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Gene: GPC3 (glypican 3) Chlorocebus sabaeus

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Symbol:

GPC3

Name:

glypican 3

RGD ID:

18715090

Description:

ENCODES a protein that exhibits peptidyl-dipeptidase inhibitor activity (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); anterior/posterior axis specification (ortholog); body morphogenesis (ortholog); PARTICIPATES IN glypican signaling pathway; Hedgehog signaling pathway; ASSOCIATED WITH Arterial Occlusive Diseases (ortholog); atypical teratoid rhabdoid tumor (ortholog); autistic disorder (ortholog); FOUND IN lysosome (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

glypican-3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GPC3 (glypican 3)	NCBI	Ortholog
Mus musculus (house mouse):	Gpc3 (glypican 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Gpc3 (glypican 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gpc3 (glypican 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GPC3 (glypican 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GPC3 (glypican 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gpc3 (glypican 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GPC3 (glypican 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gpc3 (glypican 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	108,688,706 - 109,143,653 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666065	46,279,325 - 46,740,727 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Arterial Occlusive Diseases (ISO)

atypical teratoid rhabdoid tumor (ISO)

autistic disorder (ISO)

autosomal hemophilia A (ISO)

Coronary Vessel Anomalies (ISO)

factor VIII deficiency (ISO)

genetic disease (ISO)

hepatoblastoma (ISO)

hepatocellular carcinoma (ISO)

Hereditary Neoplastic Syndromes (ISO)

HRPT-related hyperuricemia (ISO)

Human Viral Hepatitis (ISO)

intellectual disability (ISO)

liver cirrhosis (ISO)

Liver Metastasis (ISO)

Mesothelioma (ISO)

nephroblastoma (ISO)

ovarian cancer (ISO)

placental site trophoblastic tumor (ISO)

renal Wilms' tumor (ISO)

Simpson-Golabi-Behmel syndrome type 1 (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ morphogenesis (ISO)

anterior/posterior axis specification (ISO)

body morphogenesis (ISO)

bone mineralization (ISO)

branching involved in ureteric bud morphogenesis (ISO)

canonical Wnt signaling pathway (ISO)

cell proliferation involved in kidney development (ISO)

cell proliferation involved in metanephros development (ISO)

coronary vasculature development (ISO)

embryonic hindlimb morphogenesis (ISO)

epithelial cell proliferation (ISO)

kidney development (ISO)

lung development (ISO)

mesenchymal cell proliferation involved in ureteric bud development (ISO)

mesonephric duct morphogenesis (ISO)

negative regulation of canonical Wnt signaling pathway (ISO)

negative regulation of cell population proliferation (ISO)

negative regulation of epithelial cell proliferation (ISO)

negative regulation of growth (ISO)

negative regulation of smoothened signaling pathway (ISO)

osteoclast differentiation (ISO)

positive regulation of BMP signaling pathway (ISO)

positive regulation of canonical Wnt signaling pathway (ISO)

positive regulation of D-glucose import (ISO)

positive regulation of endocytosis (ISO)

positive regulation of protein catabolic process (ISO)

positive regulation of smoothened signaling pathway (ISO)

positive regulation of Wnt signaling pathway, planar cell polarity pathway (ISO)

regulation of canonical Wnt signaling pathway (ISO)

regulation of growth (ISO)

regulation of non-canonical Wnt signaling pathway (ISO)

response to bacterium (ISO)

smoothened signaling pathway (ISO)

Wnt signaling pathway, planar cell polarity pathway (ISO)

Cellular Component

lysosome (ISO)

plasma membrane (ISO)

Molecular Function

peptidyl-dipeptidase inhibitor activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

glypican signaling pathway (ISO)

Hedgehog signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

GPC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	108,688,706 - 109,143,653 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666065	46,279,325 - 46,740,727 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

GPC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	133,535,745 - 133,985,594 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	133,535,745 - 133,987,100 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	132,669,773 - 133,119,621 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	132,497,439 - 132,947,332 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	132,395,297 - 132,845,186	NCBI
Celera	X	133,056,670 - 133,506,461 (-)	NCBI		Celera
Cytogenetic Map	X	q26.2	NCBI
HuRef	X	122,070,349 - 122,518,471 (-)	NCBI		HuRef
CHM1_1	X	132,581,479 - 133,031,377 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	131,860,879 - 132,310,724 (-)	NCBI		T2T-CHM13v2.0

Gpc3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	51,361,303 - 51,702,851 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	51,361,303 - 51,702,827 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	52,272,426 - 52,613,974 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	52,272,426 - 52,613,950 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	49,625,603 - 49,967,151 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	48,517,053 - 48,858,548 (-)	NCBI		MGSCv36	mm8
Celera	X	39,684,455 - 40,028,880 (-)	NCBI		Celera
Cytogenetic Map	X	A5	NCBI
cM Map	X	28.74	NCBI

Gpc3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	136,789,770 - 137,157,598 (-)	NCBI		GRCr8
mRatBN7.2	X	131,868,986 - 132,236,824 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	131,868,990 - 132,236,798 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	134,029,733 - 134,399,032 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	137,611,682 - 137,980,983 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	135,180,258 - 135,549,530 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	139,579,268 - 139,947,093 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	139,579,268 - 139,916,883 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	139,625,383 - 139,993,328 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	139,192,115 - 139,560,649 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	139,264,617 - 139,634,082 (-)	NCBI
Celera	X	130,783,069 - 131,149,772 (-)	NCBI		Celera
Cytogenetic Map	X	q36	NCBI

Gpc3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955473	969,800 - 1,431,483 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955473	969,627 - 1,431,706 (+)	NCBI	ChiLan1.0	ChiLan1.0

GPC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	132,962,618 - 133,417,727 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	132,966,213 - 133,421,264 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	122,677,072 - 123,131,511 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	132,979,890 - 133,432,266 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	132,979,612 - 133,432,441 (-)	Ensembl	panpan1.1		panPan2

GPC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	104,313,426 - 104,751,215 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	104,313,591 - 104,751,756 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	90,423,525 - 90,861,387 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	106,172,656 - 106,610,807 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	106,172,666 - 106,610,973 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	103,586,071 - 104,023,982 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	105,451,609 - 105,889,924 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	105,234,374 - 105,675,118 (-)	NCBI		UU_Cfam_GSD_1.0

Gpc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	102,497,623 - 102,897,321 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936691	1,059,994 - 1,459,740 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936691	1,060,013 - 1,459,736 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GPC3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	109,536,504 - 109,973,607 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	109,536,495 - 109,973,605 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	125,676,131 - 126,059,402 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Gpc3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624797	13,230,932 - 13,678,742 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624797	13,234,741 - 13,678,542 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007992737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_007992737 ⟹ XP_007990928

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	X	108,688,706 - 109,143,653 (-)	NCBI
Vero_WHO_p1.0	NW_023666065	46,279,325 - 46,740,727 (-)	NCBI

Sequence:

show sequence

CAGCCCCGCCCTGCCCCGCGCCGCCAAGCGGTTCCCGCCCTCGCCCAGCGCCCAGGTAGCTGCG
AGGAAACTTTTGCAGCGGCTGGGTAGCAGCACGTCTCTTGCTCCACAGGGCCACTGCCAGGCTT
GCCGAGTCCTGGGACTGCTCTCGCTCCGGCTGCCACTCTCCCGCGCTCTCCTAGCTCCCTGCGA
AGCAGGATGGCTGGGACCGTGCGCACCGCGTGCTTGGTGGTGGCGATGCTGCTCAGCTTGGACT
TCCCGGGACAGGCGCAGCCCCCGCCGCCGCCGCCGGACGCCACCTGTCACCAAGTCCGCTCCTT
CTTCCAGAGACTGCAGCCCGGACTCAAGTGGGTGCCCGAAACTCCCGTGCCAGGATCAGATTTG
CAAGTATGTCTCCCTAAGGGCCCAACATGCTGCTCAAGAAAGATGGAAGAAAAATACCAACTAA
CAGCACGATTGAACATGGAACAGCTGCTTCAGTCTGCAAGTATGGAGCTCAAGTTCTTAATTAT
TCAGAATGCTGCAGTTTTCCAAGAGGCCTTTGAAATTGTTGTTCGCCATGCCAAGAACTACACC
AATGCCATGTTCAAGAACAACTACCCAAGCCTGACTCCACAAGCTTTTGAGTTTGTGGGTGAAT
TTTTCACAGATGTGTCTCTCTATATCTTGGGTTCTGACATCAATGTGGATGACATGGTCAATGA
ATTGTTTGATAGCCTGTTTCCAGTTATCTATACCCAACTAATGAACCCAGGCCTGCCTGATTCA
GCCTTGGACATCAATGAGTGCCTCCGAGGAGCAAGACGTGACCTGAAAGTATTTGGGAACTTCC
CCAAGCTTATTATGACCCAGGTTTCTAAGTCACTGCAAGTCACTAGGATCTTCCTTCAGGCTCT
GAATCTTGGAATTGAAGTGATCAACACAACCGATCACCTGAAGTTCAGTAAGGACTGTGGCCGA
ATGCTCACCAGAATGTGGTACTGCTCTTACTGCCAGGGACTGATGATGGTTAAACCTTGTGGCG
GTTACTGCAATGTGGTCATGCAAGGCTGTATGGCAGGTGTGGTGGAGATTGACAAGTACTGGAG
AGAATACATTCTGTCTCTTGAAGAGCTTGTGAATGGCATGTACAGAATCTATGACATGGAAAAC
GTACTGCTTGGTCTCTTTTCAACAATCCACGATTCTATCCAGTATGTCCAGAAGAATGCAGGAA
AGCTGACCACCACTATTGGCAAGCTATGTGCCCATTCTCAACAACGCCAATATAGATCTGCTTA
TTATCCTGAAGATCTGTTTATTGACAAGAAAGTATTAAAAGTTGCTCATGTAGAACATGAAGAA
ACCTTATCCAGCCGAAGAAGGGAACTAATTCAGAAGTTGAAGTCTTTCATCAGCTTCTATAGTG
CTTTGCCTGGCTACATCTGCAGCCATAGCCCTGTGGCGGAAAACGACACCCTTTGCTGGAATGG
ACAAGAACTCGTGGAGAGATACAGCCAAAAGGCGGCAAGGAATGGAATGAAAAACCAGTTCAAT
CTCCATGAGCTGAAAATGAAGGGCCCTGAGCCAGTAGTCAGTCAAATTATTGACAAATTGAAGC
ACATTAACCAGCTCCTGAGAACCATGTCTGTGCCCAAAGGTAGAGTTCTGGATAAAAACCTGGA
TGAGGAAGGGTTTGAAAGTGGAGACTGTGGTGATGATGAAGATGAGTGCATTGGAGGCTCTGGT
GATGGAATGATGAAAGTGAAGAATCAGCTCCGCTTCCTTGCAGAACTGGCCTATGATCTGGATG
TGGATGATGCACCTGGAAACAATCAGCAGGCGACTCCGAAGGACAATGAGATAAGCACCTTTCA
CAACCTCGGGAACGTTCATTCCCCGCTGAAGCTTCTCACCAGCATGGCCATCTCAGTGGTGTGC
TTCTTCTTCCTGGTGCACTGACTGCCTGGTGCCCAGCACATGTGCTGCCCTACAGCACCCTGTG
GTCTTCCTCGATAAAGGGAACCACTTTCTTATTTTTTTCTATTTTTTTTTATCCTGTATACCTC
CTCCAGCCATTAAGTAGAGGACTAACCATGTGTTATGTTTTTGAAAATCAAATGGTATCTTTTG
GAGGAAGATAAATTTTAGTGGTAGTATATAGATTGTCCTCTTGCAAAGAAAAAAAACCCATCAA
GTTGTGCCAAATTATTTTCCTATGTTTGGCTGCTAGAACATGGTTACCATGTCTTTCTCTCTGT
CTTACTCCCTCCCTTTCTATCTTTCTCTCTCTCTTTGCATGGATTTCTTTGAAAAAAAATAAAT
TGCTCAAATAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007990928	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_007990928 ⟸ XM_007992737

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	GPC3	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)