Advanced Search (OLGA)

Gene: Lrrk1 (leucine rich repeat kinase 1) Ictidomys tridecemlineatus

Subscribe to Updates

Analyze

Symbol:

Lrrk1

Name:

leucine rich repeat kinase 1

RGD ID:

12539168

Description:

ENCODES a protein that exhibits ATP binding (inferred); GTP binding (inferred); identical protein binding (inferred); INVOLVED IN negative regulation of peptidyl-tyrosine phosphorylation (ortholog); peptidyl-tyrosine phosphorylation (ortholog); positive regulation of peptidyl-tyrosine phosphorylation (ortholog); ASSOCIATED WITH chromosome 15q26-qter deletion syndrome (ortholog); genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN cytosol (inferred); mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

leucine-rich repeat serine/threonine-protein kinase 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	143,409,510 - 143,562,544 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936483	2,771,938 - 2,924,525 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936483	2,771,939 - 2,922,793 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lrrk1	Squirrel	chromosome 15q26-qter deletion syndrome		ISO	RGD:1317516	8554872	ClinVar Annotator: match by term: Chromosome 15q26-qter deletion syndrome	ClinVar	PMID:31690835
Lrrk1	Squirrel	genetic disease		ISO	RGD:1317516	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:25741868\|PMID:28492532
Lrrk1	Squirrel	Neurodevelopmental Disorders		ISO	RGD:1317516	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868
Lrrk1	Squirrel	osteosclerotic metaphyseal dysplasia		ISO	RGD:1317516	8554872	ClinVar Annotator: match by term: LRRK1-related condition \| ClinVar Annotator: match by term: Osteosclerotic metaphyseal more ...	ClinVar	PMID:25741868\|PMID:27055475\|PMID:27829680\|PMID:28492532\|PMID:31571209\|PMID:32119750\|PMID:8255649

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lrrk1	Squirrel	osteopetrosis		ISO	RGD:1317517	9068941		MouseDO

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lrrk1	Squirrel	osteosclerotic metaphyseal dysplasia		ISO	RGD:1317516	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lrrk1	Squirrel	bone resorption	acts_upstream_of_or_within	IEA	UniProtKB:Q3UHC2\|ensembl:ENSMUSP00000015277	150520179		Ensembl	GO_REF:0000107
Lrrk1	Squirrel	intracellular signal transduction	acts_upstream_of	IEA	UniProtKB:Q3UHC2\|ensembl:ENSMUSP00000015277	150520179		Ensembl	GO_REF:0000107
Lrrk1	Squirrel	negative regulation of peptidyl-tyrosine phosphorylation	acts_upstream_of_or_within	ISO	MGI:5568128	9068941	PMID:23526378	MGI	PMID:23526378
Lrrk1	Squirrel	osteoclast development	acts_upstream_of_or_within	IEA	UniProtKB:Q3UHC2\|ensembl:ENSMUSP00000015277	150520179		Ensembl	GO_REF:0000107
Lrrk1	Squirrel	peptidyl-tyrosine phosphorylation	acts_upstream_of	ISO	MGI:5568128	9068941	PMID:23526378	MGI	PMID:23526378
Lrrk1	Squirrel	positive regulation of canonical Wnt signaling pathway	involved_in	IEA	UniProtKB:Q38SD2\|ensembl:ENSP00000373600	150520179		Ensembl	GO_REF:0000107
Lrrk1	Squirrel	positive regulation of intracellular signal transduction	acts_upstream_of_or_within	IEA	UniProtKB:Q3UHC2\|ensembl:ENSMUSP00000015277	150520179		Ensembl	GO_REF:0000107
Lrrk1	Squirrel	positive regulation of peptidyl-tyrosine phosphorylation	acts_upstream_of_or_within	ISO	MGI:5568128	9068941	PMID:23526378	MGI	PMID:23526378
Lrrk1	Squirrel	regulation of signal transduction	involved_in	IEA	ARBA:ARBA00027204	150520179		UniProt	GO_REF:0000117

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lrrk1	Squirrel	cytosol	located_in	IEA	UniProtKB:Q38SD2\|ensembl:ENSP00000373600	150520179		Ensembl	GO_REF:0000107
Lrrk1	Squirrel	mitochondrion	located_in	IEA	UniProtKB:Q38SD2\|ensembl:ENSP00000373600	150520179		Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lrrk1	Squirrel	ATP binding	enables	IEA	InterPro:IPR000719	150520179		InterPro	GO_REF:0000002
Lrrk1	Squirrel	GTP binding	enables	IEA	UniProtKB-KW:KW-0342	150520179		UniProt	GO_REF:0000043
Lrrk1	Squirrel	identical protein binding	enables	IEA	UniProtKB:Q38SD2\|ensembl:ENSP00000373600	150520179		Ensembl	GO_REF:0000107
Lrrk1	Squirrel	kinase activity	enables	IEA	UniProtKB-KW:KW-0418	150520179		UniProt	GO_REF:0000043
Lrrk1	Squirrel	nucleotide binding	enables	IEA	UniProtKB-KW:KW-0547	150520179		UniProt	GO_REF:0000043
Lrrk1	Squirrel	protein binding	enables	ISO	UniProtKB:Q96SN8	9068941	PMID:26192437	IntAct	PMID:26192437
Lrrk1	Squirrel	protein binding	enables	ISO	PR:P41241	9068941	PMID:23526378	MGI	PMID:23526378
Lrrk1	Squirrel	protein binding	enables	ISO	UniProtKB:Q9UL15	9068941	PMID:24510904	IntAct	PMID:24510904
Lrrk1	Squirrel	protein binding	enables	ISO	UniProtKB:Q5S007	9068941	PMID:20144646	IntAct	PMID:20144646
Lrrk1	Squirrel	protein binding	enables	ISO	UniProtKB:P00519	9068941	PMID:20697350	IntAct	PMID:20697350
Lrrk1	Squirrel	protein binding	enables	ISO	UniProtKB:P00519\|UniProtKB:P00533\|UniProtKB:Q9UL15	9068941	PMID:24947832	IntAct	PMID:24947832
Lrrk1	Squirrel	protein binding	enables	ISO	UniProtKB:P53355\|UniProtKB:Q5S007	9068941	PMID:19712061	IntAct	PMID:19712061
Lrrk1	Squirrel	protein binding	enables	ISO	UniProtKB:P06756	9068941	PMID:32814053	IntAct	PMID:32814053
Lrrk1	Squirrel	protein kinase activity	enables	IEA	InterPro:IPR000719	150520179		InterPro	GO_REF:0000002
Lrrk1	Squirrel	protein serine/threonine kinase activity	enables	IEA	UniProtKB-KW:KW-0723	150520179		UniProt	GO_REF:0000043
Lrrk1	Squirrel	protein serine/threonine kinase activity	enables	IEA	EC:2.7.11.1	150520179		UniProt	GO_REF:0000003

PMID:22301074

Lrrk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	143,409,510 - 143,562,544 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936483	2,771,938 - 2,924,525 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936483	2,771,939 - 2,922,793 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LRRK1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	100,919,357 - 101,078,257 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	100,919,327 - 101,078,257 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	101,459,562 - 101,618,462 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	99,276,983 - 99,427,840 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	99,380,194 - 99,427,834	NCBI
Celera	15	77,872,799 - 78,023,725 (+)	NCBI		Celera
Cytogenetic Map	15	q26.3	NCBI
HuRef	15	77,581,355 - 77,732,446 (+)	NCBI		HuRef
CHM1_1	15	101,300,443 - 101,451,610 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	98,673,894 - 98,832,884 (+)	NCBI		T2T-CHM13v2.0

Lrrk1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	65,908,493 - 66,038,089 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	65,876,660 - 66,038,098 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	66,258,745 - 66,388,341 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	66,226,912 - 66,388,350 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	73,403,631 - 73,533,227 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	55,670,181 - 55,799,947 (-)	NCBI		MGSCv36	mm8
MGSCv36	7	66,137,695 - 66,267,291 (-)	NCBI		MGSCv36	mm8
Celera	7	63,712,568 - 63,843,036 (-)	NCBI		Celera
Celera	7	59,723,311 - 59,724,078 (-)	NCBI		Celera
Cytogenetic Map	7	C	NCBI
cM Map	7	35.57	NCBI

Lrrk1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	129,254,815 - 129,390,217 (-)	NCBI		GRCr8
mRatBN7.2	1	119,844,360 - 119,972,885 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	119,845,146 - 119,979,734 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	127,837,758 - 127,964,722 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	135,009,201 - 135,136,173 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	127,819,030 - 127,946,556 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	127,166,866 - 127,301,053 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	127,166,431 - 127,292,090 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	128,248,473 - 128,372,456 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	120,695,657 - 120,836,324 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	120,773,221 - 120,921,758 (-)	NCBI
Celera	1	112,054,004 - 112,179,350 (-)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

Lrrk1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	27,865,784 - 27,988,279 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	27,860,934 - 27,988,279 (+)	NCBI	ChiLan1.0	ChiLan1.0

LRRK1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	90,508,435 - 90,659,979 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	94,208,601 - 94,360,510 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	79,642,908 - 79,793,990 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	98,936,123 - 99,081,168 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	98,931,344 - 99,081,168 (+)	Ensembl	panpan1.1		panPan2

LRRK1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	40,003,299 - 40,122,326 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	40,004,557 - 40,122,320 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	42,692,357 - 42,816,723 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	40,394,683 - 40,519,058 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	40,377,843 - 40,513,734 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	39,927,716 - 40,048,483 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	40,164,544 - 40,288,876 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	40,366,423 - 40,490,768 (-)	NCBI		UU_Cfam_GSD_1.0

LRRK1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	139,494,121 - 139,624,604 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	139,494,126 - 139,624,609 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	155,637,573 - 155,853,753 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LRRK1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	19,385,149 - 19,532,440 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	19,386,170 - 19,533,686 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	27,010,221 - 27,156,563 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lrrk1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624768	3,712,049 - 3,848,651 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624768	3,701,187 - 3,848,943 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_005320082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040274732	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040274733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000009009 ⟹ ENSSTOP00000008072

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936483	2,771,938 - 2,924,525 (-)	Ensembl

RefSeq Acc Id:

XM_005320082 ⟹ XP_005320139

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	143,409,510 - 143,562,544 (+)	NCBI
SpeTri2.0	NW_004936483	2,771,939 - 2,922,793 (-)	NCBI

Sequence:

show sequence

ACTGTGAAGAAGAATATTGCAAAGGAAAGGAAATACCAGTGGACCAATATAAAGTAATTATTTGTAGGGGGTGCCAGAAAGGACAAAATCTCTTATTTTATGATGTTTTTCTCCACCAGAAGGGGAAA
AAACTCCACTCAACCATGACTGTGTGTCCGTGCCTTAACCCACCTGGGCAGCTGCAGTGGCGGTGACAACAGCAGGACCTGCCTTTGGAGATTGGCTGCCCCGAGGGTTGATGGCTGGCATGTCGCGG
GGACCACCCAGCATGTACTGGTGTGTGGGGCCGGAGGGATCAACCGTGTGTCCAGAACGCGCCATGGAGACCCATAATGGTGCTGGGGATATGGGCAGCAAGCTGTCTGCAGCAGGCGGGGACTCCAC
AGCACGGTCCCCCAGGACAGAAGACATTCACACCGCATACAAGAAGGGAGACCTCAGCAGGGCCCGCCACCTGCTCAAGGAGGCTTATGAGGAGAGCACATCCCAGCTGGAAAAGGGTCAACTTCTGA
GCATCTCAGCAGCCCATGGGGATCTGGAGATGGTCCGGTATCTACTCTCCGAGAAACAGGTGGAGCTGCCAACGGAACCCACCGATGACAACCCAGCTGTGGTGGCGGCACATTTTGGGCACACTGAA
GTTGTACATGAATTGCTTGAGTCCTTAGCAGGTCCCTGCAGCCACCAGCGGCTACTGAACTGGATGCTGGCCCTGGCTTGCCAGCGGGGGCACCTGGGGGTGGTGAAGCTCCTGGTGCTGACCCACGG
GGCCGACCCAGAGAGCTACGCGGTGAGGAAGAACGAGTTCCCTGTCATCGTCCGCTTGCCCCTCTACGCAGCCATCAAGTCAGGGAATGAAGACATTGCCATATTCCTGCTTAGACACGGGGCTTTCT
TCTGTTCCTACATCCTACTGGACAGCCCTGACCCCAGCAAACATCTCCTCAGGAAGTATTTCATCGAAGCCAGTGACTTGCCCAGCGGTCGTCCAGGAAAACCTGCCCTTCGTGTGAAGTGGTCCCAT
CTTAGGTTGCCCTGGGTGGACCTCGACTGGCTCATAGACATCTCTTGCCAGATCACGGAGCTCGATCTTTCTGCCAACTGCCTGGTTTCCCTCCCCTCAGTCATTCCCTGGGGACTCATCAACCTCCG
GAAGCTGAATCTCTCCGACAACCACCTGGGGGAGCTGCCGGGCGTGCAGTCCTCAGATGAAATCATCTGCTCCAGGCTGCTTGAAATTGACATTTCCAGCAACAAGTTGTCCCACCTCCCACCGGGGT
TCTTGCACCTCTCGAGACTTCAAAAACTGACAGCTTCCAAAAATTACTTAGAGAAATTGTTTGAAGAAGAAAGTGCCACTAACTGGATCGGTCTTCGGAAGCTACAGGACCTCGATCTGTCTGACAAT
AAATTGACAGAGCTCCCCGCCCTTTTCCTGCACTCTTTCAAGTCACTCAGTTGTCTGAATGTCTCCAGAAACAACCTGAAGGCATTTCCAGAGCCCTGGGCCTGCCCTTTGAAATGTTGTAAAGCATC
CAAAAATGCCCTGGAATCCCTGCCAGACAAAATGGCTATCTTTTGGAAAAATCACCTCAAGGATGTGGATTTTTCAGAAAATGCACTGAAAGAAGTTCCCCTGGGACTTTTTCAGCTTGATACCCTCA
TGTTCCTGAGGTTGCAGGGAAACCAGCTGGTAGCACTGCCACCTCAAGAGAAGTGGACTTGCAGACAACTCAAAACTCTAGACCTCTCCAGAAACCAACTTGGCAAAAATGAAGATGGACTTAAAACA
AAGCGTATTTCCTTTTTCACCACCAGAGGCCGCCAGCGTTCAGGAACTGAGGCAGCGTGTGTGCTGGAATTCCCGGCCTTCCTGAGTGAGTCTTTGGAAGTCCTTTGTCTGAATGACAACCACCTTGA
CGCAGTCCCTCCATCTGTTTGCCTGCTGAAGAGCTTGTCAGAGCTCTACTTGGGAAACAACCCTGGCCTCCGAGAGCTCCCTCCTGAACTGGGACAGCTGGGCAACCTATGGCAACTGGACACAGAAG
ACCTGAGCATCAGCAATGTGCCTGCAGAGATCAGAAAGGAAGGTCCCAAAGCAATGCTGTCTTTCCTGCGTGCTCAGCTGCGGAAAGCAGAGAAATGCAAGCTGATGAAGATGATCATCGTGGGTCCA
CCGCGCCAGGGCAAGTCCACCCTCCTGGAGATCTTACAGACGGGCAGGGCCCCCCAGGTGGCGTACAGTGAGGCCACCATCCGGACCACCAAGTGGGAGCTCCAGAGGCCAGCAGGCTCCAAAGCCAA
GGTTGAGTCCGTGGAATTCAACGTCTGGGACATCGGGGGCCCCGCTAGCATGGCTACCGTCAACCAGTGCTTCTTCACGGACAAGGCCCTATATGTGGTGGTCTGGAATCTGGCGCTGGGAGAGGAAG
CCGTGGCCAATCTCCAGTTCTGGCTGCTTAACATCGAGGCCAAGGCCCCAAATGCTGTGGTGCTGGTGGTTGGAACACACCTAGACTTAATTGAAGCCAAGTTCCGAGTGGAGAGAATCGCAACGCTG
CGTGCCTACGTGCTGGCGCTGTGCCGCTCGCCCTCCGGGTCCAGAGCCACGGGCTTCCCAGACATCACTTTCAAACACTTACATGAGATTTCCTGTAAGAGTCTGGAAGGCCAGGAAGGGCTGCGGCA
GCTGATTTTCCATGTCACGTGCAACATGAAGGACGTGGGCAGCACCATCGGCTGCCAGCGACTAGCAGGGAGGCTGGTCCCTAGGAGCTACCTCAGCCTGCAGGAGGCCGTGCTGGCAGAGCAGCAGC
GCCGCAGCCTTGGCGACGACGTGCAATACCTGACGGACAGGCAGCTGGAGCAGCTGGTGGAGCAGACACCTGGCAACGACATCAAAGACTATGAGGACCTGCAGTCTGCCATCAGCTTCCTCATAGAA
ACCGGCACGCTGCTGCACTTCCCGGACACCAGCCACGGCCTGAGGAACCTCTACTTCCTGGATCCCATTTGGTTATCTGAGTGTCTGCAGAGGATCTTCAACATTAAGGGCTCCAGGTCGGTGGCCAA
GAACGGGGTGATCCGTGCAGAGGACCTCAGGATGCTGCTGGTGGGGACAGGCTTCACGCAGCAAACCGAGGAGCAGTACTTCCAGTTTCTGGCCAAGTTTGAGATCGCCTTGCCCGTCGCCAATGACA
GCTACCTCCTGCCACATCTTCTTCCATCCAAACCTGGCCTGGACACCCATGGCATGCGGCACCCCACAGCCAACACAATCCAGCGGGTGTTTAAGATGAGCTTCGTTCCTGTTGGCTTCTGGCAAAGA
TTTATAGCACGGATGCTGATCAGCTTGGCCGAGATGGACCTGCAGCTTTTTGAAAACAAGAAGAATACTAAAAGCAGGAACAGAAAAGTCACCATTTACAGTTTCACGGGAAACCAGAGAAATCGCTG
TAGCACATTCAGAGTGAAAAGAAATCAGACCATCTATTGGCAGGAGGGGCTTCTGGTCACTTTTGATGGGGGCTACCTCAGCGTGGAATCCTCCGATGTGAACTGGAAAAAGAAGAAAAGTGGAGGGA
TTAAAATCATTTGCCAGTCGGAAATGAGGGACTTCTCAGCAATGGCTTTTATCACGGATCATGTCAATTCCCTGATCGATCAGTGGTTTCCTGCCCTGACAGCCACAGAAAGTGATGGGACGCCTCTC
ATGGAGCAATATGTGCCCTGCCCTGTCTGTGAGACCTCCTGGGCCCAGCACAAGGATCCCAGTGAAAAATCAGAAGGCGTGCAGTACTTCGACATGGAAGACTGTGTGCTGACGGCCATCGAGCGGGA
CTTTATCACCTGCCCTAGACACCCAGACCTCCCTGTGCCACTCCAGGAACTGGTGCCCGAGTTGTTCATGACAGACTTCCCAGCCAGGCTCTTCCTGGAGAACAGCAAGCTGGAGCACAATGAGGACG
AGAGCAGCATCCTGGGCCAAGGTGGCAGTGGCACTGTCATCTACCGAGCCCGGTACCAGGGCCAGCCTGTGGCTGTGAAGCGATTCCACATCAAGAAATTTAAGAATTTTGCTAATGTTCCAGCAGAC
ACCATGTTGAGGCACCTGCGGGCCACAGATGCCATGAAGAACTTCTCGGAGTTCCGGCAGGAGGCCAGCATGCTGCACGCCCTGCAGCACCCCTGCATCGTGTCGCTCATCGGCATCAGCATCCACCC
GCTCTGCTTCGCCCTGGAGCTCGCCCCGCTCAGCAGCCTCAACACGGTGCTGTCTGAGAACGCCAAAGATTCTTCCTTTATGCCCCTGGGACACATGCTCACCCAAAAAATAGCCTACCAGATTGCCT
CAGGCCTGGCCTACCTGCACAAAAAGAACATCATCTTCTGCGACTTGAAGTCGGACAACATCCTGGTGTGGTCCCTGGATGTCAAGGAGCACATCAACATCAAGCTGTCTGACTACGGGATCTCACGG
CAGTCCTTTCATGAGGGAGCCCTGGGTGTGGAGGGCACCCCTGGCTACCAGGCCCCAGAGATCAGGCCTCGCATCGTGTATGATGAGAAGGTAGATATGTTCTCCTATGGGATGGTGCTCTACGAGTT
GCTGTCAGGACAGCGTCCTGCACTGGGCCACCACCAGCTTCAGATTGCCAAGAAGCTGTCCAAGGGCATCCGCCCCATTCTGGGGCAGCCAGAGGAAGTGCAGTTCCATCGACTCCAGGCCCTCATGA
TGGAGTGCTGGGACACAAAACCAGAAAAGCGCCCGCTGGCCTTGTCCGTGGTGAGCCAGATGAAGGACCCGACCTTCGCCACCTTCATGTACATGCTGCCCTGTGGGAAGCAGACGGCCTTCTTCTCA
TCCCAGGGCCAGGAGTACACCGTGGTGTTTTGGGATGGAAAAGAAGAATCCAGGAACTACACGGTGGTAAACACTGAGAAAGGCCTTCTGGAAGTGCAGAGGATGACCTGTGCCGGGATGAAGATGAG
CTGCCAGCTCAAGGTCCAGAGCTCTCTGTGGACCGCCACGGAGGACCAGAAAATCTACATCTACAGCCTCAAGGGCATGTGCCCCTTGAACACACCCCAGCGGGCCTTGGACACTCCAGCTATTGTCA
CCTGCTTCTTGGCCGTACCTATTATTAAAAAGAATTCCTTCCTGGTGCTGGCTGGCCTGGCTGATGGCCTTGTGGCTGTATTTCCCGTGGTGCGGGGCACCCCGAACGACAGCTGTTGCTACCTGTGC
TCCCACACAGCCAACAGGTCCAAGTTTGGCATCCCTGACGAAGACACACGGCAGAACCCCTACCCAGTGAAGGCCATGGAGGTGGTCAACAGTGGGTCCGAGGTCTGGTACAGCAACGGGCCGGGCCT
CCTTGTCATCGACTGCATAGCCCTGGACATCAGCAGGCGGCTGGAGCCCTATGCGGCCCCCTCAGTTGTCATGTCAGTCGTGTGCAGCTCAGATTGCAGGGGGGAGGAGGTCGTCTGGTGCCTGGACG
ACAAGGCCAACTCCTTGGTTATGTACCATTCGGCCACCTACCAGCTGTGTGCCCGATACTTCTGCGGGGACCCCAGCCCCCTCAGGGACATGTTTCCCGTGCGACCCTCAGGCCCGGAACCCCCGTGC
AGCCACACAACCAGCCTGAAGGGGCCCGATGGGGACTGCATCGCAGACGTGAGCATAATGTACAGCGAGGAGCTGGGCACGCAGATCCTGACCCACCAGGACTCGCTGACCGACTACTGCTCCATGTC
CTCCTACTCCTCTTCCCCACCCCACAGGGCCACCAGGTCCCTCTCCAGCCTGCCCAGCTCCCCAGCCAGCTGTTCCAGTGTGCCTTTCTCCACTGACTACGAGGACTCCGACAGGCTGCAGGAGCCCA
GTGCTGCCTCCGACAGGTCTGAGCACGAGCTGACCCCCATGGACGGGGAGACGTTCAGCCAGCACCTGCAGGCTGTGAAGGTCCTCGCTGTCAAAGACCTCATCTGGGTCCCCAGGCGTGGCGGAGAT
GTTATTGTCATTGGCCTGGAGAAGGATTCAGGTGCCCAGCGGGGACGTGTCATGGCTGTCTTAAAAGCCCGAGAGCTGACTTCTCATGGAGTGCTGGTGGACGCAGCTGTGGTGGCAAAGGACACTGT
GGTGTGCGGCTTTGAAAACGAGAACACAGAGTGGTGCCTGGCTGTCTGGAGGGGCTGGGGCGCCAGGGAGTTCGACATTTTCTACCAGTCCTACGAGGAGCTGGGCCGGCTAGAGGCTTGCACACGCA
AGAGAAGGTAATTCCCGTGGAAGGACCCAAGCGTGGAGCCAGCTGGCCCCAGGGGTGCCGCCTGAGCCCCCTGTCTGCAGCCCTCCCAGGATCCAGAGGACGGATGGAGTTCTGCCCTGAACCCTGTG
CTGCTAAGTGCTGAGAAGCTACCTGCCTGGCTGTGGTTTGGGAGTTCTCAGGTTCTGCGGGGCAGTTACTGACTACCCTGTCCCCCTATTGCTGGTTTCAGAGCCCAAGGGAAGACAGTGGGGTCTGG
TCAGGAGGGGCCTCCTCCATCAGCTTCCAGGAGTGGGGGGGACCCCATTCTAGGCTGGGTCCCACAAAGGGGGGCCAGGCCTTCCTGGCATAATGGGCCCTCCCTGTCTCAGATGGAGTTACACTAGA
GCCTCCCTGTTGAGGAGCCGTTCGGGGGCAGGATGGGAGGAGGGCTGTGACCCCTGGCCCTTCCCCCGTAGAGACCCCAGTCACTCAGCCCATTTCCCAAGCTCAAGTCCCCAGAGCATGGGGCCCTG
CTTGAGCGAGCTGAGATCAGGTATCTTTATCTGGGCAAAGTCTCTGTGTGAGAAACCCCCAGAAGGACCCTGGGCACAGAGAGTCGCCCAAACTGGGGAATGAATGAGCTCCCTTAAGTGGCACGGCC
GGAAAACCCCATGCGAGGGCACCCGCTGGCCTTTACATTCTTCTCCCACCAACAAAAGGAAGGAGAAACCTAGTCAGCAGGATTTGCAAAGGGCCCTGTGTTTATGCTTAGTAAGATAAACTTGGACA
CAGCTGAGCACAAGCCCTGTTTGTTTGCACATGTTTATCACTTTAGCAAATTAAGTAATATCTCGGTGGTCAGGCCTCTGGTTGTGAAATCACATGGTATGGGGCTTCTACCAAATTATGTATTTGCT
CAACATTTACTGCACACGTGGACAGCAGACTATGAAAAGTGAAATTGTTAACCGGGGATGTATGGGCACGACAGGGAGCAGTTTTGTAAATCGTACGCACCCGTATCCCCATCTTTGCCAAGACTTGC
CATGTGAGACTGCTTGACCAGAGTGGACGTCCGAATGTGAGATCCCATTCCAGCTCAAGGTGATGAACCTTTCTCTAAAATTAAATTAGAAAAGTCCAACTTATGATTTGTGGAGTGTGCAGGCAGAT
GTGAGTCCTTTTATCTGAAAATAAACAGACCTTCAAGAATGAAA

hide sequence

RefSeq Acc Id:

XM_040274732 ⟹ XP_040130666

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	143,457,572 - 143,562,544 (+)	NCBI

RefSeq Acc Id:

XM_040274733 ⟹ XP_040130667

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	143,494,248 - 143,562,544 (+)	NCBI


Protein RefSeqs	XP_005320139	(Get FASTA)	NCBI Sequence Viewer
	XP_040130666	(Get FASTA)	NCBI Sequence Viewer
	XP_040130667	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000008072.3
GenBank Protein	KAG3262674	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005320139 ⟸ XM_005320082
- Peptide Label:	isoform X1
- UniProtKB:	I3MCR5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGMSRGPPSMYWCVGPEGSTVCPERAMETHNGAGDMGSKLSAAGGDSTARSPRTEDIHTAYKKGDLSRARHLLKEAYEESTSQLEKGQLLSISAAHGDLEMVRYLLSEKQVELPTEPTDDNPAVVAA HFGHTEVVHELLESLAGPCSHQRLLNWMLALACQRGHLGVVKLLVLTHGADPESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAFFCSYILLDSPDPSKHLLRKYFIEASDLPSGRPGKPAL RVKWSHLRLPWVDLDWLIDISCQITELDLSANCLVSLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSRLQKLTASKNYLEKLFEEESATNWIGLRKLQD LDLSDNKLTELPALFLHSFKSLSCLNVSRNNLKAFPEPWACPLKCCKASKNALESLPDKMAIFWKNHLKDVDFSENALKEVPLGLFQLDTLMFLRLQGNQLVALPPQEKWTCRQLKTLDLSRNQLGKN EDGLKTKRISFFTTRGRQRSGTEAACVLEFPAFLSESLEVLCLNDNHLDAVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLSISNVPAEIRKEGPKAMLSFLRAQLRKAEKCKLMK MIIVGPPRQGKSTLLEILQTGRAPQVAYSEATIRTTKWELQRPAGSKAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRV ERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCNMKDVGSTIGCQRLAGRLVPRSYLSLQEAVLAEQQRRSLGDDVQYLTDRQLEQLVEQTPGNDIKDYEDLQSA ISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMSFVP VGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGIKIICQSEMRDFSAMAFITDHVNSLIDQWFPALTATE SDGTPLMEQYVPCPVCETSWAQHKDPSEKSEGVQYFDMEDCVLTAIERDFITCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHNEDESSILGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNF ANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVSLIGISIHPLCFALELAPLSSLNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHINIKLS DYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPILGQPEEVQFHRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYMLPCGK QTAFFSSQGQEYTVVFWDGKEESRNYTVVNTEKGLLEVQRMTCAGMKMSCQLKVQSSLWTATEDQKIYIYSLKGMCPLNTPQRALDTPAIVTCFLAVPIIKKNSFLVLAGLADGLVAVFPVVRGTPND SCCYLCSHTANRSKFGIPDEDTRQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCIALDISRRLEPYAAPSVVMSVVCSSDCRGEEVVWCLDDKANSLVMYHSATYQLCARYFCGDPSPLRDMFPVRPS GPEPPCSHTTSLKGPDGDCIADVSIMYSEELGTQILTHQDSLTDYCSMSSYSSSPPHRATRSLSSLPSSPASCSSVPFSTDYEDSDRLQEPSAASDRSEHELTPMDGETFSQHLQAVKVLAVKDLIWV PRRGGDVIVIGLEKDSGAQRGRVMAVLKARELTSHGVLVDAAVVAKDTVVCGFENENTEWCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR hide sequence

RefSeq Acc Id:	XP_040130666 ⟸ XM_040274732
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_040130667 ⟸ XM_040274733
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSSTOP00000008072 ⟸ ENSSTOT00000009009

Protein Domains

Protein kinase Roc

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000008982	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000009009.3	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.20	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
	3.80.10.10	UniProtKB/TrEMBL
	ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Ankyrin_rpt	UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/TrEMBL
	COR	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/TrEMBL
	LRR_dom_sf	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	Plant_LRR-RLKs	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	ROC_dom	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Lrrk1	ENTREZGENE
PANTHER	LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED	UniProtKB/TrEMBL
	RECEPTOR PROTEIN-TYROSINE KINASE CEPR1	UniProtKB/TrEMBL
Pfam	Ank_2	UniProtKB/TrEMBL
	COR	UniProtKB/TrEMBL
	Pkinase	UniProtKB/TrEMBL
	Roc	UniProtKB/TrEMBL
PROSITE	LRR	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	ROC	UniProtKB/TrEMBL
SMART	ANK	UniProtKB/TrEMBL
	LRR_BAC	UniProtKB/TrEMBL
	LRR_TYP	UniProtKB/TrEMBL
	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	L domain-like	UniProtKB/TrEMBL
	SSF48403	UniProtKB/TrEMBL
	SSF50978	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
	SSF56112	UniProtKB/TrEMBL
UniProt	I3MCR5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
		Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM