Fam83g (family with sequence similarity 83, member G) - Rat Genome Database

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Gene: Fam83g (family with sequence similarity 83, member G) Rattus norvegicus
Analyze
Symbol: Fam83g
Name: family with sequence similarity 83, member G
RGD ID: 2322345
Description: Predicted to enable protein kinase binding activity. Predicted to be involved in BMP signaling pathway. Predicted to be active in cytosol and nucleus. Orthologous to human FAM83G (family with sequence similarity 83 member G); INTERACTS WITH (+)-schisandrin B; 3-chloropropane-1,2-diol; endosulfan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC100360307; LOC100360307
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,862,983 - 46,887,499 (+)NCBIGRCr8
mRatBN7.21046,363,029 - 46,388,030 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1046,363,051 - 46,388,019 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01047,960,735 - 47,984,083 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,961,056 - 47,983,724 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01047,753,880 - 47,777,098 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,842,945 - 47,865,224 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1045,611,073 - 45,634,421 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam83gRatautistic disorder  ISORGD:16068508554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106|PMID:30208311
Fam83gRatcommon variable immunodeficiency 2  ISORGD:16068508554872ClinVar Annotator: match by term: Immunodeficiency, common variable, 2ClinVarPMID:28492532
Fam83gRatJoubert syndrome 1  ISORGD:16068508554872ClinVar Annotator: match by term: Familial aplasia of the vermisClinVarPMID:28492532
Fam83gRatMeckel Syndrome 9  ISORGD:16068508554872ClinVar Annotator: match by term: Meckel syndrome, type 9ClinVarPMID:21493627
Fam83gRatPotocki-Lupski syndrome  ISORGD:16068508554872ClinVar Annotator: match by term: Potocki-Lupski syndromeClinVarPMID:28837307
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam83gRatpalmoplantar keratosis  ISORGD:120952889068941Hyperkeratosis, palmoplantar, FAM83G-relatedOMIAPMID:10701186|PMID:12828257|PMID:24832243|PMID:26747202|PMID:29963719|PMID:34796560|PMID:37582787

1 to 20 of 50 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam83gRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of FAM83G mRNA]CTDPMID:31150632
Fam83gRat(-)-epigallocatechin 3-gallate increases expressionISORGD:16068506480464epigallocatechin gallate results in increased expression of FAM83G proteinCTDPMID:31195006
Fam83gRat17beta-estradiol increases expressionISORGD:16068506480464Estradiol results in increased expression of FAM83G mRNACTDPMID:23019147|PMID:31614463
Fam83gRat3-chloropropane-1,2-diol increases expressionEXP 6480464alpha-Chlorohydrin results in increased expression of FAM83G mRNACTDPMID:28522335
Fam83gRat4,4'-sulfonyldiphenol affects methylationISORGD:16183486480464bisphenol S affects the methylation of FAM83G exonCTDPMID:33297965
Fam83gRataflatoxin B1 decreases methylationISORGD:16068506480464Aflatoxin B1 results in decreased methylation of FAM83G polyA tailCTDPMID:30157460
Fam83gRataflatoxin B1 increases methylationISORGD:16068506480464Aflatoxin B1 results in increased methylation of FAM83G intron; Aflatoxin B1 results in increased methylation more ...CTDPMID:30157460
Fam83gRataristolochic acid A increases expressionISORGD:16068506480464aristolochic acid I results in increased expression of FAM83G mRNACTDPMID:33212167
Fam83gRatarsane multiple interactionsISORGD:16068506480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...CTDPMID:39836092
Fam83gRatarsenic atom multiple interactionsISORGD:16068506480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...CTDPMID:39836092
Fam83gRatbenzo[a]pyrene increases methylationISORGD:16183486480464Benzo(a)pyrene results in increased methylation of FAM83G exonCTDPMID:27901495
Fam83gRatbenzo[e]pyrene decreases methylationISORGD:16068506480464benzo(e)pyrene results in decreased methylation of FAM83G polyA tailCTDPMID:30157460
Fam83gRatbisphenol A affects expressionISORGD:16068506480464bisphenol A affects the expression of FAM83G mRNACTDPMID:30903817
Fam83gRatbisphenol A increases expressionISORGD:16183486480464bisphenol A results in increased expression of FAM83G mRNACTDPMID:37894381
Fam83gRatcadmium dichloride increases expressionISORGD:16068506480464Cadmium Chloride results in increased expression of FAM83G mRNACTDPMID:38568856
Fam83gRatcaffeine increases phosphorylationISORGD:16068506480464Caffeine results in increased phosphorylation of FAM83G proteinCTDPMID:35688186
Fam83gRatchlordecone decreases expressionISORGD:16183486480464Chlordecone results in decreased expression of FAM83G mRNACTDPMID:33711761
Fam83gRatcisplatin decreases expressionISORGD:16068506480464Cisplatin results in decreased expression of FAM83G mRNACTDPMID:27392435
Fam83gRatcopper(II) chloride increases expressionISORGD:16068506480464cupric chloride results in increased expression of FAM83G mRNACTDPMID:38568856
Fam83gRatDibutyl phosphate affects expressionISORGD:16068506480464di-n-butylphosphoric acid affects the expression of FAM83G mRNACTDPMID:37042841

1 to 20 of 50 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam83gRatBMP signaling pathway involved_inISORGD:16068501624291 PMID:24554596RGDPMID:24554596
Fam83gRatBMP signaling pathway involved_inIBAPANTHER:PTN000415270|UniProtKB:A6ND361600115GO_REF:0000033GO_CentralGO_REF:0000033
Fam83gRatBMP signaling pathway involved_inIEAUniProtKB:A6ND36|ensembl:ENSP000003736471600115GO_REF:0000107EnsemblGO_REF:0000107

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam83gRatcytosol located_inISORGD:16068501624291 PMID:24554596RGDPMID:24554596
Fam83gRatcytosol located_inIEAUniProtKB:A6ND36|ensembl:ENSP000003736471600115GO_REF:0000107EnsemblGO_REF:0000107
Fam83gRatcytosol is_active_inIBAPANTHER:PTN000415270|UniProtKB:A6ND361600115GO_REF:0000033GO_CentralGO_REF:0000033
Fam83gRatcytosol located_inISORGD:1606850|UniProtKB:A6ND36-11624291 RGDGO_REF:0000052
Fam83gRatnucleus located_inIEAUniProtKB:A6ND36|ensembl:ENSP000003736471600115GO_REF:0000107EnsemblGO_REF:0000107
Fam83gRatnucleus is_active_inIBAPANTHER:PTN000415270|UniProtKB:A6ND361600115GO_REF:0000033GO_CentralGO_REF:0000033
Fam83gRatnucleus located_inISORGD:16068501624291 PMID:24554596RGDPMID:24554596

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam83gRatprotein binding enablesISORGD:16068501624291UniProtKB:P48729|UniProtKB:Q15797 PMID:23455922, PMID:24554596, PMID:29789297, PMID:32707033, PMID:33961781, PMID:35271311RGDPMID:23455922|PMID:24554596|PMID:29789297|PMID:32707033|PMID:33961781|PMID:35271311
Fam83gRatprotein kinase binding enablesIBAPANTHER:PTN008563846|UniProtKB:Q2M2I3|UniProtKB:Q5T0W9|UniProtKB:Q6ZRV2|UniProtKB:Q86UY5|UniProtKB:Q9BQN1|UniProtKB:Q9H4H81600115GO_REF:0000033GO_CentralGO_REF:0000033


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:24554596  



Fam83g
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,862,983 - 46,887,499 (+)NCBIGRCr8
mRatBN7.21046,363,029 - 46,388,030 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1046,363,051 - 46,388,019 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01047,960,735 - 47,984,083 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,961,056 - 47,983,724 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01047,753,880 - 47,777,098 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,842,945 - 47,865,224 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1045,611,073 - 45,634,421 (+)NCBICelera
Cytogenetic Map10q22NCBI
FAM83G
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381718,968,789 - 19,006,116 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1718,968,789 - 19,004,764 (-)EnsemblGRCh38hg38GRCh38
GRCh371718,872,102 - 18,908,077 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361718,815,106 - 18,848,785 (-)NCBINCBI36Build 36hg18NCBI36
Celera1720,788,727 - 20,822,409 (-)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1718,440,295 - 18,473,977 (-)NCBIHuRef
CHM1_11718,883,155 - 18,916,846 (-)NCBICHM1_1
T2T-CHM13v2.01718,915,280 - 18,952,622 (-)NCBIT2T-CHM13v2.0
Fam83g
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,574,908 - 61,600,776 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1161,574,917 - 61,600,777 (+)EnsemblGRCm39 Ensembl
GRCm381161,684,058 - 61,709,950 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,684,091 - 61,709,951 (+)EnsemblGRCm38mm10GRCm38
MGSCv371161,497,912 - 61,523,452 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361161,500,659 - 61,524,350 (+)NCBIMGSCv36mm8
MGSCv361162,113,529 - 62,137,220 (+)NCBIMGSCv36mm8
Cytogenetic Map11B2NCBI
cM Map1137.96NCBI
Fam83g
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955467595,490 - 623,566 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955467594,921 - 623,661 (+)NCBIChiLan1.0ChiLan1.0
FAM83G
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21954,039,865 - 54,075,872 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11758,662,089 - 58,698,044 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01732,237,065 - 32,273,015 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11737,169,737 - 37,204,872 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1737,169,509 - 37,204,872 (+)Ensemblpanpan1.1panPan2
FAM83G
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,054,805 - 41,085,156 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl541,055,311 - 41,084,739 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha541,195,906 - 41,226,265 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0541,162,218 - 41,192,723 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl541,162,225 - 41,192,722 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1541,130,171 - 41,160,525 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0541,077,227 - 41,107,591 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0541,269,380 - 41,299,741 (+)NCBIUU_Cfam_GSD_1.0
Fam83g
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560259,933,849 - 59,964,279 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936881622,966 - 653,421 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936881623,048 - 651,065 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM83G
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,296,820 - 60,322,650 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,296,749 - 60,322,653 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21262,944,510 - 62,958,873 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FAM83G
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11617,671,458 - 17,703,538 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1617,668,751 - 17,702,726 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660593,171,460 - 3,205,884 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam83g
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248495,398,579 - 5,428,309 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248495,396,223 - 5,428,272 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Fam83g
51 total Variants

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:98
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000027312
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 66 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat

1 to 10 of 66 rows
BI289660  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21046,387,767 - 46,387,982 (+)MAPPERmRatBN7.2
Rnor_6.01047,985,487 - 47,985,701NCBIRnor6.0
Rnor_5.01047,778,629 - 47,778,843UniSTSRnor5.0
RGSC_v3.41047,867,185 - 47,867,399UniSTSRGSC3.4
Celera1045,635,825 - 45,636,039UniSTS
RH 3.4 Map10530.17UniSTS
Cytogenetic Map10q23UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 38 103 56 55 24 25 24 6 171 86 83 45 60 31



Ensembl Acc Id: ENSRNOT00000027312   ⟹   ENSRNOP00000027312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1046,363,051 - 46,388,019 (+)Ensembl
Rnor_6.0 Ensembl1047,961,056 - 47,983,724 (+)Ensembl
RefSeq Acc Id: XM_039087606   ⟹   XP_038943534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,862,983 - 46,887,499 (+)NCBI
mRatBN7.21046,363,029 - 46,388,030 (+)NCBI
Protein RefSeqs NP_001417231 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943534 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027312
  ENSRNOP00000027312.3
Ensembl Acc Id: ENSRNOP00000027312   ⟸   ENSRNOT00000027312
RefSeq Acc Id: XP_038943534   ⟸   XM_039087606
Scaffolding anchor of CK1

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZN30-F1-model_v2 AlphaFold D3ZN30 1-814 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 15 of 15 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-24790 BioCyc
Ensembl Genes ENSRNOG00000027924 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027312 ENTREZGENE
  ENSRNOT00000027312.5 UniProtKB/TrEMBL
Gene3D-CATH Endonuclease Chain A UniProtKB/TrEMBL
InterPro DUF1669 UniProtKB/TrEMBL
  FAM83 UniProtKB/TrEMBL
NCBI Gene 100360307 ENTREZGENE
PANTHER PROTEIN FAM83A-RELATED UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam DUF1669 UniProtKB/TrEMBL
PhenoGen Fam83g PhenoGen
RatGTEx ENSRNOG00000027924 RatGTEx
Superfamily-SCOP Phospholipase D/nuclease UniProtKB/TrEMBL
UniProt D3ZN30 ENTREZGENE, UniProtKB/TrEMBL
1 to 15 of 15 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-06 Fam83g  family with sequence similarity 83, member G  LOC100360307  hypothetical protein LOC100360307  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100360307  hypothetical protein LOC100360307      Symbol and Name status set to provisional 70820 PROVISIONAL