Pdia6 (protein disulfide isomerase family A member 6) - Rat Genome Database

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Gene: Pdia6 (protein disulfide isomerase family A member 6) Heterocephalus glaber
Analyze
Symbol: Pdia6
Name: protein disulfide isomerase family A member 6
RGD ID: 18900804
Description: ENCODES a protein that exhibits isomerase activity (inferred); protein disulfide isomerase activity (inferred); protein-disulfide reductase activity (inferred); INVOLVED IN negative regulation of IRE1-mediated unfolded protein response (ortholog); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; FOUND IN endoplasmic reticulum chaperone complex (ortholog); smooth endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein disulfide-isomerase A6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248654,695,220 - 4,710,680 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248654,695,178 - 4,711,029 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pdia6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248654,695,220 - 4,710,680 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248654,695,178 - 4,711,029 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PDIA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38210,783,391 - 10,837,712 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl210,783,391 - 10,837,977 (-)EnsemblGRCh38hg38GRCh38
GRCh37210,923,517 - 10,977,838 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36210,840,968 - 10,870,411 (-)NCBINCBI36Build 36hg18NCBI36
Build 34210,874,116 - 10,903,558NCBI
Celera210,838,663 - 10,868,105 (-)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef210,774,831 - 10,804,279 (-)NCBIHuRef
CHM1_1210,853,257 - 10,882,823 (-)NCBICHM1_1
T2T-CHM13v2.0210,813,390 - 10,867,711 (-)NCBIT2T-CHM13v2.0
Pdia6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391217,316,590 - 17,334,786 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1217,316,546 - 17,334,771 (+)EnsemblGRCm39 Ensembl
GRCm381217,266,589 - 17,284,785 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1217,266,545 - 17,284,770 (+)EnsemblGRCm38mm10GRCm38
MGSCv371217,273,401 - 17,291,576 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361217,292,075 - 17,310,250 (+)NCBIMGSCv36mm8
Celera1221,149,080 - 21,150,652 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map128.06NCBI
Pdia6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8645,791,704 - 45,808,947 (+)NCBIGRCr8
mRatBN7.2640,062,980 - 40,080,223 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl640,062,926 - 40,080,613 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx640,390,413 - 40,407,661 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0640,705,108 - 40,722,356 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0640,138,354 - 40,155,605 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0642,568,269 - 42,585,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl642,568,220 - 42,585,652 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0652,289,504 - 52,306,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera639,364,155 - 39,381,355 (+)NCBICelera
Cytogenetic Map6q16NCBI
Pdia6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554875,735,698 - 5,748,015 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554875,735,698 - 5,744,601 (-)NCBIChiLan1.0ChiLan1.0
PDIA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212115,706,366 - 115,733,960 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A115,710,350 - 115,737,931 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A10,781,671 - 10,809,235 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A10,934,756 - 10,961,880 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A10,934,756 - 10,986,200 (-)Ensemblpanpan1.1panPan2
PDIA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1177,653,834 - 7,674,136 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl177,654,175 - 7,685,999 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha177,578,609 - 7,599,511 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0177,755,030 - 7,775,737 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl177,752,150 - 7,775,722 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1177,641,284 - 7,661,933 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0177,643,791 - 7,664,483 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0177,657,505 - 7,678,201 (-)NCBIUU_Cfam_GSD_1.0
Pdia6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629252,110,948 - 52,135,226 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365326,865,994 - 6,881,475 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365326,865,994 - 6,887,396 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDIA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3125,751,978 - 125,776,077 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13125,752,079 - 125,774,225 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23134,582,105 - 134,604,259 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDIA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11496,801,327 - 96,828,325 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1496,801,349 - 96,828,716 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604515,463,373 - 15,490,168 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000000469   ⟹   ENSHGLP00000000430
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248654,695,220 - 4,710,680 (+)Ensembl
RefSeq Acc Id: XM_004869959   ⟹   XP_004870016
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248654,695,178 - 4,711,029 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004870016 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000000430
GenBank Protein JAN97609 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004870016   ⟸   XM_004869959
- UniProtKB: A0A0P6JU53 (UniProtKB/TrEMBL),   G5B591 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000000430   ⟸   ENSHGLT00000000469


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000000403 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000000469 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro Disulphide_isomerase UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin_CS UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
KEGG Report hgl:101698236 UniProtKB/TrEMBL
NCBI Gene Pdia6 ENTREZGENE
PANTHER PROTEIN DISULFIDE-ISOMERASE A6 UniProtKB/TrEMBL
  PTHR45815 UniProtKB/TrEMBL
Pfam Thioredoxin UniProtKB/TrEMBL
PRINTS THIOREDOXIN UniProtKB/TrEMBL
PROSITE THIOREDOXIN_1 UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/TrEMBL
UniProt A0A0P6JU53 ENTREZGENE, UniProtKB/TrEMBL
  G5B591 ENTREZGENE, UniProtKB/TrEMBL