KCNB1 (potassium voltage-gated channel subfamily B member 1) - Rat Genome Database

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Gene: KCNB1 (potassium voltage-gated channel subfamily B member 1) Sus scrofa
Analyze
Symbol: KCNB1
Name: potassium voltage-gated channel subfamily B member 1
RGD ID: 13845113
Description: ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); outward rectifier potassium channel activity (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN action potential (ortholog); cellular response to calcium ion (ortholog); cellular response to glucose stimulus (ortholog); PARTICIPATES IN insulin secretion pathway; ASSOCIATED WITH developmental and epileptic encephalopathy (ortholog); developmental and epileptic encephalopathy 26 (ortholog); Diaphragmatic Hernia (ortholog); FOUND IN apical plasma membrane (ortholog); axon (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: delayed rectifier potassium channel 1; delayed rectifier potassium channel Kv2.1; DRK1; voltage-gated potassium channel subunit Kv2.1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1751,039,987 - 51,142,644 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,032,163 - 51,152,566 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21757,354,303 - 57,464,782 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1751,039,987 - 51,142,644 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,032,163 - 51,152,566 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21757,354,303 - 57,464,782 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382049,363,877 - 49,483,362 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2049,293,394 - 49,484,297 (-)EnsemblGRCh38hg38GRCh38
GRCh372047,980,414 - 48,099,205 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362047,421,912 - 47,532,588 (-)NCBINCBI36Build 36hg18NCBI36
Build 342047,421,911 - 47,532,588NCBI
Celera2044,693,122 - 44,803,814 (-)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2044,737,067 - 44,847,754 (-)NCBIHuRef
CHM1_12047,892,894 - 48,003,606 (-)NCBICHM1_1
T2T-CHM13v2.02051,133,489 - 51,253,649 (-)NCBIT2T-CHM13v2.0
Kcnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392166,937,889 - 167,032,088 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2166,937,889 - 167,032,075 (-)EnsemblGRCm39 Ensembl
GRCm382167,095,969 - 167,190,072 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,095,969 - 167,190,155 (-)EnsemblGRCm38mm10GRCm38
MGSCv372166,928,878 - 167,014,299 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362166,794,583 - 166,880,004 (-)NCBIMGSCv36mm8
Celera2173,043,474 - 173,128,977 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.22NCBI
Kcnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83176,239,285 - 176,332,408 (-)NCBIGRCr8
mRatBN7.23155,820,255 - 155,913,383 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,822,963 - 155,916,194 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,621,853 - 159,714,946 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03168,120,826 - 168,213,919 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,862,536 - 165,955,629 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03163,850,785 - 163,935,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3163,850,785 - 163,935,617 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03170,010,756 - 170,094,507 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,250,001 - 158,345,927 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13158,156,036 - 158,248,459 (-)NCBI
Celera3154,408,682 - 154,493,576 (-)NCBICelera
RH 3.4 Map31476.0RGD
Cytogenetic Map3q42NCBI
Kcnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554458,680,965 - 8,774,110 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554458,680,979 - 8,779,662 (+)NCBIChiLan1.0ChiLan1.0
KCNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22155,039,862 - 55,225,053 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12055,032,968 - 55,218,159 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02045,636,371 - 45,821,536 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12046,761,428 - 46,885,521 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2046,776,274 - 46,885,521 (-)Ensemblpanpan1.1panPan2
KCNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12436,016,800 - 36,118,873 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,025,472 - 36,117,934 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2435,259,329 - 35,359,756 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02436,721,821 - 36,822,593 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2436,729,609 - 36,823,404 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12435,962,506 - 36,063,208 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02436,096,677 - 36,197,268 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02436,638,300 - 36,739,394 (-)NCBIUU_Cfam_GSD_1.0
Kcnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640189,373,582 - 189,447,939 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365144,827,127 - 4,900,707 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365144,827,156 - 4,902,271 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1214,510,176 - 14,623,054 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl214,510,464 - 14,619,023 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605062,995,224 - 63,111,025 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247905,902,077 - 6,003,591 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247905,901,809 - 6,007,847 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KCNB1
3460 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
10 2 23 3 4 10 10 23 1 6

Sequence


Ensembl Acc Id: ENSSSCT00000037438   ⟹   ENSSSCP00000032335
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1751,039,987 - 51,142,644 (-)Ensembl
RefSeq Acc Id: NM_214218   ⟹   NP_999383
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11751,040,871 - 51,142,636 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021077287   ⟹   XP_020932946
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11751,032,163 - 51,152,566 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021077288   ⟹   XP_020932947
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11751,039,983 - 51,143,574 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020932946   ⟸   XM_021077287
- Peptide Label: isoform X1
- UniProtKB: A0A4X1UHF7 (UniProtKB/TrEMBL),   F1SBE6 (UniProtKB/TrEMBL),   A0A8D0JSA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020932947   ⟸   XM_021077288
- Peptide Label: isoform X1
- UniProtKB: A0A4X1UHF7 (UniProtKB/TrEMBL),   F1SBE6 (UniProtKB/TrEMBL),   A0A8D0JSA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_999383   ⟸   NM_214218
- UniProtKB: O18868 (UniProtKB/Swiss-Prot),   A0A8D0JSA1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000032335   ⟸   ENSSSCT00000037438
Protein Domains
BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000007462 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005029580 UniProtKB/TrEMBL
  ENSSSCG00015002678 UniProtKB/TrEMBL
  ENSSSCG00025076375 UniProtKB/TrEMBL
  ENSSSCG00030004118 UniProtKB/TrEMBL
  ENSSSCG00035024753 UniProtKB/TrEMBL
  ENSSSCG00040073349 UniProtKB/TrEMBL
  ENSSSCG00045003637 UniProtKB/TrEMBL
  ENSSSCG00050012769 UniProtKB/TrEMBL
  ENSSSCG00055024916 UniProtKB/TrEMBL
  ENSSSCG00060009001 UniProtKB/TrEMBL
  ENSSSCG00065073388 UniProtKB/TrEMBL
  ENSSSCG00070017364 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000037438 ENTREZGENE
  ENSSSCT00000037438.3 UniProtKB/TrEMBL
  ENSSSCT00005047067.1 UniProtKB/TrEMBL
  ENSSSCT00015003350.1 UniProtKB/TrEMBL
  ENSSSCT00025105771.1 UniProtKB/TrEMBL
  ENSSSCT00030005405.1 UniProtKB/TrEMBL
  ENSSSCT00035032554.1 UniProtKB/TrEMBL
  ENSSSCT00040101199.1 UniProtKB/TrEMBL
  ENSSSCT00045005973.1 UniProtKB/TrEMBL
  ENSSSCT00050017239.1 UniProtKB/TrEMBL
  ENSSSCT00055049179.1 UniProtKB/TrEMBL
  ENSSSCT00060011589.1 UniProtKB/TrEMBL
  ENSSSCT00065101022.1 UniProtKB/TrEMBL
  ENSSSCT00070034260.1 UniProtKB/TrEMBL
  ENSSSCT00070034276.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv2.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397433 UniProtKB/Swiss-Prot
NCBI Gene KCNB1 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY B MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kv2channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KV21CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHABCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1UHF7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0JSA1 ENTREZGENE, UniProtKB/TrEMBL
  F1SBE6 ENTREZGENE, UniProtKB/TrEMBL
  KCNB1_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:96386 ENTREZGENE