NEDD8 (NEDD8 ubiquitin like modifier) - Rat Genome Database

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Gene: NEDD8 (NEDD8 ubiquitin like modifier) Chlorocebus sabaeus
Analyze
Symbol: NEDD8
Name: NEDD8 ubiquitin like modifier
RGD ID: 18620715
Description: ENCODES a protein that exhibits ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to camptothecin (ortholog); protein localization (ortholog); protein neddylation (ortholog); PARTICIPATES IN neddylation pathway; p53 signaling pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; ASSOCIATED WITH Alcoholic Liver Diseases (ortholog); Brain-Lung-Thyroid Syndrome (ortholog); lysinuric protein intolerance (ortholog); FOUND IN cytosol (ortholog); glutamatergic synapse (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neural precursor cell expressed, developmentally down-regulated 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,199,974 - 1,215,079 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603612,884,384 - 12,899,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NEDD8Green MonkeyBrain-Lung-Thyroid Syndrome  ISONEDD8 (Homo sapiens)8554872ClinVar Annotator: match by term: Brain-lung-thyroid syndromeClinVarPMID:25741868
NEDD8Green Monkeylysinuric protein intolerance  ISONEDD8 (Homo sapiens)8554872ClinVar Annotator: match by term: Lysinuric protein intoleranceClinVarPMID:28492532
NEDD8Green MonkeySpecific Granule Deficiency  ISONEDD8 (Homo sapiens)8554872ClinVar Annotator: match by term: Specific granule deficiencyClinVarPMID:28492532


Biological Process

  

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NEDD8Green Monkeycytosol located_inISONEDD8 (Homo sapiens)9068941 HPAGO_REF:0000052
NEDD8Green Monkeyglutamatergic synapse is_active_inISONedd8 (Mus musculus)9068941 PMID:25581363SynGOPMID:25581363
NEDD8Green Monkeynucleoplasm located_inISONEDD8 (Homo sapiens)9068941 HPAGO_REF:0000052
NEDD8Green Monkeynucleus located_inISONedd8 (Mus musculus)9068941 PMID:12215427MGIPMID:12215427
NEDD8Green Monkeypostsynapse is_active_inISONedd8 (Rattus norvegicus)9068941PMID:32726795SynGOPMID:32726795 and REF_RGD_ID:405650354

Molecular Function
1 to 19 of 19 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NEDD8Green Monkeyprotein binding enablesISOUniProtKB:P610819068941 PMID:25416956 more ...IntActPMID:25416956 more ...
NEDD8Green Monkeyprotein binding enablesISOPR:P305619068941 PMID:12215427MGIPMID:12215427
NEDD8Green Monkeyprotein binding enablesISOUniProtKB:P062119068941PMID:21808025UniProtPMID:21808025 and REF_RGD_ID:13432273
NEDD8Green Monkeyprotein binding enablesISOUniProtKB:P04271 more ...9068941 PMID:32814053IntActPMID:32814053
NEDD8Green Monkeyprotein binding enablesISOUniProtKB:P61081 and UniProtKB:Q136169068941 PMID:18264111 and PMID:21765416IntActPMID:18264111 and PMID:21765416
NEDD8Green Monkeyprotein binding enablesISOUniProtKB:P099369068941 PMID:16169070IntActPMID:16169070
NEDD8Green Monkeyprotein binding enablesISOUniProtKB:O15037 more ...9068941 PMID:30659753IntActPMID:30659753
NEDD8Green Monkeyprotein binding enablesISOUniProtKB:P18124 more ...9068941 PMID:18274552IntActPMID:18274552
NEDD8Green Monkeyprotein binding enablesISOUniProtKB:Q136169068941 PMID:18723677 more ...IntActPMID:18723677 more ...
NEDD8Green Monkeyprotein binding enablesISOUniProtKB:Q13616 and UniProtKB:Q9Y2979068941 PMID:17318178IntActPMID:17318178
NEDD8Green Monkeyprotein binding enablesISOUniProtKB:P07437 more ...9068941 PMID:21145461IntActPMID:21145461
NEDD8Green Monkeyprotein binding enablesISOUniProtKB:P61081 more ...9068941 PMID:19713960IntActPMID:19713960
NEDD8Green Monkeyprotein binding enablesISOUniProtKB:Q13616 and UniProtKB:Q8WXE99068941 PMID:21102408IntActPMID:21102408
NEDD8Green Monkeyprotein binding enablesISOUniProtKB:A0A0F6B4239068941 PMID:27822540IntActPMID:27822540
NEDD8Green Monkeyprotein binding enablesISOUniProtKB:O948889068941 PMID:22466964IntActPMID:22466964
NEDD8Green Monkeyprotein binding enablesISOUniProtKB:Q9BTE79068941 PMID:24192928UniProtPMID:24192928
NEDD8Green Monkeyprotein binding enablesISOUniProtKB:Q9U3C89068941 PMID:15988528WBPMID:15988528
NEDD8Green Monkeyprotein binding enablesISOUniProtKB:Q6P9F59068941 PMID:21474709UniProtPMID:21474709
NEDD8Green Monkeyubiquitin protein ligase binding enablesISOUniProtKB:P610819068941 PMID:15694336UniProtPMID:15694336
1 to 19 of 19 rows

RGD Manual Annotations


  

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NEDD8Green Monkeyp53 signaling pathway   ISONEDD8 (Homo sapiens)9068941 PIDPID:200206
PMID:30032202  



NEDD8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,199,974 - 1,215,079 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603612,884,384 - 12,899,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NEDD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,216,857 - 24,232,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,216,857 - 24,232,367 (-)EnsemblGRCh38hg38GRCh38
GRCh371424,686,063 - 24,701,573 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,755,897 - 23,771,416 (-)NCBINCBI36Build 36hg18NCBI36
Build 341423,755,911 - 23,771,412NCBI
Celera144,550,695 - 4,566,214 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,801,062 - 4,816,345 (-)NCBIHuRef
CHM1_11424,684,707 - 24,700,199 (-)NCBICHM1_1
T2T-CHM13v2.01418,415,233 - 18,430,739 (-)NCBIT2T-CHM13v2.0
Nedd8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,899,720 - 55,909,337 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,899,720 - 55,909,581 (-)EnsemblGRCm39 Ensembl
GRCm381455,662,263 - 55,671,880 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,662,263 - 55,672,124 (-)EnsemblGRCm38mm10GRCm38
MGSCv371456,281,104 - 56,290,743 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,616,338 - 54,625,977 (-)NCBIMGSCv36mm8
Celera1453,467,340 - 53,476,979 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Nedd8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,123,505 - 33,135,522 (-)NCBIGRCr8
mRatBN7.21529,153,556 - 29,165,575 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,153,556 - 29,166,160 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,999,240 - 31,011,260 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,146,461 - 32,158,481 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,388,805 - 30,400,824 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,340,607 - 34,352,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,340,607 - 34,352,673 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,230,806 - 38,242,650 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,797,457 - 33,820,624 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,813,156 - 33,836,123 (-)NCBI
Celera1528,729,741 - 28,741,968 (-)NCBICelera
Cytogenetic Map15p13NCBI
Nedd8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540936,173,533 - 36,182,444 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540936,173,533 - 36,182,444 (+)NCBIChiLan1.0ChiLan1.0
NEDD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,571,077 - 25,586,644 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,787,569 - 24,803,136 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,993,011 - 5,008,620 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,117,271 - 23,132,249 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,117,271 - 23,132,249 (-)Ensemblpanpan1.1panPan2
NEDD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,202,621 - 4,213,090 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,202,621 - 4,213,049 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,124,303 - 4,134,768 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,313,388 - 4,323,857 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,313,388 - 4,323,818 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,003,790 - 4,014,244 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,065,590 - 4,076,046 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,327,911 - 4,338,370 (-)NCBIUU_Cfam_GSD_1.0
Nedd8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,050,496 - 36,058,043 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722331,136 - 338,496 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722331,116 - 338,496 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEDD8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,070,161 - 75,085,899 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,069,947 - 75,085,905 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,340,870 - 80,353,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Nedd8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,319,832 - 8,329,748 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,319,763 - 8,329,748 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in NEDD8
259 total Variants





RefSeq Transcripts XM_007986317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_007986317   ⟹   XP_007984508
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1241,199,974 - 1,215,079 (-)NCBI
Vero_WHO_p1.0NW_02366603612,884,384 - 12,899,520 (-)NCBI
Sequence:
Protein RefSeqs XP_007984508 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000018574.1
RefSeq Acc Id: XP_007984508   ⟸   XM_007986317
- UniProtKB: A0A0D9SCI5 (UniProtKB/TrEMBL)



1 to 18 of 18 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000019062 UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000019152.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
InterPro Nedd8-like UniProtKB/TrEMBL
  Ubiquitin-like_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
  Ubiquitin_CS UniProtKB/TrEMBL
  Ubiquitin_dom UniProtKB/TrEMBL
  Ubiquitin_ubiquitin-like UniProtKB/TrEMBL
NCBI Gene NEDD8 ENTREZGENE
PANTHER UBIQUITIN UniProtKB/TrEMBL
Pfam ubiquitin UniProtKB/TrEMBL
PRINTS UBIQUITIN UniProtKB/TrEMBL
PROSITE UBIQUITIN_1 UniProtKB/TrEMBL
  UBIQUITIN_2 UniProtKB/TrEMBL
SMART UBQ UniProtKB/TrEMBL
Superfamily-SCOP Ubiquitin-like UniProtKB/TrEMBL
UniProt A0A0D9SCI5 ENTREZGENE, UniProtKB/TrEMBL
1 to 18 of 18 rows