Slc7a12l1 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 like 1) - Rat Genome Database

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Gene: Slc7a12l1 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Slc7a12l1 (Ensembl: LOC688389)
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 like 1 (Ensembl:similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12)
RGD ID: 1589989
Description: Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be located in plasma membrane.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC688389; similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12; solute carrier family 7 member 12-like; solute carrier family 7 member 13-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8289,118,917 - 89,138,397 (-)NCBIGRCr8
mRatBN7.2287,211,534 - 87,230,685 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl287,211,468 - 87,231,259 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0288,744,527 - 88,763,968 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl288,744,597 - 88,763,733 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02108,516,968 - 108,536,244 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4288,760,922 - 88,779,520 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera282,982,091 - 83,001,532 (-)NCBICelera
Cytogenetic Map2q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Slc7a12l1
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:78
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000059424
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)276539322102785628Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)27478666494359546Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)264366971109366971Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
AW545966  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2287,332,619 - 87,332,736 (+)MAPPERmRatBN7.2
mRatBN7.28110,400,811 - 110,400,932 (+)MAPPERmRatBN7.2
Rnor_6.08118,668,950 - 118,669,070NCBIRnor6.0
Rnor_6.0288,894,022 - 88,894,138NCBIRnor6.0
Rnor_5.08118,012,643 - 118,012,763UniSTSRnor5.0
Rnor_5.02108,665,930 - 108,666,046UniSTSRnor5.0
RGSC_v3.4288,883,882 - 88,883,998UniSTSRGSC3.4
RGSC_v3.48114,802,178 - 114,802,298UniSTSRGSC3.4
Celera8109,685,814 - 109,685,934UniSTS
Celera283,103,240 - 83,103,356UniSTS
Cytogenetic Map2q23UniSTS


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 8 64 36 28 12 16 12 98 37 51 42 38 16

Sequence


Ensembl Acc Id: ENSRNOT00000059424   ⟹   ENSRNOP00000056181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl287,211,468 - 87,231,259 (-)Ensembl
Rnor_6.0 Ensembl288,744,597 - 88,763,733 (-)Ensembl
RefSeq Acc Id: XM_001066729   ⟹   XP_001066729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8289,118,917 - 89,138,397 (-)NCBI
mRatBN7.2287,211,534 - 87,230,685 (-)NCBI
Rnor_6.0288,744,527 - 88,763,965 (-)NCBI
Rnor_5.02108,516,968 - 108,536,244 (-)NCBI
RGSC_v3.4288,760,922 - 88,779,520 (-)RGD
Sequence:
RefSeq Acc Id: XM_063282865   ⟹   XP_063138935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8289,118,917 - 89,138,397 (-)NCBI
Protein Sequences
Protein RefSeqs XP_001066729 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138935 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056181.5
RefSeq Acc Id: XP_001066729   ⟸   XM_001066729
- Peptide Label: isoform X1
- UniProtKB: F1M163 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056181   ⟸   ENSRNOT00000059424
RefSeq Acc Id: XP_063138935   ⟸   XM_063282865
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M163-F1-model_v2 AlphaFold F1M163 1-465 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589989 AgrOrtholog
BioCyc Gene G2FUF-53798 BioCyc
Ensembl Genes ENSRNOG00000028582 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059424.5 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/TrEMBL
InterPro AA/rel_permease1 UniProtKB/TrEMBL
  AminoAcid_Transporter UniProtKB/TrEMBL
KEGG Report rno:688389 UniProtKB/TrEMBL
NCBI Gene 688389 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/TrEMBL
  ASC-TYPE AMINO ACID TRANSPORTER 2 UniProtKB/TrEMBL
Pfam AA_permease_2 UniProtKB/TrEMBL
PhenoGen Slc7a12l1 PhenoGen
PIRSF AA_transporter UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028582 RatGTEx
UniProt F1M163 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Slc7a12l1  solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 like 1  LOC688389  similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12  Symbol and Name Changed 1299863 APPROVED
2008-01-09 LOC688389  similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12  LOC679022  similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12  Data merged from RGD:1593102 1643240 APPROVED
2006-11-20 LOC688389  similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC679022  similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12      Symbol and Name status set to provisional 70820 PROVISIONAL