NEDD8 (NEDD8 ubiquitin like modifier) - Rat Genome Database

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Gene: NEDD8 (NEDD8 ubiquitin like modifier) Pan paniscus
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Symbol: NEDD8
Name: NEDD8 ubiquitin like modifier
RGD ID: 11712281
Description: ENCODES a protein that exhibits protein tag activity (inferred); ubiquitin protein ligase binding (inferred); INVOLVED IN protein localization (ortholog); protein neddylation (ortholog); regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN neddylation pathway; p53 signaling pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; ASSOCIATED WITH Alcoholic Liver Diseases (ortholog); Brain-Lung-Thyroid Syndrome (ortholog); lysinuric protein intolerance (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neural precursor cell expressed, developmentally down-regulated 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,571,077 - 25,586,644 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,787,569 - 24,803,136 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,993,011 - 5,008,620 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,117,271 - 23,132,249 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,117,271 - 23,132,249 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NEDD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,571,077 - 25,586,644 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,787,569 - 24,803,136 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,993,011 - 5,008,620 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,117,271 - 23,132,249 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,117,271 - 23,132,249 (-)Ensemblpanpan1.1panPan2
NEDD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,216,857 - 24,232,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,216,857 - 24,232,367 (-)EnsemblGRCh38hg38GRCh38
GRCh371424,686,063 - 24,701,573 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,755,897 - 23,771,416 (-)NCBINCBI36Build 36hg18NCBI36
Build 341423,755,911 - 23,771,412NCBI
Celera144,550,695 - 4,566,214 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,801,062 - 4,816,345 (-)NCBIHuRef
CHM1_11424,684,707 - 24,700,199 (-)NCBICHM1_1
T2T-CHM13v2.01418,415,233 - 18,430,739 (-)NCBIT2T-CHM13v2.0
Nedd8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,899,720 - 55,909,337 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,899,720 - 55,909,581 (-)EnsemblGRCm39 Ensembl
GRCm381455,662,263 - 55,671,880 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,662,263 - 55,672,124 (-)EnsemblGRCm38mm10GRCm38
MGSCv371456,281,104 - 56,290,743 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,616,338 - 54,625,977 (-)NCBIMGSCv36mm8
Celera1453,467,340 - 53,476,979 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Nedd8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,123,505 - 33,135,522 (-)NCBIGRCr8
mRatBN7.21529,153,556 - 29,165,575 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,153,556 - 29,166,160 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,999,240 - 31,011,260 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,146,461 - 32,158,481 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,388,805 - 30,400,824 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,340,607 - 34,352,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,340,607 - 34,352,673 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,230,806 - 38,242,650 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,797,457 - 33,820,624 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,813,156 - 33,836,123 (-)NCBI
Celera1528,729,741 - 28,741,968 (-)NCBICelera
Cytogenetic Map15p13NCBI
Nedd8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540936,173,533 - 36,182,444 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540936,173,533 - 36,182,444 (+)NCBIChiLan1.0ChiLan1.0
NEDD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,202,621 - 4,213,090 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,202,621 - 4,213,049 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,124,303 - 4,134,768 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,313,388 - 4,323,857 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,313,388 - 4,323,818 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,003,790 - 4,014,244 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,065,590 - 4,076,046 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,327,911 - 4,338,370 (-)NCBIUU_Cfam_GSD_1.0
Nedd8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,050,496 - 36,058,043 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722331,136 - 338,496 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722331,116 - 338,496 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEDD8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,070,161 - 75,085,899 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,069,947 - 75,085,905 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,340,870 - 80,353,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEDD8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,199,974 - 1,215,079 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603612,884,384 - 12,899,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nedd8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,319,832 - 8,329,748 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,319,763 - 8,329,748 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003809086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSPPAT00000052694   ⟹   ENSPPAP00000029842
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1423,117,271 - 23,132,249 (-)Ensembl
RefSeq Acc Id: XM_003809086   ⟹   XP_003809134
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21525,571,077 - 25,586,644 (-)NCBI
NHGRI_mPanPan11424,787,569 - 24,803,136 (-)NCBI
Mhudiblu_PPA_v0144,993,011 - 5,008,620 (-)NCBI
PanPan1.11423,117,271 - 23,132,249 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003809134 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000029842
  ENSPPAP00000029842.1
RefSeq Acc Id: XP_003809134   ⟸   XM_003809086
- UniProtKB: A0A2R9BN41 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000029842   ⟸   ENSPPAT00000052694
Protein Domains
Ubiquitin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037948 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000052694.1 UniProtKB/TrEMBL
InterPro Nedd8-like UniProtKB/TrEMBL
  Ubiquitin-like_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
  Ubiquitin_CS UniProtKB/TrEMBL
  Ubiquitin_dom UniProtKB/TrEMBL
KEGG Report pps:100977398 UniProtKB/TrEMBL
NCBI Gene NEDD8 ENTREZGENE
PANTHER NEDD8 UniProtKB/TrEMBL
  UBIQUITIN UniProtKB/TrEMBL
Pfam ubiquitin UniProtKB/TrEMBL
PRINTS UBIQUITIN UniProtKB/TrEMBL
PROSITE UBIQUITIN_1 UniProtKB/TrEMBL
  UBIQUITIN_2 UniProtKB/TrEMBL
SMART UBQ UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/TrEMBL
UniProt A0A2R9BN41 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-09 NEDD8  NEDD8 ubiquitin like modifier    neural precursor cell expressed, developmentally down-regulated 8  Symbol and/or name change 5135510 APPROVED