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Gene: RANBP2 (RAN binding protein 2) Homo sapiens
Symbol: RANBP2
Name: RAN binding protein 2
Description: Exhibits Ran GTPase binding activity and SUMO transferase activity. Predicted to contribute to GTPase activator activity. Involved in NLS-bearing protein import into nucleus; centrosome localization; and protein sumoylation. Localizes to the annulate lamellae; nuclear envelope; and nuclear inclusion body. Implicated in brain disease and inflammatory myofibroblastic tumor. Biomarker of multiple myeloma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 358 kDa nucleoporin; acute necrotizing encephalopathy 1 (autosomal dominant); ADANE; ANE1; E3 SUMO-protein ligase RanBP2; E3 SUMO-protein transferase RanBP2; IIAE3; nuclear pore complex protein Nup358; nucleoporin 358; nucleoporin Nup358; NUP358; P270; ran-binding protein 2; transformation-related protein 2; TRP1; TRP2
Mus musculus (house mouse) : Ranbp2 (RAN binding protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ranbp2 (RAN binding protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ranbp2 (RAN binding protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : RANBP2 (RAN binding protein 2)
Canis lupus familiaris (dog) : LOC474539 (E3 SUMO-protein ligase RanBP2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101974817 (E3 SUMO-protein ligase RanBP2)
Sus scrofa (pig) : LOC100511376 (E3 SUMO-protein ligase RanBP2)
Chlorocebus sabaeus (green monkey) : RANBP2 (RAN binding protein 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2108,719,482 - 108,785,809 (+)Ensembl
GRCh382108,719,446 - 109,842,301 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372109,335,902 - 109,402,267 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362108,702,369 - 108,768,699 (+)NCBINCBI36hg18NCBI36
Build 342108,794,454 - 108,859,768NCBI
Celera2103,645,916 - 103,712,243 (+)NCBI
Cytogenetic Map2q13NCBI
HuRef2102,934,349 - 103,000,733 (+)NCBIHuRef
CHM1_12109,340,280 - 109,406,595 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on RANBP2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1351414
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.