PALS2 (protein associated with LIN7 2, MAGUK p55 family member) - Rat Genome Database

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Gene: PALS2 (protein associated with LIN7 2, MAGUK p55 family member) Homo sapiens
Analyze
Symbol: PALS2
Name: protein associated with LIN7 2, MAGUK p55 family member
RGD ID: 1323497
HGNC Page HGNC:18167
Description: Predicted to be involved in protein-containing complex assembly. Located in extracellular exosome.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MAGUK p55 subfamily member 6; MAGUK protein p55T; membrane palmitoylated protein 6; membrane protein, palmitoylated 6; membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6); MPP6; p55T; protein associated with Lin7 2; protein associated with LIN7 2, MAGUK family member; VAM-1; VAM1; VELI-associated MAGUK 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38724,573,452 - 24,694,193 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl724,573,268 - 24,694,193 (+)EnsemblGRCh38hg38GRCh38
GRCh37724,613,071 - 24,733,812 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36724,579,610 - 24,694,023 (+)NCBINCBI36Build 36hg18NCBI36
Build 34724,386,324 - 24,500,737NCBI
Celera724,601,884 - 24,715,973 (+)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef724,544,555 - 24,612,058 (+)NCBIHuRef
CHM1_1724,614,653 - 24,729,063 (+)NCBICHM1_1
T2T-CHM13v2.0724,711,447 - 24,832,205 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2724,664,991 - 24,779,052 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PALS2HumanCOVID-19  HEP 28912744mRNA:decreased expression:peripheral blood mononuclear cell (human)RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PALS2Humanpleomorphic xanthoastrocytoma  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358

1 to 20 of 93 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PALS2Human(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PALS2 mRNACTDPMID:22079256
PALS2Human1,2-dimethylhydrazine decreases expressionISOPals2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of PALS2 mRNACTDPMID:22206623
PALS2Human17alpha-ethynylestradiol affects expressionISOPals2 (Mus musculus)6480464Ethinyl Estradiol affects the expression of PALS2 mRNACTDPMID:17555576
PALS2Human17alpha-ethynylestradiol increases expressionISOPals2 (Rattus norvegicus)6480464Ethinyl Estradiol results in increased expression of PALS2 mRNACTDPMID:29097150
PALS2Human17beta-estradiol multiple interactionsEXP 6480464EGF protein promotes the reaction [Estradiol results in increased expression of PALS2 mRNA]CTDPMID:24758408
PALS2Human17beta-estradiol increases expressionISOPals2 (Mus musculus)6480464Estradiol results in increased expression of PALS2 mRNACTDPMID:39298647
PALS2Human17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of PALS2 mRNACTDPMID:23019147 and PMID:24758408
PALS2Human2,3',4,4',5-Pentachlorobiphenyl increases expressionISOPals2 (Mus musculus)64804642 more ...CTDPMID:31388691
PALS2Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PALS2 mRNACTDPMID:21632981
PALS2Human2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPals2 (Mus musculus)6480464Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PALS2 promoter]CTDPMID:19654925
PALS2Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOPals2 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of PALS2 mRNACTDPMID:21215274
PALS2Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPals2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of PALS2 mRNACTDPMID:32553695
PALS2Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPals2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PALS2 mRNACTDPMID:21570461
PALS2Human2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOPals2 (Mus musculus)64804642 more ...CTDPMID:38648751
PALS2Human2-methylcholine affects expressionEXP 6480464beta-methylcholine affects the expression of PALS2 mRNACTDPMID:21179406
PALS2Human3,4-methylenedioxymethamphetamine decreases expressionISOPals2 (Rattus norvegicus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of PALS2 mRNACTDPMID:30071829
PALS2Human3-methylcholanthrene increases expressionISOPals2 (Mus musculus)6480464Methylcholanthrene results in increased expression of PALS2 mRNACTDPMID:20713471
PALS2Human4,4'-sulfonyldiphenol increases expressionISOPals2 (Mus musculus)6480464bisphenol S results in increased expression of PALS2 mRNACTDPMID:39298647
PALS2Human4-hydroxyphenyl retinamide increases expressionISOPals2 (Mus musculus)6480464Fenretinide results in increased expression of PALS2 mRNACTDPMID:28973697
PALS2Human5-aza-2'-deoxycytidine affects expressionEXP 6480464Decitabine affects the expression of PALS2 mRNACTDPMID:23300844

1 to 20 of 93 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PALS2Humanprotein-containing complex assembly involved_inNAS 150520179 PMID:11311936UniProtPMID:11311936

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PALS2Humancell-cell junction is_active_inIBAFB:FBgn0250785 more ...150520179 GO_CentralGO_REF:0000033
PALS2Humanextracellular exosome located_inHDA 150520179 PMID:20458337UniProtPMID:20458337
PALS2Humanmembrane located_inNAS 150520179 PMID:11311936UniProtPMID:11311936
PALS2Humanmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
PALS2Humanmembrane located_inIEAUniProtKB-SubCell:SL-0162150520179 UniProtGO_REF:0000044
PALS2Humanplasma membrane is_active_inIBAFB:FBgn0250785 more ...150520179 GO_CentralGO_REF:0000033
PALS2Humanplasma membrane located_inIEAUniProtKB:Q9JLB0 and ensembl:ENSMUSP00000039314150520179 EnsemblGO_REF:0000107

Molecular Function

  

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PALS2Humanribosome biogenesis pathway   TAS 9999448 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PALS2HumanPleomorphic xanthoastrocytoma  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358

#
Reference Title
Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. An overview of pre-ribosomal RNA processing in eukaryotes. Henras AK, etal., Wiley Interdiscip Rev RNA. 2015 Mar-Apr;6(2):225-42. doi: 10.1002/wrna.1269. Epub 2014 Oct 27.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
PMID:8889548   PMID:10753959   PMID:11110791   PMID:11230166   PMID:11311936   PMID:11719186   PMID:11812149   PMID:12477932   PMID:12690205   PMID:12853948   PMID:15024025   PMID:15231747  
PMID:15489334   PMID:15592455   PMID:16192290   PMID:19071123   PMID:20195357   PMID:20458337   PMID:21873635   PMID:21901101   PMID:21903422   PMID:22745667   PMID:23453885   PMID:24366813  
PMID:25921289   PMID:26053890   PMID:26186194   PMID:26496610   PMID:26549023   PMID:26760575   PMID:26972000   PMID:27483446   PMID:28514442   PMID:28611215   PMID:30021884   PMID:30575818  
PMID:31586073   PMID:31995728   PMID:32296183   PMID:32457219   PMID:32994395   PMID:33001583   PMID:33034629   PMID:33742100   PMID:33853758   PMID:33961781   PMID:34079125   PMID:35256949  
PMID:35271311   PMID:35337019   PMID:35831314   PMID:35902094   PMID:35914814   PMID:36168628   PMID:36215168   PMID:36543142   PMID:36610398   PMID:36976175   PMID:37207207   PMID:37314216  
PMID:37616343   PMID:38565536   PMID:38569033  



PALS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38724,573,452 - 24,694,193 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl724,573,268 - 24,694,193 (+)EnsemblGRCh38hg38GRCh38
GRCh37724,613,071 - 24,733,812 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36724,579,610 - 24,694,023 (+)NCBINCBI36Build 36hg18NCBI36
Build 34724,386,324 - 24,500,737NCBI
Celera724,601,884 - 24,715,973 (+)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef724,544,555 - 24,612,058 (+)NCBIHuRef
CHM1_1724,614,653 - 24,729,063 (+)NCBICHM1_1
T2T-CHM13v2.0724,711,447 - 24,832,205 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2724,664,991 - 24,779,052 (+)NCBI
Pals2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39650,087,206 - 50,176,134 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl650,087,221 - 50,175,919 (+)EnsemblGRCm39 Ensembl
GRCm38650,110,228 - 50,199,154 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl650,110,241 - 50,198,939 (+)EnsemblGRCm38mm10GRCm38
MGSCv37650,060,240 - 50,148,597 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36650,039,963 - 50,128,169 (+)NCBIMGSCv36mm8
Celera650,618,750 - 50,708,304 (+)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map624.13NCBI
Pals2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8480,504,298 - 80,584,951 (+)NCBIGRCr8
mRatBN7.2479,173,488 - 79,257,542 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl479,124,806 - 79,254,140 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx484,389,410 - 84,474,228 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0480,164,949 - 80,249,755 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0478,605,243 - 78,690,062 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0479,846,506 - 79,928,977 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl479,846,521 - 79,926,703 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04144,471,089 - 144,602,046 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4478,343,494 - 78,424,470 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1478,619,775 - 78,684,435 (+)NCBI
Celera474,082,633 - 74,162,987 (+)NCBICelera
Cytogenetic Map4q24NCBI
Pals2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541026,610,758 - 26,697,553 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541026,593,123 - 26,697,553 (+)NCBIChiLan1.0ChiLan1.0
PALS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2629,430,673 - 29,550,813 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1777,755,407 - 77,873,508 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0725,248,710 - 25,368,829 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1724,853,266 - 24,973,190 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl724,899,798 - 24,967,402 (+)Ensemblpanpan1.1panPan2
PALS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11438,095,892 - 38,206,730 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1438,095,716 - 38,213,418 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1437,645,606 - 37,756,631 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01438,032,148 - 38,142,984 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1438,031,672 - 38,142,243 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11438,145,746 - 38,256,586 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01437,838,258 - 37,949,172 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01438,180,110 - 38,291,374 (+)NCBIUU_Cfam_GSD_1.0
Pals2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511882,276,116 - 82,439,288 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364781,554,293 - 1,647,787 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364781,554,314 - 1,647,787 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PALS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1847,593,049 - 47,710,570 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11847,589,547 - 47,711,433 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21852,549,819 - 52,660,892 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PALS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12133,681,859 - 33,785,699 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2133,682,127 - 33,737,196 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604270,861,748 - 70,976,955 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pals2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247395,884,253 - 5,970,960 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247395,880,989 - 5,971,570 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in PALS2
41 total Variants

1 to 10 of 75 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 7p22.3-14.1(chr7:54185-41875885)x3 copy number gain See cases [RCV000051159] Chr7:54185..41875885 [GRCh38]
Chr7:54185..41915483 [GRCh37]
Chr7:149268..41882008 [NCBI36]
Chr7:7p22.3-14.1
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7p21.2-15.2(chr7:16234212-26167278)x3 copy number gain See cases [RCV000053531] Chr7:16234212..26167278 [GRCh38]
Chr7:16273837..26206898 [GRCh37]
Chr7:16240362..26173423 [NCBI36]
Chr7:7p21.2-15.2
pathogenic
NM_016447.3(MPP6):c.220G>A (p.Asp74Asn) single nucleotide variant Malignant melanoma [RCV000067832] Chr7:24641818 [GRCh38]
Chr7:24681437 [GRCh37]
Chr7:24647962 [NCBI36]
Chr7:7p15.3
not provided
GRCh38/hg38 7p21.1-15.2(chr7:20210912-27849400)x1 copy number loss See cases [RCV000134333] Chr7:20210912..27849400 [GRCh38]
Chr7:20250535..27889019 [GRCh37]
Chr7:20217060..27855544 [NCBI36]
Chr7:7p21.1-15.2
pathogenic
GRCh38/hg38 7p22.3-15.2(chr7:54185-26827634)x3 copy number gain See cases [RCV000136557] Chr7:54185..26827634 [GRCh38]
Chr7:54185..26867253 [GRCh37]
Chr7:149268..26833778 [NCBI36]
Chr7:7p22.3-15.2
pathogenic
GRCh38/hg38 7p22.1-15.2(chr7:5682209-27230311)x3 copy number gain See cases [RCV000136649] Chr7:5682209..27230311 [GRCh38]
Chr7:5721840..27269930 [GRCh37]
Chr7:5688366..27236455 [NCBI36]
Chr7:7p22.1-15.2
pathogenic
GRCh38/hg38 7p22.3-14.2(chr7:54185-37089712)x3 copy number gain See cases [RCV000053530] Chr7:54185..37089712 [GRCh38]
Chr7:54185..37129317 [GRCh37]
Chr7:149268..37095842 [NCBI36]
Chr7:7p22.3-14.2
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7p21.1-14.3(chr7:20561456-32005143)x1 copy number loss See cases [RCV000136775] Chr7:20561456..32005143 [GRCh38]
Chr7:20601079..32044755 [GRCh37]
Chr7:20567604..32011280 [NCBI36]
Chr7:7p21.1-14.3
pathogenic
1 to 10 of 75 rows

Predicted Target Of
Summary Value
Count of predictions:3195
Count of miRNA genes:1022
Interacting mature miRNAs:1252
Transcripts:ENST00000222644, ENST00000396475, ENST00000409761, ENST00000426450, ENST00000430180, ENST00000432190, ENST00000464384, ENST00000472674
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 29 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597055254GWAS1151328_Hsystolic blood pressure QTL GWAS1151328 (human)7e-10systolic blood pressuresystolic blood pressure (CMO:0000004)72462266124622662Human
406960003GWAS608979_Hattention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia QTL GWAS608979 (human)0.0000006attention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia72465293324652934Human
597322910GWAS1418984_Hschizophrenia QTL GWAS1418984 (human)5e-12schizophrenia72467835024678351Human
597332381GWAS1428455_HS-6-hydroxywarfarin measurement QTL GWAS1428455 (human)0.000005S-6-hydroxywarfarin measurement72466596224665963Human
597095900GWAS1191974_Hschizophrenia QTL GWAS1191974 (human)4e-09schizophrenia72467835024678351Human
597118877GWAS1214951_Happendicular lean mass QTL GWAS1214951 (human)1e-10appendicular lean mass72467998724679988Human
406998671GWAS647647_Hurate measurement QTL GWAS647647 (human)0.000001urate measurementblood uric acid level (CMO:0000501)72467998724679988Human
2289453BW297_HBody weight QTL 297 (human)3.83Body weightbody mass index72334946449349464Human
597043525GWAS1139599_Hschizophrenia QTL GWAS1139599 (human)6e-09schizophrenia72467835024678351Human
597102850GWAS1198924_Hschizophrenia, intelligence, self reported educational attainment QTL GWAS1198924 (human)4e-11schizophrenia, intelligence, self reported educational attainment72461415924614160Human

1 to 10 of 29 rows
GDB:1318172  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37724,656,627 - 24,656,797UniSTSGRCh37
Build 36724,623,152 - 24,623,322RGDNCBI36
Celera724,645,426 - 24,645,596RGD
Cytogenetic Map7p15UniSTS
HuRef724,541,511 - 24,541,681UniSTS
CRA_TCAGchr7v2724,708,515 - 24,708,685UniSTS
GDB:4585051  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37724,725,647 - 24,725,730UniSTSGRCh37
Build 36724,692,172 - 24,692,255RGDNCBI36
Celera724,714,122 - 24,714,205RGD
Cytogenetic Map7p15UniSTS
HuRef724,610,207 - 24,610,290UniSTS
CRA_TCAGchr7v2724,777,201 - 24,777,284UniSTS
D7S1786  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37724,625,151 - 24,625,292UniSTSGRCh37
Build 36724,591,676 - 24,591,817RGDNCBI36
Celera724,613,950 - 24,614,091RGD
Cytogenetic Map7p15UniSTS
HuRef724,510,043 - 24,510,184UniSTS
CRA_TCAGchr7v2724,677,056 - 24,677,197UniSTS
TNG Radiation Hybrid Map711288.0UniSTS
Stanford-G3 RH Map7886.0UniSTS
Whitehead-YAC Contig Map7 UniSTS
NCBI RH Map7415.5UniSTS
G17167  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37724,656,270 - 24,656,514UniSTSGRCh37
Build 36724,622,795 - 24,623,039RGDNCBI36
Celera724,645,069 - 24,645,313RGD
Cytogenetic Map7p15UniSTS
HuRef724,541,154 - 24,541,398UniSTS
CRA_TCAGchr7v2724,708,158 - 24,708,402UniSTS
MARC_26730-26731:1037208705:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37724,727,077 - 24,727,548UniSTSGRCh37
Build 36724,693,602 - 24,694,073RGDNCBI36
Celera724,715,552 - 24,716,023RGD
HuRef724,611,637 - 24,612,108UniSTS
CRA_TCAGchr7v2724,778,631 - 24,779,102UniSTS
MPP6  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37724,689,271 - 24,690,197UniSTSGRCh37
Celera724,677,759 - 24,678,685UniSTS
HuRef724,573,844 - 24,574,770UniSTS
CRA_TCAGchr7v2724,740,838 - 24,741,764UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2433 2788 2248 4972 1725 2351 5 624 1947 465 2269 7292 6463 53 3733 1 851 1741 1616 173 1


1 to 30 of 30 rows
RefSeq Transcripts NM_001303037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005249775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006715738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006715739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006715740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011515425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC003093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC005084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF162130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC047330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG766138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM685172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 30 rows

Ensembl Acc Id: ENST00000222644   ⟹   ENSP00000222644
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl724,573,452 - 24,694,193 (+)Ensembl
Ensembl Acc Id: ENST00000396475   ⟹   ENSP00000379737
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl724,573,466 - 24,689,540 (+)Ensembl
Ensembl Acc Id: ENST00000409761   ⟹   ENSP00000386262
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl724,573,415 - 24,687,632 (+)Ensembl
Ensembl Acc Id: ENST00000426450   ⟹   ENSP00000400515
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl724,597,120 - 24,641,812 (+)Ensembl
Ensembl Acc Id: ENST00000430180   ⟹   ENSP00000391020
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl724,574,013 - 24,666,060 (+)Ensembl
Ensembl Acc Id: ENST00000432190   ⟹   ENSP00000395859
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl724,573,268 - 24,650,712 (+)Ensembl
Ensembl Acc Id: ENST00000464384   ⟹   ENSP00000473560
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl724,665,683 - 24,687,876 (+)Ensembl
Ensembl Acc Id: ENST00000472674
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl724,663,474 - 24,666,046 (+)Ensembl
Ensembl Acc Id: ENST00000625307   ⟹   ENSP00000487215
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl724,623,668 - 24,624,070 (+)Ensembl
RefSeq Acc Id: NM_001303037   ⟹   NP_001289966
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38724,573,452 - 24,694,193 (+)NCBI
CHM1_1724,614,533 - 24,734,885 (+)NCBI
T2T-CHM13v2.0724,711,447 - 24,832,205 (+)NCBI
Sequence:
RefSeq Acc Id: NM_016447   ⟹   NP_057531
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38724,573,452 - 24,694,193 (+)NCBI
GRCh37724,613,007 - 24,733,322 (+)NCBI
Build 36724,579,610 - 24,694,023 (+)NCBI Archive
Celera724,601,884 - 24,715,973 (+)RGD
HuRef724,544,555 - 24,612,058 (+)RGD
CHM1_1724,614,533 - 24,734,885 (+)NCBI
T2T-CHM13v2.0724,711,447 - 24,832,205 (+)NCBI
CRA_TCAGchr7v2724,664,991 - 24,779,052 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: XM_005249775   ⟹   XP_005249832
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38724,624,139 - 24,694,193 (+)NCBI
GRCh37724,613,007 - 24,733,322 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006715738   ⟹   XP_006715801
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38724,574,017 - 24,694,193 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006715739   ⟹   XP_006715802
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38724,620,052 - 24,694,193 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006715740   ⟹   XP_006715803
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38724,620,052 - 24,694,193 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011515425   ⟹   XP_011513727
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38724,573,452 - 24,694,193 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017012315   ⟹   XP_016867804
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38724,620,052 - 24,694,193 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017012316   ⟹   XP_016867805
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38724,573,966 - 24,694,193 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054358393   ⟹   XP_054214368
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0724,712,012 - 24,832,205 (+)NCBI
RefSeq Acc Id: XM_054358394   ⟹   XP_054214369
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0724,711,961 - 24,832,205 (+)NCBI
RefSeq Acc Id: XM_054358395   ⟹   XP_054214370
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0724,711,447 - 24,832,205 (+)NCBI
RefSeq Acc Id: XM_054358396   ⟹   XP_054214371
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0724,758,046 - 24,832,205 (+)NCBI
RefSeq Acc Id: XM_054358397   ⟹   XP_054214372
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0724,758,046 - 24,832,205 (+)NCBI
RefSeq Acc Id: XM_054358398   ⟹   XP_054214373
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0724,758,046 - 24,832,205 (+)NCBI
RefSeq Acc Id: XM_054358399   ⟹   XP_054214374
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0724,762,133 - 24,832,205 (+)NCBI
1 to 30 of 31 rows
Protein RefSeqs NP_001289966 (Get FASTA)   NCBI Sequence Viewer  
  NP_057531 (Get FASTA)   NCBI Sequence Viewer  
  XP_005249832 (Get FASTA)   NCBI Sequence Viewer  
  XP_006715801 (Get FASTA)   NCBI Sequence Viewer  
  XP_006715802 (Get FASTA)   NCBI Sequence Viewer  
  XP_006715803 (Get FASTA)   NCBI Sequence Viewer  
  XP_011513727 (Get FASTA)   NCBI Sequence Viewer  
  XP_016867804 (Get FASTA)   NCBI Sequence Viewer  
  XP_016867805 (Get FASTA)   NCBI Sequence Viewer  
  XP_054214368 (Get FASTA)   NCBI Sequence Viewer  
  XP_054214369 (Get FASTA)   NCBI Sequence Viewer  
  XP_054214370 (Get FASTA)   NCBI Sequence Viewer  
  XP_054214371 (Get FASTA)   NCBI Sequence Viewer  
  XP_054214372 (Get FASTA)   NCBI Sequence Viewer  
  XP_054214373 (Get FASTA)   NCBI Sequence Viewer  
  XP_054214374 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD45919 (Get FASTA)   NCBI Sequence Viewer  
  AAH23638 (Get FASTA)   NCBI Sequence Viewer  
  AAQ96847 (Get FASTA)   NCBI Sequence Viewer  
  CAB66770 (Get FASTA)   NCBI Sequence Viewer  
  EAL24247 (Get FASTA)   NCBI Sequence Viewer  
  EAW93808 (Get FASTA)   NCBI Sequence Viewer  
  EAW93809 (Get FASTA)   NCBI Sequence Viewer  
  EAW93810 (Get FASTA)   NCBI Sequence Viewer  
  EAW93811 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000222644
  ENSP00000222644.4
  ENSP00000379737
  ENSP00000379737.2
  ENSP00000386262
1 to 30 of 31 rows
1 to 5 of 24 rows
1 to 5 of 24 rows
RefSeq Acc Id: NP_057531   ⟸   NM_016447
- UniProtKB: A4D157 (UniProtKB/Swiss-Prot),   Q9H0E1 (UniProtKB/Swiss-Prot),   Q9NZW5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005249832   ⟸   XM_005249775
- Peptide Label: isoform X2
- UniProtKB: B8ZZG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006715801   ⟸   XM_006715738
- Peptide Label: isoform X1
- UniProtKB: A4D157 (UniProtKB/Swiss-Prot),   Q9H0E1 (UniProtKB/Swiss-Prot),   Q9NZW5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006715802   ⟸   XM_006715739
- Peptide Label: isoform X1
- UniProtKB: A4D157 (UniProtKB/Swiss-Prot),   Q9H0E1 (UniProtKB/Swiss-Prot),   Q9NZW5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006715803   ⟸   XM_006715740
- Peptide Label: isoform X1
- UniProtKB: A4D157 (UniProtKB/Swiss-Prot),   Q9H0E1 (UniProtKB/Swiss-Prot),   Q9NZW5 (UniProtKB/Swiss-Prot)
- Sequence:
Guanylate kinase-like   L27   PDZ   SH3

Name Modeler Protein Id AA Range Protein Structure
AF-Q9NZW5-F1-model_v2 AlphaFold Q9NZW5 1-540 view protein structure

RGD ID:7210115
Promoter ID:EPDNEW_H10803
Type:initiation region
Name:MPP6_1
Description:membrane palmitoylated protein 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10804  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38724,573,339 - 24,573,399EPDNEW
RGD ID:7210117
Promoter ID:EPDNEW_H10804
Type:initiation region
Name:MPP6_2
Description:membrane palmitoylated protein 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10803  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38724,573,460 - 24,573,520EPDNEW
RGD ID:6805928
Promoter ID:HG_KWN:56595
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000409761,   OTTHUMT00000250272,   OTTHUMT00000326844,   OTTHUMT00000326846,   OTTHUMT00000326848
Position:
Human AssemblyChrPosition (strand)Source
Build 36724,579,336 - 24,580,337 (+)MPROMDB


1 to 40 of 60 rows
Database
Acc Id
Source(s)
COSMIC PALS2 COSMIC
Ensembl Genes ENSG00000105926 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000222644 ENTREZGENE
  ENST00000222644.10 UniProtKB/Swiss-Prot
  ENST00000396475 ENTREZGENE
  ENST00000396475.6 UniProtKB/Swiss-Prot
  ENST00000409761 ENTREZGENE
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
  L27 domain UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
GTEx ENSG00000105926 GTEx
HGNC ID HGNC:18167 ENTREZGENE
Human Proteome Map PALS2 Human Proteome Map
InterPro GK/Ca_channel_bsu UniProtKB/Swiss-Prot
  Guanylate_kin-like_dom UniProtKB/Swiss-Prot
  Guanylate_kinase_CS UniProtKB/Swiss-Prot
  L27_C UniProtKB/Swiss-Prot
  L27_dom UniProtKB/Swiss-Prot
  L27_dom_sf UniProtKB/Swiss-Prot
  MAGUK UniProtKB/Swiss-Prot
  MPP6_SH3 UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report hsa:51678 UniProtKB/Swiss-Prot
NCBI Gene 51678 ENTREZGENE
OMIM 606959 OMIM
PANTHER MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK UniProtKB/Swiss-Prot
Pfam Guanylate_kin UniProtKB/Swiss-Prot
  L27 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  SH3_2 UniProtKB/Swiss-Prot
PharmGKB PA166352043 PharmGKB
PROSITE GUANYLATE_KINASE_1 UniProtKB/Swiss-Prot
  GUANYLATE_KINASE_2 UniProtKB/Swiss-Prot
  L27 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
1 to 40 of 60 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-09-20 PALS2  protein associated with LIN7 2, MAGUK p55 family member  PALS2  protein associated with LIN7 2, MAGUK family member  Symbol and/or name change 19259463 PROVISIONAL
2021-02-22 PALS2  protein associated with LIN7 2, MAGUK family member  MPP6  membrane palmitoylated protein 6  Symbol and/or name change 19259463 PROVISIONAL
2016-04-12 MPP6  membrane palmitoylated protein 6  MPP6  membrane protein, palmitoylated 6  Symbol and/or name change 5135510 APPROVED
2015-12-08 MPP6  membrane protein, palmitoylated 6  MPP6  membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)  Symbol and/or name change 5135510 APPROVED