NCF4 (neutrophil cytosolic factor 4) - Rat Genome Database

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Gene: NCF4 (neutrophil cytosolic factor 4) Sus scrofa
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Symbol: NCF4
Name: neutrophil cytosolic factor 4
RGD ID: 14149629
Description: ENCODES a protein that exhibits phosphatidylinositol binding (inferred); phosphatidylinositol-3-phosphate binding (inferred); superoxide-generating NADPH oxidase activator activity (inferred); INVOLVED IN phagocytosis (inferred); respiratory burst (inferred); superoxide anion generation (inferred); ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); autosomal recessive chronic granulomatous disease 3 (ortholog); chronic granulomatous disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); endosome membrane (inferred); INTERACTS WITH deoxynivalenol; lipopolysaccharide
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NADPH oxidase cytosolic protein p40phox; neutrophil cytosol factor 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl510,874,953 - 10,994,014 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1510,876,147 - 10,994,002 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.258,477,878 - 8,593,943 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IEA)
endosome membrane  (IEA)
membrane  (IEA)
NADPH oxidase complex  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NCF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl510,874,953 - 10,994,014 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1510,876,147 - 10,994,002 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.258,477,878 - 8,593,943 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NCF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382236,861,006 - 36,878,015 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2236,860,988 - 36,878,017 (+)EnsemblGRCh38hg38GRCh38
GRCh372237,257,048 - 37,274,057 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,586,991 - 35,604,005 (+)NCBINCBI36Build 36hg18NCBI36
Build 342235,581,544 - 35,598,558NCBI
Celera2221,054,984 - 21,075,404 (+)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2220,219,193 - 20,235,709 (+)NCBIHuRef
CHM1_12237,215,777 - 37,232,815 (+)NCBICHM1_1
T2T-CHM13v2.02237,316,866 - 37,336,974 (+)NCBIT2T-CHM13v2.0
Ncf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391578,128,324 - 78,146,782 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1578,129,001 - 78,146,780 (+)EnsemblGRCm39 Ensembl
GRCm381578,244,164 - 78,262,582 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1578,244,801 - 78,262,580 (+)EnsemblGRCm38mm10GRCm38
MGSCv371578,075,241 - 78,093,010 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361578,072,089 - 78,089,829 (+)NCBIMGSCv36mm8
Celera1579,705,722 - 79,723,507 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.1NCBI
Ncf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,705,926 - 111,723,893 (+)NCBIGRCr8
mRatBN7.27109,825,420 - 109,843,389 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,826,020 - 109,843,389 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7111,575,804 - 111,592,610 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07113,799,365 - 113,816,171 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,768,035 - 113,784,810 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,481,711 - 119,499,426 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,482,272 - 119,499,425 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07119,473,732 - 119,490,872 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47116,167,621 - 116,190,630 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7106,165,444 - 106,181,739 (+)NCBICelera
Cytogenetic Map7q34NCBI
Ncf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541323,388,018 - 23,408,090 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541323,388,456 - 23,405,121 (+)NCBIChiLan1.0ChiLan1.0
NCF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22346,715,341 - 46,735,474 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12249,406,644 - 49,426,776 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02217,775,590 - 17,795,725 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12235,611,589 - 35,631,400 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2235,611,589 - 35,631,400 (+)Ensemblpanpan1.1panPan2
NCF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11027,597,296 - 27,672,199 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1027,597,486 - 27,615,261 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1027,551,611 - 27,626,188 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01028,389,229 - 28,463,826 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1028,389,225 - 28,407,201 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11028,110,753 - 28,185,319 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01028,419,256 - 28,493,843 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01028,598,068 - 28,672,687 (-)NCBIUU_Cfam_GSD_1.0
Ncf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,991,297 - 11,005,134 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364924,001,898 - 4,010,456 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364924,001,711 - 4,015,253 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11919,560,047 - 19,579,342 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1919,566,562 - 19,579,352 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045106,283,752 - 106,303,762 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ncf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475210,901,934 - 10,918,106 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475210,902,035 - 10,918,183 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NCF4
6064 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000034941   ⟹   ENSSSCP00000029266
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl510,878,442 - 10,897,987 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000036476   ⟹   ENSSSCP00000028669
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl510,874,953 - 10,894,080 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000071185   ⟹   ENSSSCP00000069842
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl510,874,953 - 10,893,017 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000075176   ⟹   ENSSSCP00000067203
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl510,874,953 - 10,892,960 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000075411   ⟹   ENSSSCP00000074298
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl510,874,953 - 10,897,885 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000081184   ⟹   ENSSSCP00000070143
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl510,875,891 - 10,944,284 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000083107   ⟹   ENSSSCP00000072784
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl510,874,953 - 10,893,409 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000087050   ⟹   ENSSSCP00000073420
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl510,874,953 - 10,897,885 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000089031   ⟹   ENSSSCP00000069815
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl510,875,891 - 10,994,014 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000105262   ⟹   ENSSSCP00000076891
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl510,874,953 - 10,886,074 (-)Ensembl
RefSeq Acc Id: XM_001924811   ⟹   XP_001924846
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1510,876,147 - 10,897,996 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013997542   ⟹   XP_013852996
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1510,876,147 - 10,897,996 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013997543   ⟹   XP_013852997
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1510,876,147 - 10,994,002 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021091535   ⟹   XP_020947194
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1510,876,147 - 10,994,002 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020947194   ⟸   XM_021091535
- Peptide Label: isoform X4
- UniProtKB: A0A480PII7 (UniProtKB/TrEMBL),   A0A8D0PUC5 (UniProtKB/TrEMBL),   A0A480PH34 (UniProtKB/TrEMBL),   A0A8D0R4P9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013852997   ⟸   XM_013997543
- Peptide Label: isoform X2
- UniProtKB: A0A480PH34 (UniProtKB/TrEMBL),   A0A8D0R4P9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_001924846   ⟸   XM_001924811
- Peptide Label: isoform X3
- UniProtKB: A0A480XKX3 (UniProtKB/TrEMBL),   A0A8D0VCR6 (UniProtKB/TrEMBL),   A0A0B8RTF7 (UniProtKB/TrEMBL),   A0A8D1UEW7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013852996   ⟸   XM_013997542
- Peptide Label: isoform X1
- UniProtKB: A0A0B8RTF7 (UniProtKB/TrEMBL),   A0A8D1UEW7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000072784   ⟸   ENSSSCT00000083107
Ensembl Acc Id: ENSSSCP00000029266   ⟸   ENSSSCT00000034941
Ensembl Acc Id: ENSSSCP00000069815   ⟸   ENSSSCT00000089031
Ensembl Acc Id: ENSSSCP00000067203   ⟸   ENSSSCT00000075176
Ensembl Acc Id: ENSSSCP00000074298   ⟸   ENSSSCT00000075411
Ensembl Acc Id: ENSSSCP00000028669   ⟸   ENSSSCT00000036476
Ensembl Acc Id: ENSSSCP00000069842   ⟸   ENSSSCT00000071185
Ensembl Acc Id: ENSSSCP00000070143   ⟸   ENSSSCT00000081184
Ensembl Acc Id: ENSSSCP00000073420   ⟸   ENSSSCT00000087050
Ensembl Acc Id: ENSSSCP00000076891   ⟸   ENSSSCT00000105262
Protein Domains
PB1   PX   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000137 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015070074 UniProtKB/TrEMBL
  ENSSSCG00025020281 UniProtKB/TrEMBL
  ENSSSCG00030007246 UniProtKB/TrEMBL
  ENSSSCG00035067295 UniProtKB/TrEMBL
  ENSSSCG00045030979 UniProtKB/TrEMBL
  ENSSSCG00050074234 UniProtKB/TrEMBL
  ENSSSCG00055030505 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000034941.4 UniProtKB/TrEMBL
  ENSSSCT00000036476.4 UniProtKB/TrEMBL
  ENSSSCT00000071185.2 UniProtKB/TrEMBL
  ENSSSCT00000075176.2 UniProtKB/TrEMBL
  ENSSSCT00000075411 ENTREZGENE
  ENSSSCT00000075411.1 UniProtKB/TrEMBL
  ENSSSCT00000081184 ENTREZGENE
  ENSSSCT00000081184.2 UniProtKB/TrEMBL
  ENSSSCT00000083107.1 UniProtKB/TrEMBL
  ENSSSCT00000087050.2 UniProtKB/TrEMBL
  ENSSSCT00000089031.2 UniProtKB/TrEMBL
  ENSSSCT00000105262.1 UniProtKB/TrEMBL
  ENSSSCT00015094911.1 UniProtKB/TrEMBL
  ENSSSCT00015095050.1 UniProtKB/TrEMBL
  ENSSSCT00025027572.1 UniProtKB/TrEMBL
  ENSSSCT00030009748.1 UniProtKB/TrEMBL
  ENSSSCT00035090977.1 UniProtKB/TrEMBL
  ENSSSCT00045053271.1 UniProtKB/TrEMBL
  ENSSSCT00045053715.1 UniProtKB/TrEMBL
  ENSSSCT00050101632.1 UniProtKB/TrEMBL
  ENSSSCT00055060788.1 UniProtKB/TrEMBL
  ENSSSCT00055060799.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1520.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro NADPH_Oxidase/PX-Domain UniProtKB/TrEMBL
  p40phox UniProtKB/TrEMBL
  p40phox_SH3 UniProtKB/TrEMBL
  PB1-like UniProtKB/TrEMBL
  PB1_dom UniProtKB/TrEMBL
  PB1_P40 UniProtKB/TrEMBL
  Phox UniProtKB/TrEMBL
  PX_dom_sf UniProtKB/TrEMBL
  PX_p40phox UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report ssc:100152055 UniProtKB/TrEMBL
NCBI Gene NCF4 ENTREZGENE
PANTHER PTHR15706:SF20 UniProtKB/TrEMBL
  SH3 MULTIPLE DOMAIN UniProtKB/TrEMBL
Pfam PB1 UniProtKB/TrEMBL
  PF00787 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
  SH3_9 UniProtKB/TrEMBL
PRINTS P40PHOX UniProtKB/TrEMBL
PROSITE PB1 UniProtKB/TrEMBL
  PS50195 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART PB1 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00312 UniProtKB/TrEMBL
Superfamily-SCOP CAD & PB1 domains UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
  SSF64268 UniProtKB/TrEMBL
UniProt A0A0B8RTF7 ENTREZGENE
  A0A480PH34 ENTREZGENE, UniProtKB/TrEMBL
  A0A480PII7 ENTREZGENE, UniProtKB/TrEMBL
  A0A480XKX3 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QZ33_PIG UniProtKB/TrEMBL
  A0A5G2QZ35_PIG UniProtKB/TrEMBL
  A0A5G2R098_PIG UniProtKB/TrEMBL
  A0A5G2R6T6_PIG UniProtKB/TrEMBL
  A0A5G2R8Y4_PIG UniProtKB/TrEMBL
  A0A5G2RAR0_PIG UniProtKB/TrEMBL
  A0A8D0PUC5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0R4P9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0VCR6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1UEW7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FF05_PIG UniProtKB/TrEMBL
  K7GLE0_PIG UniProtKB/TrEMBL
  K7GN17_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90608 ENTREZGENE