Nedd8 (neural precursor cell expressed, developmentally down-regulated gene 8) - Rat Genome Database

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Gene: Nedd8 (neural precursor cell expressed, developmentally down-regulated gene 8) Mus musculus
Analyze
Symbol: Nedd8
Name: neural precursor cell expressed, developmentally down-regulated gene 8
RGD ID: 10968
MGI Page MGI
Description: Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Acts upstream of or within protein localization and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Orthologous to human NEDD8 (NEDD8 ubiquitin like modifier).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: NEDD-8; neddylin; neural precursor cell expressed developmentally down-regulated protein 8; Rub; Rub1; ubiquitin-like protein Nedd8
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,899,720 - 55,909,337 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,899,720 - 55,909,581 (-)EnsemblGRCm39 Ensembl
GRCm381455,662,263 - 55,671,880 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,662,263 - 55,672,124 (-)EnsemblGRCm38mm10GRCm38
MGSCv371456,281,104 - 56,290,743 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,616,338 - 54,625,977 (-)NCBIMGSCv36mm8
Celera1453,467,340 - 53,476,979 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cullin-based ubiquitin ligase and its control by NEDD8-conjugating system. Chiba T and Tanaka K, Curr Protein Pept Sci 2004 Jun;5(3):177-84.
2. NEDD8 protein is involved in ubiquitinated inclusion bodies. Dil Kuazi A, etal., J Pathol 2003 Feb;199(2):259-66.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1378265   PMID:8395831   PMID:8889548   PMID:9353319   PMID:10349636   PMID:10500095   PMID:10597293   PMID:10737774   PMID:10806345   PMID:10922068   PMID:11042159   PMID:11076861  
PMID:11217851   PMID:11696557   PMID:12215427   PMID:12466851   PMID:12477932   PMID:12904583   PMID:14610273   PMID:14673145   PMID:15183309   PMID:15489334   PMID:16141072   PMID:16141073  
PMID:16537572   PMID:16602821   PMID:16735510   PMID:17119158   PMID:18799693   PMID:18826954   PMID:19799774   PMID:20059953   PMID:20937703   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:23118980   PMID:23267066   PMID:23290524   PMID:23362276   PMID:25326537   PMID:25452302   PMID:25581363   PMID:25624478   PMID:26471094   PMID:27119228   PMID:27771247   PMID:27822540  
PMID:28522566   PMID:28569775   PMID:29518331   PMID:29632206   PMID:31882005   PMID:32325033   PMID:33020269   PMID:34709266  


Genomics

Comparative Map Data
Nedd8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,899,720 - 55,909,337 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,899,720 - 55,909,581 (-)EnsemblGRCm39 Ensembl
GRCm381455,662,263 - 55,671,880 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,662,263 - 55,672,124 (-)EnsemblGRCm38mm10GRCm38
MGSCv371456,281,104 - 56,290,743 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,616,338 - 54,625,977 (-)NCBIMGSCv36mm8
Celera1453,467,340 - 53,476,979 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
NEDD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,216,857 - 24,232,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,216,857 - 24,232,367 (-)EnsemblGRCh38hg38GRCh38
GRCh371424,686,063 - 24,701,573 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,755,897 - 23,771,416 (-)NCBINCBI36Build 36hg18NCBI36
Build 341423,755,911 - 23,771,412NCBI
Celera144,550,695 - 4,566,214 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,801,062 - 4,816,345 (-)NCBIHuRef
CHM1_11424,684,707 - 24,700,199 (-)NCBICHM1_1
T2T-CHM13v2.01418,415,233 - 18,430,739 (-)NCBIT2T-CHM13v2.0
Nedd8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,123,505 - 33,135,522 (-)NCBIGRCr8
mRatBN7.21529,153,556 - 29,165,575 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,153,556 - 29,166,160 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,999,240 - 31,011,260 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,146,461 - 32,158,481 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,388,805 - 30,400,824 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,340,607 - 34,352,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,340,607 - 34,352,673 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,230,806 - 38,242,650 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,797,457 - 33,820,624 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,813,156 - 33,836,123 (-)NCBI
Celera1528,729,741 - 28,741,968 (-)NCBICelera
Cytogenetic Map15p13NCBI
Nedd8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540936,173,533 - 36,182,444 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540936,173,533 - 36,182,444 (+)NCBIChiLan1.0ChiLan1.0
NEDD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,571,077 - 25,586,644 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,787,569 - 24,803,136 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,993,011 - 5,008,620 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,117,271 - 23,132,249 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,117,271 - 23,132,249 (-)Ensemblpanpan1.1panPan2
NEDD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,202,621 - 4,213,090 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,202,621 - 4,213,049 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,124,303 - 4,134,768 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,313,388 - 4,323,857 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,313,388 - 4,323,818 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,003,790 - 4,014,244 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,065,590 - 4,076,046 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,327,911 - 4,338,370 (-)NCBIUU_Cfam_GSD_1.0
Nedd8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,050,496 - 36,058,043 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722331,136 - 338,496 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722331,116 - 338,496 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEDD8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,070,161 - 75,085,899 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,069,947 - 75,085,905 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,340,870 - 80,353,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEDD8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,199,974 - 1,215,079 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603612,884,384 - 12,899,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nedd8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,319,832 - 8,329,748 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,319,763 - 8,329,748 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nedd8
287 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:370
Count of miRNA genes:193
Interacting mature miRNAs:206
Transcripts:ENSMUST00000010520, ENSMUST00000163750
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4733525059962593Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000010520   ⟹   ENSMUSP00000010520
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,899,720 - 55,909,581 (-)Ensembl
GRCm38.p6 Ensembl1455,662,263 - 55,672,124 (-)Ensembl
RefSeq Acc Id: ENSMUST00000163750   ⟹   ENSMUSP00000130492
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,899,722 - 55,909,330 (-)Ensembl
GRCm38.p6 Ensembl1455,662,265 - 55,671,873 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227157
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,899,860 - 55,901,753 (-)Ensembl
GRCm38.p6 Ensembl1455,662,403 - 55,664,296 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227250   ⟹   ENSMUSP00000154561
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,899,721 - 55,901,318 (-)Ensembl
GRCm38.p6 Ensembl1455,662,264 - 55,663,861 (-)Ensembl
RefSeq Acc Id: ENSMUST00000228414
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,899,843 - 55,909,334 (-)Ensembl
GRCm38.p6 Ensembl1455,662,386 - 55,671,877 (-)Ensembl
RefSeq Acc Id: NM_008683   ⟹   NP_032709
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391455,899,720 - 55,909,337 (-)NCBI
GRCm381455,662,263 - 55,671,880 (-)NCBI
MGSCv371456,281,104 - 56,290,743 (-)RGD
Celera1453,467,340 - 53,476,979 (-)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032709   ⟸   NM_008683
- UniProtKB: P29595 (UniProtKB/Swiss-Prot),   Q3UI46 (UniProtKB/TrEMBL),   Q3TY05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000130492   ⟸   ENSMUST00000163750
RefSeq Acc Id: ENSMUSP00000154561   ⟸   ENSMUST00000227250
RefSeq Acc Id: ENSMUSP00000010520   ⟸   ENSMUST00000010520
Protein Domains
Ubiquitin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29595-F1-model_v2 AlphaFold P29595 1-81 view protein structure

Promoters
RGD ID:8682456
Promoter ID:EPDNEW_M19259
Type:initiation region
Name:Nedd8_1
Description:Mus musculus neural precursor cell expressed, developmentallydown-regulated gene 8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381455,671,880 - 55,671,940EPDNEW
RGD ID:6825207
Promoter ID:MM_KWN:16981
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B6
Transcripts:ENSMUST00000010520
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361456,282,886 - 56,283,787 (-)MPROMDB
RGD ID:6825041
Promoter ID:MM_KWN:16982
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_008683,   NM_177992,   UC007UAD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361456,290,706 - 56,291,257 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97301 AgrOrtholog
Ensembl Genes ENSMUSG00000010376 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000010520 ENTREZGENE
  ENSMUST00000010520.10 UniProtKB/Swiss-Prot
  ENSMUST00000163750.8 UniProtKB/Swiss-Prot
  ENSMUST00000227250.2 UniProtKB/TrEMBL
InterPro Nedd8-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin UniProtKB/Swiss-Prot
  Ubiquitin-like_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin_dom UniProtKB/Swiss-Prot
  Ubiquitin_dom UniProtKB/TrEMBL
KEGG Report mmu:18002 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97301 ENTREZGENE
NCBI Gene 18002 ENTREZGENE
PANTHER NEDD8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ubiquitin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nedd8 PhenoGen
PRINTS UBIQUITIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE UBIQUITIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART UBQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2I3BRG0_MOUSE UniProtKB/TrEMBL
  NEDD8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TY05 ENTREZGENE, UniProtKB/TrEMBL
  Q3UI46 ENTREZGENE, UniProtKB/TrEMBL