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Gene: NCF4 (neutrophil cytosolic factor 4) Homo sapiens
Symbol: NCF4
Name: neutrophil cytosolic factor 4
Description: Exhibits phosphatidylinositol-3-phosphate binding activity; superoxide-generating NADPH oxidase activator activity; and superoxide-generating NADPH oxidase activity. Involved in oxidation-reduction process. Localizes to NADPH oxidase complex; cytosol; and endosome membrane. Implicated in autosomal recessive chronic granulomatous disease cytochrome b-positive type III.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CGD3; MGC3810; NCF; NCF-4; neutrophil cytosol factor 4; neutrophil cytosolic factor 4, 40kDa; neutrophil NADPH oxidase factor 4; p40-phox; P40PHOX; SH3 and PX domain-containing protein 4; SH3PXD4
Mus musculus (house mouse) : Ncf4 (neutrophil cytosolic factor 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ncf4 (neutrophil cytosolic factor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ncf4 (neutrophil cytosolic factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : NCF4 (neutrophil cytosolic factor 4)
Canis lupus familiaris (dog) : NCF4 (neutrophil cytosolic factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ncf4 (neutrophil cytosolic factor 4)
Sus scrofa (pig) : NCF4 (neutrophil cytosolic factor 4)
Chlorocebus sabaeus (African green monkey) : NCF4 (neutrophil cytosolic factor 4)
Heterocephalus glaber (naked mole-rat) : Ncf4 (neutrophil cytosolic factor 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2236,860,988 - 36,878,017 (+)EnsemblGRCh38hg38GRCh38
GRCh382236,861,006 - 36,878,015 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372237,257,030 - 37,274,059 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,586,991 - 35,604,005 (+)NCBINCBI36hg18NCBI36
Build 342235,581,544 - 35,598,558NCBI
Celera2221,054,984 - 21,075,404 (+)NCBI
Cytogenetic Map22q12.3NCBI
HuRef2220,219,193 - 20,235,709 (+)NCBIHuRef
CHM1_12237,215,777 - 37,232,815 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NCF4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1314271
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.