NEDD8 (NEDD8 ubiquitin like modifier) - Rat Genome Database

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Gene: NEDD8 (NEDD8 ubiquitin like modifier) Canis lupus familiaris
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Symbol: NEDD8
Name: NEDD8 ubiquitin like modifier
RGD ID: 12385585
Description: ENCODES a protein that exhibits protein tag activity (inferred); ubiquitin protein ligase binding (inferred); INVOLVED IN protein localization (ortholog); protein neddylation (ortholog); regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN neddylation pathway; p53 signaling pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; ASSOCIATED WITH Alcoholic Liver Diseases (ortholog); Brain-Lung-Thyroid Syndrome (ortholog); lysinuric protein intolerance (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neural precursor cell expressed, developmentally down-regulated 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,202,621 - 4,213,090 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,202,621 - 4,213,049 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,124,303 - 4,134,768 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,313,388 - 4,323,857 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,313,388 - 4,323,818 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,003,790 - 4,014,244 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,065,590 - 4,076,046 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,327,911 - 4,338,370 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NEDD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,202,621 - 4,213,090 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,202,621 - 4,213,049 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,124,303 - 4,134,768 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,313,388 - 4,323,857 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,313,388 - 4,323,818 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,003,790 - 4,014,244 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,065,590 - 4,076,046 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,327,911 - 4,338,370 (-)NCBIUU_Cfam_GSD_1.0
NEDD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,216,857 - 24,232,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,216,857 - 24,232,367 (-)EnsemblGRCh38hg38GRCh38
GRCh371424,686,063 - 24,701,573 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,755,897 - 23,771,416 (-)NCBINCBI36Build 36hg18NCBI36
Build 341423,755,911 - 23,771,412NCBI
Celera144,550,695 - 4,566,214 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,801,062 - 4,816,345 (-)NCBIHuRef
CHM1_11424,684,707 - 24,700,199 (-)NCBICHM1_1
T2T-CHM13v2.01418,415,233 - 18,430,739 (-)NCBIT2T-CHM13v2.0
Nedd8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,899,720 - 55,909,337 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,899,720 - 55,909,581 (-)EnsemblGRCm39 Ensembl
GRCm381455,662,263 - 55,671,880 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,662,263 - 55,672,124 (-)EnsemblGRCm38mm10GRCm38
MGSCv371456,281,104 - 56,290,743 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,616,338 - 54,625,977 (-)NCBIMGSCv36mm8
Celera1453,467,340 - 53,476,979 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Nedd8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,123,505 - 33,135,522 (-)NCBIGRCr8
mRatBN7.21529,153,556 - 29,165,575 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,153,556 - 29,166,160 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,999,240 - 31,011,260 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,146,461 - 32,158,481 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,388,805 - 30,400,824 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,340,607 - 34,352,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,340,607 - 34,352,673 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,230,806 - 38,242,650 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,797,457 - 33,820,624 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,813,156 - 33,836,123 (-)NCBI
Celera1528,729,741 - 28,741,968 (-)NCBICelera
Cytogenetic Map15p13NCBI
Nedd8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540936,173,533 - 36,182,444 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540936,173,533 - 36,182,444 (+)NCBIChiLan1.0ChiLan1.0
NEDD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,571,077 - 25,586,644 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,787,569 - 24,803,136 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,993,011 - 5,008,620 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,117,271 - 23,132,249 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,117,271 - 23,132,249 (-)Ensemblpanpan1.1panPan2
Nedd8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,050,496 - 36,058,043 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722331,136 - 338,496 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722331,116 - 338,496 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEDD8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,070,161 - 75,085,899 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,069,947 - 75,085,905 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,340,870 - 80,353,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEDD8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,199,974 - 1,215,079 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603612,884,384 - 12,899,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nedd8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,319,832 - 8,329,748 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,319,763 - 8,329,748 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NEDD8
88 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 1 10 6
Low 7
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000019203   ⟹   ENSCAFP00000017809
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,202,621 - 4,213,049 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845011168   ⟹   ENSCAFP00845008710
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl84,313,388 - 4,323,818 (-)Ensembl
RefSeq Acc Id: XM_038482876   ⟹   XP_038338804
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.184,003,790 - 4,014,244 (-)NCBI
RefSeq Acc Id: XM_038544308   ⟹   XP_038400236
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.084,327,911 - 4,338,370 (-)NCBI
RefSeq Acc Id: XM_038608427   ⟹   XP_038464355
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.084,065,590 - 4,076,046 (-)NCBI
RefSeq Acc Id: XM_038673236   ⟹   XP_038529164
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.084,313,388 - 4,323,857 (-)NCBI
RefSeq Acc Id: XM_537389   ⟹   XP_537389
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.184,202,621 - 4,213,090 (-)NCBI
Dog10K_Boxer_Tasha84,124,303 - 4,134,768 (-)NCBI
Sequence:
RefSeq Acc Id: XP_537389   ⟸   XM_537389
- UniProtKB: A0A8C0PZK1 (UniProtKB/TrEMBL),   A0A8I3N2C0 (UniProtKB/TrEMBL),   A0A8C0JMM4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000017809   ⟸   ENSCAFT00000019203
RefSeq Acc Id: XP_038338804   ⟸   XM_038482876
RefSeq Acc Id: XP_038464355   ⟸   XM_038608427
RefSeq Acc Id: XP_038529164   ⟸   XM_038673236
- UniProtKB: A0A8C0PZK1 (UniProtKB/TrEMBL),   A0A8I3N2C0 (UniProtKB/TrEMBL),   A0A8C0JMM4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038400236   ⟸   XM_038544308
- UniProtKB: A0A8C0JMM4 (UniProtKB/TrEMBL),   A0A8C0PZK1 (UniProtKB/TrEMBL),   A0A8I3N2C0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845008710   ⟸   ENSCAFT00845011168
Protein Domains
Ubiquitin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012097 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030014749 UniProtKB/TrEMBL
  ENSCAFG00040003957 UniProtKB/TrEMBL
  ENSCAFG00845006300 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000019203.5 UniProtKB/TrEMBL
  ENSCAFT00030027219.1 UniProtKB/TrEMBL
  ENSCAFT00040007539.1 UniProtKB/TrEMBL
  ENSCAFT00845011168 ENTREZGENE
  ENSCAFT00845011168.1 UniProtKB/TrEMBL
InterPro Nedd8-like UniProtKB/TrEMBL
  Ubiquitin-like_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
  Ubiquitin_CS UniProtKB/TrEMBL
  Ubiquitin_dom UniProtKB/TrEMBL
KEGG Report cfa:480265 UniProtKB/TrEMBL
NCBI Gene NEDD8 ENTREZGENE
PANTHER NEDD8 UniProtKB/TrEMBL
  UBIQUITIN UniProtKB/TrEMBL
Pfam ubiquitin UniProtKB/TrEMBL
PRINTS UBIQUITIN UniProtKB/TrEMBL
PROSITE UBIQUITIN_1 UniProtKB/TrEMBL
  UBIQUITIN_2 UniProtKB/TrEMBL
SMART UBQ UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/TrEMBL
UniProt A0A8C0JMM4 ENTREZGENE
  A0A8C0PZK1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N2C0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:56061 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 NEDD8  NEDD8 ubiquitin like modifier    neural precursor cell expressed, developmentally down-regulated 8  Symbol and/or name change 5135510 APPROVED