Glrx5 (glutaredoxin 5) - Rat Genome Database

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Gene: Glrx5 (glutaredoxin 5) Heterocephalus glaber
Analyze
Symbol: Glrx5
Name: glutaredoxin 5
RGD ID: 18928295
Description: ENCODES a protein that exhibits 2 iron, 2 sulfur cluster binding (inferred); iron-sulfur cluster binding (inferred); metal ion binding (inferred); INVOLVED IN [2Fe-2S] cluster assembly (ortholog); protein maturation (ortholog); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; ASSOCIATED WITH autosomal recessive pyridoxine-refractory sideroblastic anemia 2 (ortholog); autosomal recessive pyridoxine-refractory sideroblastic anemia 3 (ortholog); Childhood-Onset Spasticity with Hyperglycinemia (ortholog); FOUND IN dendrite (ortholog); iron-sulfur cluster assembly complex (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glutaredoxin-related protein 5, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247347,987,116 - 7,995,220 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247347,986,999 - 7,995,604 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glrx5Naked Mole-Ratautosomal recessive pyridoxine-refractory sideroblastic anemia 3  ISOGLRX5 (Homo sapiens)8554872ClinVar Annotator: match by term: Sideroblastic anemia 3ClinVarPMID:17485548 more ...
Glrx5Naked Mole-RatChildhood-Onset Spasticity with Hyperglycinemia  ISOGLRX5 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:24334290 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glrx5Naked Mole-Ratautosomal recessive pyridoxine-refractory sideroblastic anemia 2  ISOGLRX5 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTD 
Glrx5Naked Mole-Ratsideroblastic anemia  ISOGLRX5 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18637800
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glrx5Naked Mole-Ratautosomal recessive pyridoxine-refractory sideroblastic anemia 3  ISOGLRX5 (Homo sapiens)7240710 OMIM 
Glrx5Naked Mole-RatChildhood-Onset Spasticity with Hyperglycinemia  ISOGLRX5 (Homo sapiens)7240710 OMIM 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glrx5Naked Mole-Rat[2Fe-2S] cluster assembly involved_inISOUniProtKB:Q027849068941 PMID:23615440UniProtPMID:23615440
Glrx5Naked Mole-Ratprotein maturation involved_inISOUniProtKB:Q027849068941 PMID:23615440UniProtPMID:23615440

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glrx5Naked Mole-Ratdendrite  ISOGlrx5 (Rattus norvegicus)9068941 RGDPMID:20620191 and REF_RGD_ID:5133712
Glrx5Naked Mole-Ratiron-sulfur cluster assembly complex part_ofISOGLRX5 (Homo sapiens)9068941 PMID:27532772ComplexPortalPMID:27532772
Glrx5Naked Mole-Ratmitochondrial matrix located_inIEAPANTHER:PTN000033566 and PANTHER:PTN000033572150520179 TreeGrafterGO_REF:0000118
Glrx5Naked Mole-Ratmitochondrion located_inIEAARBA:ARBA00026962150520179 UniProtGO_REF:0000117
Glrx5Naked Mole-Ratneuronal cell body  ISOGlrx5 (Rattus norvegicus)9068941 RGDPMID:20620191 and REF_RGD_ID:5133712

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glrx5Naked Mole-Rat2 iron, 2 sulfur cluster binding enablesIEAUniProtKB-KW:KW-0001150520179 UniProtGO_REF:0000043
Glrx5Naked Mole-Ratiron-sulfur cluster binding enablesIEAUniProtKB-KW:KW-0411150520179 UniProtGO_REF:0000043
Glrx5Naked Mole-Ratmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
Glrx5Naked Mole-Ratprotein binding enablesISOUniProtKB:Q8IWL39068941 PMID:24606901 and PMID:28380382IntActPMID:24606901 and PMID:28380382
Glrx5Naked Mole-Ratprotein binding enablesISOUniProtKB:Q53S339068941 PMID:27499296 more ...IntActPMID:27499296 more ...
Glrx5Naked Mole-Ratprotein binding enablesISOUniProtKB:Q53S33 and UniProtKB:Q9Y3E29068941 PMID:27532772IntActPMID:27532772

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glrx5Naked Mole-Ratmitochondrial iron-sulfur cluster protein biogenesis pathway   ISOGLRX5 (Homo sapiens)9068941 RGDPMID:25245479 and REF_RGD_ID:11554190


Glrx5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247347,987,116 - 7,995,220 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247347,986,999 - 7,995,604 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
GLRX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381495,535,050 - 95,544,714 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1495,533,503 - 95,544,724 (+)EnsemblGRCh38hg38GRCh38
GRCh371496,001,387 - 96,011,051 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361495,071,076 - 95,080,808 (+)NCBINCBI36Build 36hg18NCBI36
Build 341495,071,075 - 95,080,808NCBI
Celera1476,057,010 - 76,066,743 (+)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1476,186,979 - 76,196,711 (+)NCBIHuRef
CHM1_11495,939,246 - 95,948,981 (+)NCBICHM1_1
T2T-CHM13v2.01489,765,742 - 89,775,402 (+)NCBIT2T-CHM13v2.0
Glrx5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912104,998,877 - 105,007,170 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12104,998,947 - 105,009,165 (+)EnsemblGRCm39 Ensembl
GRCm3812105,032,618 - 105,040,911 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12105,032,688 - 105,042,906 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712106,270,899 - 106,279,120 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612105,433,739 - 105,441,960 (+)NCBIMGSCv36mm8
Celera12106,265,134 - 106,273,355 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1255.04NCBI
Glrx5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86129,752,902 - 129,763,278 (+)NCBIGRCr8
mRatBN7.26123,988,461 - 123,998,545 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,988,134 - 123,998,545 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6124,118,169 - 124,128,237 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06124,413,421 - 124,423,489 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06123,785,337 - 123,795,417 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06128,750,503 - 128,760,880 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6128,750,795 - 128,760,880 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06137,947,583 - 137,957,960 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46129,233,209 - 129,243,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16129,236,842 - 129,245,795 (+)NCBI
Celera6121,459,083 - 121,469,162 (+)NCBICelera
Cytogenetic Map6q32NCBI
Glrx5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543817,066,955 - 17,075,789 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543817,067,017 - 17,076,162 (-)NCBIChiLan1.0ChiLan1.0
GLRX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21596,688,753 - 96,698,490 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11495,905,267 - 95,914,996 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01476,162,541 - 76,172,291 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11495,486,818 - 95,496,438 (+)NCBIpanpan1.1PanPan1.1panPan2
GLRX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1864,383,203 - 64,392,886 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl864,383,227 - 64,383,841 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha863,961,948 - 63,972,042 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0864,651,949 - 64,662,047 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl864,652,309 - 64,662,049 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1864,326,648 - 64,336,722 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0864,385,664 - 64,395,761 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0864,710,831 - 64,720,934 (+)NCBIUU_Cfam_GSD_1.0
GLRX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7116,787,432 - 116,800,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17116,787,346 - 116,797,477 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27124,001,745 - 124,011,835 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLRX5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12473,387,941 - 73,398,208 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2473,387,641 - 73,398,233 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605360,564,346 - 60,574,102 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSHGLT00000010894   ⟹   ENSHGLP00000010772
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247347,987,116 - 7,995,220 (+)Ensembl
RefSeq Acc Id: XM_004837011   ⟹   XP_004837068
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247347,987,042 - 7,995,604 (+)NCBI
RefSeq Acc Id: XM_021244709   ⟹   XP_021100368
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247347,986,999 - 7,995,221 (+)NCBI
RefSeq Acc Id: XM_021244710   ⟹   XP_021100369
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247347,987,000 - 7,995,604 (+)NCBI
Protein RefSeqs XP_004837068 (Get FASTA)   NCBI Sequence Viewer  
  XP_021100368 (Get FASTA)   NCBI Sequence Viewer  
  XP_021100369 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021100368   ⟸   XM_021244709
- Peptide Label: isoform X2
- UniProtKB: A0AAX6RUB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021100369   ⟸   XM_021244710
- Peptide Label: isoform X3
- UniProtKB: A0AAX6RUR4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004837068   ⟸   XM_004837011
- Peptide Label: isoform X1
- UniProtKB: A0AAX6NUA8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000010772   ⟸   ENSHGLT00000010894



1 to 15 of 15 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000007731 Ensembl
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro Glutaredoxin UniProtKB/TrEMBL
  GRX_PICOT-like UniProtKB/TrEMBL
  Monothiol_GRX-rel UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
NCBI Gene Glrx5 ENTREZGENE
PANTHER GLUTAREDOXIN FAMILY MEMBER UniProtKB/TrEMBL
  GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam Glutaredoxin UniProtKB/TrEMBL
PROSITE GLUTAREDOXIN_2 UniProtKB/TrEMBL
Superfamily-SCOP Thioredoxin-like UniProtKB/TrEMBL
UniProt A0AAX6NUA8 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RUB1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RUR4 ENTREZGENE, UniProtKB/TrEMBL
1 to 15 of 15 rows