RALGAPB (Ral GTPase activating protein non-catalytic subunit beta) - Rat Genome Database

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Gene: RALGAPB (Ral GTPase activating protein non-catalytic subunit beta) Homo sapiens
Analyze
Symbol: RALGAPB
Name: Ral GTPase activating protein non-catalytic subunit beta
RGD ID: 1603624
HGNC Page HGNC
Description: Exhibits protein heterodimerization activity. Predicted to be involved in Ral protein signal transduction; activation of GTPase activity; and regulation of exocyst localization; INTERACTS WITH (-)-epigallocatechin 3-gallate; aflatoxin B1; antirheumatic drug.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dJ1100H13.1; DKFZp686N19168; DKFZp781M2411; FLJ43270; FLJ43928; KIAA1219; p170; Ral GTPase activating protein non-catalytic beta subunit; Ral GTPase activating protein, beta subunit (non-catalytic); ral GTPase-activating protein beta subunit; ral GTPase-activating protein subunit beta; RalGAPbeta; RP5-1100H13.1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2038,472,816 - 38,578,859 (+)EnsemblGRCh38hg38GRCh38
GRCh382038,472,820 - 38,578,861 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372037,101,486 - 37,207,501 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362036,534,900 - 36,640,918 (+)NCBINCBI36hg18NCBI36
Celera2033,812,295 - 33,918,296 (+)NCBI
Cytogenetic Map20q11.23NCBI
HuRef2033,838,335 - 33,944,354 (+)NCBIHuRef
CHM1_12037,005,683 - 37,111,714 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:10574462   PMID:11780052   PMID:12168954   PMID:12477932   PMID:14702039   PMID:15302935   PMID:15489334   PMID:16490346   PMID:17474147   PMID:19520869   PMID:21697133   PMID:21873635  
PMID:23934111   PMID:24255178   PMID:24814574   PMID:25363760   PMID:25921289   PMID:26186194   PMID:27880917   PMID:28514442   PMID:28611215   PMID:29507755   PMID:29509190   PMID:29568061  
PMID:30232004   PMID:30564305   PMID:31091453   PMID:31527615   PMID:32296183   PMID:32694731   PMID:33060197   PMID:33957083  


Genomics

Comparative Map Data
RALGAPB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2038,472,816 - 38,578,859 (+)EnsemblGRCh38hg38GRCh38
GRCh382038,472,820 - 38,578,861 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372037,101,486 - 37,207,501 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362036,534,900 - 36,640,918 (+)NCBINCBI36hg18NCBI36
Celera2033,812,295 - 33,918,296 (+)NCBI
Cytogenetic Map20q11.23NCBI
HuRef2033,838,335 - 33,944,354 (+)NCBIHuRef
CHM1_12037,005,683 - 37,111,714 (+)NCBICHM1_1
Ralgapb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392158,251,722 - 158,341,173 (+)NCBIGRCm39mm39
GRCm39 Ensembl2158,251,768 - 158,341,173 (+)Ensembl
GRCm382158,409,830 - 158,499,253 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2158,409,848 - 158,499,253 (+)EnsemblGRCm38mm10GRCm38
MGSCv372158,235,589 - 158,324,989 (+)NCBIGRCm37mm9NCBIm37
MGSCv362158,101,294 - 158,190,694 (+)NCBImm8
Celera2164,346,414 - 164,436,672 (+)NCBICelera
Cytogenetic Map2H1NCBI
Ralgapb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23147,062,443 - 147,152,090 (+)NCBI
Rnor_6.0 Ensembl3154,905,141 - 154,983,021 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03154,910,291 - 154,983,021 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03160,623,751 - 160,696,177 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43149,137,224 - 149,212,377 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13149,031,561 - 149,118,099 (+)NCBI
Celera3145,780,077 - 145,852,667 (+)NCBICelera
Cytogenetic Map3q42NCBI
Ralgapb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544518,140,944 - 18,241,128 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544518,146,316 - 18,241,128 (-)NCBIChiLan1.0ChiLan1.0
RALGAPB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12035,906,029 - 36,011,685 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2035,906,029 - 36,011,685 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02034,797,472 - 34,903,367 (+)NCBIMhudiblu_PPA_v0panPan3
RALGAPB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12426,948,626 - 27,032,092 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2426,961,628 - 27,070,850 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2426,594,210 - 26,677,570 (+)NCBI
ROS_Cfam_1.02427,645,025 - 27,728,261 (+)NCBI
UMICH_Zoey_3.12426,919,244 - 27,002,002 (+)NCBI
UNSW_CanFamBas_1.02427,027,094 - 27,110,307 (+)NCBI
UU_Cfam_GSD_1.02427,515,215 - 27,598,354 (+)NCBI
Ralgapb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640175,840,609 - 175,945,320 (+)NCBI
SpeTri2.0NW_0049365612,806,195 - 2,908,909 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RALGAPB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1741,507,806 - 41,606,898 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11741,507,756 - 41,606,903 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21746,951,706 - 47,014,116 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RALGAPB
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1225,177,380 - 25,285,938 (-)NCBI
ChlSab1.1 Ensembl225,176,956 - 25,307,991 (-)Ensembl
Vero_WHO_p1.0NW_02366605074,014,842 - 74,123,559 (-)NCBI
Ralgapb
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248421,067,651 - 1,167,779 (-)NCBI

Position Markers
STS-AA024902  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372037,205,283 - 37,205,508UniSTSGRCh37
Build 362036,638,697 - 36,638,922RGDNCBI36
Celera2033,916,073 - 33,916,298RGD
Cytogenetic Map20q11.23UniSTS
HuRef2033,942,131 - 33,942,356UniSTS
GeneMap99-GB4 RH Map20210.97UniSTS
D20S1028  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372037,139,685 - 37,139,863UniSTSGRCh37
Build 362036,573,099 - 36,573,277RGDNCBI36
Celera2033,850,485 - 33,850,663RGD
Cytogenetic Map20q11.23UniSTS
HuRef2033,876,544 - 33,876,722UniSTS
Whitehead-RH Map20234.9UniSTS
Whitehead-YAC Contig Map20 UniSTS
SHGC-81042  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372037,166,519 - 37,166,820UniSTSGRCh37
Build 362036,599,933 - 36,600,234RGDNCBI36
Celera2033,877,308 - 33,877,609RGD
Cytogenetic Map20q11.2UniSTS
Cytogenetic Map20q11.23UniSTS
HuRef2033,903,366 - 33,903,667UniSTS
TNG Radiation Hybrid Map2017251.0UniSTS
SHGC-132362  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372037,207,243 - 37,207,454UniSTSGRCh37
Build 362036,640,657 - 36,640,868RGDNCBI36
Celera2033,918,035 - 33,918,246RGD
Cytogenetic Map20q11.23UniSTS
HuRef2033,944,093 - 33,944,304UniSTS
TNG Radiation Hybrid Map2017187.0UniSTS
RH67965  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372037,204,276 - 37,204,400UniSTSGRCh37
Build 362036,637,690 - 36,637,814RGDNCBI36
Celera2033,915,066 - 33,915,190RGD
Cytogenetic Map20q11.23UniSTS
HuRef2033,941,124 - 33,941,248UniSTS
GeneMap99-GB4 RH Map20220.51UniSTS
RH65522  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372037,204,565 - 37,204,715UniSTSGRCh37
Build 362036,637,979 - 36,638,129RGDNCBI36
Celera2033,915,355 - 33,915,505RGD
Cytogenetic Map20q11.23UniSTS
HuRef2033,941,413 - 33,941,563UniSTS
GeneMap99-GB4 RH Map20220.51UniSTS
SHGC-52414  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372037,199,360 - 37,199,521UniSTSGRCh37
Build 362036,632,774 - 36,632,935RGDNCBI36
Celera2033,910,150 - 33,910,311RGD
Cytogenetic Map20q11.23UniSTS
HuRef2033,936,208 - 33,936,369UniSTS
GeneMap99-G3 RH Map202044.0UniSTS
RH69489  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372037,202,105 - 37,202,228UniSTSGRCh37
Build 362036,635,519 - 36,635,642RGDNCBI36
Celera2033,912,895 - 33,913,018RGD
Cytogenetic Map20q11.23UniSTS
HuRef2033,938,953 - 33,939,076UniSTS
GeneMap99-GB4 RH Map20220.51UniSTS
D20S795  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372037,112,866 - 37,112,973UniSTSGRCh37
Build 362036,546,280 - 36,546,387RGDNCBI36
Celera2033,823,667 - 33,823,774RGD
Cytogenetic Map20q11.23UniSTS
HuRef2033,849,732 - 33,849,839UniSTS
TNG Radiation Hybrid Map2017148.0UniSTS
Stanford-G3 RH Map202011.0UniSTS
NCBI RH Map20348.8UniSTS
Z94367  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372037,198,887 - 37,199,010UniSTSGRCh37
Build 362036,632,301 - 36,632,424RGDNCBI36
Celera2033,909,677 - 33,909,800RGD
Cytogenetic Map20q11.23UniSTS
HuRef2033,935,735 - 33,935,858UniSTS
SHGC-2403  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372037,207,243 - 37,207,441UniSTSGRCh37
Build 362036,640,657 - 36,640,855RGDNCBI36
Celera2033,918,035 - 33,918,233RGD
Cytogenetic Map20q11.23UniSTS
HuRef2033,944,093 - 33,944,291UniSTS
Stanford-G3 RH Map202015.0UniSTS
GeneMap99-GB4 RH Map20214.11UniSTS
Whitehead-RH Map20234.1UniSTS
GeneMap99-G3 RH Map202048.0UniSTS
WI-13938  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372037,207,353 - 37,207,464UniSTSGRCh37
Build 362036,640,767 - 36,640,878RGDNCBI36
Celera2033,918,145 - 33,918,256RGD
Cytogenetic Map20q11.23UniSTS
HuRef2033,944,203 - 33,944,314UniSTS
GeneMap99-GB4 RH Map20213.88UniSTS
Whitehead-RH Map20242.1UniSTS
NCBI RH Map20348.8UniSTS
D20S690  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372037,204,998 - 37,205,129UniSTSGRCh37
Build 362036,638,412 - 36,638,543RGDNCBI36
Celera2033,915,788 - 33,915,919RGD
Cytogenetic Map20q11.23UniSTS
HuRef2033,941,846 - 33,941,977UniSTS
GeneMap99-GB4 RH Map20215.25UniSTS
NCBI RH Map20321.8UniSTS
RH48061  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372037,206,494 - 37,206,667UniSTSGRCh37
Build 362036,639,908 - 36,640,081RGDNCBI36
Celera2033,917,286 - 33,917,459RGD
Cytogenetic Map20q11.23UniSTS
HuRef2033,943,344 - 33,943,517UniSTS
GeneMap99-GB4 RH Map20231.37UniSTS
NCBI RH Map20340.9UniSTS
RH98514  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372037,202,917 - 37,203,521UniSTSGRCh37
Celera2033,913,707 - 33,914,311UniSTS
Cytogenetic Map20q11.23UniSTS
HuRef2033,939,765 - 33,940,369UniSTS
GeneMap99-GB4 RH Map20232.04UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6834
Count of miRNA genes:1110
Interacting mature miRNAs:1365
Transcripts:ENST00000262879, ENST00000397038, ENST00000397040, ENST00000397042, ENST00000438490, ENST00000461147, ENST00000461423, ENST00000490114, ENST00000495949, ENST00000537204
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2292 1630 1323 247 1282 96 3886 1328 2304 282 1434 1589 168 1 1134 2333 6 2
Low 147 1358 403 377 666 369 471 869 1430 137 26 24 7 70 455
Below cutoff 3 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001282917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005260462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005260463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005260464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005260465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001754350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB033045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB621815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK026771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK123576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL035419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL049868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL132998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL834436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC047482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE669526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX641080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR936800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DR002520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000262879   ⟹   ENSP00000262879
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2038,472,843 - 38,578,858 (+)Ensembl
RefSeq Acc Id: ENST00000397040   ⟹   ENSP00000380233
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2038,472,900 - 38,578,859 (+)Ensembl
RefSeq Acc Id: ENST00000397042   ⟹   ENSP00000380235
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2038,472,816 - 38,578,859 (+)Ensembl
RefSeq Acc Id: ENST00000438490   ⟹   ENSP00000416646
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2038,497,480 - 38,575,070 (+)Ensembl
RefSeq Acc Id: ENST00000461147
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2038,568,467 - 38,578,065 (+)Ensembl
RefSeq Acc Id: ENST00000461423
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2038,509,085 - 38,548,106 (+)Ensembl
RefSeq Acc Id: ENST00000490114
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2038,573,659 - 38,575,993 (+)Ensembl
RefSeq Acc Id: ENST00000495949
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2038,497,438 - 38,500,003 (+)Ensembl
RefSeq Acc Id: ENST00000632792   ⟹   ENSP00000487816
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2038,525,515 - 38,577,226 (+)Ensembl
RefSeq Acc Id: NM_001282917   ⟹   NP_001269846
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382038,472,843 - 38,578,858 (+)NCBI
HuRef2033,838,298 - 33,944,354 (+)NCBI
CHM1_12037,005,683 - 37,111,714 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001282918   ⟹   NP_001269847
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382038,472,843 - 38,578,858 (+)NCBI
HuRef2033,838,298 - 33,944,354 (+)NCBI
CHM1_12037,005,683 - 37,111,714 (+)NCBI
Sequence:
RefSeq Acc Id: NM_020336   ⟹   NP_065069
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382038,472,843 - 38,578,858 (+)NCBI
GRCh372037,101,486 - 37,207,504 (+)NCBI
Build 362036,534,900 - 36,640,918 (+)NCBI Archive
Celera2033,812,295 - 33,918,296 (+)RGD
HuRef2033,838,298 - 33,944,354 (+)NCBI
CHM1_12037,005,683 - 37,111,714 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005260462   ⟹   XP_005260519
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382038,472,820 - 38,578,859 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005260463   ⟹   XP_005260520
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382038,472,820 - 38,578,859 (+)NCBI
GRCh372037,101,486 - 37,207,504 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005260464   ⟹   XP_005260521
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382038,472,820 - 38,578,859 (+)NCBI
GRCh372037,101,486 - 37,207,504 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005260465   ⟹   XP_005260522
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382038,472,820 - 38,578,859 (+)NCBI
GRCh372037,101,486 - 37,207,504 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017027966   ⟹   XP_016883455
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382038,472,820 - 38,578,859 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017027967   ⟹   XP_016883456
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382038,472,820 - 38,578,859 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017027968   ⟹   XP_016883457
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382038,493,043 - 38,578,859 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017027969   ⟹   XP_016883458
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382038,472,860 - 38,578,859 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017027970   ⟹   XP_016883459
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382038,538,702 - 38,578,859 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001754350
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382038,472,820 - 38,578,861 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001269846 (Get FASTA)   NCBI Sequence Viewer  
  NP_001269847 (Get FASTA)   NCBI Sequence Viewer  
  NP_065069 (Get FASTA)   NCBI Sequence Viewer  
  XP_005260519 (Get FASTA)   NCBI Sequence Viewer  
  XP_005260520 (Get FASTA)   NCBI Sequence Viewer  
  XP_005260521 (Get FASTA)   NCBI Sequence Viewer  
  XP_005260522 (Get FASTA)   NCBI Sequence Viewer  
  XP_016883455 (Get FASTA)   NCBI Sequence Viewer  
  XP_016883456 (Get FASTA)   NCBI Sequence Viewer  
  XP_016883457 (Get FASTA)   NCBI Sequence Viewer  
  XP_016883458 (Get FASTA)   NCBI Sequence Viewer  
  XP_016883459 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH10916 (Get FASTA)   NCBI Sequence Viewer  
  AAH18668 (Get FASTA)   NCBI Sequence Viewer  
  AAH47482 (Get FASTA)   NCBI Sequence Viewer  
  BAA86533 (Get FASTA)   NCBI Sequence Viewer  
  BAC85649 (Get FASTA)   NCBI Sequence Viewer  
  BAG54177 (Get FASTA)   NCBI Sequence Viewer  
  BAG65110 (Get FASTA)   NCBI Sequence Viewer  
  BAK64151 (Get FASTA)   NCBI Sequence Viewer  
  CAB61346 (Get FASTA)   NCBI Sequence Viewer  
  CAD39096 (Get FASTA)   NCBI Sequence Viewer  
  CAE46039 (Get FASTA)   NCBI Sequence Viewer  
  EAW76018 (Get FASTA)   NCBI Sequence Viewer  
  EAW76019 (Get FASTA)   NCBI Sequence Viewer  
  EAW76020 (Get FASTA)   NCBI Sequence Viewer  
  EAW76021 (Get FASTA)   NCBI Sequence Viewer  
  EAW76022 (Get FASTA)   NCBI Sequence Viewer  
  EAW76023 (Get FASTA)   NCBI Sequence Viewer  
  EAW76024 (Get FASTA)   NCBI Sequence Viewer  
  Q86X10 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_065069   ⟸   NM_020336
- Peptide Label: isoform 1
- UniProtKB: Q86X10 (UniProtKB/Swiss-Prot),   Q6MZJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005260519   ⟸   XM_005260462
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005260520   ⟸   XM_005260463
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005260521   ⟸   XM_005260464
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005260522   ⟸   XM_005260465
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: NP_001269847   ⟸   NM_001282918
- Peptide Label: isoform 2
- UniProtKB: Q86X10 (UniProtKB/Swiss-Prot),   Q6MZJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001269846   ⟸   NM_001282917
- Peptide Label: isoform 1
- UniProtKB: Q86X10 (UniProtKB/Swiss-Prot),   Q6MZJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016883455   ⟸   XM_017027966
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016883456   ⟸   XM_017027967
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_016883458   ⟸   XM_017027969
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_016883457   ⟸   XM_017027968
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_016883459   ⟸   XM_017027970
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: ENSP00000416646   ⟸   ENST00000438490
RefSeq Acc Id: ENSP00000262879   ⟸   ENST00000262879
RefSeq Acc Id: ENSP00000487816   ⟸   ENST00000632792
RefSeq Acc Id: ENSP00000380235   ⟸   ENST00000397042
RefSeq Acc Id: ENSP00000380233   ⟸   ENST00000397040
Protein Domains
Rap-GAP

Promoters
RGD ID:6798742
Promoter ID:HG_KWN:39395
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000304939,   ENST00000397038,   ENST00000397040,   OTTHUMT00000079191,   UC002XIX.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362036,534,509 - 36,535,009 (+)MPROMDB
RGD ID:13206917
Promoter ID:EPDNEW_H27039
Type:initiation region
Name:RALGAPB_2
Description:Ral GTPase activating protein non-catalytic beta subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H27040  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382038,472,451 - 38,472,511EPDNEW
RGD ID:13206919
Promoter ID:EPDNEW_H27040
Type:initiation region
Name:RALGAPB_1
Description:Ral GTPase activating protein non-catalytic beta subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H27039  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382038,472,847 - 38,472,907EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20q11.22-12(chr20:34541747-39663219)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052766]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052766]|See cases [RCV000052766] Chr20:34541747..39663219 [GRCh38]
Chr20:33129551..38291861 [GRCh37]
Chr20:32593212..37725275 [NCBI36]
Chr20:20q11.22-12
pathogenic
GRCh38/hg38 20q11.22-13.11(chr20:34249453-43359749)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053002]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053002]|See cases [RCV000053002] Chr20:34249453..43359749 [GRCh38]
Chr20:32837259..41988389 [GRCh37]
Chr20:32300920..41421803 [NCBI36]
Chr20:20q11.22-13.11
pathogenic
GRCh38/hg38 20p12.2-q12(chr20:9811433-39316956)x3 copy number gain See cases [RCV000052999] Chr20:9811433..39316956 [GRCh38]
Chr20:9792081..37945599 [GRCh37]
Chr20:9740081..37379013 [NCBI36]
Chr20:20p12.2-q12
pathogenic
NM_020336.3(RALGAPB):c.2236A>G (p.Arg746Gly) single nucleotide variant Malignant melanoma [RCV000072627] Chr20:38532850 [GRCh38]
Chr20:37161493 [GRCh37]
Chr20:36594907 [NCBI36]
Chr20:20q11.23
not provided
NM_020336.3(RALGAPB):c.2237G>A (p.Arg746Lys) single nucleotide variant Malignant melanoma [RCV000063729] Chr20:38532851 [GRCh38]
Chr20:37161494 [GRCh37]
Chr20:36594908 [NCBI36]
Chr20:20q11.23
not provided
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33
pathogenic
GRCh38/hg38 20q11.22-13.12(chr20:35237946-47631818)x1 copy number loss See cases [RCV000140816] Chr20:35237946..47631818 [GRCh38]
Chr20:33825749..46260562 [GRCh37]
Chr20:33289165..45693969 [NCBI36]
Chr20:20q11.22-13.12
pathogenic
NM_020336.4(RALGAPB):c.2324G>T (p.Arg775Leu) single nucleotide variant Septo-optic dysplasia sequence [RCV000509009] Chr20:38535152 [GRCh38]
Chr20:37163795 [GRCh37]
Chr20:20q11.23
likely pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
Chr20:20p13-q13.33
pathogenic
NM_020336.4(RALGAPB):c.4095G>A (p.Glu1365=) single nucleotide variant not provided [RCV000971343] Chr20:38570800 [GRCh38]
Chr20:37199443 [GRCh37]
Chr20:20q11.23
benign
NM_020336.4(RALGAPB):c.1258T>C (p.Ser420Pro) single nucleotide variant Severe Myopia [RCV000785685] Chr20:38517841 [GRCh38]
Chr20:37146484 [GRCh37]
Chr20:20q11.23
uncertain significance
NM_020336.4(RALGAPB):c.457C>T (p.Arg153Cys) single nucleotide variant Marfanoid habitus and intellectual disability [RCV000850412] Chr20:38497420 [GRCh38]
Chr20:37126063 [GRCh37]
Chr20:20q11.23
uncertain significance
Single allele deletion Focal seizures [RCV001004039] Chr20:34980430..46806549 [GRCh37]
Chr20:20q11.23-13.13
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:29221 AgrOrtholog
COSMIC RALGAPB COSMIC
Ensembl Genes ENSG00000170471 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000262879 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000380233 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000380235 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000416646 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000487816 UniProtKB/TrEMBL
Ensembl Transcript ENST00000262879 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000397040 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000397042 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000438490 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000632792 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.11210 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000170471 GTEx
HGNC ID HGNC:29221 ENTREZGENE
Human Proteome Map RALGAPB Human Proteome Map
InterPro RALGAPB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rap/Ran-GAP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rap_GAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:57148 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 57148 ENTREZGENE
OMIM 618833 OMIM
PANTHER PTHR21344 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA165392608 PharmGKB
PROSITE RAPGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF111347 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0J9YW54_HUMAN UniProtKB/TrEMBL
  A2A2F0_HUMAN UniProtKB/TrEMBL
  G1UI28_HUMAN UniProtKB/TrEMBL
  Q6MZJ2 ENTREZGENE, UniProtKB/TrEMBL
  Q86X10 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2A2E8 UniProtKB/Swiss-Prot
  A2A2E9 UniProtKB/Swiss-Prot
  Q5TG31 UniProtKB/Swiss-Prot
  Q8N3D1 UniProtKB/Swiss-Prot
  Q8WWC0 UniProtKB/Swiss-Prot
  Q9H3X8 UniProtKB/Swiss-Prot
  Q9UJR1 UniProtKB/Swiss-Prot
  Q9ULK1 UniProtKB/Swiss-Prot
  Q9Y3G9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-03 RALGAPB  Ral GTPase activating protein non-catalytic subunit beta  RALGAPB  Ral GTPase activating protein non-catalytic beta subunit  Symbol and/or name change 5135510 APPROVED
2016-02-02 RALGAPB  Ral GTPase activating protein non-catalytic beta subunit    Ral GTPase activating protein, beta subunit (non-catalytic)  Symbol and/or name change 5135510 APPROVED
2011-07-27 RALGAPB  Ral GTPase activating protein, beta subunit (non-catalytic)  KIAA1219  KIAA1219  Symbol and/or name change 5135510 APPROVED