Lrrk1 (leucine-rich repeat kinase 1) - Rat Genome Database

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Gene: Lrrk1 (leucine-rich repeat kinase 1) Rattus norvegicus
Analyze
Symbol: Lrrk1
Name: leucine-rich repeat kinase 1
RGD ID: 1308000
Description: Predicted to enable identical protein binding activity and protein kinase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway and signal transduction. Predicted to act upstream of or within several processes, including bone resorption; osteoclast development; and regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in cytosol and mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in osteosclerotic metaphyseal dysplasia. Orthologous to human LRRK1 (leucine rich repeat kinase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: leucine-rich repeat serine/threonine-protein kinase 1; LOC308703
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Lrrk1em1SageLrrk2em1Sage   Lrrk1em1Sage  
Genetic Models: LE-Lrrk1em1Sage-/-Lrrk2em1Sage-/- LE-Lrrk1em1SageLrrk2em1Sage LE-Lrrk1em1Sage-/- LE-Lrrk1em1Sage
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81129,254,815 - 129,390,217 (-)NCBIGRCr8
mRatBN7.21119,844,360 - 119,972,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1119,845,146 - 119,979,734 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1127,837,758 - 127,964,722 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01135,009,201 - 135,136,173 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01127,819,030 - 127,946,556 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01127,166,866 - 127,301,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1127,166,431 - 127,292,090 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01128,248,473 - 128,372,456 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41120,695,657 - 120,836,324 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11120,773,221 - 120,921,758 (-)NCBI
Celera1112,054,004 - 112,179,350 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
cobalt dichloride  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
fenamidone  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
lead diacetate  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (ISO)
methidathion  (ISO)
methimazole  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nickel sulfate  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
titanium dioxide  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA,ISO)
mitochondrion  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18272292   PMID:19712061   PMID:22899650   PMID:22952686   PMID:23526378  


Genomics

Comparative Map Data
Lrrk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81129,254,815 - 129,390,217 (-)NCBIGRCr8
mRatBN7.21119,844,360 - 119,972,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1119,845,146 - 119,979,734 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1127,837,758 - 127,964,722 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01135,009,201 - 135,136,173 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01127,819,030 - 127,946,556 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01127,166,866 - 127,301,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1127,166,431 - 127,292,090 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01128,248,473 - 128,372,456 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41120,695,657 - 120,836,324 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11120,773,221 - 120,921,758 (-)NCBI
Celera1112,054,004 - 112,179,350 (-)NCBICelera
Cytogenetic Map1q22NCBI
LRRK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3815100,919,357 - 101,078,257 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl15100,919,327 - 101,078,257 (+)EnsemblGRCh38hg38GRCh38
GRCh3715101,459,562 - 101,618,462 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361599,276,983 - 99,427,840 (+)NCBINCBI36Build 36hg18NCBI36
Build 341599,380,194 - 99,427,834NCBI
Celera1577,872,799 - 78,023,725 (+)NCBICelera
Cytogenetic Map15q26.3NCBI
HuRef1577,581,355 - 77,732,446 (+)NCBIHuRef
CHM1_115101,300,443 - 101,451,610 (+)NCBICHM1_1
T2T-CHM13v2.01598,673,894 - 98,832,884 (+)NCBIT2T-CHM13v2.0
Lrrk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39765,908,493 - 66,038,089 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl765,876,660 - 66,038,098 (-)EnsemblGRCm39 Ensembl
GRCm38766,258,745 - 66,388,341 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl766,226,912 - 66,388,350 (-)EnsemblGRCm38mm10GRCm38
MGSCv37773,403,631 - 73,533,227 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36755,670,181 - 55,799,947 (-)NCBIMGSCv36mm8
MGSCv36766,137,695 - 66,267,291 (-)NCBIMGSCv36mm8
Celera763,712,568 - 63,843,036 (-)NCBICelera
Celera759,723,311 - 59,724,078 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map735.57NCBI
Lrrk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541627,865,784 - 27,988,279 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541627,860,934 - 27,988,279 (+)NCBIChiLan1.0ChiLan1.0
LRRK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21690,508,435 - 90,659,979 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11594,208,601 - 94,360,510 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01579,642,908 - 79,793,990 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11598,936,123 - 99,081,168 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1598,931,344 - 99,081,168 (+)Ensemblpanpan1.1panPan2
LRRK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1340,003,299 - 40,122,326 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl340,004,557 - 40,122,320 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha342,692,357 - 42,816,723 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0340,394,683 - 40,519,058 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl340,377,843 - 40,513,734 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1339,927,716 - 40,048,483 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0340,164,544 - 40,288,876 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0340,366,423 - 40,490,768 (-)NCBIUU_Cfam_GSD_1.0
Lrrk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640143,409,510 - 143,562,544 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364832,771,938 - 2,924,525 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364832,771,939 - 2,922,793 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1139,494,121 - 139,624,604 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11139,494,126 - 139,624,609 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21155,637,573 - 155,853,753 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRRK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12919,385,149 - 19,532,440 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2919,386,170 - 19,533,686 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605927,010,221 - 27,156,563 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247683,712,049 - 3,848,651 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247683,701,187 - 3,848,943 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrrk1
1577 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:221
Count of miRNA genes:143
Interacting mature miRNAs:156
Transcripts:ENSRNOT00000016959
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
631569Bp93Blood pressure QTL 930.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847121834139Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat

Markers in Region
D1Mco70  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21119,897,087 - 119,897,283 (+)MAPPERmRatBN7.2
Rnor_6.01127,219,581 - 127,219,776NCBIRnor6.0
Rnor_5.01128,300,402 - 128,300,597UniSTSRnor5.0
RGSC_v3.41120,747,637 - 120,747,832UniSTSRGSC3.4
Celera1112,106,555 - 112,106,750UniSTS
Cytogenetic Map1q22UniSTS


Genetic Models
This gene Lrrk1 is modified in the following models/strains:
LE-Lrrk1em1Sage-/-Lrrk2em1Sage-/-     LE-Lrrk1em1SageLrrk2em1Sage     LE-Lrrk1em1Sage-/-     LE-Lrrk1em1Sage    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000016959   ⟹   ENSRNOP00000016959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1119,845,146 - 119,979,734 (-)Ensembl
Rnor_6.0 Ensembl1127,166,431 - 127,292,090 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106564   ⟹   ENSRNOP00000094655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1119,845,146 - 119,972,885 (-)Ensembl
RefSeq Acc Id: NM_001191624   ⟹   NP_001178553
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,255,601 - 129,383,130 (-)NCBI
mRatBN7.21119,845,146 - 119,972,885 (-)NCBI
Rnor_6.01127,167,652 - 127,291,972 (-)NCBI
Rnor_5.01128,248,473 - 128,372,456 (-)NCBI
Celera1112,054,004 - 112,179,350 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039112688   ⟹   XP_038968616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,254,815 - 129,291,014 (-)NCBI
mRatBN7.21119,844,360 - 119,880,557 (-)NCBI
RefSeq Acc Id: XM_063262476   ⟹   XP_063118546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,254,815 - 129,390,112 (-)NCBI
RefSeq Acc Id: XM_063262478   ⟹   XP_063118548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,254,815 - 129,390,112 (-)NCBI
RefSeq Acc Id: XM_063262481   ⟹   XP_063118551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,254,815 - 129,390,217 (-)NCBI
RefSeq Acc Id: XM_063262490   ⟹   XP_063118560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,262,860 - 129,390,124 (-)NCBI
RefSeq Acc Id: XM_063262498   ⟹   XP_063118568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,267,619 - 129,390,120 (-)NCBI
RefSeq Acc Id: XR_010052148
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,262,885 - 129,390,124 (-)NCBI
RefSeq Acc Id: NP_001178553   ⟸   NM_001191624
- UniProtKB: D3ZRJ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016959   ⟸   ENSRNOT00000016959
RefSeq Acc Id: XP_038968616   ⟸   XM_039112688
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000094655   ⟸   ENSRNOT00000106564
RefSeq Acc Id: XP_063118551   ⟸   XM_063262481
- Peptide Label: isoform X2
- UniProtKB: A0A8I6B1B9 (UniProtKB/TrEMBL),   D3ZRJ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118546   ⟸   XM_063262476
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063118548   ⟸   XM_063262478
- Peptide Label: isoform X1
- UniProtKB: D3ZRJ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118560   ⟸   XM_063262490
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063118568   ⟸   XM_063262498
- Peptide Label: isoform X4
Protein Domains
Protein kinase   Roc

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZRJ7-F1-model_v2 AlphaFold D3ZRJ7 1-2013 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308000 AgrOrtholog
BioCyc Gene G2FUF-59010 BioCyc
Ensembl Genes ENSRNOG00000012730 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016959.7 UniProtKB/TrEMBL
  ENSRNOT00000106564.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
  ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  COR UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_receptor-like_kinase UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  ROC_GTPase UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene 308703 ENTREZGENE
PANTHER LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1 UniProtKB/TrEMBL
  LEUCINE-RICH REPEAT SERINE_THREONINE-PROTEIN KINASE 1 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  COR UniProtKB/TrEMBL
  LRR_1 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  Roc UniProtKB/TrEMBL
PhenoGen Lrrk1 PhenoGen
PROSITE LRR UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  ROC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012730 RatGTEx
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  L domain-like UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6B1B9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZRJ7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Lrrk1  leucine-rich repeat kinase 1   Lrrk1_predicted  leucine-rich repeat kinase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Lrrk1_predicted  leucine-rich repeat kinase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED