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Gene: GPC3 (glypican 3) Homo sapiens
Symbol: GPC3
Name: glypican 3
Description: Exhibits peptidyl-dipeptidase inhibitor activity. Involved in positive regulation of canonical Wnt signaling pathway and regulation of non-canonical Wnt signaling pathway. Localizes to the plasma membrane. Implicated in Simpson-Golabi-Behmel syndrome type 1 and nephroblastoma. Biomarker of hepatocellular carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DGSX; glypican proteoglycan 3; glypican-3; GTR2-2; heparan sulphate proteoglycan; intestinal protein OCI-5; MXR7; OCI-5; SDYS; secreted glypican-3; SGB; SGBS; SGBS1
Mus musculus (house mouse) : Gpc3 (glypican 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gpc3 (glypican 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpc3 (glypican 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GPC3 (glypican 3)
Canis lupus familiaris (dog) : GPC3 (glypican 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpc3 (glypican 3)
Sus scrofa (pig) : GPC3 (glypican 3)
Chlorocebus sabaeus (African green monkey) : GPC3 (glypican 3)
Heterocephalus glaber (naked mole-rat) : Gpc3 (glypican 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX133,535,745 - 133,985,594 (-)Ensembl
GRCh38 EnsemblX133,535,745 - 133,985,895 (-)Ensembl
GRCh38X133,535,745 - 133,985,616 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X132,669,773 - 133,119,673 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X132,497,439 - 132,947,332 (-)NCBINCBI36hg18NCBI36
Build 34X132,395,297 - 132,845,186NCBI
CeleraX133,056,670 - 133,506,461 (-)NCBI
Cytogenetic MapXq26.2NCBI
HuRefX122,070,349 - 122,518,471 (-)NCBIHuRef
CHM1_1X132,581,479 - 133,031,377 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on GPC3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737615
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.