Aamdc (adipogenesis associated, Mth938 domain containing)

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Gene: Aamdc (adipogenesis associated, Mth938 domain containing) Rattus norvegicus

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Symbol:

Aamdc

Name:

adipogenesis associated, Mth938 domain containing

RGD ID:

1561459

Description:

Predicted to be involved in positive regulation of fat cell differentiation. Predicted to act upstream of or within negative regulation of apoptotic process and positive regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm. Orthologous to human AAMDC (adipogenesis associated Mth938 domain containing); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

hypothetical protein LOC361606; LOC361606; Mth938 domain-containing protein; RGD1561459; similar to RIKEN cDNA 1810020D17; uncharacterized protein LOC361606

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	161,273,205 - 161,303,253 (-)	NCBI		GRCr8
mRatBN7.2	1	151,861,990 - 151,893,621 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	151,845,255 - 151,892,398 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	159,849,903 - 159,880,199 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	167,030,069 - 167,060,371 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	159,903,573 - 159,933,862 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	162,519,513 - 162,549,211 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	162,519,521 - 162,533,893 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	168,726,362 - 168,755,990 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	154,786,525 - 154,817,248 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	149,960,470 - 149,989,795 (-)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

intellectual disability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

actinomycin D (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

caffeine (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

dioxygen (ISO)

doxorubicin (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

formaldehyde (ISO)

glafenine (EXP)

indole-3-methanol (EXP)

indometacin (ISO)

ivermectin (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nickel atom (ISO)

nitrogen dioxide (ISO)

Nutlin-3 (ISO)

paracetamol (EXP)

potassium chromate (ISO)

resveratrol (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (EXP,ISO)

vincristine (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of apoptotic process (ISO)

positive regulation of fat cell differentiation (IBA,ISO)

positive regulation of transcription by RNA polymerase II (ISO)

transcription by RNA polymerase II (ISO)

Cellular Component

cytoplasm (IBA,ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:21622130	PMID:22279136

Genomics

Comparative Map Data

Aamdc
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	161,273,205 - 161,303,253 (-)	NCBI		GRCr8
mRatBN7.2	1	151,861,990 - 151,893,621 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	151,845,255 - 151,892,398 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	159,849,903 - 159,880,199 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	167,030,069 - 167,060,371 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	159,903,573 - 159,933,862 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	162,519,513 - 162,549,211 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	162,519,521 - 162,533,893 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	168,726,362 - 168,755,990 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	154,786,525 - 154,817,248 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	149,960,470 - 149,989,795 (-)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

AAMDC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	77,821,144 - 77,906,024 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	77,821,109 - 77,918,432 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	77,532,190 - 77,617,070 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	77,209,856 - 77,261,046 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	11	74,840,499 - 74,891,881 (+)	NCBI		Celera
Cytogenetic Map	11	q14.1	NCBI
HuRef	11	73,830,417 - 73,881,401 (+)	NCBI		HuRef
CHM1_1	11	77,415,222 - 77,466,597 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	77,754,365 - 77,839,260 (+)	NCBI		T2T-CHM13v2.0

Aamdc
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	97,199,538 - 97,228,723 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	97,199,538 - 97,228,704 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	97,550,329 - 97,579,557 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	97,550,331 - 97,579,497 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	104,698,841 - 104,728,007 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	97,425,532 - 97,454,607 (-)	NCBI		MGSCv36	mm8
Celera	7	97,865,538 - 97,897,586 (-)	NCBI		Celera
Cytogenetic Map	7	E1	NCBI
cM Map	7	53.54	NCBI

Aamdc
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	14,058,445 - 14,085,652 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	14,058,445 - 14,085,652 (-)	NCBI	ChiLan1.0	ChiLan1.0

AAMDC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	78,753,779 - 78,805,085 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	79,802,064 - 79,853,364 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	72,885,166 - 72,936,482 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	76,525,129 - 76,605,124 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	76,525,145 - 76,621,992 (+)	Ensembl	panpan1.1		panPan2

AAMDC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	20,931,438 - 20,968,420 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	20,898,398 - 20,967,911 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	20,823,768 - 20,860,748 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	21,130,165 - 21,167,387 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	21,097,153 - 21,166,873 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	20,906,650 - 20,943,632 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	21,121,568 - 21,159,841 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	21,046,461 - 21,083,451 (-)	NCBI		UU_Cfam_GSD_1.0

Aamdc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	64,831,285 - 64,864,192 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936498	6,432,443 - 6,463,795 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936498	6,432,416 - 6,463,795 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AAMDC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	12,278,570 - 12,305,436 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	12,278,527 - 12,305,217 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	13,640,859 - 13,643,448 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AAMDC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	69,029,713 - 69,082,976 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	69,030,106 - 69,083,485 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	56,688,664 - 56,740,927 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aamdc
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624863	858,257 - 884,582 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624863	858,234 - 884,582 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Aamdc
179 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	180
Count of miRNA genes:	140
Interacting mature miRNAs:	157
Transcripts:	ENSRNOT00000016783
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61442	Strs1	Sensitivity to stroke QTL 1	7.4		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	1	121767634	166767634	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
1598866	Bp287	Blood pressure QTL 287	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
1578770	Stresp23	Stress response QTL 23			kidney sympathetic nerve activity (VT:0004050)	stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)	1	123350408	182418476	Rat
70160	Bw18	Body weight QTL 18	5.7		body mass (VT:0001259)	body weight (CMO:0000012)	1	144267353	196383668	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
631199	Cm23	Cardiac mass QTL 23	4.6	0.0004	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	115585465	172949803	Rat
1354636	Lmblg1	Limb length QTL 1	6.4		tibia length (VT:0004357)	tibia length (CMO:0000450)	1	151162512	201278233	Rat
1598850	Bp297	Blood pressure QTL 297	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	123556856	242907031	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
1354634	Kidm12	Kidney mass QTL 12	3.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	1	151162512	201278233	Rat
152025232	Bw192	Body weight QTL 192	3.93		body mass (VT:0001259)		1	117917486	196963478	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
61343	Bp28	Blood pressure QTL 28			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	151646613	196646613	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	90508614	173018436	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	90508614	180359386	Rat
61348	Bp30	Blood pressure QTL 30	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144017057	197814409	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	100357752	183970443	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat
631202	Gluco13	Glucose level QTL 13		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	131763437	159756369	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118944897	199050459	Rat
1300158	Bp173	Blood pressure QTL 173	3.48		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	1	115540693	185145286	Rat
631206	Niddm40	Non-insulin dependent diabetes mellitus QTL 40			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	136745990	163747690	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	94494440	181830018	Rat
9685799	Bp375	Blood pressure QTL 375			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
2293140	Bp313	Blood pressure QTL 313			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121833674	166833674	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
9685802	Bp376	Blood pressure QTL 376			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	126540680	171540680	Rat
1641895	Bp298	Blood pressure QTL 298			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	123350408	182418476	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
634315	Niddm45	Non-insulin dependent diabetes mellitus QTL 45	7.16		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	144267916	172949660	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
61379	Bp44	Blood pressure QTL 44	19.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144267916	174133260	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94494440	172949803	Rat
2313060	Bss71	Bone structure and strength QTL 71	2.6	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	1	118944747	163944747	Rat
6893347	Bw98	Body weight QTL 98	0.2	0.53	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	102813953	201278233	Rat
724550	Thym3	Thymus enlargement QTL 3	7.82	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
71118	Thym1	Thymus enlargement QTL 1	10.17	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	136830018	181830018	Rat
6893361	Bw104	Body weight QTL 104	0.59	0.27	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
738006	Anxrr14	Anxiety related response QTL 14	4	0.00035	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
1558645	Bw55	Body weight QTL 55	3.2	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	102813953	201278233	Rat
634348	Bp138	Blood pressure QTL 138			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	168883176	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
738028	Anxrr12	Anxiety related response QTL 12	4.9	0.00001	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
1354620	Kidm19	Kidney mass QTL 19	4		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	201278233	Rat
8693608	Alc24	Alcohol consumption QTL 24	2.3	0.74	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	150452391	168228760	Rat
631654	Bp107	Blood pressure QTL 107			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
631544	Bp84	Blood pressure QTL 84	5.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350408	181759564	Rat
152025212	Bw190	Body weight QTL 190	5.7		body mass (VT:0001259)		1	123556856	196963478	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350581	201284552	Rat
1358189	Cstrr1	Cold stress response QTL 1		0.0001	catecholamine amount (VT:0010543)	urine norepinephrine level (CMO:0001629)	1	123350408	182418476	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
1354602	Bw35	Body weight QTL 35	12.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	201278233	Rat

Markers in Region

RH131158

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	148,111,834 - 148,112,053 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	146,962,278 - 146,962,496	NCBI	Rnor6.0
Rnor_5.0	4	210,252,058 - 210,252,276	UniSTS	Rnor5.0
RGSC_v3.4	4	151,179,938 - 151,180,156	UniSTS	RGSC3.4
Celera	4	137,006,755 - 137,006,973	UniSTS
RH 3.4 Map	4	950.71	UniSTS
Cytogenetic Map	1	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108493	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006229768	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017589374	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000016783 ⟹ ENSRNOP00000016783

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	151,861,990 - 151,888,131 (-)	Ensembl
Rnor_6.0 Ensembl	1	162,519,521 - 162,533,893 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099902 ⟹ ENSRNOP00000089158

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	151,861,990 - 151,892,398 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000101275 ⟹ ENSRNOP00000083992

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	151,862,249 - 151,888,131 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102753 ⟹ ENSRNOP00000087566

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	151,858,244 - 151,876,300 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105468 ⟹ ENSRNOP00000097606

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	151,845,255 - 151,876,300 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113509 ⟹ ENSRNOP00000086695

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	151,860,505 - 151,876,300 (-)	Ensembl

RefSeq Acc Id:

NM_001108493 ⟹ NP_001101963

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	161,273,205 - 161,303,253 (-)	NCBI
mRatBN7.2	1	151,861,990 - 151,892,044 (-)	NCBI
Rnor_6.0	1	162,519,513 - 162,549,205 (-)	NCBI
Rnor_5.0	1	168,726,362 - 168,755,990 (-)	NCBI
RGSC_v3.4	1	154,786,525 - 154,817,248 (-)	RGD
Celera	1	149,960,470 - 149,989,795 (-)	RGD

Sequence:

show sequence

GCTTCGGGTGTCAGCTGGCAGAAGGCTAGTTCCAGGCCTGGTAGCTGAACGGCCGTGGCTCAGA
ATCTCTCAGCTAGCTGCAGGGAGAGGTAGAGCGCGGAGCCGACTGGAGGAGCAACCGAAGAACA
GAAGCGCTGCGCAGGATACCATGAGCCCTGCTTTATCTCTAACTGCCTGTGTATGTGAGGTTCC
TTGAACTCCTCCCCACCTTACACGGGCTGGGATTGCAGATTTCAGTTCACATGCTTATGGCTTC
CCCTAAAATTGCTTCCCTCTCTTGGGGACAAATGAAAGTTCAAGGCTCTACCTTAACCTATAAG
GATTGCAAAGTATGGCCAGGAGGCAGTCGGGCTTGGGATTGGAGAGAAACAGGAACTGAGCATT
CTCCTGGAGTGCAGCCAGCAGACGTAAAGGAAGTTGCTGAGAAGGGTGTACAGACTCTTGTGAT
TGGCAGAGGAATGAGCGAGGCCTTGAAGGTGCCTCCATCGACTGTGGAGTACCTCGAGAAACAA
GGCATTGATGTGCGAGTCCTCCAGACAGAGCAGGCAGTGAAGGAGTACAATGCCTTGGCTGCCC
GGGGGATAAGGGTAGGAGGTGTCTTCCATTCCACCTGCTGATGGAGCCTACAGAGGAGAATAAA
CCTCTGGGCAGCAATGCCTTACCATCTCCACATCAGCCTCCTCTGTGTACTTTGGACACATGTT
CATGTTCTTGGAACAGATTGATGGGAGGCTAAGGCAAAGTTCTTGCCCTCCAGGTTGCTTAAAT
CAGAAGAGAGATTTGCTGATTTTAGTATTGTACTATGTGTTCGGTTCAAAGTATGAGAAAGTTC
ATACAAAAATAAAGGTTGAAGCTTAGAAGCCAACGAGAAAGGTT

hide sequence

RefSeq Acc Id:

XM_006229768 ⟹ XP_006229830

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	161,273,216 - 161,303,251 (-)	NCBI
mRatBN7.2	1	151,862,001 - 151,892,060 (-)	NCBI
Rnor_6.0	1	162,519,524 - 162,549,211 (-)	NCBI
Rnor_5.0	1	168,726,362 - 168,755,990 (-)	NCBI

Sequence:

show sequence

GGCGGAGCTTCGGGTGTCAGCTGGCAGAAGGCTAGTTCCAGGCCTGGTAGCTGAACGGCCGTGG
CTCAGAATCTCTCAGCTAGCTGCAGGGAGAGGTAGAGCGCGGAGCCGACTGGAGGAGCAACCGA
AGAACAGAAGCGCTGCATTTCAGTTCACATGCTTATGGCTTCCCCTAAAATTGCTTCCCTCTCT
TGGGGACAAATGAAAGTTCAAGGCTCTACCTTAACCTATAAGGATTGCAAAGTATGGCCAGGAG
GCAGTCGGGCTTGGGATTGGAGAGAAACAGGAACTGAGCATTCTCCTGGAGTGCAGCCAGCAGA
CGTAAAGGAAGTTGCTGAGAAGGGTGTACAGACTCTTGTGATTGGCAGAGGAATGAGCGAGGCC
TTGAAGGTGCCTCCATCGACTGTGGAGTACCTCGAGAAACAAGGCATTGATGTGCGAGTCCTCC
AGACAGAGCAGGCAGTGAAGGAGTACAATGCCTTGGCTGCCCGGGGGATAAGGGTAGGAGGTGT
CTTCCATTCCACCTGCTGATGGAGCCTACAGAGGAGAATAAACCTCTGGGCAGCAATGCCTTAC
CATCTCCACATCAGCCTCCTCTGTGTACTTTGGACACATGTTCATGTTCTTGGAACAGATTGAT
GGGAGGCTAAGGCAAAGTTCTTGCCCTCCAGGTTGCTTAAATCAGAAGAGAGATTTGCTGATTT
TAGTATTGTACTATGTGTTCGGTTCAAAGTATGAGAAAGTTCATACAAAAATAAAGGTTGAAGC
TTAGAAGCCAA

hide sequence

RefSeq Acc Id:

XM_017589374 ⟹ XP_017444863

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	161,273,216 - 161,303,252 (-)	NCBI
mRatBN7.2	1	151,862,001 - 151,892,039 (-)	NCBI
Rnor_6.0	1	162,519,524 - 162,549,211 (-)	NCBI

Sequence:

show sequence

GGCGGAGCTTCGGGTGTCAGCTGGCAGAAGGCTAGTTCCAGGCCTGGTAGCTGAACGGCCGTGG
CTCAGAATCTCTCAGCTAGCTGCAGGGAGAGGTAGAGCGCGGAGCCGACTGGAGGAGCAACCGA
AGAACAGAAGCGCTGCGTGGCAAAGGCAGGAAGAACACCGAGTTCAGGCCAGCTAGGGCTATAA
GATTTCAGTTCACATGCTTATGGCTTCCCCTAAAATTGCTTCCCTCTCTTGGGGACAAATGAAA
GTTCAAGGCTCTACCTTAACCTATAAGGATTGCAAAGTATGGCCAGGAGGCAGTCGGGCTTGGG
ATTGGAGAGAAACAGGAACTGAGCATTCTCCTGGAGTGCAGCCAGCAGACGTAAAGGAAGTTGC
TGAGAAGGGTGTACAGACTCTTGTGATTGGCAGAGGAATGAGCGAGGCCTTGAAGGTGCCTCCA
TCGACTGTGGAGTACCTCGAGAAACAAGGCATTGATGTGCGAGTCCTCCAGACAGAGCAGGCAG
TGAAGGAGTACAATGCCTTGGCTGCCCGGGGGATAAGGGTAGGAGGTGTCTTCCATTCCACCTG
CTGATGGAGCCTACAGAGGAGAATAAACCTCTGGGCAGCAATGCCTTACCATCTCCACATCAGC
CTCCTCTGTGTACTTTGGACACATGTTCATGTTCTTGGAACAGATTGATGGGAGGCTAAGGCAA
AGTTCTTGCCCTCCAGGTTGCTTAAATCAGAAGAGAGATTTGCTGATTTTAGTATTGTACTATG
TGTTCGGTTCAAAGTATGAGAAAGTTCATACAAAAATAAAGGTTGAAGCTTAGAAGCCAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001101963	(Get FASTA)	NCBI Sequence Viewer
	XP_006229830	(Get FASTA)	NCBI Sequence Viewer
	XP_017444863	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM18473	(Get FASTA)	NCBI Sequence Viewer
	EDM18474	(Get FASTA)	NCBI Sequence Viewer
	EDM18475	(Get FASTA)	NCBI Sequence Viewer
	EDM18476	(Get FASTA)	NCBI Sequence Viewer
	EDM18477	(Get FASTA)	NCBI Sequence Viewer
	EDM18478	(Get FASTA)	NCBI Sequence Viewer
	EDM18479	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000016783.6
	ENSRNOP00000083992.1
	ENSRNOP00000086695.1
	ENSRNOP00000087566.1
	ENSRNOP00000089158.1
	ENSRNOP00000097606.1

RefSeq Acc Id:	NP_001101963 ⟸ NM_001108493
- UniProtKB:	A6I6A6 (UniProtKB/TrEMBL), A0A8I6GF83 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLMASPKIASLSWGQMKVQGSTLTYKDCKVWPGGSRAWDWRETGTEHSPGVQPADVKEVAEKGV QTLVIGRGMSEALKVPPSTVEYLEKQGIDVRVLQTEQAVKEYNALAARGIRVGGVFHSTC hide sequence

RefSeq Acc Id:	XP_006229830 ⟸ XM_006229768
- Peptide Label:	isoform X1
- UniProtKB:	A6I6A6 (UniProtKB/TrEMBL), A0A8I6GF83 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLMASPKIASLSWGQMKVQGSTLTYKDCKVWPGGSRAWDWRETGTEHSPGVQPADVKEVAEKGV QTLVIGRGMSEALKVPPSTVEYLEKQGIDVRVLQTEQAVKEYNALAARGIRVGGVFHSTC hide sequence

RefSeq Acc Id:	XP_017444863 ⟸ XM_017589374
- Peptide Label:	isoform X1
- UniProtKB:	A6I6A6 (UniProtKB/TrEMBL), A0A8I6GF83 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLMASPKIASLSWGQMKVQGSTLTYKDCKVWPGGSRAWDWRETGTEHSPGVQPADVKEVAEKGV QTLVIGRGMSEALKVPPSTVEYLEKQGIDVRVLQTEQAVKEYNALAARGIRVGGVFHSTC hide sequence

Ensembl Acc Id:

ENSRNOP00000016783 ⟸ ENSRNOT00000016783

Ensembl Acc Id:

ENSRNOP00000097606 ⟸ ENSRNOT00000105468

Ensembl Acc Id:

ENSRNOP00000083992 ⟸ ENSRNOT00000101275

Ensembl Acc Id:

ENSRNOP00000086695 ⟸ ENSRNOT00000113509

Ensembl Acc Id:

ENSRNOP00000089158 ⟸ ENSRNOT00000099902

Ensembl Acc Id:

ENSRNOP00000087566 ⟸ ENSRNOT00000102753

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZZQ4-F1-model_v2	AlphaFold	D3ZZQ4	1-124	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561459	AgrOrtholog
BioCyc Gene	G2FUF-58443	BioCyc
Ensembl Genes	ENSRNOG00000012584	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000016783.7	UniProtKB/TrEMBL
	ENSRNOT00000099902.1	UniProtKB/TrEMBL
	ENSRNOT00000101275.1	UniProtKB/TrEMBL
	ENSRNOT00000102753.1	UniProtKB/TrEMBL
	ENSRNOT00000105468.1	UniProtKB/TrEMBL
	ENSRNOT00000113509.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.1230.10	UniProtKB/TrEMBL
InterPro	AAMDC	UniProtKB/TrEMBL
	DUF498	UniProtKB/TrEMBL
	MTH938-like_sf	UniProtKB/TrEMBL
KEGG Report	rno:361606	UniProtKB/TrEMBL
NCBI Gene	361606	ENTREZGENE
PANTHER	MTH938 DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	MTH938 DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
Pfam	DUF498	UniProtKB/TrEMBL
PhenoGen	Aamdc	PhenoGen
RatGTEx	ENSRNOG00000012584	RatGTEx
Superfamily-SCOP	DUF498	UniProtKB/TrEMBL
UniProt	A0A8I5ZY84_RAT	UniProtKB/TrEMBL
	A0A8I6AGT5_RAT	UniProtKB/TrEMBL
	A0A8I6GF83	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GHU8_RAT	UniProtKB/TrEMBL
	A6I6A6	ENTREZGENE, UniProtKB/TrEMBL
	D3ZZQ4_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-17	Aamdc	adipogenesis associated, Mth938 domain containing	RGD1561459	similar to RIKEN cDNA 1810020D17	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1561459	similar to RIKEN cDNA 1810020D17	RGD1561459_predicted	similar to RIKEN cDNA 1810020D17 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1561459_predicted	similar to RIKEN cDNA 1810020D17 (predicted)	LOC361606	similar to RIKEN cDNA 1810020D17	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC361606	similar to RIKEN cDNA 1810020D17			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar