Rdh12 (retinol dehydrogenase 12) - Rat Genome Database

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Gene: Rdh12 (retinol dehydrogenase 12) Heterocephalus glaber
Analyze
Symbol: Rdh12
Name: retinol dehydrogenase 12
RGD ID: 18908333
Description: ENCODES a protein that exhibits all-trans-retinol dehydrogenase (NAD+) activity (inferred); all-trans-retinol dehydrogenase (NADP+) activity (inferred); oxidoreductase activity (inferred); INVOLVED IN cellular detoxification of aldehyde (inferred); retinol metabolic process (inferred); visual perception (inferred); PARTICIPATES IN altered retinoid cycle metabolic pathway; retinitis pigmentosa pathway; retinoid cycle metabolic pathway; ASSOCIATED WITH cone-rod dystrophy (ortholog); Eye Abnormalities (ortholog); fundus dystrophy (ortholog); FOUND IN photoreceptor inner segment (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473433,254,432 - 33,266,140 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473433,256,469 - 33,266,085 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rdh12Naked Mole-RatLeber hereditary optic neuropathy  ISORDH12 (Homo sapiens)9068941 RGDPMID:15322982 and REF_RGD_ID:1599415
1 to 20 of 25 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rdh12Naked Mole-Ratcone-rod dystrophy  ISORDH12 (Homo sapiens)8554872ClinVar Annotator: match by term: Cone-rod degenerationClinVarPMID:15258582 more ...
Rdh12Naked Mole-Ratcone-rod dystrophy  ISORDH12 (Homo sapiens)8554872ClinVar Annotator: match by term: Cone-rod dystrophyClinVarPMID:15258582 more ...
Rdh12Naked Mole-RatEye Abnormalities  ISORDH12 (Homo sapiens)8554872ClinVar Annotator: match by term: Abnormality of the eyeClinVarPMID:15258582 more ...
Rdh12Naked Mole-Ratfundus dystrophy  ISORDH12 (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:15258582 more ...
Rdh12Naked Mole-Ratgenetic disease  ISORDH12 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
Rdh12Naked Mole-RatLeber congenital amaurosis  ISORDH12 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15258582 more ...
Rdh12Naked Mole-RatLeber congenital amaurosis  ISORDH12 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15258582 more ...
Rdh12Naked Mole-RatLeber congenital amaurosis  ISORDH12 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15258582 more ...
Rdh12Naked Mole-RatLeber congenital amaurosis  ISORDH12 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15258582 more ...
Rdh12Naked Mole-RatLeber congenital amaurosis  ISORDH12 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15258582 more ...
Rdh12Naked Mole-RatLeber congenital amaurosis  ISORDH12 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15258582 more ...
Rdh12Naked Mole-RatLeber congenital amaurosis  ISORDH12 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15258582 more ...
Rdh12Naked Mole-RatLeber congenital amaurosis  ISORDH12 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15258582 more ...
Rdh12Naked Mole-RatLeber congenital amaurosis 13  ISORDH12 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15258582 more ...
Rdh12Naked Mole-Ratmacular degeneration  ISORDH12 (Homo sapiens)8554872ClinVar Annotator: match by term: Macular dystrophyClinVarPMID:16269441 more ...
Rdh12Naked Mole-Ratoptic atrophy  ISORDH12 (Homo sapiens)8554872ClinVar Annotator: match by term: Optic atrophyClinVarPMID:16269441 more ...
Rdh12Naked Mole-Ratparaplegia  ISORDH12 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegiaClinVarPMID:18394578 more ...
Rdh12Naked Mole-Ratretinitis pigmentosa  ISORDH12 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15258582 more ...
Rdh12Naked Mole-Ratretinitis pigmentosa  ISORDH12 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15258582 more ...
Rdh12Naked Mole-Ratretinitis pigmentosa  ISORDH12 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15258582 more ...
1 to 20 of 25 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rdh12Naked Mole-Ratretinal degeneration  ISORDH12 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:16269441
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rdh12Naked Mole-RatLeber congenital amaurosis 13  ISORDH12 (Homo sapiens)7240710 OMIM 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rdh12Naked Mole-Ratcellular detoxification of aldehyde involved_inIEAUniProtKB:Q8BYK4 more ...150520179 EnsemblGO_REF:0000107
Rdh12Naked Mole-Ratretinol metabolic process involved_inIEAUniProtKB:Q8BYK4 more ...150520179 EnsemblGO_REF:0000107
Rdh12Naked Mole-Ratvisual perception involved_inIEAUniProtKB:Q8BYK4 more ...150520179 EnsemblGO_REF:0000107

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rdh12Naked Mole-Ratphotoreceptor inner segment located_inIEAUniProtKB:Q8BYK4 and ensembl:ENSMUSP00000021548150520179 EnsemblGO_REF:0000107

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rdh12Naked Mole-Ratall-trans-retinol dehydrogenase (NAD+) activity enablesIEAUniProtKB:Q8BYK4 more ...150520179 EnsemblGO_REF:0000107
Rdh12Naked Mole-Ratall-trans-retinol dehydrogenase (NADP+) activity enablesIEAUniProtKB:Q96NR8 and ensembl:ENSP00000449079150520179 EnsemblGO_REF:0000107
Rdh12Naked Mole-Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-0560150520179 UniProtGO_REF:0000043
Rdh12Naked Mole-Ratprotein binding enablesISOUniProtKB:Q930629068941 PMID:25416956IntActPMID:25416956
Rdh12Naked Mole-Ratprotein binding enablesISOUniProtKB:Q93062-39068941 PMID:25910212IntActPMID:25910212
Rdh12Naked Mole-Ratprotein binding enablesISOUniProtKB:Q6IQ23-29068941 PMID:32296183IntActPMID:32296183
Rdh12Naked Mole-Ratprotein binding enablesISOUniProtKB:P0CG489068941 PMID:20006610IntActPMID:20006610

RGD Manual Annotations


  

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rdh12Naked Mole-Ratretinol metabolic pathway   ISORDH12 (Homo sapiens)9068941 SMPDBSMP:00074
Rdh12Naked Mole-Ratvitamin A deficiency pathway  ISORDH12 (Homo sapiens)9068941 SMPDBSMP:00336


Rdh12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473433,254,432 - 33,266,140 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473433,256,469 - 33,266,085 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
RDH12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381467,701,886 - 67,734,451 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1467,701,886 - 67,734,451 (+)EnsemblGRCh38hg38GRCh38
GRCh371468,168,603 - 68,201,168 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361467,258,943 - 67,270,921 (+)NCBINCBI36Build 36hg18NCBI36
Build 341467,258,942 - 67,270,920NCBI
Celera1448,227,645 - 48,260,203 (+)NCBICelera
Cytogenetic Map14q24.1NCBI
HuRef1448,338,282 - 48,370,752 (+)NCBIHuRef
CHM1_11468,107,353 - 68,139,905 (+)NCBICHM1_1
T2T-CHM13v2.01461,909,008 - 61,941,569 (+)NCBIT2T-CHM13v2.0
Rdh12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391279,255,687 - 79,269,438 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1279,255,688 - 79,269,439 (+)EnsemblGRCm39 Ensembl
GRCm381279,208,913 - 79,222,664 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1279,208,914 - 79,222,665 (+)EnsemblGRCm38mm10GRCm38
MGSCv371280,309,901 - 80,323,648 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361280,127,754 - 80,141,501 (+)NCBIMGSCv36mm8
Celera1280,673,293 - 80,687,040 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1235.51NCBI
Rdh12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86103,748,457 - 103,761,379 (+)NCBIGRCr8
mRatBN7.2698,015,465 - 98,028,388 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl698,015,465 - 98,028,388 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx698,444,920 - 98,457,864 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0698,744,060 - 98,757,001 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0698,130,385 - 98,143,366 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06102,392,828 - 102,405,750 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6102,392,828 - 102,405,750 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06115,079,502 - 115,092,424 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46101,982,815 - 101,995,737 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16101,978,778 - 101,998,720 (+)NCBI
Celera696,400,484 - 96,413,406 (+)NCBICelera
Cytogenetic Map6q24NCBI
Rdh12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554662,473,096 - 2,487,623 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554662,473,145 - 2,485,779 (-)NCBIChiLan1.0ChiLan1.0
RDH12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21568,832,854 - 68,844,898 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11468,049,366 - 68,061,408 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01448,297,854 - 48,314,502 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11467,180,696 - 67,192,345 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1467,180,696 - 67,192,345 (+)Ensemblpanpan1.1panPan2
RDH12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1841,685,045 - 41,696,120 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl841,684,996 - 41,695,447 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha841,376,188 - 41,387,256 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0841,915,013 - 41,926,089 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl841,915,087 - 41,926,101 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1841,530,993 - 41,542,054 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0841,604,398 - 41,615,461 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0841,963,799 - 41,974,867 (+)NCBIUU_Cfam_GSD_1.0
Rdh12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864063,069,723 - 63,080,452 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649511,111,105 - 11,121,341 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649511,111,247 - 11,121,976 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RDH12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl791,481,272 - 91,493,809 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1791,481,238 - 91,493,838 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2797,788,539 - 97,802,631 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RDH12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12444,957,854 - 44,971,855 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2444,959,921 - 44,971,836 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605333,183,713 - 33,200,221 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.
RefSeq Transcripts XM_004837343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01009994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GEBF01001517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000027589   ⟹   ENSHGLP00000027347
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473433,254,432 - 33,266,140 (-)Ensembl
RefSeq Acc Id: XM_004837343   ⟹   XP_004837400
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473433,256,469 - 33,266,085 (-)NCBI
Protein RefSeqs XP_004837400 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000027347
GenBank Protein JAO02116 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004837400   ⟸   XM_004837343
- UniProtKB: A0A0P6JDP3 (UniProtKB/TrEMBL),   G5C7X3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000027347   ⟸   ENSHGLT00000027589



1 to 15 of 15 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000019444 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000027589 ENTREZGENE
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  SDR_fam UniProtKB/TrEMBL
KEGG Report hgl:101715642 UniProtKB/TrEMBL
NCBI Gene Rdh12 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED UniProtKB/TrEMBL
  RETINOL DEHYDROGENASE 12 UniProtKB/TrEMBL
Pfam adh_short UniProtKB/TrEMBL
PRINTS GDHRDH UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
UniProt A0A0P6JDP3 ENTREZGENE, UniProtKB/TrEMBL
  G5C7X3 ENTREZGENE, UniProtKB/TrEMBL
1 to 15 of 15 rows