GLRX5 (glutaredoxin 5) - Rat Genome Database

Name: GLRX5
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: GLRX5 (glutaredoxin 5) Sus scrofa

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Symbol:

GLRX5

Name:

glutaredoxin 5

RGD ID:

13938310

Description:

ENCODES a protein that exhibits 2 iron, 2 sulfur cluster binding (inferred); metal ion binding (inferred); INVOLVED IN [2Fe-2S] cluster assembly (inferred); protein maturation by [2Fe-2S] cluster transfer (inferred); protein maturation by [4Fe-4S] cluster transfer (inferred); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; ASSOCIATED WITH autosomal recessive pyridoxine-refractory sideroblastic anemia 2 (ortholog); autosomal recessive pyridoxine-refractory sideroblastic anemia 3 (ortholog); Childhood-Onset Spasticity with Hyperglycinemia (ortholog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

glutaredoxin-related protein 5, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GLRX5 (glutaredoxin 5)	HGNC	EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Glrx5 (glutaredoxin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Glrx5 (glutaredoxin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Glrx5 (glutaredoxin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GLRX5 (glutaredoxin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GLRX5 (glutaredoxin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GLRX5 (glutaredoxin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Glrx5 (glutaredoxin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	116,787,432 - 116,800,554 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	116,787,346 - 116,797,477 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	124,001,745 - 124,011,835 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive pyridoxine-refractory sideroblastic anemia 2 (ISO)

autosomal recessive pyridoxine-refractory sideroblastic anemia 3 (ISO)

Childhood-Onset Spasticity with Hyperglycinemia (ISO)

sideroblastic anemia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

[2Fe-2S] cluster assembly (IEA)

protein maturation by [2Fe-2S] cluster transfer (IEA)

protein maturation by [4Fe-4S] cluster transfer (IEA)

Cellular Component

dendrite (ISO)

iron-sulfur cluster assembly complex (IEA)

mitochondrial matrix (IBA,IEA)

mitochondrion (IEA)

neuronal cell body (ISO)

Molecular Function

2 iron, 2 sulfur cluster binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mitochondrial iron-sulfur cluster protein biogenesis pathway (ISO)

References

Genomics

Comparative Map Data

GLRX5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	116,787,432 - 116,800,554 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	116,787,346 - 116,797,477 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	124,001,745 - 124,011,835 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GLRX5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	95,535,050 - 95,544,714 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	95,533,503 - 95,544,724 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	96,001,387 - 96,011,051 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	95,071,076 - 95,080,808 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	95,071,075 - 95,080,808	NCBI
Celera	14	76,057,010 - 76,066,743 (+)	NCBI		Celera
Cytogenetic Map	14	q32.13	NCBI
HuRef	14	76,186,979 - 76,196,711 (+)	NCBI		HuRef
CHM1_1	14	95,939,246 - 95,948,981 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	89,765,742 - 89,775,402 (+)	NCBI		T2T-CHM13v2.0

Glrx5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	104,998,877 - 105,007,170 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	104,998,947 - 105,009,165 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	105,032,618 - 105,040,911 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	105,032,688 - 105,042,906 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	106,270,899 - 106,279,120 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	105,433,739 - 105,441,960 (+)	NCBI		MGSCv36	mm8
Celera	12	106,265,134 - 106,273,355 (+)	NCBI		Celera
Cytogenetic Map	12	E	NCBI
cM Map	12	55.04	NCBI

Glrx5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	129,752,902 - 129,763,278 (+)	NCBI		GRCr8
mRatBN7.2	6	123,988,461 - 123,998,545 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	123,988,134 - 123,998,545 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	124,118,169 - 124,128,237 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	124,413,421 - 124,423,489 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	123,785,337 - 123,795,417 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	128,750,503 - 128,760,880 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	128,750,795 - 128,760,880 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	137,947,583 - 137,957,960 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	129,233,209 - 129,243,293 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	129,236,842 - 129,245,795 (+)	NCBI
Celera	6	121,459,083 - 121,469,162 (+)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

Glrx5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955438	17,066,955 - 17,075,789 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955438	17,067,017 - 17,076,162 (-)	NCBI	ChiLan1.0	ChiLan1.0

GLRX5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	96,688,753 - 96,698,490 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	95,905,267 - 95,914,996 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	76,162,541 - 76,172,291 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	95,486,818 - 95,496,438 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

GLRX5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	64,383,203 - 64,392,886 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	64,383,227 - 64,383,841 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	63,961,948 - 63,972,042 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	64,651,949 - 64,662,047 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	64,652,309 - 64,662,049 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	64,326,648 - 64,336,722 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	64,385,664 - 64,395,761 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	64,710,831 - 64,720,934 (+)	NCBI		UU_Cfam_GSD_1.0

GLRX5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	73,387,941 - 73,398,208 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	73,387,641 - 73,398,233 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	60,564,346 - 60,574,102 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Glrx5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	7,987,116 - 7,995,220 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	7,986,999 - 7,995,604 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in GLRX5
573 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	hemolymphoid system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
10	4	23	3	2	5	14	12	23	3	6	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_001928993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK389549	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY609918	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CT867964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01034306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000002774 ⟹ ENSSSCP00000002703

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	7	116,787,432 - 116,800,554 (+)	Ensembl

RefSeq Acc Id:

XM_001928993 ⟹ XP_001929028

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	7	116,787,346 - 116,797,477 (+)	NCBI

Sequence:

show sequence

CGTAGAGCTATTCGGAGCCGGTCCAATGAGGGTCTCCGGGGGACGGGGCGGGCCGCCGCTGGCC
AGGCCCCAGCGAGGCTCCTGCTGTCTAACTCAGGTCCCGAGCTGTCCAGGGCTCCGGCGAGCGT
ACGGGGATGAGCGCGTCCCTGGGCCGGGCGGCGGCGGCTCTGCTCCGCTGGGGGCGCGGCGTAG
GCGGTGGTCTGTGGGTCCCGGGCGTGCGGGCGGCGAGCTCGGGCGGGAGCGGCTCAGCGGAGCA
TCTGGACACGCTGGTGAAGAAGGACAAGGTGGTGGTCTTCCTCAAGGGGACGCCAGAGCAGCCC
CAGTGTGGCTTCAGCAACGCCGTGGTGCAGATCCTGCGGCTGCACGGCGTCCGCGACTACGCGG
CCTACAACGTGCTGGACGACCCCCAGCTCCGGCAAGGCATTAAAGACTATTCCAACTGGCCCAC
CATCCCGCAAGTGTACCTCAACGGCGAGTTCGTGGGGGGCTGTGACATTCTTCTGCAGATGCAC
CAGAACGGGGACCTGGTGGAAGAGCTGAAAAAGCTGGGGATCCGCTCCGCCCTTTTAGATGAAA
AGACAGACCAAGACTCGAAGTGAGGGTGGCCCCGGGCGAGGGAGCCCCTGGGGTCAGAGACTCA
CTGCCAGAAAAGCCTTACGATTTGGGTGTCCCTCTTCAGACAGCTGCTTTGCACTGATTCTTCC
AGTTTGTAAGCAGCCCAGTGATTTTAGGGTGTCTGGGGTTTGGGGCAAAGAAAAACTTCTTGTG
AACGTAATTGTAACCACTGCACTGTAATTAATCACCACCGGTGTTAGGAGATTGCTGTAGACAC
ATTCCTTCTTGTGTTGTCCTGTGTCCTGTGCCTGATTCCGAATCATTGTTACCATTCACAAGTC
TTCTGCAGATGTGTCAGTCCGCAGACATAATAGAGCCCTCTCCTCTGATTTTTTGTAACTTGTT
CTGTAAGAAAATGATGGACAAGGAAGAACATATGATAACCGGCTGTTGTTTTTTAAATAAACCA
ATCCAGGGATACCGTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_001929028	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000002703
	ENSSSCP00000002703.2
	ENSSSCP00015039082.1
	ENSSSCP00025044268.1
	ENSSSCP00030005984.1
	ENSSSCP00035018670.1
	ENSSSCP00040039264.1
	ENSSSCP00045009548.1
	ENSSSCP00050014145.1
	ENSSSCP00055047407.1
	ENSSSCP00060021178.1
	ENSSSCP00065036223.1
	ENSSSCP00070000103.1

RefSeq Acc Id:	XP_001929028 ⟸ XM_001928993
- UniProtKB:	F1SAR5 (UniProtKB/TrEMBL), A0A4X1SD79 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSASLGRAAAALLRWGRGVGGGLWVPGVRAASSGGSGSAEHLDTLVKKDKVVVFLKGTPEQPQC GFSNAVVQILRLHGVRDYAAYNVLDDPQLRQGIKDYSNWPTIPQVYLNGEFVGGCDILLQMHQN GDLVEELKKLGIRSALLDEKTDQDSK hide sequence

Ensembl Acc Id:

ENSSSCP00000002703 ⟸ ENSSSCT00000002774

Protein Domains

Glutaredoxin

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000002496	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015071011	UniProtKB/TrEMBL
	ENSSSCG00025072921	UniProtKB/TrEMBL
	ENSSSCG00030009723	UniProtKB/TrEMBL
	ENSSSCG00035035247	UniProtKB/TrEMBL
	ENSSSCG00040065421	UniProtKB/TrEMBL
	ENSSSCG00045008212	UniProtKB/TrEMBL
	ENSSSCG00050025282	UniProtKB/TrEMBL
	ENSSSCG00055029776	UniProtKB/TrEMBL
	ENSSSCG00060036540	UniProtKB/TrEMBL
	ENSSSCG00065060703	UniProtKB/TrEMBL
	ENSSSCG00070000084	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000002774	ENTREZGENE
	ENSSSCT00000002774.4	UniProtKB/TrEMBL
	ENSSSCT00015095196.1	UniProtKB/TrEMBL
	ENSSSCT00025100309.1	UniProtKB/TrEMBL
	ENSSSCT00030013305.1	UniProtKB/TrEMBL
	ENSSSCT00035046703.1	UniProtKB/TrEMBL
	ENSSSCT00040089305.1	UniProtKB/TrEMBL
	ENSSSCT00045013801.1	UniProtKB/TrEMBL
	ENSSSCT00050034027.1	UniProtKB/TrEMBL
	ENSSSCT00055059189.1	UniProtKB/TrEMBL
	ENSSSCT00060049495.1	UniProtKB/TrEMBL
	ENSSSCT00065083140.1	UniProtKB/TrEMBL
	ENSSSCT00070000121.1	UniProtKB/TrEMBL
Gene3D-CATH	Glutaredoxin	UniProtKB/TrEMBL
InterPro	Glutaredoxin	UniProtKB/TrEMBL
	GRX_PICOT-like	UniProtKB/TrEMBL
	Monothiol_GRX-rel	UniProtKB/TrEMBL
	Thioredoxin-like_sf	UniProtKB/TrEMBL
KEGG Report	ssc:100154744	UniProtKB/TrEMBL
NCBI Gene	GLRX5	ENTREZGENE
PANTHER	GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL	UniProtKB/TrEMBL
	PTHR10293	UniProtKB/TrEMBL
Pfam	Glutaredoxin	UniProtKB/TrEMBL
PROSITE	GLUTAREDOXIN_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52833	UniProtKB/TrEMBL
UniProt	A0A4X1SD79	ENTREZGENE, UniProtKB/TrEMBL
	F1SAR5	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:88496	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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RGD Manual Annotations