Evx2 (even-skipped homeobox 2) - Rat Genome Database

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Gene: Evx2 (even-skipped homeobox 2) Mus musculus
Analyze
Symbol: Evx2
Name: even-skipped homeobox 2
RGD ID: 1313716
MGI Page MGI
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within limb morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; limb; limb bud; and sensory organ. Orthologous to human EVX2 (even-skipped homeobox 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: even skipped homeotic gene 2 homolog; Evx-; Evx-2; homeobox even-skipped homolog protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39274,483,333 - 74,491,864 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl274,483,335 - 74,489,901 (-)EnsemblGRCm39 Ensembl
GRCm38274,652,989 - 74,661,520 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl274,652,991 - 74,659,557 (-)EnsemblGRCm38mm10GRCm38
MGSCv37274,493,673 - 74,497,476 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36274,456,455 - 74,460,258 (-)NCBIMGSCv36mm8
Celera276,325,721 - 76,329,525 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map244.13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1349539   PMID:1611218   PMID:1684419   PMID:1971786   PMID:2064805   PMID:7579515   PMID:7896287   PMID:8674109   PMID:8751373   PMID:8900279   PMID:8978061   PMID:8978698  
PMID:10075849   PMID:10319820   PMID:11239429   PMID:11544178   PMID:11567614   PMID:11902682   PMID:12403721   PMID:12435628   PMID:12466851   PMID:12477932   PMID:12679098   PMID:12732147  
PMID:12874134   PMID:14723851   PMID:15236237   PMID:15578713   PMID:16322559   PMID:16399081   PMID:16602821   PMID:17245451   PMID:18245448   PMID:18287559   PMID:20059953   PMID:20081190  
PMID:21098566   PMID:21145498   PMID:21195707   PMID:21267068   PMID:21423180   PMID:21637793   PMID:21677750   PMID:21873635   PMID:22118467   PMID:22988430   PMID:23134724   PMID:23818637  
PMID:24075990   PMID:24146773   PMID:24398455   PMID:24553291   PMID:24952961   PMID:25960414   PMID:27198226   PMID:27974206   PMID:29273679   PMID:30177510   PMID:30917309   PMID:31152445  
PMID:31299961  


Genomics

Comparative Map Data
Evx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39274,483,333 - 74,491,864 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl274,483,335 - 74,489,901 (-)EnsemblGRCm39 Ensembl
GRCm38274,652,989 - 74,661,520 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl274,652,991 - 74,659,557 (-)EnsemblGRCm38mm10GRCm38
MGSCv37274,493,673 - 74,497,476 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36274,456,455 - 74,460,258 (-)NCBIMGSCv36mm8
Celera276,325,721 - 76,329,525 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map244.13NCBI
EVX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382176,077,472 - 176,083,962 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2176,077,472 - 176,083,962 (-)EnsemblGRCh38hg38GRCh38
GRCh372176,942,200 - 176,948,690 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362176,653,081 - 176,656,936 (-)NCBINCBI36Build 36hg18NCBI36
Celera2170,553,985 - 170,557,840 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2168,822,321 - 168,826,177 (-)NCBIHuRef
CHM1_12176,950,682 - 176,954,537 (-)NCBICHM1_1
T2T-CHM13v2.02176,565,581 - 176,572,075 (-)NCBIT2T-CHM13v2.0
Evx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8379,965,630 - 79,969,700 (-)NCBIGRCr8
mRatBN7.2359,558,197 - 59,562,267 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl359,558,197 - 59,561,872 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0361,564,917 - 61,581,598 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl361,578,229 - 61,581,598 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0368,032,231 - 68,048,055 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4357,262,625 - 57,274,916 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1357,166,866 - 57,172,821 (-)NCBI
Celera359,080,928 - 59,084,154 (-)NCBICelera
Cytogenetic Map3q23NCBI
Evx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540320,578,813 - 20,582,409 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540320,578,813 - 20,582,409 (+)NCBIChiLan1.0ChiLan1.0
EVX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21378,745,037 - 78,752,561 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B78,760,013 - 78,767,481 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B63,359,892 - 63,364,762 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B181,069,133 - 181,073,347 (-)NCBIpanpan1.1PanPan1.1panPan2
EVX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13619,887,095 - 19,891,772 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3619,887,524 - 19,891,247 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3619,897,402 - 19,901,132 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03620,028,549 - 20,032,283 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3620,028,549 - 20,032,913 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13620,102,621 - 20,106,351 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03620,103,583 - 20,107,304 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03620,215,301 - 20,219,023 (-)NCBIUU_Cfam_GSD_1.0
Evx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303137,010,758 - 137,017,688 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365095,566,432 - 5,571,005 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365095,566,432 - 5,571,005 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EVX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1581,881,362 - 81,885,193 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11581,881,362 - 81,884,994 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21591,345,989 - 91,354,707 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EVX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11061,650,763 - 61,659,724 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1061,654,829 - 61,658,494 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040137,951,216 - 137,955,814 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Evx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478713,221,382 - 13,224,978 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478713,221,382 - 13,224,989 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Evx2
243 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2604
Count of miRNA genes:830
Interacting mature miRNAs:1171
Transcripts:ENSMUST00000001867, ENSMUST00000173623
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
1301480Pbwg1_mpostnatal body weight growth 1 (mouse)Not determined24182071975820843Mouse
4141069Pbwg1.5_mpostnatal body weight growth 1.5 (mouse)Not determined4352061277520756Mouse
1300788Cia2_mcollagen induced arthritis QTL 2 (mouse)Not determined24352061277520756Mouse
1300671Cia4_mcollagen induced arthritis QTL 4 (mouse)Not determined24352061277520756Mouse
1301402Ap2q_malcohol preference 2 QTL (mouse)Not determined24352061277520756Mouse
1301411Pitm1_mprion incubation time 1 (mouse)Not determined24352061277520756Mouse
10755532Lymph5_mlymphocyte differential 5 (mouse)24419901778199017Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
11532740Pbwg1.10_mpostnatal body weight growth 1.10 (mouse)24813241282132495Mouse
1558820Moo1_mmodifier of Odc1 (mouse)Not determined174826974682269934Mouse
1301747Eae21_mexperimental allergic encephalomyelitis 21 (mouse)Not determined24826974682269934Mouse
1301235Alcw4_malcohol withdrawal 4 (mouse)Not determined24826974682269934Mouse
1300568Hdl1_mhigh density lipoprotein (HDL) level 1 (mouse)Not determined24826974682269934Mouse
10755526Lymph1_mlymphocyte differential 1 (mouse)25081931484819314Mouse
1300875Taste1_mtaste-saccharin preference 1 (mouse)Not determined25092317584923278Mouse
1300761Lgth1_mbody length 1 (mouse)Not determined25170327685703425Mouse
13464141Hbbcq3_mhemoglobin concentration QTL 3 (mouse)25244801986448136Mouse
13463471Hctq6_mhematocrit QTL 6 (mouse)25244801986448136Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25752411791524288Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25791999191919991Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26300595497006113Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26300595497006113Mouse
1301405Etohr_methanol response acute (mouse)Not determined26300595497006113Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26300595497006113Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26300595497006113Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26300595497006113Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26357015497570301Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
1301059Hrtfm1_mheart failure modifier 1 (mouse)Not determined26759194074964933Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267647887101648142Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267647887101648142Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268724269102724407Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268724269102724407Mouse

Markers in Region
D2Tfv7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38274,657,541 - 74,657,770UniSTSGRCm38
MGSCv37274,495,598 - 74,495,827UniSTSGRCm37
Celera276,327,647 - 76,327,876UniSTS
Cytogenetic Map2C3UniSTS
cM Map245.0UniSTS
cM Map2 UniSTS
Evx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38274,658,028 - 74,659,022UniSTSGRCm38
MGSCv37274,496,085 - 74,497,079UniSTSGRCm37
Celera276,328,134 - 76,329,128UniSTS
Cytogenetic Map2C3UniSTS
cM Map245.0UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000001867   ⟹   ENSMUSP00000001867
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl274,483,335 - 74,489,901 (-)Ensembl
GRCm38.p6 Ensembl274,652,991 - 74,659,557 (-)Ensembl
RefSeq Acc Id: ENSMUST00000173623   ⟹   ENSMUSP00000134131
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl274,485,960 - 74,489,763 (-)Ensembl
GRCm38.p6 Ensembl274,655,616 - 74,659,419 (-)Ensembl
RefSeq Acc Id: NM_007967   ⟹   NP_031993
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39274,483,335 - 74,489,901 (-)NCBI
GRCm38274,652,991 - 74,659,557 (-)NCBI
MGSCv37274,493,673 - 74,497,476 (-)RGD
Celera276,325,721 - 76,329,525 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006498728   ⟹   XP_006498791
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39274,483,333 - 74,491,864 (-)NCBI
GRCm38274,652,989 - 74,661,520 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006498729   ⟹   XP_006498792
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39274,483,333 - 74,491,864 (-)NCBI
GRCm38274,652,989 - 74,661,520 (-)NCBI
Sequence:
RefSeq Acc Id: NP_031993   ⟸   NM_007967
- UniProtKB: P49749 (UniProtKB/Swiss-Prot),   G5E813 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006498792   ⟸   XM_006498729
- Peptide Label: isoform X1
- UniProtKB: P49749 (UniProtKB/Swiss-Prot),   G5E813 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006498791   ⟸   XM_006498728
- Peptide Label: isoform X1
- UniProtKB: P49749 (UniProtKB/Swiss-Prot),   G5E813 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000134131   ⟸   ENSMUST00000173623
RefSeq Acc Id: ENSMUSP00000001867   ⟸   ENSMUST00000001867
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49749-F1-model_v2 AlphaFold P49749 1-475 view protein structure

Promoters
RGD ID:6877646
Promoter ID:EPDNEW_M2274
Type:single initiation site
Name:Evx2_1
Description:Mus musculus even-skipped homeobox 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38274,659,595 - 74,659,655EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95462 AgrOrtholog
Ensembl Genes ENSMUSG00000001815 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000001867 ENTREZGENE
  ENSMUST00000001867.13 UniProtKB/TrEMBL
  ENSMUST00000173623.2 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14029 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95462 ENTREZGENE
NCBI Gene 14029 ENTREZGENE
PANTHER HOMEOBOX EVEN-SKIPPED HOMOLOG PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEGMENTATION PROTEIN EVEN-SKIPPED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Evx2 PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EVX2_MOUSE UniProtKB/Swiss-Prot
  G5E813 ENTREZGENE, UniProtKB/TrEMBL
  P49749 ENTREZGENE
  Q6P7W9_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-29 Evx2  even-skipped homeobox 2    even skipped homeotic gene 2 homolog  Symbol and/or name change 5135510 APPROVED