RGD Reference Report - Cullin-based ubiquitin ligase and its control by NEDD8-conjugating system. - Rat Genome Database

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Cullin-based ubiquitin ligase and its control by NEDD8-conjugating system.

Authors: Chiba, T  Tanaka, K 
Citation: Chiba T and Tanaka K, Curr Protein Pept Sci 2004 Jun;5(3):177-84.
RGD ID: 1549457
Pubmed: PMID:15180522   (View Abstract at PubMed)

Several studies have examined the importance of ubiquitin-like posttranslational modifiers (which consist of an unexpectedly large family). Of these, NEDD8 (also called Rub1, related to ubiquitin 1) with a high homology to ubiquitin is covalently linked to all members of cullin (Cul)-family proteins through an enzymatic cascade analogous to ubiquitylation. Cul-family proteins are scaffold proteins for a wide series of ubiquitin-protein ligase complexes, such as SCFs (Skp1, Cul-1, Roc1, and F-box proteins), which regulate the degradation of broad range of cellular proteins. Unlike ubiquitin, which mostly acts as a degradation signal for the target proteins, NEDD8 acts as an activation signal for Cul-family proteins; i.e., Cul-based ubiquitin-protein ligases. Accordingly, the NEDD8 conjugation pathway regulating Cul-protein function is responsible for a diverse array of biologically important processes, such as the cell cycle progression, signalling cascades and developmental programs. Furthermore, recent studies have revealed that the COP9/Signalosome complex interacts physically and genetically with Cul-family proteins, and catalyzes deconjugation of NEDD8 ligated to Cul-family proteins. This review summarizes recent advances in biochemical and genetic studies on how the NEDD8-modifying system regulates Cul-family proteins and their physiology.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Nedd8  (NEDD8 ubiquitin like modifier)

Genes (Mus musculus)
Nedd8  (neural precursor cell expressed, developmentally down-regulated gene 8)

Genes (Homo sapiens)
NEDD8  (NEDD8 ubiquitin like modifier)


Additional Information