNK7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065437   ⟸   ENSRNOT00000072144
Protein Domains
Ammonium_transp

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TNK7-F1-model_v2 AlphaFold Q7TNK7 1-450 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61871 AgrOrtholog
BioCyc Gene G2FUF-28081 BioCyc
Ensembl Genes ENSRNOG00000050121 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000065437 ENTREZGENE
  ENSRNOP00000065437.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072144 ENTREZGENE
  ENSRNOT00000072144.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.3430.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ammonium/urea_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NH4_transpt_AmtB-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhesusRHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65207 UniProtKB/Swiss-Prot
NCBI Gene 65207 ENTREZGENE
Pfam Ammonium_transp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rhag PhenoGen
PRINTS RHESUSRHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC221198
UniProt G3V9I8_RAT UniProtKB/TrEMBL
  O88300 ENTREZGENE
  Q7TNK7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O88300 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-17 Rhag  Rh-associated glycoprotein  LOC100361616  Rhesus blood group-associated A glycoprotein-like  Data Merged 737654 PROVISIONAL
2010-05-05 LOC100361616  Rhesus blood group-associated A glycoprotein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-09 Rhag  Rh-associated glycoprotein  Rhag  Rhesus blood group-associated A glycoprotein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Rhag  Rhesus blood group-associated A glycoprotein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_evolution evolving two times more slowly than Rh blood group antigens; predicted to be a product of Rh gene duplication 200-300 million years ago; evolution may be result of Darwinian selection 61731