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Gene: LRIG3 (leucine rich repeats and immunoglobulin like domains 3) Homo sapiens

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Symbol:

LRIG3

Name:

leucine rich repeats and immunoglobulin like domains 3

RGD ID:

1347856

HGNC Page

HGNC:30991

Description:

Predicted to act upstream of or within otolith morphogenesis. Located in extracellular space.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

FLJ26573; FLJ90440; KIAA3016; leucine-rich repeats and immunoglobulin like domains 3; leucine-rich repeats and immunoglobulin-like domains 3; leucine-rich repeats and immunoglobulin-like domains protein 3; LIG-3; LIG3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	58,872,155 - 58,920,504 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	58,872,149 - 58,920,504 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	59,265,937 - 59,314,285 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	57,552,204 - 57,600,529 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	57,552,204 - 57,600,529	NCBI
Celera	12	58,927,578 - 58,975,904 (-)	NCBI		Celera
Cytogenetic Map	12	q14.1	NCBI
HuRef	12	56,314,531 - 56,362,936 (-)	NCBI		HuRef
CHM1_1	12	59,233,510 - 59,281,893 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	58,852,431 - 58,900,780 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LRIG3	Human	basal cell carcinoma		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:36428691

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LRIG3	Human	(+)-schisandrin B	multiple interactions	ISO	Lrig3 (Rattus norvegicus)	6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of LRIG3 mRNA]	CTD	PMID:31150632
LRIG3	Human	1,2-dimethylhydrazine	decreases expression	ISO	Lrig3 (Mus musculus)	6480464	1 and 2-Dimethylhydrazine results in decreased expression of LRIG3 mRNA	CTD	PMID:22206623
LRIG3	Human	1,2-dimethylhydrazine	multiple interactions	ISO	Lrig3 (Mus musculus)	6480464	[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of LRIG3 mRNA	CTD	PMID:22206623
LRIG3	Human	17beta-estradiol	multiple interactions	ISO	Lrig3 (Rattus norvegicus)	6480464	[bisphenol A co-treated with Estradiol] results in increased expression of LRIG3 mRNA	CTD	PMID:26496021
LRIG3	Human	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	Lrig3 (Mus musculus)	6480464	Tetrachlorodibenzodioxin affects the expression of LRIG3 mRNA	CTD	PMID:21570461
LRIG3	Human	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	Lrig3 (Rattus norvegicus)	6480464	Tetrachlorodibenzodioxin results in increased expression of LRIG3 mRNA	CTD	PMID:33387578
LRIG3	Human	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of LRIG3 mRNA	CTD	PMID:23152189
LRIG3	Human	acrylamide	decreases expression	EXP		6480464	Acrylamide results in decreased expression of LRIG3 mRNA	CTD	PMID:32763439
LRIG3	Human	aflatoxin B1	increases expression	ISO	Lrig3 (Mus musculus)	6480464	Aflatoxin B1 results in increased expression of LRIG3 mRNA	CTD	PMID:19770486
LRIG3	Human	aflatoxin B1	decreases methylation	EXP		6480464	Aflatoxin B1 results in decreased methylation of LRIG3 gene	CTD	PMID:27153756
LRIG3	Human	all-trans-retinoic acid	multiple interactions	ISO	Lrig3 (Mus musculus)	6480464	[bisphenol F co-treated with Tretinoin] results in decreased expression of LRIG3 mRNA	CTD	PMID:30951980
LRIG3	Human	aristolochic acid A	decreases expression	EXP		6480464	aristolochic acid I results in decreased expression of LRIG3 mRNA	CTD	PMID:33212167
LRIG3	Human	arsane	multiple interactions	EXP		6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of LRIG3 mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of LRIG3 mRNA	CTD	PMID:39836092
LRIG3	Human	arsenic atom	multiple interactions	EXP		6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of LRIG3 mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of LRIG3 mRNA	CTD	PMID:39836092
LRIG3	Human	benzo[a]pyrene	increases expression	ISO	Lrig3 (Mus musculus)	6480464	Benzo(a)pyrene results in increased expression of LRIG3 mRNA	CTD	PMID:19770486
LRIG3	Human	benzo[a]pyrene	decreases expression	EXP		6480464	Benzo(a)pyrene results in decreased expression of LRIG3 mRNA	CTD	PMID:21632981
LRIG3	Human	benzo[b]fluoranthene	decreases expression	ISO	Lrig3 (Mus musculus)	6480464	benzo(b)fluoranthene results in decreased expression of LRIG3 mRNA	CTD	PMID:26377693
LRIG3	Human	bis(2-ethylhexyl) phthalate	decreases expression	ISO	Lrig3 (Mus musculus)	6480464	Diethylhexyl Phthalate results in decreased expression of LRIG3 mRNA	CTD	PMID:34319233
LRIG3	Human	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of LRIG3 mRNA	CTD	PMID:25047013
LRIG3	Human	bisphenol A	decreases methylation	ISO	Lrig3 (Mus musculus)	6480464	bisphenol A results in decreased methylation of LRIG3 promoter	CTD	PMID:27312807
LRIG3	Human	bisphenol A	increases expression	ISO	Lrig3 (Rattus norvegicus)	6480464	bisphenol A results in increased expression of LRIG3 mRNA	CTD	PMID:30816183
LRIG3	Human	bisphenol A	decreases expression	ISO	Lrig3 (Rattus norvegicus)	6480464	bisphenol A results in decreased expression of LRIG3 mRNA	CTD	PMID:25181051
LRIG3	Human	bisphenol A	multiple interactions	ISO	Lrig3 (Rattus norvegicus)	6480464	[bisphenol A co-treated with Estradiol] results in increased expression of LRIG3 mRNA	CTD	PMID:26496021
LRIG3	Human	bisphenol F	multiple interactions	ISO	Lrig3 (Mus musculus)	6480464	[bisphenol F co-treated with Tretinoin] results in decreased expression of LRIG3 mRNA	CTD	PMID:30951980
LRIG3	Human	cadmium dichloride	increases expression	ISO	Lrig3 (Rattus norvegicus)	6480464	Cadmium Chloride results in increased expression of LRIG3 mRNA	CTD	PMID:33453195
LRIG3	Human	cadmium dichloride	decreases expression	EXP		6480464	Cadmium Chloride results in decreased expression of LRIG3 mRNA	CTD	PMID:38568856
LRIG3	Human	calcitriol	decreases expression	EXP		6480464	Calcitriol results in decreased expression of LRIG3 mRNA	CTD	PMID:16002434
LRIG3	Human	carbon nanotube	decreases expression	ISO	Lrig3 (Mus musculus)	6480464	Nanotubes more ...	CTD	PMID:25554681
LRIG3	Human	chromium(6+)	multiple interactions	EXP		6480464	[zinc chromate results in increased abundance of chromium hexavalent ion] which results in increased expression of LRIG3 mRNA	CTD	PMID:38479592
LRIG3	Human	clofibrate	decreases expression	ISO	Lrig3 (Mus musculus)	6480464	Clofibrate results in decreased expression of LRIG3 mRNA	CTD	PMID:23811191
LRIG3	Human	cobalt dichloride	decreases expression	EXP		6480464	cobaltous chloride results in decreased expression of LRIG3 mRNA	CTD	PMID:19320972
LRIG3	Human	cobalt dichloride	increases expression	ISO	Lrig3 (Rattus norvegicus)	6480464	cobaltous chloride results in increased expression of LRIG3 mRNA	CTD	PMID:24386269
LRIG3	Human	copper atom	multiple interactions	EXP		6480464	[NSC 689534 binds to Copper] which results in decreased expression of LRIG3 mRNA	CTD	PMID:20971185
LRIG3	Human	copper(0)	multiple interactions	EXP		6480464	[NSC 689534 binds to Copper] which results in decreased expression of LRIG3 mRNA	CTD	PMID:20971185
LRIG3	Human	copper(II) sulfate	decreases expression	EXP		6480464	Copper Sulfate results in decreased expression of LRIG3 mRNA	CTD	PMID:19549813
LRIG3	Human	cyclosporin A	decreases expression	EXP		6480464	Cyclosporine results in decreased expression of LRIG3 mRNA	CTD	PMID:27989131
LRIG3	Human	decabromodiphenyl ether	increases expression	ISO	Lrig3 (Rattus norvegicus)	6480464	decabromobiphenyl ether results in increased expression of LRIG3 mRNA	CTD	PMID:23914054
LRIG3	Human	diethyl maleate	decreases expression	ISO	Lrig3 (Rattus norvegicus)	6480464	diethyl maleate results in decreased expression of LRIG3 mRNA	CTD	PMID:21161181
LRIG3	Human	dorsomorphin	multiple interactions	EXP		6480464	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ...	CTD	PMID:27188386
LRIG3	Human	doxorubicin	decreases expression	EXP		6480464	Doxorubicin results in decreased expression of LRIG3 mRNA	CTD	PMID:29803840
LRIG3	Human	folic acid	multiple interactions	ISO	Lrig3 (Mus musculus)	6480464	[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of LRIG3 mRNA	CTD	PMID:22206623
LRIG3	Human	fonofos	increases methylation	EXP		6480464	Fonofos results in increased methylation of LRIG3 promoter	CTD	PMID:22847954
LRIG3	Human	formaldehyde	decreases expression	EXP		6480464	Formaldehyde results in decreased expression of LRIG3 mRNA	CTD	PMID:20655997
LRIG3	Human	gentamycin	increases expression	ISO	Lrig3 (Rattus norvegicus)	6480464	Gentamicins results in increased expression of LRIG3 mRNA	CTD	PMID:33387578
LRIG3	Human	lead(0)	affects expression	EXP		6480464	Lead affects the expression of LRIG3 mRNA	CTD	PMID:28903495
LRIG3	Human	leflunomide	increases expression	EXP		6480464	leflunomide results in increased expression of LRIG3 mRNA	CTD	PMID:28988120
LRIG3	Human	lipopolysaccharide	multiple interactions	EXP		6480464	[S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of LRIG3 mRNA	CTD	PMID:35811015
LRIG3	Human	manganese atom	multiple interactions	EXP		6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of LRIG3 mRNA	CTD	PMID:39836092
LRIG3	Human	manganese(0)	multiple interactions	EXP		6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of LRIG3 mRNA	CTD	PMID:39836092
LRIG3	Human	manganese(II) chloride	multiple interactions	EXP		6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of LRIG3 mRNA	CTD	PMID:39836092
LRIG3	Human	melphalan	decreases expression	EXP		6480464	Melphalan results in decreased expression of LRIG3 mRNA	CTD	PMID:22363485
LRIG3	Human	methamphetamine	increases expression	ISO	Lrig3 (Rattus norvegicus)	6480464	Methamphetamine results in increased expression of LRIG3 mRNA	CTD	PMID:19564919
LRIG3	Human	nickel sulfate	increases expression	EXP		6480464	nickel sulfate results in increased expression of LRIG3 mRNA	CTD	PMID:22714537
LRIG3	Human	oxaliplatin	multiple interactions	ISO	Lrig3 (Rattus norvegicus)	6480464	[oxaliplatin co-treated with Topotecan] results in increased expression of LRIG3 mRNA	CTD	PMID:25729387
LRIG3	Human	paracetamol	affects expression	ISO	Lrig3 (Mus musculus)	6480464	Acetaminophen affects the expression of LRIG3 mRNA	CTD	PMID:17562736
LRIG3	Human	paracetamol	increases expression	ISO	Lrig3 (Rattus norvegicus)	6480464	Acetaminophen results in increased expression of LRIG3 mRNA	CTD	PMID:33387578
LRIG3	Human	paracetamol	decreases expression	EXP		6480464	Acetaminophen results in decreased expression of LRIG3 mRNA	CTD	PMID:29067470
LRIG3	Human	parathion	increases methylation	EXP		6480464	Parathion results in increased methylation of LRIG3 promoter	CTD	PMID:22847954
LRIG3	Human	pirinixic acid	decreases expression	ISO	Lrig3 (Mus musculus)	6480464	pirinixic acid results in decreased expression of LRIG3 mRNA	CTD	PMID:23811191
LRIG3	Human	potassium chromate	decreases expression	EXP		6480464	potassium chromate(VI) results in decreased expression of LRIG3 mRNA	CTD	PMID:22714537
LRIG3	Human	quercetin	decreases expression	EXP		6480464	Quercetin results in decreased expression of LRIG3 mRNA	CTD	PMID:21632981
LRIG3	Human	resorcinol	decreases expression	EXP		6480464	resorcinol results in decreased expression of LRIG3 mRNA	CTD	PMID:22623647
LRIG3	Human	S-(1,2-dichlorovinyl)-L-cysteine	multiple interactions	EXP		6480464	[S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of LRIG3 mRNA	CTD	PMID:35811015
LRIG3	Human	SB 431542	multiple interactions	EXP		6480464	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ...	CTD	PMID:27188386
LRIG3	Human	sodium arsenite	decreases expression	EXP		6480464	sodium arsenite results in decreased expression of LRIG3 mRNA	CTD	PMID:38568856
LRIG3	Human	sodium arsenite	multiple interactions	EXP		6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of LRIG3 mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of LRIG3 mRNA	CTD	PMID:39836092
LRIG3	Human	terbufos	increases methylation	EXP		6480464	terbufos results in increased methylation of LRIG3 promoter	CTD	PMID:22847954
LRIG3	Human	testosterone	increases expression	ISO	Lrig3 (Mus musculus)	6480464	Testosterone deficiency results in increased expression of LRIG3 mRNA	CTD	PMID:33848595
LRIG3	Human	tetrachloromethane	multiple interactions	ISO	Lrig3 (Rattus norvegicus)	6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of LRIG3 mRNA]	CTD	PMID:31150632
LRIG3	Human	tetrachloromethane	decreases expression	ISO	Lrig3 (Rattus norvegicus)	6480464	Carbon Tetrachloride results in decreased expression of LRIG3 mRNA	CTD	PMID:30723492 and PMID:31150632
LRIG3	Human	tetracycline	increases expression	ISO	Lrig3 (Mus musculus)	6480464	Tetracycline results in increased expression of LRIG3 mRNA	CTD	PMID:16917069
LRIG3	Human	thioacetamide	increases expression	ISO	Lrig3 (Rattus norvegicus)	6480464	Thioacetamide results in increased expression of LRIG3 mRNA	CTD	PMID:34492290
LRIG3	Human	thiram	decreases expression	EXP		6480464	Thiram results in decreased expression of LRIG3 mRNA	CTD	PMID:38568856
LRIG3	Human	titanium dioxide	decreases methylation	ISO	Lrig3 (Mus musculus)	6480464	titanium dioxide results in decreased methylation of LRIG3 gene	CTD	PMID:35295148
LRIG3	Human	topotecan	multiple interactions	ISO	Lrig3 (Rattus norvegicus)	6480464	[oxaliplatin co-treated with Topotecan] results in increased expression of LRIG3 mRNA	CTD	PMID:25729387
LRIG3	Human	toxaphene	increases expression	ISO	Lrig3 (Rattus norvegicus)	6480464	Toxaphene results in increased expression of LRIG3 mRNA	CTD	PMID:23153324
LRIG3	Human	trichloroethene	increases expression	ISO	Lrig3 (Rattus norvegicus)	6480464	Trichloroethylene results in increased expression of LRIG3 mRNA	CTD	PMID:33387578
LRIG3	Human	trichostatin A	decreases expression	EXP		6480464	trichostatin A results in decreased expression of LRIG3 mRNA	CTD	PMID:24935251 and PMID:26272509
LRIG3	Human	trichostatin A	multiple interactions	EXP		6480464	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG3 mRNA	CTD	PMID:27188386
LRIG3	Human	trimellitic anhydride	decreases expression	ISO	Lrig3 (Mus musculus)	6480464	trimellitic anhydride results in decreased expression of LRIG3 mRNA	CTD	PMID:19042947
LRIG3	Human	valproic acid	decreases methylation	EXP		6480464	Valproic Acid results in decreased methylation of LRIG3 gene	CTD	PMID:29154799
LRIG3	Human	valproic acid	increases expression	ISO	Lrig3 (Mus musculus)	6480464	Valproic Acid results in increased expression of LRIG3 mRNA	CTD	PMID:24896083
LRIG3	Human	valproic acid	multiple interactions	EXP		6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG3 mRNA	CTD	PMID:27188386
LRIG3	Human	valproic acid	decreases expression	EXP		6480464	Valproic Acid results in decreased expression of LRIG3 mRNA	CTD	PMID:23179753 more ...

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LRIG3	Human	otolith morphogenesis	acts_upstream_of_or_within	IEA	UniProtKB:Q6P1C6 and ensembl:ENSMUSP00000074360	150520179		Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LRIG3	Human	cytoplasmic vesicle	located_in	IEA	UniProtKB-KW:KW-0968	150520179		UniProt	GO_REF:0000043
LRIG3	Human	cytoplasmic vesicle membrane	located_in	IEA	UniProtKB-SubCell:SL-0089	150520179		UniProt	GO_REF:0000044
LRIG3	Human	extracellular matrix	is_active_in	IBA	MGI:3036284 more ...	150520179		GO_Central	GO_REF:0000033
LRIG3	Human	extracellular space	located_in	HDA		150520179	PMID:22664934	UniProt	PMID:22664934
LRIG3	Human	extracellular space	is_active_in	IBA	FB:FBgn0268063 more ...	150520179		GO_Central	GO_REF:0000033
LRIG3	Human	membrane	located_in	IEA	UniProtKB-KW:KW-0472	150520179		UniProt	GO_REF:0000043
LRIG3	Human	plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0039	150520179		UniProt	GO_REF:0000044
LRIG3	Human	plasma membrane	located_in	IEA	UniProtKB-KW:KW-1003	150520179		UniProt	GO_REF:0000043

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LRIG3	Human	protein binding	enables	IPI	UniProtKB:Q96JA1	150520179	PMID:23723069 and PMID:33961781	IntAct	PMID:23723069 and PMID:33961781
LRIG3	Human	protein binding	enables	IPI	UniProtKB:Q8WWI1-3 and UniProtKB:Q9UPQ0-1	150520179	PMID:30429017	IntAct	PMID:30429017

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:12477932	PMID:12975309	PMID:14702039	PMID:15203213	PMID:16344560	PMID:16532360	PMID:17393120	PMID:18037903	PMID:19200647	PMID:19216216	PMID:19224171	PMID:19448407
PMID:20126551	PMID:20379614	PMID:20445134	PMID:20446891	PMID:21145461	PMID:21505989	PMID:21873635	PMID:22199357	PMID:22664934	PMID:23165628	PMID:23392718	PMID:23723069
PMID:24823311	PMID:24998916	PMID:25708990	PMID:26186194	PMID:26390694	PMID:26517670	PMID:27628597	PMID:28514442	PMID:29507755	PMID:30412760	PMID:30429017	PMID:30745168
PMID:31753913	PMID:31871319	PMID:32107843	PMID:33222697	PMID:33287939	PMID:33469151	PMID:33845483	PMID:33961781	PMID:34079125	PMID:34432599	PMID:34709727	PMID:34839782
PMID:35337019	PMID:35844135	PMID:36639372	PMID:38569033

LRIG3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	58,872,155 - 58,920,504 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	58,872,149 - 58,920,504 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	59,265,937 - 59,314,285 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	57,552,204 - 57,600,529 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	57,552,204 - 57,600,529	NCBI
Celera	12	58,927,578 - 58,975,904 (-)	NCBI		Celera
Cytogenetic Map	12	q14.1	NCBI
HuRef	12	56,314,531 - 56,362,936 (-)	NCBI		HuRef
CHM1_1	12	59,233,510 - 59,281,893 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	58,852,431 - 58,900,780 (-)	NCBI		T2T-CHM13v2.0

Lrig3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	125,802,088 - 125,851,228 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	125,802,037 - 125,851,228 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	125,966,219 - 126,015,359 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	125,966,168 - 126,015,359 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	125,403,275 - 125,452,415 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	125,369,225 - 125,418,184 (+)	NCBI		MGSCv36	mm8
Celera	10	128,374,213 - 128,423,610 (+)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	73.66	NCBI

Lrig3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	63,701,724 - 63,751,898 (+)	NCBI		GRCr8
mRatBN7.2	7	61,816,313 - 61,866,275 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	61,816,342 - 61,866,481 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	7	69,213,098 - 69,263,251 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	69,213,147 - 69,263,142 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	69,404,280 - 69,454,372 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	66,012,273 - 66,062,608 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	58,970,827 - 59,020,519 (+)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

Lrig3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	6,562,167 - 6,601,517 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	6,562,167 - 6,601,517 (-)	NCBI	ChiLan1.0	ChiLan1.0

LRIG3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	35,419,946 - 35,468,463 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	35,416,855 - 35,465,234 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	30,012,251 - 30,060,570 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	30,275,789 - 30,323,781 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	30,275,498 - 30,323,358 (+)	Ensembl	panpan1.1		panPan2

LRIG3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	2,723,836 - 2,772,630 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	2,724,951 - 2,772,636 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	2,789,369 - 2,838,992 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	2,737,466 - 2,787,369 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	2,739,331 - 2,787,479 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	2,714,388 - 2,764,026 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	2,956,608 - 3,006,074 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	3,082,721 - 3,131,801 (-)	NCBI		UU_Cfam_GSD_1.0

Lrig3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	55,940,378 - 55,981,106 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936646	2,886,069 - 2,929,552 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936646	2,889,331 - 2,929,836 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LRIG3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	24,066,623 - 24,117,970 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	24,066,611 - 24,117,971 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	25,903,031 - 25,952,707 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LRIG3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	54,806,138 - 54,853,811 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	54,806,579 - 54,853,645 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	191,070,125 - 191,117,716 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lrig3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	8,801,280 - 8,848,024 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624802	8,801,368 - 8,848,718 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in LRIG3
88 total Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 12q14.1(chr12:58773370-59370427)x1	copy number loss	See cases [RCV000050368]	Chr12:58773370..59370427 [GRCh38] Chr12:59167152..59764208 [GRCh37] Chr12:57453419..58050475 [NCBI36] Chr12:12q14.1	uncertain significance\|conflicting data from submitters
GRCh38/hg38 12q13.3-14.2(chr12:57013355-63042498)x1	copy number loss	See cases [RCV000052813]	Chr12:57013355..63042498 [GRCh38] Chr12:57407139..63436278 [GRCh37] Chr12:55693406..61722545 [NCBI36] Chr12:12q13.3-14.2	pathogenic
GRCh38/hg38 12q13.3-14.1(chr12:57041158-60273934)x1	copy number loss	See cases [RCV000052814]	Chr12:57041158..60273934 [GRCh38] Chr12:57434942..60667715 [GRCh37] Chr12:55721209..58953982 [NCBI36] Chr12:12q13.3-14.1	pathogenic
NM_001136051.2(LRIG3):c.2603C>T (p.Pro868Leu)	single nucleotide variant	Malignant melanoma [RCV000062573]	Chr12:58874486 [GRCh38] Chr12:59268268 [GRCh37] Chr12:57554535 [NCBI36] Chr12:12q14.1	not provided
NM_001136051.2(LRIG3):c.885C>T (p.Phe295=)	single nucleotide variant	Malignant melanoma [RCV000062574]	Chr12:58887815 [GRCh38] Chr12:59281597 [GRCh37] Chr12:57567864 [NCBI36] Chr12:12q14.1	not provided
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3	copy number gain	See cases [RCV000139555]	Chr12:121271..133196807 [GRCh38] Chr12:282465..133773393 [GRCh37] Chr12:100698..132283466 [NCBI36] Chr12:12p13.33-q24.33	pathogenic
GRCh38/hg38 12q14.1(chr12:58802649-59703763)x3	copy number gain	See cases [RCV000143275]	Chr12:58802649..59703763 [GRCh38] Chr12:59196431..60097544 [GRCh37] Chr12:57482698..58383811 [NCBI36] Chr12:12q14.1	uncertain significance
GRCh38/hg38 12q14.1(chr12:58773370-59370427)x1	copy number loss	See cases [RCV000148053]	Chr12:58773370..59370427 [GRCh38] Chr12:59167152..59764208 [GRCh37] Chr12:57453419..58050475 [NCBI36] Chr12:12q14.1	uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3	copy number gain	See cases [RCV000258805]	Chr12:1..133851895 [GRCh37] Chr12:12p13.33-q24.33	pathogenic\|likely pathogenic
GRCh37/hg19 12q14.1(chr12:59167152-60244566)x3	copy number gain	See cases [RCV000445904]	Chr12:59167152..60244566 [GRCh37] Chr12:12q14.1	likely benign
NM_153377.5(LRIG3):c.1583C>G (p.Ser528Cys)	single nucleotide variant	not specified [RCV004286309]	Chr12:58880799 [GRCh38] Chr12:59274581 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2338G>A (p.Val780Met)	single nucleotide variant	not specified [RCV004314129]	Chr12:58877598 [GRCh38] Chr12:59271380 [GRCh37] Chr12:12q14.1	uncertain significance
GRCh37/hg19 12q14.1(chr12:58544526-59353323)x3	copy number gain	not provided [RCV000683449]	Chr12:58544526..59353323 [GRCh37] Chr12:12q14.1	uncertain significance
GRCh37/hg19 12q14.1(chr12:59148987-59769685)x1	copy number loss	not provided [RCV000683443]	Chr12:59148987..59769685 [GRCh37] Chr12:12q14.1	uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3	copy number gain	not provided [RCV000750253]	Chr12:621220..133779118 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
NM_153377.5(LRIG3):c.2634CCA[2] (p.His880del)	microsatellite	not provided [RCV000962269]	Chr12:58876498..58876500 [GRCh38] Chr12:59270280..59270282 [GRCh37] Chr12:12q14.1	benign
NM_153377.5(LRIG3):c.3158A>G (p.Tyr1053Cys)	single nucleotide variant	not specified [RCV004318410]	Chr12:58872774 [GRCh38] Chr12:59266556 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.3098C>G (p.Ser1033Trp)	single nucleotide variant	not specified [RCV004295878]	Chr12:58874072 [GRCh38] Chr12:59267854 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1283A>G (p.Asn428Ser)	single nucleotide variant	not specified [RCV004326615]	Chr12:58883553 [GRCh38] Chr12:59277335 [GRCh37] Chr12:12q14.1	uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3	copy number gain	See cases [RCV000510482]	Chr12:173787..133777902 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)	copy number gain	See cases [RCV000511643]	Chr12:173787..133777902 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3	copy number gain	not provided [RCV000750246]	Chr12:191619..133777645 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
NM_153377.5(LRIG3):c.1132A>G (p.Met378Val)	single nucleotide variant	not provided [RCV000888079]	Chr12:58886850 [GRCh38] Chr12:59280632 [GRCh37] Chr12:12q14.1	likely benign
NM_153377.5(LRIG3):c.2694T>A (p.Ser898Arg)	single nucleotide variant	not provided [RCV000957289]	Chr12:58876446 [GRCh38] Chr12:59270228 [GRCh37] Chr12:12q14.1	benign
GRCh37/hg19 12q13.2-14.1(chr12:55552371-62126304)x3	copy number gain	not provided [RCV001006505]	Chr12:55552371..62126304 [GRCh37] Chr12:12q13.2-14.1	pathogenic
GRCh37/hg19 12q14.1(chr12:59136522-62410625)x1	copy number loss	not provided [RCV001259616]	Chr12:59136522..62410625 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.424A>G (p.Lys142Glu)	single nucleotide variant	not specified [RCV004138150]	Chr12:58890756 [GRCh38] Chr12:59284538 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.7G>T (p.Ala3Ser)	single nucleotide variant	not specified [RCV004201674]	Chr12:58920229 [GRCh38] Chr12:59314010 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2759G>A (p.Cys920Tyr)	single nucleotide variant	not specified [RCV004244167]	Chr12:58874510 [GRCh38] Chr12:59268292 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2551C>T (p.Pro851Ser)	single nucleotide variant	not specified [RCV004127866]	Chr12:58876589 [GRCh38] Chr12:59270371 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.118G>A (p.Gly40Arg)	single nucleotide variant	not specified [RCV004194842]	Chr12:58920118 [GRCh38] Chr12:59313899 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2491T>C (p.Tyr831His)	single nucleotide variant	not specified [RCV004233746]	Chr12:58877445 [GRCh38] Chr12:59271227 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2503C>T (p.Arg835Trp)	single nucleotide variant	not specified [RCV004216005]	Chr12:58877433 [GRCh38] Chr12:59271215 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.3287A>G (p.His1096Arg)	single nucleotide variant	not specified [RCV004223818]	Chr12:58872645 [GRCh38] Chr12:59266427 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1055A>T (p.Asp352Val)	single nucleotide variant	not specified [RCV004243572]	Chr12:58887825 [GRCh38] Chr12:59281607 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2101C>T (p.Arg701Trp)	single nucleotide variant	not specified [RCV004130221]	Chr12:58877835 [GRCh38] Chr12:59271617 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.533G>A (p.Arg178Gln)	single nucleotide variant	not specified [RCV004171253]	Chr12:58890122 [GRCh38] Chr12:59283904 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.914A>T (p.Asp305Val)	single nucleotide variant	not specified [RCV004100464]	Chr12:58888362 [GRCh38] Chr12:59282144 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1664A>G (p.Gln555Arg)	single nucleotide variant	not specified [RCV004136989]	Chr12:58880718 [GRCh38] Chr12:59274500 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2233T>C (p.Phe745Leu)	single nucleotide variant	not specified [RCV004148557]	Chr12:58877703 [GRCh38] Chr12:59271485 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.943G>A (p.Glu315Lys)	single nucleotide variant	not specified [RCV004172326]	Chr12:58888333 [GRCh38] Chr12:59282115 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1190G>A (p.Arg397Gln)	single nucleotide variant	not specified [RCV004155860]	Chr12:58885885 [GRCh38] Chr12:59279667 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1847C>A (p.Ala616Asp)	single nucleotide variant	not specified [RCV004154280]	Chr12:58879060 [GRCh38] Chr12:59272842 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2279G>T (p.Ser760Ile)	single nucleotide variant	not specified [RCV004151176]	Chr12:58877657 [GRCh38] Chr12:59271439 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2342G>A (p.Arg781His)	single nucleotide variant	not specified [RCV004206913]	Chr12:58877594 [GRCh38] Chr12:59271376 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1990G>A (p.Val664Met)	single nucleotide variant	not specified [RCV004231115]	Chr12:58878917 [GRCh38] Chr12:59272699 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.524A>G (p.Asn175Ser)	single nucleotide variant	not specified [RCV004224968]	Chr12:58890131 [GRCh38] Chr12:59283913 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1063T>C (p.Phe355Leu)	single nucleotide variant	not specified [RCV004094678]	Chr12:58887817 [GRCh38] Chr12:59281599 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1657C>T (p.Arg553Trp)	single nucleotide variant	not specified [RCV004201536]	Chr12:58880725 [GRCh38] Chr12:59274507 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2102G>T (p.Arg701Leu)	single nucleotide variant	not specified [RCV004106743]	Chr12:58877834 [GRCh38] Chr12:59271616 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1526C>T (p.Ser509Leu)	single nucleotide variant	not specified [RCV004209187]	Chr12:58880856 [GRCh38] Chr12:59274638 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2112G>C (p.Leu704Phe)	single nucleotide variant	not specified [RCV004273621]	Chr12:58877824 [GRCh38] Chr12:59271606 [GRCh37] Chr12:12q14.1	uncertain significance
GRCh37/hg19 12q13.3-14.1(chr12:57064059-59314016)x1	copy number loss	not provided [RCV003222783]	Chr12:57064059..59314016 [GRCh37] Chr12:12q13.3-14.1	likely pathogenic
NM_153377.5(LRIG3):c.1733A>G (p.Lys578Arg)	single nucleotide variant	not specified [RCV004286808]	Chr12:58880649 [GRCh38] Chr12:59274431 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1969G>A (p.Glu657Lys)	single nucleotide variant	not specified [RCV004282943]	Chr12:58878938 [GRCh38] Chr12:59272720 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2019A>G (p.Val673=)	single nucleotide variant	not provided [RCV003390275]	Chr12:58878888 [GRCh38] Chr12:59272670 [GRCh37] Chr12:12q14.1	likely benign
NM_153377.5(LRIG3):c.1380G>A (p.Ala460=)	single nucleotide variant	not provided [RCV003391942]	Chr12:58882969 [GRCh38] Chr12:59276751 [GRCh37] Chr12:12q14.1	likely benign
GRCh37/hg19 12q14.1(chr12:59148987-59769685)x1	copy number loss	not specified [RCV003986990]	Chr12:59148987..59769685 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1690A>G (p.Thr564Ala)	single nucleotide variant	not specified [RCV004634116]	Chr12:58880692 [GRCh38] Chr12:59274474 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2245A>C (p.Asn749His)	single nucleotide variant	not specified [RCV004412951]	Chr12:58877691 [GRCh38] Chr12:59271473 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1849G>A (p.Gly617Arg)	single nucleotide variant	not specified [RCV004325934]	Chr12:58879058 [GRCh38] Chr12:59272840 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.661G>A (p.Glu221Lys)	single nucleotide variant	not specified [RCV004347464]	Chr12:58888961 [GRCh38] Chr12:59282743 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1169G>A (p.Arg390Gln)	single nucleotide variant	not specified [RCV004412946]	Chr12:58886813 [GRCh38] Chr12:59280595 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1478G>T (p.Cys493Phe)	single nucleotide variant	not specified [RCV004412947]	Chr12:58882871 [GRCh38] Chr12:59276653 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1869G>C (p.Glu623Asp)	single nucleotide variant	not specified [RCV004412948]	Chr12:58879038 [GRCh38] Chr12:59272820 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1984T>C (p.Phe662Leu)	single nucleotide variant	not specified [RCV004412949]	Chr12:58878923 [GRCh38] Chr12:59272705 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2200G>A (p.Asp734Asn)	single nucleotide variant	not specified [RCV004412950]	Chr12:58877736 [GRCh38] Chr12:59271518 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2777C>T (p.Thr926Ile)	single nucleotide variant	not specified [RCV004412952]	Chr12:58874492 [GRCh38] Chr12:59268274 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2941T>A (p.Cys981Ser)	single nucleotide variant	not specified [RCV004412953]	Chr12:58874229 [GRCh38] Chr12:59268011 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2952C>A (p.Ser984Arg)	single nucleotide variant	not specified [RCV004412954]	Chr12:58874218 [GRCh38] Chr12:59268000 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.3076C>T (p.Pro1026Ser)	single nucleotide variant	not specified [RCV004412955]	Chr12:58874094 [GRCh38] Chr12:59267876 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.499C>G (p.Leu167Val)	single nucleotide variant	not specified [RCV004412956]	Chr12:58890681 [GRCh38] Chr12:59284463 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.913G>A (p.Asp305Asn)	single nucleotide variant	not specified [RCV004412957]	Chr12:58888363 [GRCh38] Chr12:59282145 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.92G>A (p.Gly31Asp)	single nucleotide variant	not specified [RCV004412958]	Chr12:58920144 [GRCh38] Chr12:59313925 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.941G>A (p.Ser314Asn)	single nucleotide variant	not specified [RCV004412959]	Chr12:58888335 [GRCh38] Chr12:59282117 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2599A>G (p.Arg867Gly)	single nucleotide variant	not specified [RCV004634117]	Chr12:58876541 [GRCh38] Chr12:59270323 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.320A>G (p.Asn107Ser)	single nucleotide variant	not specified [RCV004637541]	Chr12:58914045 [GRCh38] Chr12:59307826 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2336A>G (p.Asn779Ser)	single nucleotide variant	not specified [RCV004637543]	Chr12:58877600 [GRCh38] Chr12:59271382 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1505C>T (p.Thr502Met)	single nucleotide variant	not specified [RCV004637547]	Chr12:58880877 [GRCh38] Chr12:59274659 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.224G>C (p.Trp75Ser)	single nucleotide variant	not specified [RCV004637545]	Chr12:58920012 [GRCh38] Chr12:59313793 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1638G>A (p.Met546Ile)	single nucleotide variant	not specified [RCV004637548]	Chr12:58880744 [GRCh38] Chr12:59274526 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2062A>G (p.Asn688Asp)	single nucleotide variant	not specified [RCV004637549]	Chr12:58878845 [GRCh38] Chr12:59272627 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.335C>T (p.Thr112Ile)	single nucleotide variant	not specified [RCV004634115]	Chr12:58914030 [GRCh38] Chr12:59307811 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.842G>C (p.Gly281Ala)	single nucleotide variant	not specified [RCV004637542]	Chr12:58888434 [GRCh38] Chr12:59282216 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2665G>A (p.Gly889Arg)	single nucleotide variant	not specified [RCV004637546]	Chr12:58876475 [GRCh38] Chr12:59270257 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.3033A>T (p.Lys1011Asn)	single nucleotide variant	not specified [RCV004938198]	Chr12:58874137 [GRCh38] Chr12:59267919 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1675G>T (p.Val559Leu)	single nucleotide variant	not specified [RCV004634114]	Chr12:58880707 [GRCh38] Chr12:59274489 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.418C>T (p.His140Tyr)	single nucleotide variant	not specified [RCV004938192]	Chr12:58890762 [GRCh38] Chr12:59284544 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2944G>A (p.Glu982Lys)	single nucleotide variant	not specified [RCV004938193]	Chr12:58874226 [GRCh38] Chr12:59268008 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.785T>C (p.Leu262Pro)	single nucleotide variant	not specified [RCV004938197]	Chr12:58888837 [GRCh38] Chr12:59282619 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.3098C>T (p.Ser1033Leu)	single nucleotide variant	not specified [RCV004938202]	Chr12:58874072 [GRCh38] Chr12:59267854 [GRCh37] Chr12:12q14.1	likely benign
NM_153377.5(LRIG3):c.1706G>A (p.Arg569His)	single nucleotide variant	not specified [RCV004938194]	Chr12:58880676 [GRCh38] Chr12:59274458 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.749G>C (p.Gly250Ala)	single nucleotide variant	not specified [RCV004938195]	Chr12:58888873 [GRCh38] Chr12:59282655 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.3239G>T (p.Gly1080Val)	single nucleotide variant	not specified [RCV004938200]	Chr12:58872693 [GRCh38] Chr12:59266475 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2948G>A (p.Arg983Gln)	single nucleotide variant	not specified [RCV004938201]	Chr12:58874222 [GRCh38] Chr12:59268004 [GRCh37] Chr12:12q14.1	likely benign
NM_153377.5(LRIG3):c.2521A>G (p.Ser841Gly)	single nucleotide variant	not specified [RCV004938203]	Chr12:58877415 [GRCh38] Chr12:59271197 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1808C>T (p.Pro603Leu)	single nucleotide variant	not specified [RCV004930102]	Chr12:58879099 [GRCh38] Chr12:59272881 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.19C>G (p.Arg7Gly)	single nucleotide variant	not specified [RCV004938196]	Chr12:58920217 [GRCh38] Chr12:59313998 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1121C>G (p.Thr374Ser)	single nucleotide variant	not specified [RCV004938199]	Chr12:58886861 [GRCh38] Chr12:59280643 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.1370A>G (p.Gln457Arg)	single nucleotide variant	not specified [RCV004938204]	Chr12:58882979 [GRCh38] Chr12:59276761 [GRCh37] Chr12:12q14.1	uncertain significance
GRCh37/hg19 12q14.1(chr12:59212889-61346388)x3	copy number gain	not provided [RCV004819576]	Chr12:59212889..61346388 [GRCh37] Chr12:12q14.1	uncertain significance
NM_153377.5(LRIG3):c.2729A>G (p.Asp910Gly)	single nucleotide variant	not specified [RCV004930101]	Chr12:58874540 [GRCh38] Chr12:59268322 [GRCh37] Chr12:12q14.1	uncertain significance

Predicted Target Of

	Summary Value
Count of predictions:	2182
Count of miRNA genes:	892
Interacting mature miRNAs:	1061
Transcripts:	ENST00000320743, ENST00000379141, ENST00000433272, ENST00000547329, ENST00000548968, ENST00000550304, ENST00000550825, ENST00000552267, ENST00000552646
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
597176141	GWAS1272215_H	leucine-rich repeats and immunoglobulin-like domains protein 3 measurement QTL GWAS1272215 (human)		2e-42	leucine-rich repeats and immunoglobulin-like domains protein 3 measurement		12	58879191	58879192	Human
597267295	GWAS1363369_H	leucine-rich repeats and immunoglobulin-like domains protein 3 measurement QTL GWAS1363369 (human)		9e-50	leucine-rich repeats and immunoglobulin-like domains protein 3 measurement		12	58890047	58890048	Human
597315036	GWAS1411110_H	cognitive function measurement QTL GWAS1411110 (human)		0.00001	cognitive behavior trait (VT:0010450)		12	58904296	58904297	Human
597126560	GWAS1222634_H	total hip arthroplasty, osteoarthritis QTL GWAS1222634 (human)		7e-13	total hip arthroplasty, osteoarthritis		12	58895568	58895569	Human
597297984	GWAS1394058_H	leucine-rich repeats and immunoglobulin-like domains protein 3 measurement QTL GWAS1394058 (human)		5e-14	leucine-rich repeats and immunoglobulin-like domains protein 3 measurement		12	58879191	58879192	Human
597113181	GWAS1209255_H	osteoarthritis, hip QTL GWAS1209255 (human)		1e-09	osteoarthritis, hip		12	58895817	58895818	Human
597512758	GWAS1608832_H	anthropometric measurement QTL GWAS1608832 (human)		6e-09	anthropometric measurement	body morphological measurement (CMO:0000021)	12	58913844	58913845	Human
597304484	GWAS1400558_H	leucine-rich repeats and immunoglobulin-like domains protein 3 measurement QTL GWAS1400558 (human)		9e-20	leucine-rich repeats and immunoglobulin-like domains protein 3 measurement		12	58890047	58890048	Human

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
1204	2436	2788	2232	4967	1723	2345	3	624	1676	465	2270	7042	6211	51	3727	1	851	1742	1610	175	1


RefSeq Transcripts	NM_001136051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_153377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017018790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054371063	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC078963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK074921	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK130083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK292857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK301162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL833710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY358288	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY358295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY505340	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC012380	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC126169	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC126171	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC143960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068266	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DA456424	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KF511180	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000320743 ⟹ ENSP00000326759

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	58,872,155 - 58,920,504 (-)	Ensembl

Ensembl Acc Id:

ENST00000379141 ⟹ ENSP00000368436

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	58,872,149 - 58,919,546 (-)	Ensembl

Ensembl Acc Id:

ENST00000433272 ⟹ ENSP00000413143

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	58,872,548 - 58,920,434 (-)	Ensembl

Ensembl Acc Id:

ENST00000547329

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	58,880,360 - 58,882,886 (-)	Ensembl

Ensembl Acc Id:

ENST00000548968

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	58,913,495 - 58,920,156 (-)	Ensembl

Ensembl Acc Id:

ENST00000550304

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	58,885,880 - 58,887,035 (-)	Ensembl

Ensembl Acc Id:

ENST00000550825 ⟹ ENSP00000449169

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	58,873,551 - 58,874,572 (-)	Ensembl

Ensembl Acc Id:

ENST00000552267 ⟹ ENSP00000449109

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	58,888,874 - 58,914,583 (-)	Ensembl

Ensembl Acc Id:

ENST00000552646

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	58,874,053 - 58,877,494 (-)	Ensembl

RefSeq Acc Id:

NM_001136051 ⟹ NP_001129523

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	12	58,872,155 - 58,919,505 (-)	NCBI
GRCh37	12	59,265,937 - 59,314,319 (-)	NCBI
HuRef	12	56,314,531 - 56,362,936 (-)	NCBI
CHM1_1	12	59,233,510 - 59,280,901 (-)	NCBI
T2T-CHM13v2.0	12	58,852,431 - 58,899,781 (-)	NCBI

Sequence:

show sequence

AGAATTCGGTCATTCTCCAAGTTATGGTGGACGTACTTCTGTTGTTCTCCCTCTGCTTGCTTTTTCACATTAGCAGACCGGACTTAAGTCACAACAGATTATCTTTCATCAAGGCAAGTTCCATGAGC
CACCTTCAAAGCCTTCGAGAAGTGAAACTGAACAACAATGAATTGGAGACCATTCCAAATCTGGGACCAGTCTCGGCAAATATTACACTTCTCTCCTTGGCTGGAAACAGGATTGTTGAAATACTCCC
TGAACATCTGAAAGAGTTTCAGTCCCTTGAAACTTTGGACCTTAGCAGCAACAATATTTCAGAGCTCCAAACTGCATTTCCAGCCCTACAGCTCAAATATCTGTATCTCAACAGCAACCGAGTCACAT
CAATGGAACCTGGGTATTTTGACAATTTGGCCAACACACTCCTTGTGTTAAAGCTGAACAGGAACCGAATCTCAGCTATCCCACCCAAGATGTTTAAACTGCCCCAACTGCAACATCTCGAATTGAAC
CGAAACAAGATTAAAAATGTAGATGGACTGACATTCCAAGGCCTTGGTGCTCTGAAGTCTCTGAAAATGCAAAGAAATGGAGTAACGAAACTTATGGATGGAGCTTTTTGGGGGCTGAGCAACATGGA
AATTTTGCAGCTGGACCATAACAACCTAACAGAGATTACCAAAGGCTGGCTTTACGGCTTGCTGATGCTGCAGGAACTTCATCTCAGCCAAAATGCCATCAACAGGATCAGCCCTGATGCCTGGGAGT
TCTGCCAGAAGCTCAGTGAGCTGGACCTAACTTTCAATCACTTATCAAGGTTAGATGATTCAAGCTTCCTTGGCCTAAGCTTACTAAATACACTGCACATTGGGAACAACAGAGTCAGCTACATTGCT
GATTGTGCCTTCCGGGGGCTTTCCAGTTTAAAGACTTTGGATCTGAAGAACAATGAAATTTCCTGGACTATTGAAGACATGAATGGTGCTTTCTCTGGGCTTGACAAACTGAGGCGACTGATACTCCA
AGGAAATCGGATCCGTTCTATTACTAAAAAAGCCTTCACTGGTTTGGATGCATTGGAGCATCTAGACCTGAGTGACAACGCAATCATGTCTTTACAAGGCAATGCATTTTCACAAATGAAGAAACTGC
AACAATTGCATTTAAATACATCAAGCCTTTTGTGCGATTGCCAGCTAAAATGGCTCCCACAGTGGGTGGCGGAAAACAACTTTCAGAGCTTTGTAAATGCCAGTTGTGCCCATCCTCAGCTGCTAAAA
GGAAGAAGCATTTTTGCTGTTAGCCCAGATGGCTTTGTGTGTGATGATTTTCCCAAACCCCAGATCACGGTTCAGCCAGAAACACAGTCGGCAATAAAAGGTTCCAATTTGAGTTTCATCTGCTCAGC
TGCCAGCAGCAGTGATTCCCCAATGACTTTTGCTTGGAAAAAAGACAATGAACTACTGCATGATGCTGAAATGGAAAATTATGCACACCTCCGGGCCCAAGGTGGCGAGGTGATGGAGTATACCACCA
TCCTTCGGCTGCGCGAGGTGGAATTTGCCAGTGAGGGGAAATATCAGTGTGTCATCTCCAATCACTTTGGTTCATCCTACTCTGTCAAAGCCAAGCTTACAGTAAATATGCTTCCCTCATTCACCAAG
ACCCCCATGGATCTCACCATCCGAGCTGGGGCCATGGCACGCTTGGAGTGTGCTGCTGTGGGGCACCCAGCCCCCCAGATAGCCTGGCAGAAGGATGGGGGCACAGACTTCCCAGCTGCACGGGAGAG
ACGCATGCATGTGATGCCCGAGGATGACGTGTTCTTTATCGTGGATGTGAAGATAGAGGACATTGGGGTATACAGCTGCACAGCTCAGAACAGTGCAGGAAGTATTTCAGCAAATGCAACTCTGACTG
TCCTAGAAACACCATCATTTTTGCGGCCACTGTTGGACCGAACTGTAACCAAGGGAGAAACAGCCGTCCTACAGTGCATTGCTGGAGGAAGCCCTCCCCCTAAACTGAACTGGACCAAAGATGATAGC
CCATTGGTGGTAACCGAGAGGCACTTTTTTGCAGCAGGCAATCAGCTTCTGATTATTGTGGACTCAGATGTCAGTGATGCTGGGAAATACACATGTGAGATGTCTAACACCCTTGGCACTGAGAGAGG
AAACGTGCGCCTCAGTGTGATCCCCACTCCAACCTGCGACTCCCCTCAGATGACAGCCCCATCGTTAGACGATGACGGATGGGCCACTGTGGGTGTCGTGATCATAGCCGTGGTTTGCTGTGTGGTGG
GCACGTCACTCGTGTGGGTGGTCATCATATACCACACAAGGCGGAGGAATGAAGATTGCAGCATTACCAACACAGATGAGACCAACTTGCCAGCAGATATTCCTAGTTATTTGTCATCTCAGGGAACG
TTAGCTGACAGGCAGGATGGGTACGTGTCTTCAGAAAGTGGAAGCCACCACCAGTTTGTCACATCTTCAGGTGCTGGATTTTTCTTACCACAACATGACAGTAGTGGGACCTGCCATATTGACAATAG
CAGTGAAGCTGATGTGGAAGCTGCCACAGATCTGTTCCTTTGTCCGTTTTTGGGATCCACAGGCCCTATGTATTTGAAGGGAAATGTGTATGGCTCAGATCCTTTTGAAACATATCATACAGGTTGCA
GTCCTGACCCAAGAACAGTTTTAATGGACCACTATGAGCCCAGTTACATAAAGAAAAAGGAGTGCTACCCATGTTCTCATCCTTCAGAAGAATCCTGCGAACGGAGCTTCAGTAATATATCGTGGCCT
TCACATGTGAGGAAGCTACTTAACACTAGTTACTCTCACAATGAAGGACCTGGAATGAAAAATCTGTGTCTAAACAAGTCCTCTTTAGATTTTAGTGCAAATCCAGAGCCAGCGTCGGTTGCCTCGAG
TAATTCTTTCATGGGTACCTTTGGAAAAGCTCTCAGGAGACCTCACCTAGATGCCTATTCAAGCTTTGGACAGCCATCAGATTGTCAGCCAAGAGCCTTTTATTTGAAAGCTCATTCTTCCCCAGACT
TGGACTCTGGGTCAGAGGAAGATGGGAAAGAAAGGACAGATTTTCAGGAAGAAAATCACATTTGTACCTTTAAACAGACTTTAGAAAACTACAGGACTCCAAATTTTCAGTCTTATGACTTGGACACA
TAGACTGAATGAGACCAAAGGAAAAGCTTAACATACTACCTCAAGTGAACTTTTATTTAAAAGAGAGAGAATCTTATGTTTTTTAAATGGAGTTATGAATTTTAAAAGGATAAAAATGCTTTATTTAT
ACAGATGAACCAAAATTACAAAAAGTTATGAAAATTTTTATACTGGGAATGATGCTCATATAAGAATACCTTTTTAAACTATTTTTTAACTTTGTTTTATGCAAAAAAGTATCTTACGTAAATTAATG
ATATAAATCATGATTATTTTATGTATTTTTATAATGCCAGATTTCTTTTTATGGAAAATGAGTTACTAAAGCATTTTAAATAATACCTGCCTTGTACCATTTTTTAAATAGAAGTTACTTCATTATAT
TTTGCACATTATATTTAATAAAATGTGTCAATTTGA

hide sequence

RefSeq Acc Id:

NM_153377 ⟹ NP_700356

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	12	58,872,155 - 58,920,504 (-)	NCBI
GRCh37	12	59,265,937 - 59,314,319 (-)	NCBI
Build 36	12	57,552,204 - 57,600,529 (-)	NCBI Archive
HuRef	12	56,314,531 - 56,362,936 (-)	NCBI
CHM1_1	12	59,233,510 - 59,281,893 (-)	NCBI
T2T-CHM13v2.0	12	58,852,431 - 58,900,780 (-)	NCBI

Sequence:

show sequence

GCAGACAAGAAGGGGCTTCGGCGAGCCGACGCTGCTCAAGCTGCAACTCTGTTGCAGTTGGCAG
TTCTTTTCGGTTTCCCTCCTGCTGTTTGGGGGCATGAAAGGGCTTCGCCGCCGGGAGTAAAAGAAGGAATTGACCGGGCAGCGCGAGGGAGGAGCGCGCACGCGACCGCGAGGGCGGGCGTGCACCCT
CGGCTGGAAGTTTGTGCCGGGCCCCGAGCGCGCGCCGGCTGGGAGCTTCGGGTAGAGACCTAGGCCGCTGGACCGCGATGAGCGCGCCGAGCCTCCGTGCGCGCGCCGCGGGGTTGGGGCTGCTGCTG
TGCGCGGTGCTGGGGCGCGCTGGCCGGTCAGACAGCGGCGGTCGCGGGGAACTCGGGCAGCCCTCTGGGGTAGCCGCCGAGCGCCCATGCCCCACTACCTGCCGCTGCCTCGGGGACCTGCTGGACTG
CAGTCGTAAGCGGCTAGCGCGTCTTCCCGAGCCACTCCCGTCCTGGGTCGCTCGGCTGGACTTAAGTCACAACAGATTATCTTTCATCAAGGCAAGTTCCATGAGCCACCTTCAAAGCCTTCGAGAAG
TGAAACTGAACAACAATGAATTGGAGACCATTCCAAATCTGGGACCAGTCTCGGCAAATATTACACTTCTCTCCTTGGCTGGAAACAGGATTGTTGAAATACTCCCTGAACATCTGAAAGAGTTTCAG
TCCCTTGAAACTTTGGACCTTAGCAGCAACAATATTTCAGAGCTCCAAACTGCATTTCCAGCCCTACAGCTCAAATATCTGTATCTCAACAGCAACCGAGTCACATCAATGGAACCTGGGTATTTTGA
CAATTTGGCCAACACACTCCTTGTGTTAAAGCTGAACAGGAACCGAATCTCAGCTATCCCACCCAAGATGTTTAAACTGCCCCAACTGCAACATCTCGAATTGAACCGAAACAAGATTAAAAATGTAG
ATGGACTGACATTCCAAGGCCTTGGTGCTCTGAAGTCTCTGAAAATGCAAAGAAATGGAGTAACGAAACTTATGGATGGAGCTTTTTGGGGGCTGAGCAACATGGAAATTTTGCAGCTGGACCATAAC
AACCTAACAGAGATTACCAAAGGCTGGCTTTACGGCTTGCTGATGCTGCAGGAACTTCATCTCAGCCAAAATGCCATCAACAGGATCAGCCCTGATGCCTGGGAGTTCTGCCAGAAGCTCAGTGAGCT
GGACCTAACTTTCAATCACTTATCAAGGTTAGATGATTCAAGCTTCCTTGGCCTAAGCTTACTAAATACACTGCACATTGGGAACAACAGAGTCAGCTACATTGCTGATTGTGCCTTCCGGGGGCTTT
CCAGTTTAAAGACTTTGGATCTGAAGAACAATGAAATTTCCTGGACTATTGAAGACATGAATGGTGCTTTCTCTGGGCTTGACAAACTGAGGCGACTGATACTCCAAGGAAATCGGATCCGTTCTATT
ACTAAAAAAGCCTTCACTGGTTTGGATGCATTGGAGCATCTAGACCTGAGTGACAACGCAATCATGTCTTTACAAGGCAATGCATTTTCACAAATGAAGAAACTGCAACAATTGCATTTAAATACATC
AAGCCTTTTGTGCGATTGCCAGCTAAAATGGCTCCCACAGTGGGTGGCGGAAAACAACTTTCAGAGCTTTGTAAATGCCAGTTGTGCCCATCCTCAGCTGCTAAAAGGAAGAAGCATTTTTGCTGTTA
GCCCAGATGGCTTTGTGTGTGATGATTTTCCCAAACCCCAGATCACGGTTCAGCCAGAAACACAGTCGGCAATAAAAGGTTCCAATTTGAGTTTCATCTGCTCAGCTGCCAGCAGCAGTGATTCCCCA
ATGACTTTTGCTTGGAAAAAAGACAATGAACTACTGCATGATGCTGAAATGGAAAATTATGCACACCTCCGGGCCCAAGGTGGCGAGGTGATGGAGTATACCACCATCCTTCGGCTGCGCGAGGTGGA
ATTTGCCAGTGAGGGGAAATATCAGTGTGTCATCTCCAATCACTTTGGTTCATCCTACTCTGTCAAAGCCAAGCTTACAGTAAATATGCTTCCCTCATTCACCAAGACCCCCATGGATCTCACCATCC
GAGCTGGGGCCATGGCACGCTTGGAGTGTGCTGCTGTGGGGCACCCAGCCCCCCAGATAGCCTGGCAGAAGGATGGGGGCACAGACTTCCCAGCTGCACGGGAGAGACGCATGCATGTGATGCCCGAG
GATGACGTGTTCTTTATCGTGGATGTGAAGATAGAGGACATTGGGGTATACAGCTGCACAGCTCAGAACAGTGCAGGAAGTATTTCAGCAAATGCAACTCTGACTGTCCTAGAAACACCATCATTTTT
GCGGCCACTGTTGGACCGAACTGTAACCAAGGGAGAAACAGCCGTCCTACAGTGCATTGCTGGAGGAAGCCCTCCCCCTAAACTGAACTGGACCAAAGATGATAGCCCATTGGTGGTAACCGAGAGGC
ACTTTTTTGCAGCAGGCAATCAGCTTCTGATTATTGTGGACTCAGATGTCAGTGATGCTGGGAAATACACATGTGAGATGTCTAACACCCTTGGCACTGAGAGAGGAAACGTGCGCCTCAGTGTGATC
CCCACTCCAACCTGCGACTCCCCTCAGATGACAGCCCCATCGTTAGACGATGACGGATGGGCCACTGTGGGTGTCGTGATCATAGCCGTGGTTTGCTGTGTGGTGGGCACGTCACTCGTGTGGGTGGT
CATCATATACCACACAAGGCGGAGGAATGAAGATTGCAGCATTACCAACACAGATGAGACCAACTTGCCAGCAGATATTCCTAGTTATTTGTCATCTCAGGGAACGTTAGCTGACAGGCAGGATGGGT
ACGTGTCTTCAGAAAGTGGAAGCCACCACCAGTTTGTCACATCTTCAGGTGCTGGATTTTTCTTACCACAACATGACAGTAGTGGGACCTGCCATATTGACAATAGCAGTGAAGCTGATGTGGAAGCT
GCCACAGATCTGTTCCTTTGTCCGTTTTTGGGATCCACAGGCCCTATGTATTTGAAGGGAAATGTGTATGGCTCAGATCCTTTTGAAACATATCATACAGGTTGCAGTCCTGACCCAAGAACAGTTTT
AATGGACCACTATGAGCCCAGTTACATAAAGAAAAAGGAGTGCTACCCATGTTCTCATCCTTCAGAAGAATCCTGCGAACGGAGCTTCAGTAATATATCGTGGCCTTCACATGTGAGGAAGCTACTTA
ACACTAGTTACTCTCACAATGAAGGACCTGGAATGAAAAATCTGTGTCTAAACAAGTCCTCTTTAGATTTTAGTGCAAATCCAGAGCCAGCGTCGGTTGCCTCGAGTAATTCTTTCATGGGTACCTTT
GGAAAAGCTCTCAGGAGACCTCACCTAGATGCCTATTCAAGCTTTGGACAGCCATCAGATTGTCAGCCAAGAGCCTTTTATTTGAAAGCTCATTCTTCCCCAGACTTGGACTCTGGGTCAGAGGAAGA
TGGGAAAGAAAGGACAGATTTTCAGGAAGAAAATCACATTTGTACCTTTAAACAGACTTTAGAAAACTACAGGACTCCAAATTTTCAGTCTTATGACTTGGACACATAGACTGAATGAGACCAAAGGA
AAAGCTTAACATACTACCTCAAGTGAACTTTTATTTAAAAGAGAGAGAATCTTATGTTTTTTAAATGGAGTTATGAATTTTAAAAGGATAAAAATGCTTTATTTATACAGATGAACCAAAATTACAAA
AAGTTATGAAAATTTTTATACTGGGAATGATGCTCATATAAGAATACCTTTTTAAACTATTTTTTAACTTTGTTTTATGCAAAAAAGTATCTTACGTAAATTAATGATATAAATCATGATTATTTTAT
GTATTTTTATAATGCCAGATTTCTTTTTATGGAAAATGAGTTACTAAAGCATTTTAAATAATACCTGCCTTGTACCATTTTTTAAATAGAAGTTACTTCATTATATTTTGCACATTATATTTAATAAA
ATGTGTCAATTTGA

hide sequence

RefSeq Acc Id:

XM_017018790 ⟹ XP_016874279

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	12	58,880,273 - 58,920,504 (-)	NCBI

Sequence:

show sequence

GAAAAAGTTTCTTTTGCAGACAAGAAGGGGCTTCGGCGAGCCGACGCTGCTCAAGCTGCAACTC
TGTTGCAGTTGGCAGTTCTTTTCGGTTTCCCTCCTGCTGTTTGGGGGCATGAAAGGGCTTCGCCGCCGGGAGTAAAAGAAGGAATTGACCGGGCAGCGCGAGGGAGGAGCGCGCACGCGACCGCGAGG
GCGGGCGTGCACCCTCGGCTGGAAGTTTGTGCCGGGCCCCGAGCGCGCGCCGGCTGGGAGCTTCGGGTAGAGACCTAGGCCGCTGGACCGCGATGAGCGCGCCGAGCCTCCGTGCGCGCGCCGCGGGG
TTGGGGCTGCTGCTGTGCGCGGTGCTGGGGCGCGCTGGCCGGTCAGACAGCGGCGGTCGCGGGGAACTCGGGCAGCCCTCTGGGGTAGCCGCCGAGCGCCCATGCCCCACTACCTGCCGCTGCCTCGG
GGACCTGCTGGACTGCAGTCGTAAGCGGCTAGCGCGTCTTCCCGAGCCACTCCCGTCCTGGGTCGCTCGGCTGGACTTAAGTCACAACAGATTATCTTTCATCAAGGCAAGTTCCATGAGCCACCTTC
AAAGCCTTCGAGAAGTGAAACTGAACAACAATGAATTGGAGACCATTCCAAATCTGGGACCAGTCTCGGCAAATATTACACTTCTCTCCTTGGCTGGAAACAGGATTGTTGAAATACTCCCTGAACAT
CTGAAAGAGTTTCAGTCCCTTGAAACTTTGGACCTTAGCAGCAACAATATTTCAGAGCTCCAAACTGCATTTCCAGCCCTACAGCTCAAATATCTGTATCTCAACAGCAACCGAGTCACATCAATGGA
ACCTGGGTATTTTGACAATTTGGCCAACACACTCCTTGTGTTAAAGCTGAACAGGAACCGAATCTCAGCTATCCCACCCAAGATGTTTAAACTGCCCCAACTGCAACATCTCGAATTGAACCGAAACA
AGATTAAAAATGTAGATGGACTGACATTCCAAGGCCTTGGTGCTCTGAAGTCTCTGAAAATGCAAAGAAATGGAGTAACGAAACTTATGGATGGAGCTTTTTGGGGGCTGAGCAACATGGAAATTTTG
CAGCTGGACCATAACAACCTAACAGAGATTACCAAAGGCTGGCTTTACGGCTTGCTGATGCTGCAGGAACTTCATCTCAGCCAAAATGCCATCAACAGGATCAGCCCTGATGCCTGGGAGTTCTGCCA
GAAGCTCAGTGAGCTGGACCTAACTTTCAATCACTTATCAAGGTTAGATGATTCAAGCTTCCTTGGCCTAAGCTTACTAAATACACTGCACATTGGGAACAACAGAGTCAGCTACATTGCTGATTGTG
CCTTCCGGGGGCTTTCCAGTTTAAAGACTTTGGATCTGAAGAACAATGAAATTTCCTGGACTATTGAAGACATGAATGGTGCTTTCTCTGGGCTTGACAAACTGAGGCGACTGATACTCCAAGGAAAT
CGGATCCGTTCTATTACTAAAAAAGCCTTCACTGGTTTGGATGCATTGGAGCATCTAGACCTGAGTGACAACGCAATCATGTCTTTACAAGGCAATGCATTTTCACAAATGAAGAAACTGCAACAATT
GCATTTAAATACATCAAGCCTTTTGTGCGATTGCCAGCTAAAATGGCTCCCACAGTGGGTGGCGGAAAACAACTTTCAGAGCTTTGTAAATGCCAGTTGTGCCCATCCTCAGCTGCTAAAAGGAAGAA
GCATTTTTGCTGTTAGCCCAGATGGCTTTGTGTGTGATGATTTTCCCAAACCCCAGATCACGGTTCAGCCAGAAACACAGTCGGCAATAAAAGGTTCCAATTTGAGTTTCATCTGCTCAGCTGCCAGC
AGCAGTGATTCCCCAATGACTTTTGCTTGGAAAAAAGACAATGAACTACTGCATGATGCTGAAATGGAAAATTATGCACACCTCCGGGCCCAAGGTGGCGAGGTGATGGAGTATACCACCATCCTTCG
GCTGCGCGAGGTGGAATTTGCCAGTGAGGGGAAATATCAGTGTGTCATCTCCAATCACTTTGGTTCATCCTACTCTGTCAAAGCCAAGCTTACAGTAAATATTCCCCACCTGACTCTTCCTTTCCCTA
CCTTTCATTCCACAAAATTAAGATTCTTGGTTATTTGTATCTAAACCTGCAATTATGTTGAAGACGACACCGTACTCAGTGTGGTGAGTAACACAGAGATGAACCAGACATGTTTTTGCTCTTTTTTT
TTTCTTTTTCTTTTTTTTTTTTTTGAGACGGAATCTTGCACTGTCACCCA

hide sequence

RefSeq Acc Id:

XM_054371063 ⟹ XP_054227038

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	12	58,860,549 - 58,900,780 (-)	NCBI


Protein RefSeqs	NP_001129523	(Get FASTA)	NCBI Sequence Viewer
	NP_700356	(Get FASTA)	NCBI Sequence Viewer
	XP_016874279	(Get FASTA)	NCBI Sequence Viewer
	XP_054227038	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI26170	(Get FASTA)	NCBI Sequence Viewer
	AAI26172	(Get FASTA)	NCBI Sequence Viewer
	AAQ88655	(Get FASTA)	NCBI Sequence Viewer
	AAQ88662	(Get FASTA)	NCBI Sequence Viewer
	AAR98629	(Get FASTA)	NCBI Sequence Viewer
	BAC11295	(Get FASTA)	NCBI Sequence Viewer
	BAF85546	(Get FASTA)	NCBI Sequence Viewer
	BAG62752	(Get FASTA)	NCBI Sequence Viewer
	EAW97094	(Get FASTA)	NCBI Sequence Viewer
	EAW97095	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000326759
	ENSP00000326759.3
	ENSP00000368436
	ENSP00000368436.4
	ENSP00000413143
GenBank Protein	Q6UXM1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_700356 ⟸ NM_153377
- Peptide Label:	isoform 2 precursor
- UniProtKB:	Q6UXL7 (UniProtKB/Swiss-Prot), Q8NC72 (UniProtKB/Swiss-Prot), Q6UXM1 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSL AGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD GAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSG LDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIK GSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDG GTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCE MSNTLGTERGNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHD SSGTCHIDNSSEADVEAATDLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSA NPEPASVASSNSFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSGSEEDGKERTDFQEENHICTFKQTLENYRTPNFQSYDLDT hide sequence

RefSeq Acc Id:	NP_001129523 ⟸ NM_001136051
- Peptide Label:	isoform 1 precursor
- UniProtKB:	Q6UXM1 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MVDVLLLFSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFD NLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSEL DLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTS SLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVE FASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFL RPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVV IIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAATDLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVL MDHYEPSYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSNSFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSGSEED GKERTDFQEENHICTFKQTLENYRTPNFQSYDLDT hide sequence

RefSeq Acc Id:	XP_016874279 ⟸ XM_017018790
- Peptide Label:	isoform X1
- UniProtKB:	C9K080 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDCSRKR LARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLAN TLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTF NHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLC DCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASE GKYQCVISNHFGSSYSVKAKLTVNIPHLTLPFPTFHSTKLRFLVICI hide sequence

Ensembl Acc Id:

ENSP00000326759 ⟸ ENST00000320743

Ensembl Acc Id:

ENSP00000368436 ⟸ ENST00000379141

Protein Domains

Ig-like Ig-like C2-type LRRCT LRRNT

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6UXM1-F1-model_v2	AlphaFold	Q6UXM1	1-1119	view protein structure

RGD ID:

6790224

Promoter ID:

HG_KWN:16022

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

HeLa_S3, K562, Lymphoblastoid

Transcripts:

NM_153377, UC009ZQH.1

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	12	57,599,631 - 57,600,632 (-)	MPROMDB

RGD ID:

7224629

Promoter ID:

EPDNEW_H18060

Type:

initiation region

Name:

LRIG3_2

Description:

leucine rich repeats and immunoglobulin like domains 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H18061

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	12	58,919,505 - 58,919,565	EPDNEW

RGD ID:

7224631

Promoter ID:

EPDNEW_H18061

Type:

initiation region

Name:

LRIG3_1

Description:

leucine rich repeats and immunoglobulin like domains 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H18060

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	12	58,920,490 - 58,920,550	EPDNEW

Database	Acc Id	Source(s)
COSMIC	LRIG3	COSMIC
Ensembl Genes	ENSG00000139263	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000320743	ENTREZGENE
	ENST00000320743.8	UniProtKB/Swiss-Prot
	ENST00000379141	ENTREZGENE
	ENST00000379141.8	UniProtKB/Swiss-Prot
	ENST00000433272	ENTREZGENE
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot
	3.80.10.10	UniProtKB/Swiss-Prot
GTEx	ENSG00000139263	GTEx
HGNC ID	HGNC:30991	ENTREZGENE
Human Proteome Map	LRIG3	Human Proteome Map
InterPro	Cys-rich_flank_reg_C	UniProtKB/Swiss-Prot
	Ig-like_dom	UniProtKB/Swiss-Prot
	Ig-like_dom_sf	UniProtKB/Swiss-Prot
	Ig-like_fold	UniProtKB/Swiss-Prot
	Ig_I-set	UniProtKB/Swiss-Prot
	Ig_sub	UniProtKB/Swiss-Prot
	Ig_sub2	UniProtKB/Swiss-Prot
	Leu-rich_rpt	UniProtKB/Swiss-Prot
	Leu-rich_rpt_typical-subtyp	UniProtKB/Swiss-Prot
	LRFN	UniProtKB/Swiss-Prot
	LRR_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	hsa:121227	UniProtKB/Swiss-Prot
NCBI Gene	121227	ENTREZGENE
OMIM	608870	OMIM
PANTHER	KEKKON 5, ISOFORM A	UniProtKB/Swiss-Prot
	SYNAPTIC ADHESION-LIKE MOLECULE SALM	UniProtKB/Swiss-Prot
Pfam	I-set	UniProtKB/Swiss-Prot
	Ig_3	UniProtKB/Swiss-Prot
	LRR_1	UniProtKB/Swiss-Prot
	LRR_8	UniProtKB/Swiss-Prot
PharmGKB	PA134864136	PharmGKB
PROSITE	IG_LIKE	UniProtKB/Swiss-Prot
	LRR	UniProtKB/Swiss-Prot
SMART	IGc2	UniProtKB/Swiss-Prot
	LRR_SD22	UniProtKB/Swiss-Prot
	LRR_TYP	UniProtKB/Swiss-Prot
	LRRCT	UniProtKB/Swiss-Prot
	SM00409	UniProtKB/Swiss-Prot
Superfamily-SCOP	L domain-like	UniProtKB/Swiss-Prot
	RNI-like	UniProtKB/Swiss-Prot
	SSF48726	UniProtKB/Swiss-Prot
UniProt	C9K080	ENTREZGENE, UniProtKB/TrEMBL
	F8VYZ5_HUMAN	UniProtKB/TrEMBL
	H0YID8_HUMAN	UniProtKB/TrEMBL
	LRIG3_HUMAN	UniProtKB/Swiss-Prot
	Q6UXL7	ENTREZGENE
	Q6UXM1	ENTREZGENE
	Q8NC72	ENTREZGENE
UniProt Secondary	Q6UXL7	UniProtKB/Swiss-Prot
	Q8NC72	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-14	LRIG3	leucine rich repeats and immunoglobulin like domains 3		leucine-rich repeats and immunoglobulin like domains 3	Symbol and/or name change	5135510	APPROVED
2016-03-14	LRIG3	leucine-rich repeats and immunoglobulin like domains 3		leucine-rich repeats and immunoglobulin-like domains 3	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - CTD