MIR708 (microRNA 708) - Rat Genome Database

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Gene: MIR708 (microRNA 708) Homo sapiens
Analyze
Symbol: MIR708
Name: microRNA 708
RGD ID: 2290222
HGNC Page HGNC:33654
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in negative regulation of gene expression and regulation of pattern recognition receptor signaling pathway. Predicted to be part of RISC complex.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-708; MIRN708
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381179,402,022 - 79,402,109 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1179,402,022 - 79,402,109 (-)EnsemblGRCh38hg38GRCh38
GRCh371179,113,066 - 79,113,153 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361178,790,713 - 78,790,800 (-)NCBINCBI36Build 36hg18NCBI36
Celera1176,422,187 - 76,422,274 (-)NCBICelera
Cytogenetic Map11q14.1NCBI
HuRef1175,409,416 - 75,409,503 (-)NCBIHuRef
CHM1_11178,995,903 - 78,995,990 (-)NCBICHM1_1
T2T-CHM13v2.01179,336,291 - 79,336,378 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR708HumanAlzheimer's disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25992776
MIR708HumanExperimental Liver Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21035526
MIR708HumanNeoplasm Invasiveness  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:34652879

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR708Human2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of MIR708 mRNACTDPMID:30096437
MIR708Human3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOMir708 (Mus musculus)6480464[2-ethylhexyldiphenylphosphate co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MIR708 mRNACTDPMID:36764644
MIR708Humanaflatoxin B1 multiple interactionsEXP 6480464[CYP2A13 protein co-treated with Aflatoxin B1] results in decreased expression of MIR708 mRNACTDPMID:26084420
MIR708Humanall-trans-retinoic acid multiple interactionsEXP 6480464[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3 and 3-bis(2-aminoethyl)-1-triazene] results in decreased expression of MIR708 mRNACTDPMID:23284745
MIR708Humanarsenite(3-) multiple interactionsISOMir708 (Rattus norvegicus)6480464[sodium arsenite results in increased abundance of arsenite] which results in decreased expression of MIR708 mRNA and [sodium arsenite results in increased abundance of arsenite] which results in increased expression of MIR708 mRNACTDPMID:31555879
MIR708Humanatrazine increases expressionISOMir708 (Rattus norvegicus)6480464Atrazine results in increased expression of MIR708 mRNACTDPMID:36841081
MIR708Humanbenzo[a]pyrene increases methylationEXP 6480464Benzo(a)pyrene results in increased methylation of MIR708 promoterCTDPMID:27901495
MIR708Humanbis(2-chloroethyl) sulfide decreases expressionISOMir708 (Mus musculus)6480464Mustard Gas results in decreased expression of MIR708 mRNACTDPMID:26456178
MIR708Humanbis(2-ethylhexyl) phthalate increases expressionISOMir708 (Mus musculus)6480464Diethylhexyl Phthalate results in increased expression of MIR708CTDPMID:31920986
MIR708Humanbis(2-ethylhexyl) phthalate multiple interactionsISOMir708 (Mus musculus)6480464[ovalbumin-alum co-treated with Diethylhexyl Phthalate] results in decreased expression of MIR708CTDPMID:36508822
MIR708Humancadmium dichloride increases expressionISOMir708 (Mus musculus)6480464Cadmium Chloride results in increased expression of MIR708 mRNACTDPMID:35183672
MIR708Humancarbon atom increases expressionEXP 6480464Carbon results in increased expression of MIR708 mRNACTDPMID:26068961
MIR708Humancholine multiple interactionsISOMir708 (Mus musculus)6480464[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MIR708 mRNACTDPMID:20548288
MIR708Humancisplatin increases expressionISOMir708 (Rattus norvegicus)6480464Cisplatin results in increased expression of MIR708 mRNACTDPMID:24880025
MIR708Humancisplatin increases expressionISOMir708 (Mus musculus)6480464Cisplatin results in increased expression of MIR708 mRNACTDPMID:28119452
MIR708Humandexamethasone multiple interactionsISOMir708 (Mus musculus)6480464[2-ethylhexyldiphenylphosphate co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MIR708 mRNACTDPMID:36764644
MIR708Humandexamethasone increases expressionISOMir708 (Rattus norvegicus)6480464Dexamethasone results in increased expression of MIR708 mRNACTDPMID:33619658
MIR708Humandoxorubicin increases expressionEXP 6480464Doxorubicin results in increased expression of MIR708 mRNACTDPMID:26842497
MIR708Humanelemental carbon increases expressionEXP 6480464Carbon results in increased expression of MIR708 mRNACTDPMID:26068961
MIR708Humanfolic acid multiple interactionsISOMir708 (Mus musculus)6480464[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MIR708 mRNACTDPMID:20548288

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Biological Process
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR708Humancellular response to amino acid stimulus acts_upstream_of_or_withinISOMir708 (Mus musculus)9068941 PMID:20548288MGIPMID:20548288
MIR708Humancellular response to estrogen stimulus acts_upstream_of_or_withinISOMir708 (Mus musculus)9068941 PMID:18791161MGIPMID:18791161
MIR708HumanmiRNA-mediated gene silencing by mRNA destabilization involved_inIDA 150520179 PMID:26932538BHF-UCLPMID:26932538
MIR708HumanmiRNA-mediated post-transcriptional gene silencing involved_inIEARfam:RF00655 and Rfam:RF00917150520179 RNAcentralGO_REF:0000115
MIR708HumanmiRNA-mediated post-transcriptional gene silencing involved_inIDA 150520179 PMID:31599428ARUK-UCLPMID:31599428
MIR708Humannegative regulation of gene expression involved_inIDA 150520179 PMID:31599428ARUK-UCLPMID:31599428
MIR708Humannegative regulation of interleukin-1 beta production acts_upstream_ofIMP 150520179 PMID:31599428ARUK-UCLPMID:31599428
MIR708Humannegative regulation of interleukin-6 production acts_upstream_ofIMP 150520179 PMID:31599428ARUK-UCLPMID:31599428
MIR708Humannegative regulation of toll-like receptor 4 signaling pathway involved_inIMP 150520179 PMID:31599428ARUK-UCLPMID:31599428
MIR708Humannegative regulation of tumor necrosis factor production acts_upstream_ofIMP 150520179 PMID:31599428ARUK-UCLPMID:31599428
MIR708Humannegative regulation of type II interferon production involved_inIMP 150520179 PMID:31599428ARUK-UCLPMID:31599428
MIR708Humanregulation of cytoplasmic pattern recognition receptor signaling pathway involved_inIDA 150520179 PMID:31599428ARUK-UCLPMID:31599428
1 to 12 of 12 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR708HumanRISC complex part_ofISOMir708 (Mus musculus)9068941 PMID:23185045MGIPMID:23185045

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR708HumanmRNA 3'-UTR binding enablesIDA 150520179 PMID:31599428ARUK-UCLPMID:31599428
MIR708HumanmRNA base-pairing translational repressor activity enablesIDA 150520179 PMID:26932538 and PMID:31599428ARUK-UCLPMID:26932538 and PMID:31599428


#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:16381832   PMID:17604727   PMID:17616659   PMID:21852381   PMID:22552290   PMID:22573352   PMID:22723308   PMID:23328481   PMID:23568547   PMID:23754151   PMID:25175907   PMID:25569036  
PMID:25704289   PMID:26211597   PMID:26678031   PMID:26833707   PMID:26870998   PMID:26932538   PMID:26998837   PMID:27092874   PMID:27864917   PMID:28647289   PMID:28685895   PMID:28963640  
PMID:28972040   PMID:29128627   PMID:29575368   PMID:29703249   PMID:30003745   PMID:30229816   PMID:30322266   PMID:30470587   PMID:30679387   PMID:30683474   PMID:30726934   PMID:31171769  
PMID:31273952   PMID:31468594   PMID:31599428   PMID:31768018   PMID:31894343   PMID:31962101   PMID:32463570   PMID:32535381   PMID:32721464   PMID:33322976   PMID:34426596   PMID:34581937  
PMID:36444911   PMID:36553642   PMID:37083947   PMID:37224029   PMID:38036217  



MIR708
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381179,402,022 - 79,402,109 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1179,402,022 - 79,402,109 (-)EnsemblGRCh38hg38GRCh38
GRCh371179,113,066 - 79,113,153 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361178,790,713 - 78,790,800 (-)NCBINCBI36Build 36hg18NCBI36
Celera1176,422,187 - 76,422,274 (-)NCBICelera
Cytogenetic Map11q14.1NCBI
HuRef1175,409,416 - 75,409,503 (-)NCBIHuRef
CHM1_11178,995,903 - 78,995,990 (-)NCBICHM1_1
T2T-CHM13v2.01179,336,291 - 79,336,378 (-)NCBIT2T-CHM13v2.0
Mir708
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39795,898,631 - 95,898,739 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl795,898,631 - 95,898,739 (+)EnsemblGRCm39 Ensembl
GRCm38796,249,424 - 96,249,532 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl796,249,424 - 96,249,532 (+)EnsemblGRCm38mm10GRCm38
MGSCv377103,397,934 - 103,398,042 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Cytogenetic Map7E1NCBI
cM Map752.54NCBI
Mir708
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81160,011,158 - 160,011,245 (+)NCBIGRCr8
mRatBN7.21150,599,876 - 150,599,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1150,599,876 - 150,599,963 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1158,583,701 - 158,583,788 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01165,763,871 - 165,763,958 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01158,637,325 - 158,637,412 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01161,221,246 - 161,221,333 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1161,221,246 - 161,221,333 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01167,436,243 - 167,436,330 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1148,707,350 - 148,707,437 (+)NCBICelera
Cytogenetic Map1q32NCBI
MIR708
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12119,542,577 - 19,542,645 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2119,542,577 - 19,542,645 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2119,437,542 - 19,437,610 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02119,738,865 - 19,738,933 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2119,738,865 - 19,738,933 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12119,524,078 - 19,524,146 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02119,737,931 - 19,737,999 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02119,661,690 - 19,661,758 (+)NCBIUU_Cfam_GSD_1.0
MIR708
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl913,780,171 - 13,780,250 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1913,780,171 - 13,780,250 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2915,120,477 - 15,120,556 (-)NCBISscrofa10.2Sscrofa10.2susScr3

.

1 to 5 of 5 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 11q13.5-22.1(chr11:75941754-98357960)x1 copy number loss See cases [RCV000133838] Chr11:75941754..98357960 [GRCh38]
Chr11:75652798..98228688 [GRCh37]
Chr11:75330446..97733898 [NCBI36]
Chr11:11q13.5-22.1		 pathogenic
GRCh38/hg38 11q14.1(chr11:79187266-81105711)x3 copy number gain See cases [RCV000051930] Chr11:79187266..81105711 [GRCh38]
Chr11:78898311..80816754 [GRCh37]
Chr11:78575959..80494402 [NCBI36]
Chr11:11q14.1		 uncertain significance
GRCh38/hg38 11q13.4-14.1(chr11:71923251-79662025)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|See cases [RCV000052684] Chr11:71923251..79662025 [GRCh38]
Chr11:71634297..79373069 [GRCh37]
Chr11:71311945..79050717 [NCBI36]
Chr11:11q13.4-14.1		 pathogenic
GRCh38/hg38 11q14.1-22.3(chr11:78232836-106779420)x1 copy number loss See cases [RCV000052710] Chr11:78232836..106779420 [GRCh38]
Chr11:77943882..106650146 [GRCh37]
Chr11:77621530..106155356 [NCBI36]
Chr11:11q14.1-22.3		 pathogenic
GRCh38/hg38 11q14.1-14.2(chr11:78362208-86165380)x3 copy number gain See cases [RCV000053637] Chr11:78362208..86165380 [GRCh38]
Chr11:78073254..85876422 [GRCh37]
Chr11:77750902..85554070 [NCBI36]
Chr11:11q14.1-14.2		 pathogenic
1 to 5 of 5 rows

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
AKT2hsa-miR-708-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI22552290
TMEM88hsa-miR-708-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI22573352
RANBP2hsa-miR-708-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
TMEM88hsa-miR-708-5pOncomiRDBexternal_infoNANA22573352
CD44hsa-miR-708-5pOncomiRDBexternal_infoNANA22552290
TEX261hsa-miR-708-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20445018
MPLhsa-miR-708-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20445018
BMI1hsa-miR-708-3pMirecordsexternal_infoNANA21852381
BIRC5hsa-miR-708-3pMirecordsexternal_info{changed}NA21852381

Predicted Targets
Summary Value
Count of predictions:37186
Count of gene targets:13739
Count of transcripts:28459
Interacting mature miRNAs:hsa-miR-708-3p, hsa-miR-708-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1357380BW64_HBody weight QTL 64 (human)2.2Body weightpercent fat after exercise training116097893786978937Human




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
32 98 178 86 619 159 251 11 97 10 371 370 295 21 259 144 214 223 6



Ensembl Acc Id: ENST00000390708
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1179,402,022 - 79,402,109 (-)Ensembl
RefSeq Acc Id: NR_030598
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381179,402,022 - 79,402,109 (-)NCBI
GRCh371179,113,066 - 79,113,153 (-)RGD
Celera1176,422,187 - 76,422,274 (-)RGD
HuRef1175,409,416 - 75,409,503 (-)ENTREZGENE
CHM1_11178,995,903 - 78,995,990 (-)NCBI
T2T-CHM13v2.01179,336,291 - 79,336,378 (-)NCBI
Sequence:


1 to 13 of 13 rows
Database
Acc Id
Source(s)
COSMIC MIR708 COSMIC
Ensembl Genes ENSG00000211997 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000390708 ENTREZGENE
GTEx ENSG00000211997 GTEx
HGNC ID HGNC:33654 ENTREZGENE
Human Proteome Map MIR708 Human Proteome Map
miRBase MI0005543 ENTREZGENE
NCBI Gene 100126333 ENTREZGENE
OMIM 620733 OMIM
PharmGKB PA164722969 PharmGKB
RNAcentral URS000019D79B RNACentral
  URS000049EEDF RNACentral
  URS000062A2F0 RNACentral
1 to 13 of 13 rows