Ppp1r3d (protein phosphatase 1, regulatory subunit 3D) - Rat Genome Database

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Gene: Ppp1r3d (protein phosphatase 1, regulatory subunit 3D) Mus musculus
Analyze
Symbol: Ppp1r3d
Name: protein phosphatase 1, regulatory subunit 3D
RGD ID: 1622963
MGI Page MGI
Description: Predicted to enable glycogen binding activity and protein phosphatase 1 binding activity. Predicted to contribute to phosphoprotein phosphatase activity. Predicted to be involved in regulation of glycogen biosynthetic process and regulation of glycogen catabolic process. Predicted to be located in glycogen granule. Predicted to be part of protein phosphatase type 1 complex. Orthologous to human PPP1R3D (protein phosphatase 1 regulatory subunit 3D).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2610024M03Rik; Gm359; protein phosphatase 1 regulatory subunit 3D
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392178,052,999 - 178,056,256 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2178,052,999 - 178,056,265 (-)EnsemblGRCm39 Ensembl
GRCm382178,411,206 - 178,414,463 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2178,411,206 - 178,414,472 (-)EnsemblGRCm38mm10GRCm38
MGSCv372178,145,911 - 178,149,177 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362178,340,614 - 178,343,929 (-)NCBIMGSCv36mm8
Celera2182,497,614 - 182,500,880 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map299.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The level of the glycogen targetting regulatory subunit R5 of protein phosphatase 1 is decreased in the livers of insulin-dependent diabetic rats and starved rats. Browne GJ, etal., Biochem J. 2001 Dec 1;360(Pt 2):449-59.
2. AMP-activated protein kinase: also regulated by ADP? Hardie DG, etal., Trends Biochem Sci. 2011 Sep;36(9):470-7. doi: 10.1016/j.tibs.2011.06.004. Epub 2011 Jul 23.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:23927422   PMID:32892347  


Genomics

Comparative Map Data
Ppp1r3d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392178,052,999 - 178,056,256 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2178,052,999 - 178,056,265 (-)EnsemblGRCm39 Ensembl
GRCm382178,411,206 - 178,414,463 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2178,411,206 - 178,414,472 (-)EnsemblGRCm38mm10GRCm38
MGSCv372178,145,911 - 178,149,177 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362178,340,614 - 178,343,929 (-)NCBIMGSCv36mm8
Celera2182,497,614 - 182,500,880 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map299.91NCBI
PPP1R3D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382059,936,663 - 59,940,305 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2059,936,663 - 59,940,305 (-)EnsemblGRCh38hg38GRCh38
GRCh372058,511,718 - 58,515,360 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362057,945,282 - 57,948,747 (-)NCBINCBI36Build 36hg18NCBI36
Build 342057,945,282 - 57,948,747NCBI
Celera2055,252,565 - 55,256,030 (-)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2055,299,100 - 55,302,565 (-)NCBIHuRef
CHM1_12058,412,949 - 58,416,414 (-)NCBICHM1_1
T2T-CHM13v2.02061,720,935 - 61,724,577 (-)NCBIT2T-CHM13v2.0
Ppp1r3d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83185,880,087 - 185,883,158 (-)NCBIGRCr8
mRatBN7.23165,502,384 - 165,505,455 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3165,502,384 - 165,505,455 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3169,876,489 - 169,879,560 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03178,835,577 - 178,838,648 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03175,501,947 - 175,505,018 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03173,950,613 - 173,953,684 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3173,950,613 - 173,953,684 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03183,137,515 - 183,140,586 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43167,505,678 - 167,508,749 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3167,056,456 - 167,059,527 (+)NCBICelera
Cytogenetic Map3q43NCBI
Ppp1r3d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555283,804,557 - 3,807,309 (+)NCBIChiLan1.0ChiLan1.0
PPP1R3D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22165,705,083 - 65,708,325 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12065,698,203 - 65,701,298 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02056,292,457 - 56,295,977 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12057,644,184 - 57,647,585 (-)NCBIpanpan1.1PanPan1.1panPan2
PPP1R3D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12444,550,028 - 44,551,556 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2444,550,320 - 44,551,219 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2443,794,436 - 43,795,617 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02445,416,651 - 45,417,832 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2445,416,933 - 45,417,832 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12444,518,184 - 44,519,364 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02444,637,780 - 44,638,960 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02445,297,767 - 45,298,948 (-)NCBIUU_Cfam_GSD_1.0
Ppp1r3d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640192,897,627 - 192,900,141 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365148,352,513 - 8,353,409 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365148,350,275 - 8,353,782 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R3D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1759,964,585 - 59,967,113 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11759,963,560 - 59,967,143 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21767,406,676 - 67,409,825 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R3D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.124,207,963 - 4,211,630 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl24,208,351 - 4,209,250 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605052,250,088 - 52,253,648 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r3d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474126,207,096 - 26,207,827 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474126,205,076 - 26,208,158 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:824
Count of miRNA genes:475
Interacting mature miRNAs:570
Transcripts:ENSMUST00000058678
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300688Nidd2k_mNidd2 on KK-A (mouse)Not determined2158078337178442452Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
1300676Prdt2_mprion disease incubation time 2 (mouse)Not determined2164515154181755017Mouse
1558991Tailq4_mtail length QTL 4 (mouse)Not determined2162736926178442452Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155823920181755017Mouse
12910811Pwbwq3_mpre-weaning body weight QTL 3 (mouse)2169794802178920791Mouse
1302003Sluc17_msusceptibility to lung cancer 17 (mouse)Not determined2162433493181755017Mouse
12738409Lfibq1_mliver fibrosis QTL 1 (mouse)2167716420179207088Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
1357435Epfq2_mepididymal fat pad weight QTL 2 (mouse)Not determined2162736926178442452Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156196464181755017Mouse
1301348Alcp5_malcohol preference locus 5 (mouse)Not determined2163486407181755017Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1301677Alcp6_malcohol preference locus 6 (mouse)Not determined2163486407181755017Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000058678   ⟹   ENSMUSP00000061402
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2178,052,999 - 178,056,265 (-)Ensembl
GRCm38.p6 Ensembl2178,411,206 - 178,414,472 (-)Ensembl
RefSeq Acc Id: NM_001085501   ⟹   NP_001078970
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392178,052,999 - 178,056,256 (-)NCBI
GRCm382178,411,206 - 178,414,463 (-)NCBI
MGSCv372178,145,911 - 178,149,177 (-)RGD
Celera2182,497,614 - 182,500,871 (-)NCBI
cM Map2 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001078970 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL07288 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000061402
  ENSMUSP00000061402.5
RefSeq Acc Id: NP_001078970   ⟸   NM_001085501
- UniProtKB: A2AJW4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000061402   ⟸   ENSMUST00000058678
Protein Domains
CBM21

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A2AJW4-F1-model_v2 AlphaFold A2AJW4 1-279 view protein structure

Promoters
RGD ID:6832369
Promoter ID:MM_KWN:33488
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   MEF_B4
Transcripts:NM_001085501,   OTTMUST00000039325,   OTTMUST00000039326
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362178,145,411 - 178,149,507 (+)MPROMDB
RGD ID:6880018
Promoter ID:EPDNEW_M3460
Type:initiation region
Name:Ppp1r3d_1
Description:Mus musculus protein phosphatase 1, regulatory subunit 3D , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382178,414,474 - 178,414,534EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1917664 AgrOrtholog
Ensembl Genes ENSMUSG00000049999 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000058678 ENTREZGENE
  ENSMUST00000058678.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.2440 UniProtKB/TrEMBL
InterPro CBM21_dom_sf UniProtKB/TrEMBL
  CBM_21 UniProtKB/TrEMBL
  Pase-1_Glycogen_target-su_met UniProtKB/TrEMBL
  PP1_regulatory_subunit_3 UniProtKB/TrEMBL
KEGG Report mmu:228966 UniProtKB/TrEMBL
MGD MGI:1917664 ENTREZGENE
NCBI Gene Ppp1r3d ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT UniProtKB/TrEMBL
  PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3D UniProtKB/TrEMBL
Pfam CBM_21 UniProtKB/TrEMBL
PhenoGen Ppp1r3d PhenoGen
PIRSF PP1_GT_animal UniProtKB/TrEMBL
PROSITE CBM21 UniProtKB/TrEMBL
UniProt A2AJW4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Ppp1r3d  protein phosphatase 1, regulatory subunit 3D  2610024M03Rik  RIKEN cDNA 2610024M03 gene  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 2610024M03Rik  RIKEN cDNA 2610024M03 gene  Ppp1r3d  protein phosphatase 1, regulatory subunit 3D  Symbol and/or name change 5135510 APPROVED