ENPP5 (ectonucleotide pyrophosphatase/phosphodiesterase family member 5) - Rat Genome Database

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Gene: ENPP5 (ectonucleotide pyrophosphatase/phosphodiesterase family member 5) Homo sapiens
Analyze
Symbol: ENPP5
Name: ectonucleotide pyrophosphatase/phosphodiesterase family member 5
RGD ID: 1349666
HGNC Page HGNC:13717
Description: Enables NAD+ diphosphatase activity and zinc ion binding activity. Predicted to be involved in cell communication. Predicted to be located in plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: E-NPP 5; ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative function); ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative); KIAA0879; NPP-5; NPP5
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38646,159,185 - 46,170,980 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl646,159,185 - 46,170,980 (-)EnsemblGRCh38hg38GRCh38
GRCh37646,126,922 - 46,138,717 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36646,235,721 - 46,246,676 (-)NCBINCBI36Build 36hg18NCBI36
Build 34646,235,720 - 46,246,676NCBI
Celera647,680,299 - 47,691,261 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef645,850,807 - 45,861,762 (-)NCBIHuRef
CHM1_1646,131,010 - 46,141,952 (-)NCBICHM1_1
T2T-CHM13v2.0645,994,273 - 46,006,158 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell communication  (IEA,ISS)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:11027689   PMID:12477932   PMID:12975309   PMID:15489334   PMID:17207965   PMID:19490893   PMID:21873635   PMID:28611215   PMID:28898552   PMID:33961781   PMID:35156780   PMID:35914814  
PMID:37352273   PMID:38436793  


Genomics

Comparative Map Data
ENPP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38646,159,185 - 46,170,980 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl646,159,185 - 46,170,980 (-)EnsemblGRCh38hg38GRCh38
GRCh37646,126,922 - 46,138,717 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36646,235,721 - 46,246,676 (-)NCBINCBI36Build 36hg18NCBI36
Build 34646,235,720 - 46,246,676NCBI
Celera647,680,299 - 47,691,261 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef645,850,807 - 45,861,762 (-)NCBIHuRef
CHM1_1646,131,010 - 46,141,952 (-)NCBICHM1_1
T2T-CHM13v2.0645,994,273 - 46,006,158 (-)NCBIT2T-CHM13v2.0
Enpp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391744,389,693 - 44,397,458 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1744,389,704 - 44,397,458 (+)EnsemblGRCm39 Ensembl
GRCm381744,078,802 - 44,086,567 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1744,078,813 - 44,086,567 (+)EnsemblGRCm38mm10GRCm38
MGSCv371744,215,795 - 44,223,516 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361743,541,924 - 43,549,614 (+)NCBIMGSCv36mm8
Celera1747,500,370 - 47,508,072 (+)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1720.3NCBI
Enpp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8924,407,574 - 24,415,029 (-)NCBIGRCr8
mRatBN7.2916,910,187 - 16,917,633 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl916,910,831 - 16,917,480 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx925,494,836 - 25,501,470 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0930,569,359 - 30,575,993 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0928,858,569 - 28,865,203 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0919,469,276 - 19,476,684 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl919,469,706 - 19,476,646 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0918,347,773 - 18,355,164 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4912,574,480 - 12,581,130 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1912,571,802 - 12,578,452 (-)NCBI
Celera914,637,055 - 14,643,705 (-)NCBICelera
Cytogenetic Map9q13NCBI
Enpp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543711,195,391 - 11,204,728 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543711,195,846 - 11,204,000 (-)NCBIChiLan1.0ChiLan1.0
ENPP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2560,642,891 - 60,664,298 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1656,508,953 - 56,530,294 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0645,735,167 - 45,751,671 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1647,013,701 - 47,025,523 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl647,013,699 - 47,025,523 (-)Ensemblpanpan1.1panPan2
ENPP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11214,376,278 - 14,387,883 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1214,377,565 - 14,385,171 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1214,408,235 - 14,419,802 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01214,876,522 - 14,888,437 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1214,877,806 - 14,888,470 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11214,392,730 - 14,404,121 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01214,480,941 - 14,492,536 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01214,577,456 - 14,589,058 (-)NCBIUU_Cfam_GSD_1.0
Enpp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494649,781,793 - 49,790,968 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647614,169,148 - 14,179,151 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647614,169,298 - 14,178,930 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENPP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl740,920,031 - 40,933,326 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1740,920,030 - 40,936,380 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2747,233,579 - 47,249,978 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ENPP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11726,082,427 - 26,091,526 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1726,082,451 - 26,092,900 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604446,165,201 - 46,175,504 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Enpp5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475414,286,371 - 14,295,501 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475414,286,337 - 14,294,529 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ENPP5
27 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p21.1-12.3(chr6:41638061-46512949)x1 copy number loss See cases [RCV000052182] Chr6:41638061..46512949 [GRCh38]
Chr6:41605799..46480686 [GRCh37]
Chr6:41713777..46588645 [NCBI36]
Chr6:6p21.1-12.3		 pathogenic
GRCh38/hg38 6p21.1-12.3(chr6:44985760-47986838)x3 copy number gain See cases [RCV000135580] Chr6:44985760..47986838 [GRCh38]
Chr6:44953497..47954574 [GRCh37]
Chr6:45061475..48062533 [NCBI36]
Chr6:6p21.1-12.3		 likely pathogenic
GRCh38/hg38 6p21.1-12.1(chr6:45681671-54212044)x1 copy number loss See cases [RCV000138349] Chr6:45681671..54212044 [GRCh38]
Chr6:45649408..54076842 [GRCh37]
Chr6:45757386..54184801 [NCBI36]
Chr6:6p21.1-12.1		 pathogenic|uncertain significance
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3		 pathogenic
GRCh37/hg19 6p21.1-12.3(chr6:43636308-50947320)x1 copy number loss See cases [RCV000446897] Chr6:43636308..50947320 [GRCh37]
Chr6:6p21.1-12.3		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
NM_001290072.2(ENPP5):c.499G>A (p.Val167Ile) single nucleotide variant not specified [RCV004325519] Chr6:46167764 [GRCh38]
Chr6:46135501 [GRCh37]
Chr6:6p21.1		 uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1		 pathogenic
GRCh37/hg19 6p21.1(chr6:45284656-46157024)x3 copy number gain not provided [RCV001834542] Chr6:45284656..46157024 [GRCh37]
Chr6:6p21.1		 likely pathogenic
GRCh37/hg19 6p21.1-12.3(chr6:43636308-50947320) copy number loss not specified [RCV002053568] Chr6:43636308..50947320 [GRCh37]
Chr6:6p21.1-12.3		 pathogenic
GRCh37/hg19 6p21.1-q12(chr6:43636308-64947206)x3 copy number gain not provided [RCV002221457] Chr6:43636308..64947206 [GRCh37]
Chr6:6p21.1-q12		 likely pathogenic
NM_001290072.2(ENPP5):c.926A>G (p.Tyr309Cys) single nucleotide variant not specified [RCV004236104] Chr6:46165467 [GRCh38]
Chr6:46133204 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.1051A>G (p.Ile351Val) single nucleotide variant not specified [RCV004162447] Chr6:46161709 [GRCh38]
Chr6:46129446 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.791T>C (p.Ile264Thr) single nucleotide variant not specified [RCV004122866] Chr6:46167472 [GRCh38]
Chr6:46135209 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.44T>C (p.Leu15Pro) single nucleotide variant not specified [RCV004185726] Chr6:46168219 [GRCh38]
Chr6:46135956 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.956T>C (p.Val319Ala) single nucleotide variant not specified [RCV004116393] Chr6:46165437 [GRCh38]
Chr6:46133174 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.400A>T (p.Ser134Cys) single nucleotide variant not specified [RCV004175932] Chr6:46167863 [GRCh38]
Chr6:46135600 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.797A>T (p.Gln266Leu) single nucleotide variant not specified [RCV004073673] Chr6:46167466 [GRCh38]
Chr6:46135203 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.162T>G (p.Ile54Met) single nucleotide variant not specified [RCV004229314] Chr6:46168101 [GRCh38]
Chr6:46135838 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.1336G>T (p.Val446Leu) single nucleotide variant not specified [RCV004127337] Chr6:46161424 [GRCh38]
Chr6:46129161 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.1069C>T (p.Pro357Ser) single nucleotide variant not specified [RCV004234427] Chr6:46161691 [GRCh38]
Chr6:46129428 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.524C>T (p.Thr175Met) single nucleotide variant not specified [RCV004090357] Chr6:46167739 [GRCh38]
Chr6:46135476 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.142A>G (p.Thr48Ala) single nucleotide variant not specified [RCV004251141] Chr6:46168121 [GRCh38]
Chr6:46135858 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.901G>C (p.Val301Leu) single nucleotide variant not specified [RCV004293297] Chr6:46165492 [GRCh38]
Chr6:46133229 [GRCh37]
Chr6:6p21.1		 uncertain significance
GRCh37/hg19 6p21.1(chr6:44861182-46170500)x1 copy number loss See cases [RCV004442796] Chr6:44861182..46170500 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.143C>T (p.Thr48Met) single nucleotide variant not specified [RCV004384889] Chr6:46168120 [GRCh38]
Chr6:46135857 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.445C>T (p.Arg149Cys) single nucleotide variant not specified [RCV004384891] Chr6:46167818 [GRCh38]
Chr6:46135555 [GRCh37]
Chr6:6p21.1		 likely benign
NM_001290072.2(ENPP5):c.631A>G (p.Ile211Val) single nucleotide variant not specified [RCV004384894] Chr6:46167632 [GRCh38]
Chr6:46135369 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.844G>A (p.Val282Ile) single nucleotide variant not specified [RCV004384895] Chr6:46165549 [GRCh38]
Chr6:46133286 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.612G>A (p.Met204Ile) single nucleotide variant not specified [RCV004384893] Chr6:46167651 [GRCh38]
Chr6:46135388 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.283A>G (p.Met95Val) single nucleotide variant not specified [RCV004384890] Chr6:46167980 [GRCh38]
Chr6:46135717 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.593G>A (p.Gly198Glu) single nucleotide variant not specified [RCV004384892] Chr6:46167670 [GRCh38]
Chr6:46135407 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.1145A>G (p.Asn382Ser) single nucleotide variant not specified [RCV004384888] Chr6:46161615 [GRCh38]
Chr6:46129352 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.269T>G (p.Ile90Ser) single nucleotide variant not specified [RCV004625098] Chr6:46167994 [GRCh38]
Chr6:46135731 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.86A>G (p.Lys29Arg) single nucleotide variant not specified [RCV004625099] Chr6:46168177 [GRCh38]
Chr6:46135914 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001290072.2(ENPP5):c.1267G>A (p.Ala423Thr) single nucleotide variant not specified [RCV004625101] Chr6:46161493 [GRCh38]
Chr6:46129230 [GRCh37]
Chr6:6p21.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1534
Count of miRNA genes:632
Interacting mature miRNAs:693
Transcripts:ENST00000230565, ENST00000371383, ENST00000492313
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406995648GWAS644624_Hlevel of ectonucleotide pyrophosphatase/phosphodiesterase family member 5 in blood serum QTL GWAS644624 (human)1e-27level of ectonucleotide pyrophosphatase/phosphodiesterase family member 5 in blood serum64616100846161009Human
407211543GWAS860519_Hblood protein measurement QTL GWAS860519 (human)4e-240blood protein measurementblood protein measurement (CMO:0000028)64616100846161009Human
406944786GWAS593762_Hectonucleotide pyrophosphatase/phosphodiesterase family member 5 measurement QTL GWAS593762 (human)2e-1111ectonucleotide pyrophosphatase/phosphodiesterase family member 5 measurement64616308846163089Human
406945208GWAS594184_Hectonucleotide pyrophosphatase/phosphodiesterase family member 5 measurement QTL GWAS594184 (human)8e-61ectonucleotide pyrophosphatase/phosphodiesterase family member 5 measurement64616901246169013Human
406893854GWAS542830_Hectonucleotide pyrophosphatase/phosphodiesterase family member 5 measurement QTL GWAS542830 (human)8e-299ectonucleotide pyrophosphatase/phosphodiesterase family member 5 measurement64616100846161009Human

Markers in Region
ENPP5__7592  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37646,128,027 - 46,128,877UniSTSGRCh37
Build 36646,235,986 - 46,236,836RGDNCBI36
Celera647,680,564 - 47,681,414RGD
HuRef645,851,072 - 45,851,922UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2414 2788 2243 4908 1693 2288 5 596 1863 437 2241 7168 6380 27 3690 1 839 1718 1582 172 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_033986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001290072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001290073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005249260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011514786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054356138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054356139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK292842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL035701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF593433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC321540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC332590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000230565   ⟹   ENSP00000230565
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl646,160,415 - 46,170,971 (-)Ensembl
Ensembl Acc Id: ENST00000371383   ⟹   ENSP00000360436
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl646,159,185 - 46,170,980 (-)Ensembl
Ensembl Acc Id: ENST00000492313
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl646,164,957 - 46,167,551 (-)Ensembl
RefSeq Acc Id: NM_001290072   ⟹   NP_001277001
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38646,159,185 - 46,170,980 (-)NCBI
CHM1_1646,130,166 - 46,141,982 (-)NCBI
T2T-CHM13v2.0645,994,273 - 46,006,068 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001290073   ⟹   NP_001277002
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38646,159,185 - 46,170,980 (-)NCBI
CHM1_1646,130,166 - 46,141,982 (-)NCBI
T2T-CHM13v2.0645,994,273 - 46,006,068 (-)NCBI
Sequence:
RefSeq Acc Id: NM_021572   ⟹   NP_067547
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38646,159,185 - 46,170,980 (-)NCBI
GRCh37646,126,922 - 46,138,737 (-)NCBI
Build 36646,235,721 - 46,246,676 (-)NCBI Archive
Celera647,680,299 - 47,691,261 (-)RGD
HuRef645,850,807 - 45,861,762 (-)ENTREZGENE
CHM1_1646,130,166 - 46,141,982 (-)NCBI
T2T-CHM13v2.0645,994,273 - 46,006,068 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005249260   ⟹   XP_005249317
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38646,159,185 - 46,170,980 (-)NCBI
GRCh37646,126,922 - 46,138,737 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011514786   ⟹   XP_011513088
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38646,159,185 - 46,170,980 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054356138   ⟹   XP_054212113
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0645,994,273 - 46,006,147 (-)NCBI
RefSeq Acc Id: XM_054356139   ⟹   XP_054212114
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0645,994,273 - 46,006,158 (-)NCBI
RefSeq Acc Id: NP_067547   ⟸   NM_021572
- Peptide Label: isoform 1 precursor
- UniProtKB: Q5TFV2 (UniProtKB/Swiss-Prot),   Q6UX49 (UniProtKB/Swiss-Prot),   Q9UJA9 (UniProtKB/Swiss-Prot),   A8K9X7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005249317   ⟸   XM_005249260
- Peptide Label: isoform X1
- UniProtKB: Q5TFV2 (UniProtKB/Swiss-Prot),   Q6UX49 (UniProtKB/Swiss-Prot),   Q9UJA9 (UniProtKB/Swiss-Prot),   A8K9X7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277002   ⟸   NM_001290073
- Peptide Label: isoform 2
- UniProtKB: B4DHN2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277001   ⟸   NM_001290072
- Peptide Label: isoform 1 precursor
- UniProtKB: Q5TFV2 (UniProtKB/Swiss-Prot),   Q6UX49 (UniProtKB/Swiss-Prot),   Q9UJA9 (UniProtKB/Swiss-Prot),   A8K9X7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011513088   ⟸   XM_011514786
- Peptide Label: isoform X1
- UniProtKB: Q5TFV2 (UniProtKB/Swiss-Prot),   Q6UX49 (UniProtKB/Swiss-Prot),   Q9UJA9 (UniProtKB/Swiss-Prot),   A8K9X7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000360436   ⟸   ENST00000371383
Ensembl Acc Id: ENSP00000230565   ⟸   ENST00000230565
RefSeq Acc Id: XP_054212114   ⟸   XM_054356139
- Peptide Label: isoform X1
- UniProtKB: Q6UX49 (UniProtKB/Swiss-Prot),   Q9UJA9 (UniProtKB/Swiss-Prot),   Q5TFV2 (UniProtKB/Swiss-Prot),   A8K9X7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054212113   ⟸   XM_054356138
- Peptide Label: isoform X1
- UniProtKB: Q6UX49 (UniProtKB/Swiss-Prot),   Q9UJA9 (UniProtKB/Swiss-Prot),   Q5TFV2 (UniProtKB/Swiss-Prot),   A8K9X7 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UJA9-F1-model_v2 AlphaFold Q9UJA9 1-477 view protein structure

Promoters
RGD ID:7208235
Promoter ID:EPDNEW_H9864
Type:initiation region
Name:ENPP5_1
Description:ectonucleotide pyrophosphatase/phosphodiesterase 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38646,170,971 - 46,171,031EPDNEW
RGD ID:6805000
Promoter ID:HG_KWN:53735
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   Lymphoblastoid
Transcripts:ENST00000230565,   UC003OYA.1,   UC010JZC.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36646,246,356 - 46,246,856 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:13717 AgrOrtholog
COSMIC ENPP5 COSMIC
Ensembl Genes ENSG00000112796 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000230565 ENTREZGENE
  ENST00000230565.3 UniProtKB/Swiss-Prot
  ENST00000371383 ENTREZGENE
  ENST00000371383.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1360.180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.720.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000112796 GTEx
HGNC ID HGNC:13717 ENTREZGENE
Human Proteome Map ENPP5 Human Proteome Map
InterPro Alkaline_phosphatase_core_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphodiest/P_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:59084 UniProtKB/Swiss-Prot
NCBI Gene 59084 ENTREZGENE
OMIM 617001 OMIM
PANTHER ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Phosphodiest UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ENPP5 RGD, PharmGKB
Superfamily-SCOP SSF53649 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K9X7 ENTREZGENE, UniProtKB/TrEMBL
  B4DHN2 ENTREZGENE, UniProtKB/TrEMBL
  ENPP5_HUMAN UniProtKB/Swiss-Prot
  Q5TFV2 ENTREZGENE
  Q6UX49 ENTREZGENE
  Q9UJA9 ENTREZGENE
UniProt Secondary Q5TFV2 UniProtKB/Swiss-Prot
  Q6UX49 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-05 ENPP5  ectonucleotide pyrophosphatase/phosphodiesterase family member 5    ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)  Symbol and/or name change 5135510 APPROVED
2011-07-27 ENPP5  ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)  ENPP5  ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative function)  Symbol and/or name change 5135510 APPROVED