PDIA6 (protein disulfide isomerase family A member 6) - Rat Genome Database

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Gene: PDIA6 (protein disulfide isomerase family A member 6) Canis lupus familiaris
Analyze
Symbol: PDIA6
Name: protein disulfide isomerase family A member 6
RGD ID: 12093358
Description: ENCODES a protein that exhibits protein disulfide isomerase activity (inferred); protein-disulfide reductase activity (inferred); INVOLVED IN negative regulation of IRE1-mediated unfolded protein response (ortholog); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; ASSOCIATED WITH genetic disease (ortholog); FOUND IN endoplasmic reticulum chaperone complex (ortholog); smooth endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein disulfide-isomerase A6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1177,653,834 - 7,674,136 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl177,654,175 - 7,685,999 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha177,578,609 - 7,599,511 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0177,755,030 - 7,775,737 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl177,752,150 - 7,775,722 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1177,641,284 - 7,661,933 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0177,643,791 - 7,664,483 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0177,657,505 - 7,678,201 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PDIA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1177,653,834 - 7,674,136 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl177,654,175 - 7,685,999 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha177,578,609 - 7,599,511 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0177,755,030 - 7,775,737 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl177,752,150 - 7,775,722 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1177,641,284 - 7,661,933 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0177,643,791 - 7,664,483 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0177,657,505 - 7,678,201 (-)NCBIUU_Cfam_GSD_1.0
PDIA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38210,783,391 - 10,837,712 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl210,783,391 - 10,837,977 (-)EnsemblGRCh38hg38GRCh38
GRCh37210,923,517 - 10,977,838 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36210,840,968 - 10,870,411 (-)NCBINCBI36Build 36hg18NCBI36
Build 34210,874,116 - 10,903,558NCBI
Celera210,838,663 - 10,868,105 (-)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef210,774,831 - 10,804,279 (-)NCBIHuRef
CHM1_1210,853,257 - 10,882,823 (-)NCBICHM1_1
T2T-CHM13v2.0210,813,390 - 10,867,711 (-)NCBIT2T-CHM13v2.0
Pdia6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391217,316,590 - 17,334,786 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1217,316,546 - 17,334,771 (+)EnsemblGRCm39 Ensembl
GRCm381217,266,589 - 17,284,785 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1217,266,545 - 17,284,770 (+)EnsemblGRCm38mm10GRCm38
MGSCv371217,273,401 - 17,291,576 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361217,292,075 - 17,310,250 (+)NCBIMGSCv36mm8
Celera1221,149,080 - 21,150,652 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map128.06NCBI
Pdia6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8645,791,704 - 45,808,947 (+)NCBIGRCr8
mRatBN7.2640,062,980 - 40,080,223 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl640,062,926 - 40,080,613 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx640,390,413 - 40,407,661 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0640,705,108 - 40,722,356 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0640,138,354 - 40,155,605 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0642,568,269 - 42,585,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl642,568,220 - 42,585,652 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0652,289,504 - 52,306,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera639,364,155 - 39,381,355 (+)NCBICelera
Cytogenetic Map6q16NCBI
Pdia6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554875,735,698 - 5,748,015 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554875,735,698 - 5,744,601 (-)NCBIChiLan1.0ChiLan1.0
PDIA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212115,706,366 - 115,733,960 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A115,710,350 - 115,737,931 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A10,781,671 - 10,809,235 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A10,934,756 - 10,961,880 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A10,934,756 - 10,986,200 (-)Ensemblpanpan1.1panPan2
Pdia6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629252,110,948 - 52,135,226 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365326,865,994 - 6,881,475 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365326,865,994 - 6,887,396 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDIA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3125,751,978 - 125,776,077 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13125,752,079 - 125,774,225 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23134,582,105 - 134,604,259 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDIA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11496,801,327 - 96,828,325 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1496,801,349 - 96,828,716 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604515,463,373 - 15,490,168 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdia6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248654,695,220 - 4,710,680 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248654,695,178 - 4,711,029 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PDIA6
299 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 1 12 8 10 6
Low 5
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000037603   ⟹   ENSCAFP00000033141
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl177,654,175 - 7,674,135 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000066337   ⟹   ENSCAFP00000063383
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl177,654,175 - 7,672,446 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000092495   ⟹   ENSCAFP00000064087
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl177,654,175 - 7,685,999 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845047695   ⟹   ENSCAFP00845037426
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl177,752,150 - 7,775,722 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845047819   ⟹   ENSCAFP00845037519
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl177,752,150 - 7,774,048 (-)Ensembl
RefSeq Acc Id: XM_038498233   ⟹   XP_038354161
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1177,641,284 - 7,661,933 (-)NCBI
RefSeq Acc Id: XM_038560770   ⟹   XP_038416698
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0177,657,505 - 7,678,201 (-)NCBI
RefSeq Acc Id: XM_038624798   ⟹   XP_038480726
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0177,643,791 - 7,664,483 (-)NCBI
RefSeq Acc Id: XM_038690707   ⟹   XP_038546635
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0177,755,030 - 7,775,737 (-)NCBI
RefSeq Acc Id: XM_532876   ⟹   XP_532876
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1177,653,834 - 7,674,136 (-)NCBI
Dog10K_Boxer_Tasha177,578,609 - 7,599,511 (-)NCBI
Sequence:
RefSeq Acc Id: XP_532876   ⟸   XM_532876
- UniProtKB: A0A8C0LTL2 (UniProtKB/TrEMBL),   A0A8C0MEJ6 (UniProtKB/TrEMBL),   A0A8I3Q0F7 (UniProtKB/TrEMBL),   A0A8C0QCS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000063383   ⟸   ENSCAFT00000066337
RefSeq Acc Id: ENSCAFP00000033141   ⟸   ENSCAFT00000037603
RefSeq Acc Id: ENSCAFP00000064087   ⟸   ENSCAFT00000092495
RefSeq Acc Id: XP_038354161   ⟸   XM_038498233
RefSeq Acc Id: XP_038480726   ⟸   XM_038624798
RefSeq Acc Id: XP_038546635   ⟸   XM_038690707
- UniProtKB: A0A8C0LTL2 (UniProtKB/TrEMBL),   A0A8C0MEJ6 (UniProtKB/TrEMBL),   A0A8I3Q0F7 (UniProtKB/TrEMBL),   A0A8C0QCS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038416698   ⟸   XM_038560770
- UniProtKB: A0A8C0LTL2 (UniProtKB/TrEMBL),   A0A8C0MEJ6 (UniProtKB/TrEMBL),   A0A8C0QCS6 (UniProtKB/TrEMBL),   A0A8I3Q0F7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845037519   ⟸   ENSCAFT00845047819
RefSeq Acc Id: ENSCAFP00845037426   ⟸   ENSCAFT00845047695
Protein Domains
Thioredoxin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003477 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006435 UniProtKB/TrEMBL
  ENSCAFG00040007342 UniProtKB/TrEMBL
  ENSCAFG00845026954 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000037603.4 UniProtKB/TrEMBL
  ENSCAFT00000066337.2 UniProtKB/TrEMBL
  ENSCAFT00030011867.1 UniProtKB/TrEMBL
  ENSCAFT00030011950.1 UniProtKB/TrEMBL
  ENSCAFT00030012052.1 UniProtKB/TrEMBL
  ENSCAFT00030012080.1 UniProtKB/TrEMBL
  ENSCAFT00030012162.1 UniProtKB/TrEMBL
  ENSCAFT00040013699.1 UniProtKB/TrEMBL
  ENSCAFT00845047695 ENTREZGENE
  ENSCAFT00845047695.1 UniProtKB/TrEMBL
  ENSCAFT00845047819.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro Disulphide_isomerase UniProtKB/TrEMBL
  PDIA6-like UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin_CS UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
KEGG Report cfa:475668 UniProtKB/TrEMBL
NCBI Gene PDIA6 ENTREZGENE
PANTHER PROTEIN DISULFIDE-ISOMERASE A6 UniProtKB/TrEMBL
  PTHR45815 UniProtKB/TrEMBL
Pfam Thioredoxin UniProtKB/TrEMBL
PRINTS THIOREDOXIN UniProtKB/TrEMBL
PROSITE THIOREDOXIN_1 UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/TrEMBL
UniProt A0A8C0LTL2 ENTREZGENE
  A0A8C0ME67_CANLF UniProtKB/TrEMBL
  A0A8C0MEA2_CANLF UniProtKB/TrEMBL
  A0A8C0MEJ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0MEQ5_CANLF UniProtKB/TrEMBL
  A0A8C0MI04_CANLF UniProtKB/TrEMBL
  A0A8C0QCS6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q0F7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3SAL0_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:103696 ENTREZGENE