Lrig3 (leucine rich repeats and immunoglobulin like domains 3) - Rat Genome Database

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Gene: Lrig3 (leucine rich repeats and immunoglobulin like domains 3) Ictidomys tridecemlineatus
Analyze
Symbol: Lrig3
Name: leucine rich repeats and immunoglobulin like domains 3 (Ensembl:leucine-rich repeats and immunoglobulin-like domains protein 3)
RGD ID: 12701137
Description: INVOLVED IN otolith morphogenesis (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine-rich repeats and immunoglobulin-like domains protein 3; LOC101961083
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494555,940,378 - 55,981,106 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366462,886,069 - 2,929,552 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366462,889,331 - 2,929,836 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Lrig3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494555,940,378 - 55,981,106 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366462,886,069 - 2,929,552 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366462,889,331 - 2,929,836 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRIG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381258,872,155 - 58,920,504 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1258,872,149 - 58,920,504 (-)EnsemblGRCh38hg38GRCh38
GRCh371259,265,937 - 59,314,285 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361257,552,204 - 57,600,529 (-)NCBINCBI36Build 36hg18NCBI36
Build 341257,552,204 - 57,600,529NCBI
Celera1258,927,578 - 58,975,904 (-)NCBICelera
Cytogenetic Map12q14.1NCBI
HuRef1256,314,531 - 56,362,936 (-)NCBIHuRef
CHM1_11259,233,510 - 59,281,893 (-)NCBICHM1_1
T2T-CHM13v2.01258,852,431 - 58,900,780 (-)NCBIT2T-CHM13v2.0
Lrig3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910125,802,088 - 125,851,228 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10125,802,037 - 125,851,228 (+)EnsemblGRCm39 Ensembl
GRCm3810125,966,219 - 126,015,359 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10125,966,168 - 126,015,359 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710125,403,275 - 125,452,415 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610125,369,225 - 125,418,184 (+)NCBIMGSCv36mm8
Celera10128,374,213 - 128,423,610 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1073.66NCBI
Lrig3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8763,701,724 - 63,751,898 (+)NCBIGRCr8
mRatBN7.2761,816,313 - 61,866,275 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl761,816,342 - 61,866,481 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0769,213,098 - 69,263,251 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl769,213,147 - 69,263,142 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0769,404,280 - 69,454,372 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4766,012,273 - 66,062,608 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera758,970,827 - 59,020,519 (+)NCBICelera
Cytogenetic Map7q22NCBI
Lrig3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554586,562,167 - 6,601,517 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554586,562,167 - 6,601,517 (-)NCBIChiLan1.0ChiLan1.0
LRIG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21035,419,946 - 35,468,463 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11235,416,855 - 35,465,234 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01230,012,251 - 30,060,570 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11230,275,789 - 30,323,781 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1230,275,498 - 30,323,358 (+)Ensemblpanpan1.1panPan2
LRIG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1102,723,836 - 2,772,630 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl102,724,951 - 2,772,636 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha102,789,369 - 2,838,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0102,737,466 - 2,787,369 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl102,739,331 - 2,787,479 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1102,714,388 - 2,764,026 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0102,956,608 - 3,006,074 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0103,082,721 - 3,131,801 (-)NCBIUU_Cfam_GSD_1.0
LRIG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl524,066,623 - 24,117,970 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1524,066,611 - 24,117,971 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2525,903,031 - 25,952,707 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRIG3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11154,806,138 - 54,853,811 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1154,806,579 - 54,853,645 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037191,070,125 - 191,117,716 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrig3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248028,801,280 - 8,848,024 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248028,801,368 - 8,848,718 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021733544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSSTOT00000002288   ⟹   ENSSTOP00000002045
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366462,886,069 - 2,929,552 (-)Ensembl
RefSeq Acc Id: XM_021733544   ⟹   XP_021589219
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494555,940,378 - 55,981,106 (+)NCBI
SpeTri2.0NW_0049366462,889,331 - 2,929,836 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_021589219 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000002045.3
GenBank Protein KAG3291482 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021589219   ⟸   XM_021733544
- UniProtKB: I3M049 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000002045   ⟸   ENSSTOT00000002288
Protein Domains
Ig-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000002283 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000002288.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
NCBI Gene Lrig3 ENTREZGENE
PANTHER LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS 3 UniProtKB/TrEMBL
  SYNAPTIC ADHESION-LIKE MOLECULE SALM UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
  Ig_3 UniProtKB/TrEMBL
  LRR_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
PRINTS LEURICHRPT UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  LRR UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt I3M049 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 Lrig3  leucine rich repeats and immunoglobulin like domains 3  LOC101961083  leucine-rich repeats and immunoglobulin-like domains protein 3  Symbol and/or name change 5135510 APPROVED
2017-07-13 LOC101961083  leucine-rich repeats and immunoglobulin-like domains protein 3  Lrig3  leucine rich repeats and immunoglobulin like domains 3  Symbol and/or name change 5135510 APPROVED