Slc6a11 (solute carrier family 6 (neurotransmitter transporter, GABA), member 11) - Rat Genome Database

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Gene: Slc6a11 (solute carrier family 6 (neurotransmitter transporter, GABA), member 11) Mus musculus
Analyze
Symbol: Slc6a11
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 11
RGD ID: 1557910
MGI Page MGI
Description: Enables gamma-aminobutyric acid:sodium:chloride symporter activity and taurine:sodium symporter activity. Involved in neurotransmitter uptake. Is active in synapse. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and liver and biliary system. Orthologous to human SLC6A11 (solute carrier family 6 member 11).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: D930045G19Rik; E130202I16Rik; Gabt; Gabt4; gamma-aminobutyric acid (GABA-A) transporter 4; GAT; GAT-3; GAT-4; Gat3; GAT4; sodium- and chloride-dependent GABA transporter 3; sodium- and chloride-dependent GABA transporter 4; solute carrier family 6 member 11
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396114,108,202 - 114,226,847 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6114,108,202 - 114,226,913 (+)EnsemblGRCm39 Ensembl
GRCm386114,131,241 - 114,249,886 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6114,131,241 - 114,249,952 (+)EnsemblGRCm38mm10GRCm38
MGSCv376114,081,235 - 114,199,880 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366114,096,836 - 114,215,481 (+)NCBIMGSCv36mm8
Celera6115,952,329 - 116,070,890 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slc6a11MouseExperimental Seizures treatmentISOSlc6a11 (Rattus norvegicus)1643196 RGD 
Slc6a11MouseReperfusion Injury  ISOSlc6a11 (Rattus norvegicus)1299345 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slc6a11MouseAtrioventricular Septal Defect 2  ISOSLC6A11 (Homo sapiens)8554872ClinVar Annotator: match by term: Atrioventricular septal defect more ...ClinVarPMID:28492532
Slc6a11Mousemyoclonic-atonic epilepsy  ISOSLC6A11 (Homo sapiens)8554872ClinVar Annotator: match by term: Generalized myoclonic-atonic seizureClinVarPMID:25865495 more ...
Slc6a11MouseNeurodevelopmental Disorders  ISOSLC6A11 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slc6a11Mousemelanoma  ISOSLC6A11 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21499247

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slc6a11Mouse(+)-pilocarpine decreases expressionEXP 6480464Pilocarpine results in decreased expression of SLC6A11 mRNACTDPMID:21219332
Slc6a11Mouse1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of SLC6A11 mRNACTDPMID:22206623
Slc6a11Mouse17beta-estradiol multiple interactionsISOSLC6A11 (Homo sapiens)6480464[Progesterone co-treated with Estradiol] results in decreased expression of SLC6A11 mRNACTDPMID:18692832
Slc6a11Mouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISOSLC6A11 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of SLC6A11 mRNACTDPMID:20106945
Slc6a11Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOSlc6a11 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of SLC6A11 mRNACTDPMID:32109520
Slc6a11Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of SLC6A11 mRNACTDPMID:24680724
Slc6a11Mouse2,3,7,8-Tetrachlorodibenzofuran decreases expressionISOSlc6a11 (Rattus norvegicus)64804642 more ...CTDPMID:32109520
Slc6a11Mouse2-hydroxypropanoic acid decreases expressionISOSLC6A11 (Homo sapiens)6480464Lactic Acid results in decreased expression of SLC6A11 mRNACTDPMID:30851411
Slc6a11Mouse2-palmitoylglycerol increases expressionISOSLC6A11 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of SLC6A11 mRNACTDPMID:37199045
Slc6a11Mouse4,4'-sulfonyldiphenol decreases expressionEXP 6480464bisphenol S results in decreased expression of SLC6A11 mRNACTDPMID:30951980
Slc6a11Mouse4,4'-sulfonyldiphenol decreases methylationISOSLC6A11 (Homo sapiens)6480464bisphenol S results in decreased methylation of SLC6A11 geneCTDPMID:31601247
Slc6a11Mouse6-propyl-2-thiouracil decreases expressionISOSlc6a11 (Rattus norvegicus)6480464Propylthiouracil results in decreased expression of SLC6A11 mRNACTDPMID:24780913
Slc6a11Mouseacrylamide decreases expressionISOSlc6a11 (Rattus norvegicus)6480464Acrylamide results in decreased expression of SLC6A11 mRNACTDPMID:28959563
Slc6a11Mouseaflatoxin B1 affects methylationISOSLC6A11 (Homo sapiens)6480464Aflatoxin B1 affects the methylation of SLC6A11 intronCTDPMID:30157460
Slc6a11Mouseaflatoxin B1 decreases methylationISOSLC6A11 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of SLC6A11 3' UTRCTDPMID:30157460
Slc6a11MouseAflatoxin B2 alpha increases methylationISOSLC6A11 (Homo sapiens)6480464aflatoxin B2 results in increased methylation of SLC6A11 exon and aflatoxin B2 results in increased methylation of SLC6A11 intronCTDPMID:30157460
Slc6a11Mouseall-trans-retinoic acid multiple interactionsEXP 6480464[bisphenol F co-treated with Tretinoin] results in increased expression of SLC6A11 mRNACTDPMID:30951980
Slc6a11Mouseammonium chloride affects expressionISOSlc6a11 (Rattus norvegicus)6480464Ammonium Chloride affects the expression of SLC6A11 mRNACTDPMID:16483693
Slc6a11Mouseatrazine affects methylationISOSlc6a11 (Rattus norvegicus)6480464Atrazine affects the methylation of SLC6A11 geneCTDPMID:35440735
Slc6a11MouseAzoxymethane multiple interactionsEXP 6480464[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of SLC6A11 mRNACTDPMID:29950665

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Biological Process
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Object Symbol
Species
Term
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Original Reference(s)
Slc6a11Mouseamino acid transmembrane transport involved_inIEAGO:00052832290270 GOCGO_REF:0000108
Slc6a11Mouseamino acid transport involved_inIBAPANTHER:PTN000907004 more ...2290270 GO_CentralGO_REF:0000033
Slc6a11Mousegamma-aminobutyric acid transport involved_inIEAGO:00053322290270 GOCGO_REF:0000108
Slc6a11Mousemonocarboxylic acid transport involved_inISOUniProtKB:P480662290270 GO_CentralGO_REF:0000119
Slc6a11Mousemonocarboxylic acid transport involved_inIEAUniProtKB:P48066 and ensembl:ENSP000002544882290270 EnsemblGO_REF:0000107
Slc6a11Mouseneurotransmitter transport  ISOSlc6a11 (Rattus norvegicus)9068941 RGDPMID:1400419 and REF_RGD_ID:727560
Slc6a11Mouseneurotransmitter transport involved_inISOSlc6a11 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Slc6a11Mouseneurotransmitter uptake involved_inIDA 2290270 PMID:8420981SynGOPMID:8420981
Slc6a11Mouseneurotransmitter uptake involved_inNAS 2290270 PMID:8420981SynGOPMID:8420981
Slc6a11Mouseneurotransmitter uptake involved_inIMP 2290270 PMID:8420981SynGOPMID:8420981
Slc6a11Mouseresponse to xenobiotic stimulus  ISOSlc6a11 (Rattus norvegicus)9068941levetiracetamRGDPMID:17408599 and REF_RGD_ID:1643196
Slc6a11Mouseresponse to xenobiotic stimulus involved_inIEAUniProtKB:P31647 and ensembl:ENSRNOP000000083422290270 EnsemblGO_REF:0000107
Slc6a11Mousesodium ion transmembrane transport involved_inIBAPANTHER:PTN000177662 and UniProtKB:P305312290270 GO_CentralGO_REF:0000033
Slc6a11Mousesodium ion transmembrane transport involved_inIEAGO:00052832290270 GOCGO_REF:0000108
Slc6a11Mousetaurine transmembrane transport involved_inIEAGO:00053692290270 GOCGO_REF:0000108
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Cellular Component
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Object Symbol
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Original Reference(s)
Slc6a11Mousecell projection is_active_inIBAPANTHER:PTN008325672 more ...2290270 GO_CentralGO_REF:0000033
Slc6a11Mousecell projection located_inISOSlc6a11 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Slc6a11Mousecell projection located_inIEAUniProtKB:P31647 and ensembl:ENSRNOP000000083422290270 EnsemblGO_REF:0000107
Slc6a11Mousecell projection  ISOSlc6a11 (Rattus norvegicus)9068941 RGDPMID:12898208 and REF_RGD_ID:2316969
Slc6a11MouseGABA-ergic synapse located_inIEAUniProtKB:P31647 and ensembl:ENSRNOP000000083422290270 EnsemblGO_REF:0000107
Slc6a11MouseGABA-ergic synapse is_active_inISOSlc6a11 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Slc6a11Mouseplasma membrane located_inISOSlc6a11 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Slc6a11Mouseplasma membrane is_active_inIBAPANTHER:PTN000177662 more ...2290270 GO_CentralGO_REF:0000033
Slc6a11Mousepostsynaptic membrane is_active_inISOSlc6a11 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Slc6a11Mousepostsynaptic membrane located_inIEAUniProtKB:P31647 and ensembl:ENSRNOP000000083422290270 EnsemblGO_REF:0000107
Slc6a11Mousepresynaptic membrane located_inIEAUniProtKB:P31647 and ensembl:ENSRNOP000000083422290270 EnsemblGO_REF:0000107
Slc6a11Mousepresynaptic membrane is_active_inISOSlc6a11 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Slc6a11Mousesynapse is_active_inEXP 2290270 PMID:24534009SynGOPMID:24534009
Slc6a11Mousesynapse is_active_inIDA 2290270 PMID:24534009SynGOPMID:24534009
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Molecular Function
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Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Slc6a11Mouseamino acid binding  ISOSlc6a11 (Rattus norvegicus)9068941inhibitory neurotransmitter GABARGDPMID:1400419 and REF_RGD_ID:727560
Slc6a11Mouseamino acid binding enablesISOSlc6a11 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Slc6a11Mouseamino acid binding enablesIEAUniProtKB:P31647 and ensembl:ENSRNOP000000083422290270 EnsemblGO_REF:0000107
Slc6a11Mouseamino acid:sodium symporter activity enablesIDA 2290270 PMID:30270321 and PMID:8420981UniProtPMID:30270321 and PMID:8420981
Slc6a11Mousegamma-aminobutyric acid:sodium:chloride symporter activity enablesISOSlc6a11 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Slc6a11Mousegamma-aminobutyric acid:sodium:chloride symporter activity enablesIDA 2290270 PMID:30270321 and PMID:8420981UniProtPMID:30270321 and PMID:8420981
Slc6a11Mousegamma-aminobutyric acid:sodium:chloride symporter activity enablesISOUniProtKB:P480662290270 GO_CentralGO_REF:0000119
Slc6a11Mousegamma-aminobutyric acid:sodium:chloride symporter activity enablesIBAPANTHER:PTN002480995 more ...2290270 GO_CentralGO_REF:0000033
Slc6a11Mousegamma-aminobutyric acid:sodium:chloride symporter activity  ISOSlc6a11 (Rattus norvegicus)9068941 RGDPMID:1400419 and REF_RGD_ID:727560
Slc6a11Mousemonocarboxylic acid transmembrane transporter activity enablesISOUniProtKB:P480662290270 GO_CentralGO_REF:0000119
Slc6a11Mousetaurine:sodium symporter activity enablesIDA 2290270 PMID:8420981UniProtPMID:8420981
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Object Symbol
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Evidence
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Reference
Notes
Source
Original Reference(s)
Slc6a11Mousedecreased susceptibility to pharmacologically induced seizures  IEA 5509061 MGI 
Slc6a11Mousepreweaning lethality, complete penetrance  IEA 5509061 MGI 

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#
Reference Title
Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Transient focal ischemia triggers neuronal expression of GAT-3 in the rat perilesional cortex. Melone M, etal., Neurobiol Dis 2003 Oct;14(1):120-32.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Effect of levetiracetam on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl3 injection. Ueda Y, etal., Brain Res. 2007 Jun 2;1151:55-61. Epub 2007 Mar 13.
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PMID:8420981   PMID:8956109   PMID:9615221   PMID:9697703   PMID:10348670   PMID:10349636   PMID:11042159   PMID:11076861   PMID:15226823   PMID:15342728   PMID:15829583   PMID:16125675  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:18985723   PMID:19805126   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22794259   PMID:22896705   PMID:24412234   PMID:24534009  
PMID:24952961   PMID:25103283   PMID:29160736   PMID:29370841   PMID:29742425   PMID:30068389   PMID:30270321   PMID:30635555   PMID:33009395   PMID:36293380   PMID:36417873   PMID:38697303  
PMID:38878858  



Slc6a11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396114,108,202 - 114,226,847 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6114,108,202 - 114,226,913 (+)EnsemblGRCm39 Ensembl
GRCm386114,131,241 - 114,249,886 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6114,131,241 - 114,249,952 (+)EnsemblGRCm38mm10GRCm38
MGSCv376114,081,235 - 114,199,880 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366114,096,836 - 114,215,481 (+)NCBIMGSCv36mm8
Celera6115,952,329 - 116,070,890 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.98NCBI
SLC6A11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38310,816,228 - 10,940,714 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl310,816,201 - 10,940,714 (+)EnsemblGRCh38hg38GRCh38
GRCh37310,857,913 - 10,982,400 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36310,832,917 - 10,955,146 (+)NCBINCBI36Build 36hg18NCBI36
Build 34310,832,916 - 10,955,146NCBI
Celera310,793,362 - 10,915,588 (+)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef310,792,720 - 10,914,941 (+)NCBIHuRef
CHM1_1310,807,894 - 10,930,156 (+)NCBICHM1_1
T2T-CHM13v2.0310,810,506 - 10,935,188 (+)NCBIT2T-CHM13v2.0
Slc6a11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84148,853,557 - 148,968,895 (+)NCBIGRCr8
mRatBN7.24147,297,972 - 147,413,319 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4147,297,969 - 147,413,443 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4152,683,360 - 152,799,077 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04148,464,228 - 148,579,951 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04147,093,650 - 147,209,370 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04146,106,386 - 146,223,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4146,106,386 - 146,223,228 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04209,399,633 - 209,516,846 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44150,067,441 - 150,196,237 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14150,312,278 - 150,441,202 (+)NCBI
Celera4135,850,824 - 135,965,196 (+)NCBICelera
Cytogenetic Map4q42NCBI
Slc6a11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542913,774,455 - 13,880,690 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542913,774,455 - 13,880,690 (+)NCBIChiLan1.0ChiLan1.0
SLC6A11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2210,813,514 - 10,938,397 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1310,818,275 - 10,943,122 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0310,753,412 - 10,878,333 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1311,101,054 - 11,225,277 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl311,101,336 - 11,222,948 (+)Ensemblpanpan1.1panPan2
SLC6A11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1207,431,015 - 7,559,903 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl207,433,194 - 7,560,564 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha207,466,514 - 7,595,315 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0207,461,064 - 7,589,938 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl207,461,068 - 7,590,345 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1207,177,316 - 7,306,087 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0207,533,511 - 7,658,605 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0207,505,503 - 7,630,735 (-)NCBIUU_Cfam_GSD_1.0
Slc6a11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494216,345,399 - 16,469,940 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366022,439,813 - 2,564,313 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366022,437,653 - 2,564,309 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC6A11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1366,998,336 - 67,115,907 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11366,998,113 - 67,115,918 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21374,203,510 - 74,218,549 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC6A11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12246,857,117 - 46,978,652 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2246,857,569 - 46,978,088 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041119,545,103 - 119,668,158 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc6a11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624943692,513 - 804,023 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624943694,447 - 803,993 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Slc6a11
6538 total Variants

Predicted Target Of
Summary Value
Count of predictions:981
Count of miRNA genes:500
Interacting mature miRNAs:601
Transcripts:ENSMUST00000032451
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
8552704Cia43_mcollagen induced arthritis QTL 43 (mouse)Not determined6114159241119737532Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
12792979Fbmd2_mfemoral bone mineral density 2, females only (mouse)675026989115026943Mouse

1 to 10 of 38 rows
Slc6a11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6E3UniSTS
cM Map649.6UniSTS
D6Mit329  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386114,182,280 - 114,182,454UniSTSGRCm38
MGSCv376114,132,274 - 114,132,448UniSTSGRCm37
Celera6116,003,300 - 116,003,474UniSTS
Cytogenetic Map6E3UniSTS
cM Map650.5UniSTS
Whitehead Genetic647.0UniSTS
Whitehead/MRC_RH61173.03UniSTS
Whitehead_YAC6 UniSTS
D6Mit383  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386114,135,752 - 114,135,842UniSTSGRCm38
MGSCv376114,085,746 - 114,085,836UniSTSGRCm37
Celera6115,956,840 - 115,956,930UniSTS
Cytogenetic Map6E3UniSTS
cM Map648.0UniSTS
Whitehead_YAC6 UniSTS
Gabt4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386114,249,716 - 114,249,913UniSTSGRCm38
MGSCv376114,199,710 - 114,199,907UniSTSGRCm37
Celera6116,070,720 - 116,070,917UniSTS
Cytogenetic Map6E3UniSTS
cM Map649.6UniSTS
Gabt4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386114,247,746 - 114,248,083UniSTSGRCm38
MGSCv376114,197,740 - 114,198,077UniSTSGRCm37
Celera6116,068,749 - 116,069,086UniSTS
Cytogenetic Map6E3UniSTS
cM Map649.6UniSTS
Slc6a11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6E3UniSTS
Slc6a11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6E3UniSTS







Ensembl Acc Id: ENSMUST00000032451   ⟹   ENSMUSP00000032451
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6114,108,202 - 114,226,913 (+)Ensembl
GRCm38.p6 Ensembl6114,131,241 - 114,249,952 (+)Ensembl
Ensembl Acc Id: ENSMUST00000203105
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6114,108,380 - 114,109,396 (+)Ensembl
GRCm38.p6 Ensembl6114,131,419 - 114,132,435 (+)Ensembl
RefSeq Acc Id: NM_172890   ⟹   NP_766478
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396114,108,202 - 114,226,847 (+)NCBI
GRCm386114,131,241 - 114,249,886 (+)ENTREZGENE
MGSCv376114,081,235 - 114,199,880 (+)RGD
Celera6115,952,329 - 116,070,890 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Protein RefSeqs NP_766478 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC35259 (Get FASTA)   NCBI Sequence Viewer  
  BAC35326 (Get FASTA)   NCBI Sequence Viewer  
  BAE24379 (Get FASTA)   NCBI Sequence Viewer  
  EDK99507 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000032451
  ENSMUSP00000032451.7
GenBank Protein P31650 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_766478   ⟸   NM_172890
- UniProtKB: Q8BWA7 (UniProtKB/Swiss-Prot),   P31650 (UniProtKB/Swiss-Prot),   Q8BKG0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000032451   ⟸   ENSMUST00000032451

Name Modeler Protein Id AA Range Protein Structure
AF-P31650-F1-model_v2 AlphaFold P31650 1-627 view protein structure

RGD ID:6890688
Promoter ID:EPDNEW_M8795
Type:multiple initiation site
Name:Slc6a11_1
Description:Mus musculus solute carrier family 6 (neurotransmitter transporter,GABA), member 11 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386114,131,239 - 114,131,299EPDNEW


1 to 25 of 25 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000030307 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032451 ENTREZGENE
  ENSMUST00000032451.9 UniProtKB/Swiss-Prot
InterPro Na/ntran_symport UniProtKB/Swiss-Prot
  Na/ntran_symport_GABA_GAT3 UniProtKB/Swiss-Prot
  SNS_sf UniProtKB/Swiss-Prot
KEGG Report mmu:243616 UniProtKB/Swiss-Prot
MGD MGI:95630 ENTREZGENE
NCBI Gene Slc6a11 ENTREZGENE
PANTHER PTHR11616 UniProtKB/Swiss-Prot
  SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 3 UniProtKB/Swiss-Prot
Pfam SNF UniProtKB/Swiss-Prot
PharmGKB SLC6A11 RGD
PhenoGen Slc6a11 PhenoGen
PRINTS GAT3TRNSPORT UniProtKB/Swiss-Prot
  NANEUSMPORT UniProtKB/Swiss-Prot
PROSITE NA_NEUROTRAN_SYMP_1 UniProtKB/Swiss-Prot
  NA_NEUROTRAN_SYMP_2 UniProtKB/Swiss-Prot
  NA_NEUROTRAN_SYMP_3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF161070 UniProtKB/Swiss-Prot
UniProt P31650 ENTREZGENE
  Q8BKG0 ENTREZGENE, UniProtKB/TrEMBL
  Q8BWA7 ENTREZGENE
  S6A11_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q8BWA7 UniProtKB/Swiss-Prot
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Slc6a11  solute carrier family 6 (neurotransmitter transporter, GABA), member 11  Gabt4  gamma-aminobutyric acid (GABA-A) transporter 4  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 Gabt4  gamma-aminobutyric acid (GABA-A) transporter 4  Slc6a11  solute carrier family 6 (neurotransmitter transporter, GABA), member 11  Symbol and/or name change 5135510 APPROVED
2016-02-26 Slc6a11  solute carrier family 6 (neurotransmitter transporter, GABA), member 11  Gabt4    Data merged from RGD:732373 737654 PROVISIONAL