Rad51ap2 (RAD51 associated protein 2) - Rat Genome Database

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Gene: Rad51ap2 (RAD51 associated protein 2) Rattus norvegicus
Analyze
Symbol: Rad51ap2
Name: RAD51 associated protein 2
RGD ID: 2322652
Description: Predicted to be part of protein-containing complex. Orthologous to human RAD51AP2 (RAD51 associated protein 2); INTERACTS WITH paracetamol; trichloroethene; 2-hydroxypropanoic acid (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100360197; RAD51-associated protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8639,901,251 - 39,908,203 (+)NCBIGRCr8
mRatBN7.2634,182,177 - 34,189,129 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl634,182,201 - 34,189,041 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx634,477,030 - 34,483,976 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0634,792,971 - 34,799,917 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0634,265,275 - 34,272,234 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0637,144,747 - 37,151,642 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl637,144,787 - 37,151,468 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0646,895,029 - 46,901,844 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4634,917,939 - 34,924,620 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera633,580,165 - 33,586,989 (+)NCBICelera
Cytogenetic Map6q15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:16990250  


Genomics

Comparative Map Data
Rad51ap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8639,901,251 - 39,908,203 (+)NCBIGRCr8
mRatBN7.2634,182,177 - 34,189,129 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl634,182,201 - 34,189,041 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx634,477,030 - 34,483,976 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0634,792,971 - 34,799,917 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0634,265,275 - 34,272,234 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0637,144,747 - 37,151,642 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl637,144,787 - 37,151,468 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0646,895,029 - 46,901,844 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4634,917,939 - 34,924,620 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera633,580,165 - 33,586,989 (+)NCBICelera
Cytogenetic Map6q15NCBI
RAD51AP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38217,510,579 - 17,537,859 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl217,510,579 - 17,518,440 (-)EnsemblGRCh38hg38GRCh38
GRCh37217,691,846 - 17,711,681 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36217,555,467 - 17,563,187 (-)NCBINCBI36Build 36hg18NCBI36
Celera217,571,800 - 17,579,522 (-)NCBICelera
Cytogenetic Map2p24.2NCBI
HuRef217,467,067 - 17,474,789 (-)NCBIHuRef
CHM1_1217,621,382 - 17,629,106 (-)NCBICHM1_1
T2T-CHM13v2.0217,542,340 - 17,569,626 (-)NCBIT2T-CHM13v2.0
Rad51ap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391211,506,024 - 11,513,154 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1211,506,080 - 11,512,929 (+)EnsemblGRCm39 Ensembl
GRCm381211,456,023 - 11,463,153 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1211,456,079 - 11,462,928 (+)EnsemblGRCm38mm10GRCm38
MGSCv371211,462,885 - 11,469,734 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361211,484,348 - 11,489,271 (+)NCBIMGSCv36mm8
Celera1211,804,142 - 11,810,990 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map125.58NCBI
Rad51ap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955469312,601 - 320,227 (-)NCBIChiLan1.0ChiLan1.0
RAD51AP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212108,988,264 - 109,016,049 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A108,992,230 - 109,019,598 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A17,495,213 - 17,505,411 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A17,621,863 - 17,629,471 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A17,621,874 - 17,629,471 (-)Ensemblpanpan1.1panPan2
RAD51AP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11712,991,562 - 12,998,975 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1712,991,746 - 12,998,945 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1712,943,494 - 12,951,120 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01713,127,543 - 13,135,164 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1713,127,728 - 13,136,088 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11712,986,247 - 12,993,879 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01712,997,378 - 13,005,006 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01713,023,398 - 13,031,026 (-)NCBIUU_Cfam_GSD_1.0
Rad51ap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629257,451,355 - 57,456,035 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493649313,383,563 - 13,387,979 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAD51AP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3120,318,249 - 120,327,406 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13120,318,238 - 120,327,050 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23128,466,321 - 128,474,910 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAD51AP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11490,148,178 - 90,156,429 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1490,148,383 - 90,156,206 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604522,057,235 - 22,065,403 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rad51ap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624738473,782 - 480,663 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rad51ap2
35 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:25
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000075503
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 2 20 68 41 35 14 24 14 4 116 60 50 35 57 21

Sequence


Ensembl Acc Id: ENSRNOT00000075503   ⟹   ENSRNOP00000065456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl634,182,201 - 34,189,041 (+)Ensembl
Rnor_6.0 Ensembl637,144,787 - 37,151,468 (+)Ensembl
RefSeq Acc Id: NM_001399054   ⟹   NP_001385983
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8639,901,251 - 39,908,203 (+)NCBI
mRatBN7.2634,182,177 - 34,189,129 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001385983 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03105 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065456.2
Ensembl Acc Id: ENSRNOP00000065456   ⟸   ENSRNOT00000075503
RefSeq Acc Id: NP_001385983   ⟸   NM_001399054
- UniProtKB: A6HAQ0 (UniProtKB/TrEMBL),   M0R7M4 (UniProtKB/TrEMBL)
Protein Domains
RAD51 interacting motif

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R7M4-F1-model_v2 AlphaFold M0R7M4 1-973 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2322652 AgrOrtholog
BioCyc Gene G2FUF-38140 BioCyc
Ensembl Genes ENSRNOG00000049271 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075503.2 UniProtKB/TrEMBL
InterPro RAD51-associated UniProtKB/TrEMBL
  RAD51_interact UniProtKB/TrEMBL
NCBI Gene 100360197 ENTREZGENE
PANTHER MCG1037962 UniProtKB/TrEMBL
  RAD51-ASSOCIATED PROTEIN 2 UniProtKB/TrEMBL
Pfam RAD51_interact UniProtKB/TrEMBL
PhenoGen Rad51ap2 PhenoGen
RatGTEx ENSRNOG00000049271 RatGTEx
UniProt A6HAQ0 ENTREZGENE, UniProtKB/TrEMBL
  M0R7M4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-31 Rad51ap2  RAD51 associated protein 2  LOC100360197  RAD51 associated protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100360197  RAD51 associated protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL