Lrrk1 (leucine-rich repeat kinase 1) - Rat Genome Database

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Gene: Lrrk1 (leucine-rich repeat kinase 1) Mus musculus
Analyze
Symbol: Lrrk1
Name: leucine-rich repeat kinase 1
RGD ID: 1317517
MGI Page MGI
Description: Predicted to enable identical protein binding activity and protein kinase activity. Acts upstream of or within several processes, including bone resorption; osteoclast development; and regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in cytosol and mitochondrion. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Used to study osteopetrosis. Human ortholog(s) of this gene implicated in osteosclerotic metaphyseal dysplasia. Orthologous to human LRRK1 (leucine rich repeat kinase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW319595; C230002E15Rik; D130026O16Rik; expressed sequence AW319595; leucine-rich repeat serine/threonine-protein kinase 1; MGC28646; mKIAA1790
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39765,908,493 - 66,038,089 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl765,876,660 - 66,038,098 (-)EnsemblGRCm39 Ensembl
GRCm38766,258,745 - 66,388,341 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl766,226,912 - 66,388,350 (-)EnsemblGRCm38mm10GRCm38
MGSCv37773,403,631 - 73,533,227 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36755,670,181 - 55,799,947 (-)NCBIMGSCv36mm8
MGSCv36766,137,695 - 66,267,291 (-)NCBIMGSCv36mm8
Celera763,712,568 - 63,843,036 (-)NCBICelera
Celera759,723,311 - 59,724,078 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map735.57NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lrrk1Mousechromosome 15q26-qter deletion syndrome  ISOLRRK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 15q26-qter deletion syndromeClinVarPMID:31690835
Lrrk1Mousegenetic disease  ISOLRRK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Lrrk1MouseNeurodevelopmental Disorders  ISOLRRK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Lrrk1Mouseosteosclerotic metaphyseal dysplasia  ISOLRRK1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Object Symbol
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Original Reference(s)
Lrrk1Mouseosteopetrosis  IAGP 13592920 MouseDO 
Object Symbol
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Original Reference(s)
Lrrk1Mouseosteosclerotic metaphyseal dysplasia  ISOLRRK1 (Homo sapiens)7240710 OMIM 

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Object Symbol
Species
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Original Reference(s)
Lrrk1Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of LRRK1 mRNACTDPMID:15652763
Lrrk1Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOLrrk1 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of LRRK1 mRNACTDPMID:33387578 and PMID:34747641
Lrrk1Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of LRRK1 mRNACTDPMID:21570461
Lrrk1Mouse2,4-dinitrotoluene affects expressionISOLrrk1 (Rattus norvegicus)64804642 and 4-dinitrotoluene affects the expression of LRRK1 mRNACTDPMID:21346803
Lrrk1Mouse3,4-methylenedioxymethamphetamine increases expressionEXP 6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of LRRK1 mRNACTDPMID:26251327
Lrrk1Mouse4,4'-sulfonyldiphenol increases expressionEXP 6480464bisphenol S results in increased expression of LRRK1 mRNACTDPMID:30951980
Lrrk1Mouse4,4'-sulfonyldiphenol increases methylationISOLRRK1 (Homo sapiens)6480464bisphenol S results in increased methylation of LRRK1 geneCTDPMID:31601247
Lrrk1Mouse4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol S co-treated with Tretinoin] results in decreased expression of LRRK1 mRNACTDPMID:30951980
Lrrk1Mouse6-propyl-2-thiouracil decreases expressionISOLrrk1 (Rattus norvegicus)6480464Propylthiouracil results in decreased expression of LRRK1 mRNACTDPMID:30047161
Lrrk1Mouseacetamide increases expressionISOLrrk1 (Rattus norvegicus)6480464acetamide results in increased expression of LRRK1 mRNACTDPMID:31881176
Lrrk1MouseAflatoxin B2 alpha decreases methylationISOLRRK1 (Homo sapiens)6480464aflatoxin B2 results in decreased methylation of LRRK1 intronCTDPMID:30157460
Lrrk1Mouseall-trans-retinoic acid increases expressionISOLrrk1 (Rattus norvegicus)6480464Tretinoin results in increased expression of LRRK1 mRNACTDPMID:20488242
Lrrk1Mouseall-trans-retinoic acid multiple interactionsEXP 6480464[bisphenol A co-treated with Tretinoin] results in decreased expression of LRRK1 mRNA more ...CTDPMID:30951980
Lrrk1Mouseall-trans-retinoic acid decreases expressionISOLRRK1 (Homo sapiens)6480464Tretinoin results in decreased expression of LRRK1 mRNACTDPMID:23724009 and PMID:33167477
Lrrk1Mouseamitrole decreases expressionISOLrrk1 (Rattus norvegicus)6480464Amitrole results in decreased expression of LRRK1 mRNACTDPMID:30047161
Lrrk1Mousearsane affects methylationISOLRRK1 (Homo sapiens)6480464Arsenic affects the methylation of LRRK1 geneCTDPMID:25304211
Lrrk1Mousearsenic atom affects methylationISOLRRK1 (Homo sapiens)6480464Arsenic affects the methylation of LRRK1 geneCTDPMID:25304211
Lrrk1Mousearsenite(3-) multiple interactionsISOLRRK1 (Homo sapiens)6480464arsenite inhibits the reaction [G3BP1 protein binds to LRRK1 mRNA]CTDPMID:32406909
Lrrk1Mousearsenous acid multiple interactionsISOLRRK1 (Homo sapiens)6480464Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to LRRK1 protein]CTDPMID:26598702
Lrrk1Mousearsenous acid increases expressionISOLRRK1 (Homo sapiens)6480464Arsenic Trioxide results in increased expression of LRRK1 mRNACTDPMID:20458559

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Biological Process
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Original Reference(s)
Lrrk1Mousebone resorption acts_upstream_of_or_withinIMPMGI:55681282290270 PMID:23526378MGIPMID:23526378
Lrrk1Mousechromatin remodeling involved_inIEAGO:00359792290270 GOCGO_REF:0000108
Lrrk1Mouseintracellular signal transduction acts_upstream_ofIGIMGI:983972290270 PMID:23526378MGIPMID:23526378
Lrrk1Mousenegative regulation of peptidyl-tyrosine phosphorylation acts_upstream_of_or_withinIMPMGI:55681282290270 PMID:23526378MGIPMID:23526378
Lrrk1Mouseosteoclast development acts_upstream_of_or_withinIMPMGI:55681282290270 PMID:23526378MGIPMID:23526378
Lrrk1Mouseosteoclast development acts_upstream_of_or_withinIGIMGI:983972290270 PMID:23526378MGIPMID:23526378
Lrrk1Mousepeptidyl-tyrosine phosphorylation acts_upstream_ofIMPMGI:55681282290270 PMID:23526378MGIPMID:23526378
Lrrk1Mousepositive regulation of canonical Wnt signaling pathway involved_inIEAUniProtKB:Q38SD2 and ensembl:ENSP000003736002290270 EnsemblGO_REF:0000107
Lrrk1Mousepositive regulation of canonical Wnt signaling pathway involved_inISOUniProtKB:Q38SD22290270 GO_CentralGO_REF:0000119
Lrrk1Mousepositive regulation of intracellular signal transduction acts_upstream_of_or_withinIGIMGI:983972290270 PMID:23526378MGIPMID:23526378
Lrrk1Mousepositive regulation of peptidyl-tyrosine phosphorylation acts_upstream_of_or_withinIMPMGI:55681282290270 PMID:23526378MGIPMID:23526378
Lrrk1Mousesignal transduction involved_inIBAPANTHER:PTN001148170 more ...2290270 GO_CentralGO_REF:0000033
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Cellular Component

  
Object Symbol
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Original Reference(s)
Lrrk1Mousecytoplasm is_active_inIBAPANTHER:PTN001148170 more ...2290270 GO_CentralGO_REF:0000033
Lrrk1Mousecytosol located_inIEAUniProtKB:Q38SD2 and ensembl:ENSP000003736002290270 EnsemblGO_REF:0000107
Lrrk1Mousecytosol located_inISOUniProtKB:Q38SD22290270 GO_CentralGO_REF:0000119
Lrrk1Mousemitochondrion located_inIEAUniProtKB:Q38SD2 and ensembl:ENSP000003736002290270 EnsemblGO_REF:0000107
Lrrk1Mousemitochondrion located_inISOUniProtKB:Q38SD22290270 GO_CentralGO_REF:0000119
Lrrk1Mouseplasma membrane located_inIEAUniProtKB-SubCell:SL-00392290270 UniProtGO_REF:0000044

Molecular Function
1 to 20 of 28 rows

  
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Original Reference(s)
Lrrk1Mouse3-phosphoinositide-dependent protein kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Lrrk1MouseAMP-activated protein kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Lrrk1MouseATP binding enablesIEAUniProtKB-KW:KW-00672290270 UniProtGO_REF:0000043
Lrrk1MouseDNA-dependent protein kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Lrrk1Mouseeukaryotic translation initiation factor 2alpha kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Lrrk1MouseGTP binding enablesIEAUniProtKB-KW:KW-03422290270 UniProtGO_REF:0000043
Lrrk1Mousehistone H2AS1 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Lrrk1Mousehistone H2AS121 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Lrrk1Mousehistone H2AT120 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Lrrk1Mousehistone H2AXS139 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Lrrk1Mousehistone H2BS14 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Lrrk1Mousehistone H2BS36 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Lrrk1Mousehistone H3S10 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Lrrk1Mousehistone H3S28 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Lrrk1Mousehistone H3S57 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Lrrk1Mousehistone H3T11 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Lrrk1Mousehistone H3T3 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Lrrk1Mousehistone H3T45 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Lrrk1Mousehistone H3T6 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Lrrk1Mousehistone H4S1 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
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Object Symbol
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Qualifier
Evidence
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Reference
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Source
Original Reference(s)
Lrrk1Mouseabnormal bone marrow cavity morphology  IAGP 5509061 MGIPMID:23526378
Lrrk1Mouseabnormal bone mineralization  IAGP 5509061 MGIPMID:23526378
Lrrk1Mouseabnormal clavicle morphology  IEA 5509061 MGI 
Lrrk1Mouseabnormal eyelid morphology  IEA 5509061 MGI 
Lrrk1Mouseabnormal facial morphology  IAGP 5509061 MGIPMID:23526378
Lrrk1Mouseabnormal femur morphology  IEA 5509061 MGI 
Lrrk1Mouseabnormal fibula morphology  IEA 5509061 MGI 
Lrrk1Mouseabnormal gait  IEA 5509061 MGI 
Lrrk1Mouseabnormal humerus morphology  IEA 5509061 MGI 
Lrrk1Mouseabnormal joint morphology  IEA 5509061 MGI 
Lrrk1Mouseabnormal locomotor behavior  IEA 5509061 MGI 
Lrrk1Mouseabnormal long bone metaphysis morphology  IAGP 5509061 MGIPMID:23526378
Lrrk1Mouseabnormal long bone morphology  IAGP 5509061 MGIPMID:23526378
Lrrk1Mouseabnormal mandible morphology  IEA 5509061 MGI 
Lrrk1Mouseabnormal maxilla morphology  IEA 5509061 MGI 
Lrrk1Mouseabnormal osteoclast physiology  IAGP 5509061 MGIPMID:23526378
Lrrk1Mouseabnormal pelvic girdle bone morphology  IEA 5509061 MGI 
Lrrk1Mouseabnormal radius morphology  IEA 5509061 MGI 
Lrrk1Mouseabnormal rib morphology  IEA 5509061 MGI 
Lrrk1Mouseabnormal snout morphology  IEA 5509061 MGI 
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#
Reference Title
Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Aug 31;10(4):167-80.
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:18045479   PMID:18799693   PMID:20403420  
PMID:20697350   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23526378   PMID:23675505   PMID:24046356   PMID:24194600   PMID:25455687   PMID:25917818   PMID:26100023   PMID:27166870  
PMID:27600824   PMID:27626380   PMID:29056298   PMID:30136304   PMID:32325033   PMID:33459343   PMID:33905568   PMID:35534227   PMID:38355793  



Lrrk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39765,908,493 - 66,038,089 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl765,876,660 - 66,038,098 (-)EnsemblGRCm39 Ensembl
GRCm38766,258,745 - 66,388,341 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl766,226,912 - 66,388,350 (-)EnsemblGRCm38mm10GRCm38
MGSCv37773,403,631 - 73,533,227 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36755,670,181 - 55,799,947 (-)NCBIMGSCv36mm8
MGSCv36766,137,695 - 66,267,291 (-)NCBIMGSCv36mm8
Celera763,712,568 - 63,843,036 (-)NCBICelera
Celera759,723,311 - 59,724,078 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map735.57NCBI
LRRK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3815100,919,357 - 101,078,257 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl15100,919,327 - 101,078,257 (+)EnsemblGRCh38hg38GRCh38
GRCh3715101,459,562 - 101,618,462 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361599,276,983 - 99,427,840 (+)NCBINCBI36Build 36hg18NCBI36
Build 341599,380,194 - 99,427,834NCBI
Celera1577,872,799 - 78,023,725 (+)NCBICelera
Cytogenetic Map15q26.3NCBI
HuRef1577,581,355 - 77,732,446 (+)NCBIHuRef
CHM1_115101,300,443 - 101,451,610 (+)NCBICHM1_1
T2T-CHM13v2.01598,673,894 - 98,832,884 (+)NCBIT2T-CHM13v2.0
Lrrk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81129,254,815 - 129,390,217 (-)NCBIGRCr8
mRatBN7.21119,844,360 - 119,972,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1119,845,146 - 119,979,734 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1127,837,758 - 127,964,722 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01135,009,201 - 135,136,173 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01127,819,030 - 127,946,556 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01127,166,866 - 127,301,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1127,166,431 - 127,292,090 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01128,248,473 - 128,372,456 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41120,695,657 - 120,836,324 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11120,773,221 - 120,921,758 (-)NCBI
Celera1112,054,004 - 112,179,350 (-)NCBICelera
Cytogenetic Map1q22NCBI
Lrrk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541627,865,784 - 27,988,279 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541627,860,934 - 27,988,279 (+)NCBIChiLan1.0ChiLan1.0
LRRK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21690,508,435 - 90,659,979 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11594,208,601 - 94,360,510 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01579,642,908 - 79,793,990 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11598,936,123 - 99,081,168 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1598,931,344 - 99,081,168 (+)Ensemblpanpan1.1panPan2
LRRK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1340,003,299 - 40,122,326 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl340,004,557 - 40,122,320 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha342,692,357 - 42,816,723 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0340,394,683 - 40,519,058 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl340,377,843 - 40,513,734 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1339,927,716 - 40,048,483 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0340,164,544 - 40,288,876 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0340,366,423 - 40,490,768 (-)NCBIUU_Cfam_GSD_1.0
Lrrk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640143,409,510 - 143,562,544 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364832,771,938 - 2,924,525 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364832,771,939 - 2,922,793 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1139,494,121 - 139,624,604 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11139,494,126 - 139,624,609 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21155,637,573 - 155,853,753 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRRK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12919,385,149 - 19,532,440 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2919,386,170 - 19,533,686 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605927,010,221 - 27,156,563 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247683,712,049 - 3,848,651 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247683,701,187 - 3,848,943 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Lrrk1
9608 total Variants

Predicted Target Of
Summary Value
Count of predictions:1888
Count of miRNA genes:768
Interacting mature miRNAs:966
Transcripts:ENSMUST00000015277, ENSMUST00000130438, ENSMUST00000131239, ENSMUST00000137181, ENSMUST00000145954, ENSMUST00000154893, ENSMUST00000167705
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
13506761Tbthq1_mtrabecular bone thickness QTL 1 (mouse)76234974867749748Mouse
26884381Bzwq2_mbi-zygomatic width QTL 2, 5 week (mouse)76524974896949207Mouse
1301663Skull9_mskull morphology 9 (mouse)Not determined75732612191326352Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse

1 to 10 of 50 rows
AW319595  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38766,258,857 - 66,258,949UniSTSGRCm38
MGSCv37773,403,743 - 73,403,835UniSTSGRCm37
Celera759,723,421 - 59,723,513UniSTS
Cytogenetic Map7CUniSTS
Whitehead/MRC_RH7863.11UniSTS
D7Dcr28  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38766,340,062 - 66,340,165UniSTSGRCm38
MGSCv37773,484,948 - 73,485,051UniSTSGRCm37
Celera763,792,816 - 63,792,948UniSTS
Cytogenetic Map7CUniSTS
cM Map7 UniSTS






1 to 24 of 24 rows
RefSeq Transcripts NM_146191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_391340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC091324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC127595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC080819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY024941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 24 of 24 rows

Ensembl Acc Id: ENSMUST00000015277   ⟹   ENSMUSP00000015277
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl765,908,493 - 66,038,098 (-)Ensembl
GRCm38.p6 Ensembl766,258,745 - 66,388,350 (-)Ensembl
Ensembl Acc Id: ENSMUST00000130438
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl765,990,428 - 65,993,013 (-)Ensembl
GRCm38.p6 Ensembl766,340,680 - 66,343,265 (-)Ensembl
Ensembl Acc Id: ENSMUST00000131239
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl765,915,938 - 65,919,548 (-)Ensembl
GRCm38.p6 Ensembl766,266,190 - 66,269,800 (-)Ensembl
Ensembl Acc Id: ENSMUST00000137181
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl765,908,500 - 65,915,319 (-)Ensembl
GRCm38.p6 Ensembl766,258,752 - 66,265,571 (-)Ensembl
Ensembl Acc Id: ENSMUST00000145954   ⟹   ENSMUSP00000114938
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl765,908,932 - 65,931,965 (-)Ensembl
GRCm38.p6 Ensembl766,259,184 - 66,282,217 (-)Ensembl
Ensembl Acc Id: ENSMUST00000154893
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl765,991,418 - 66,038,055 (-)Ensembl
GRCm38.p6 Ensembl766,341,670 - 66,388,307 (-)Ensembl
Ensembl Acc Id: ENSMUST00000167705
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl765,876,660 - 65,912,218 (-)Ensembl
GRCm38.p6 Ensembl766,226,912 - 66,262,470 (-)Ensembl
RefSeq Acc Id: NM_146191   ⟹   NP_666303
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39765,908,493 - 66,038,089 (-)NCBI
GRCm38766,258,745 - 66,388,341 (-)ENTREZGENE
MGSCv37773,403,631 - 73,533,227 (-)RGD
Celera759,723,311 - 59,724,078 (-)NCBI
Celera763,712,568 - 63,843,036 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540838   ⟹   XP_006540901
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39765,908,493 - 65,993,022 (-)NCBI
GRCm38766,258,745 - 66,343,280 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006540839   ⟹   XP_006540902
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39765,908,923 - 66,027,399 (-)NCBI
GRCm38766,258,745 - 66,377,658 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006540840   ⟹   XP_006540903
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39765,908,923 - 65,947,499 (-)NCBI
GRCm38766,258,745 - 66,297,897 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006540841   ⟹   XP_006540904
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39765,908,493 - 66,038,055 (-)NCBI
GRCm38766,258,745 - 66,294,883 (-)NCBI
Sequence:
RefSeq Acc Id: XR_391340
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39765,912,356 - 65,993,029 (-)NCBI
GRCm38766,262,608 - 66,343,288 (-)NCBI
Sequence:
RefSeq Acc Id: NP_666303   ⟸   NM_146191
- UniProtKB: Q8R085 (UniProtKB/Swiss-Prot),   Q8BVV2 (UniProtKB/Swiss-Prot),   Q8BUY0 (UniProtKB/Swiss-Prot),   Q8BU93 (UniProtKB/Swiss-Prot),   Q8BKP3 (UniProtKB/Swiss-Prot),   Q6ZPI4 (UniProtKB/Swiss-Prot),   Q6NZF5 (UniProtKB/Swiss-Prot),   Q6GQR9 (UniProtKB/Swiss-Prot),   Q66JQ4 (UniProtKB/Swiss-Prot),   Q3UHC2 (UniProtKB/Swiss-Prot),   Q3U476 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006540902   ⟸   XM_006540839
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006540901   ⟸   XM_006540838
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006540903   ⟸   XM_006540840
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006540904   ⟸   XM_006540841
- Peptide Label: isoform X4
- Sequence:
COR   Protein kinase   Roc

Name Modeler Protein Id AA Range Protein Structure
AF-Q3UHC2-F1-model_v2 AlphaFold Q3UHC2 1-2014 view protein structure

RGD ID:8664381
Promoter ID:EPDNEW_M10221
Type:multiple initiation site
Name:Lrrk1_1
Description:Mus musculus leucine-rich repeat kinase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38766,388,308 - 66,388,368EPDNEW
RGD ID:6841476
Promoter ID:MM_KWN:50951
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:UC009HHC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36773,409,886 - 73,410,386 (-)MPROMDB
RGD ID:6841477
Promoter ID:MM_KWN:50954
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B6
Transcripts:OTTMUST00000061380
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36773,488,061 - 73,488,561 (-)MPROMDB
RGD ID:6841473
Promoter ID:MM_KWN:50956
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000077207,   ENSMUST00000089025,   OTTMUST00000061293,   UC009HHG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36773,533,156 - 73,534,162 (-)MPROMDB


1 to 40 of 69 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000015133 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000015277 ENTREZGENE
  ENSMUST00000015277.14 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
  ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  COR UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Plant_LRR-RLKs UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Quino_amine_DH_bsu UniProtKB/Swiss-Prot
  ROC_dom UniProtKB/Swiss-Prot
KEGG Report mmu:233328 UniProtKB/Swiss-Prot
MGD MGI:2142227 ENTREZGENE
NCBI Gene Lrrk1 ENTREZGENE
PANTHER LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED UniProtKB/Swiss-Prot
  RECEPTOR PROTEIN-TYROSINE KINASE CEPR1 UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot
  COR UniProtKB/Swiss-Prot
  LRR_1 UniProtKB/Swiss-Prot
  LRR_8 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  Roc UniProtKB/Swiss-Prot
PhenoGen Lrrk1 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  LRR UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  ROC UniProtKB/Swiss-Prot
SMART ANK UniProtKB/Swiss-Prot
  LRR_BAC UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
1 to 40 of 69 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-21 Lrrk1  leucine-rich repeat kinase 1  AW319595  expressed sequence AW319595  Symbol and/or name change 5135510 APPROVED
2024-08-21 AW319595  expressed sequence AW319595  Lrrk1  leucine-rich repeat kinase 1  Symbol and/or name change 5135510 APPROVED