EVX2 (even-skipped homeobox 2) - Rat Genome Database

Name: EVX2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: EVX2 (even-skipped homeobox 2) Sus scrofa

Analyze

Symbol:

EVX2

Name:

even-skipped homeobox 2

RGD ID:

14260704

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); RNA polymerase II cis-regulatory region sequence-specific DNA binding (inferred); INVOLVED IN limb morphogenesis (ortholog); ASSOCIATED WITH genetic disease (ortholog); split hand-foot malformation 5 (ortholog); FOUND IN nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

homeobox even-skipped homolog protein 2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EVX2 (even-skipped homeobox 2)	HGNC	EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Evx2 (even-skipped homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Evx2 (even-skipped homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Evx2 (even-skipped homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EVX2 (even-skipped homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EVX2 (even-skipped homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Evx2 (even-skipped homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EVX2 (even-skipped homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Evx2 (even-skipped homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	81,881,362 - 81,885,193 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	81,881,362 - 81,884,994 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	91,345,989 - 91,354,707 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

split hand-foot malformation 5 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

limb morphogenesis (ISO)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IBA,IEA)

Cellular Component

nucleus (IBA,IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA)

sequence-specific double-stranded DNA binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

EVX2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	81,881,362 - 81,885,193 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	81,881,362 - 81,884,994 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	91,345,989 - 91,354,707 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EVX2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	176,077,472 - 176,083,962 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	176,077,472 - 176,083,962 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	176,942,200 - 176,948,690 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	176,653,081 - 176,656,936 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	170,553,985 - 170,557,840 (-)	NCBI		Celera
Cytogenetic Map	2	q31.1	NCBI
HuRef	2	168,822,321 - 168,826,177 (-)	NCBI		HuRef
CHM1_1	2	176,950,682 - 176,954,537 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	176,565,581 - 176,572,075 (-)	NCBI		T2T-CHM13v2.0

Evx2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	74,483,333 - 74,491,864 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	74,483,335 - 74,489,901 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	74,652,989 - 74,661,520 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	74,652,991 - 74,659,557 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	74,493,673 - 74,497,476 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	74,456,455 - 74,460,258 (-)	NCBI		MGSCv36	mm8
Celera	2	76,325,721 - 76,329,525 (-)	NCBI		Celera
Cytogenetic Map	2	C3	NCBI
cM Map	2	44.13	NCBI

Evx2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	79,965,630 - 79,969,700 (-)	NCBI		GRCr8
mRatBN7.2	3	59,558,197 - 59,562,267 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	59,558,197 - 59,561,872 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	3	61,564,917 - 61,581,598 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	61,578,229 - 61,581,598 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	68,032,231 - 68,048,055 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	57,262,625 - 57,274,916 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	57,166,866 - 57,172,821 (-)	NCBI
Celera	3	59,080,928 - 59,084,154 (-)	NCBI		Celera
Cytogenetic Map	3	q23	NCBI

Evx2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	20,578,813 - 20,582,409 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	20,578,813 - 20,582,409 (+)	NCBI	ChiLan1.0	ChiLan1.0

EVX2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	78,745,037 - 78,752,561 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	78,760,013 - 78,767,481 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	63,359,892 - 63,364,762 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	181,069,133 - 181,073,347 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

EVX2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	19,887,095 - 19,891,772 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	19,887,524 - 19,891,247 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	19,897,402 - 19,901,132 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	20,028,549 - 20,032,283 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	20,028,549 - 20,032,913 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	20,102,621 - 20,106,351 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	20,103,583 - 20,107,304 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	20,215,301 - 20,219,023 (-)	NCBI		UU_Cfam_GSD_1.0

Evx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	137,010,758 - 137,017,688 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936509	5,566,432 - 5,571,005 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936509	5,566,432 - 5,571,005 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EVX2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	61,650,763 - 61,659,724 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	61,654,829 - 61,658,494 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	137,951,216 - 137,955,814 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Evx2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624787	13,221,382 - 13,224,978 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624787	13,221,382 - 13,224,989 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in EVX2
46 total Variants

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021075278	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000100	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000028295 ⟹ ENSSSCP00000023174

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	15	81,881,362 - 81,885,193 (-)	Ensembl

RefSeq Acc Id:

XM_021075278 ⟹ XP_020930937

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	15	81,881,362 - 81,884,994 (-)	NCBI

Sequence:

show sequence

ATGATGGAAAGAATAAGAAAAGAGATGATTCTGATGGAGAGAGGGCTGCACAGCCCCACGGCCG
GCAAGAGGTTCTCCAATTTGTCCGACTCAGCTGGCAATGCTGTACTCGAGGCCCTGGAAAATTC
GCAGCACCCGGCTCGCCTCAGCCCTCGCCTGCCGTCCGCCCCCCTGCACAGCGCTCTGGGAGAC
CTCCCTGCCAAGGGCAAATTCGAAATAGACACTTTGTTCAACCTGCAGCACCCGGGCAGCGAAA
GCACCGTCTCCTCCGAAATTGCGTCCGCCGCGGAGGGCCGCAAAAAGCCGGGCCATTATTCAGA
GGCTGCCGCTGAGGCGGACATGAGCAGCGACGTGGAGGTGGGCTGCTCCGCGCTGCGCTCCCCC
GGCGGCCTCGGCGCCGCGCCGCTCAAGGAAAACAATGGCAAAGGGTACGCGGAGAGTGGCTCAG
CTGCGGGCACCACGACGTCTGCGTCGGGCTCTGGCCTCGGCAGCCTGCATGGAGGCGGTGGCAG
CGGAGGCAGCGGCGGGGGCCCGGCTCTGGGAGGCTCCGGCTCCGGCGCGGATCAGGTGCGGCGC
TACCGCACGGCGTTCACCCGAGAACAGATCGCGCGCCTGGAGAAGGAGTTCTACAGGGAGAACT
ATGTGTCGCGTCCCCGCCGGTGCGAGCTGGCTGCTGCGCTCAACCTGCCCGAAACCACTATCAA
GGTGTGGTTCCAGAACCGACGCATGAAGGACAAGCGGCAGCGCCTGGCCATGTCCTGGCCGCAC
CCGGCCGACCCCAGCTTCTATACCTACATGATGACGCACGCGGCCGCCACCGGAAGCCTGCCCT
ACCCCTTCCACTCGCACGTGCCGCTGCATTACTACCCGCACGTGGGTGTTACGGCTGCGGCCGC
GGCGGCTGCGGCCTCTGGCGCAGCCGCCGCGGCCTCATCGCCCTTCGCCACTTCTATCCGCCCG
CTGGACACCTTTCGCGCCCTCTCGCACCCCTACTCTCGGCCGGAGCTGCTGTGCAGCTTCCGAC
ACCCAGGCCTCTACCAGACGCCTGCGGCCGCCGCGGGGCTCAACAGCGCGGCCTCGGCCGCGGC
CGCGGCGGCGGCGGCTGCGGCCGCGGCCTCCTCGGCCGCGGCAGCCGGGGCGCCCCCCAGCGGC
GGCTCCGCGCCCTGCTCGTGCCTCAGTTGTCACAGCAGTCAATCCGCCGCGGCGGCAGCCGCGG
CCGCCGCCGCTGCTCTGGGGTCCCGGGGTGGCGGCGGGGGCGGCGGGGGTGGCGGCGGCGGCGC
GGGGGCCGCCGGAGGCTCGGACTTCGGCTGCAGCGCAGCGGCGCCGCGCTCTGAGAGCGGCTTC
CTGCCCTATTCAGCTGCTGTGCTTAGCAAGACCGCGGTGAGCCCGCCGGACCAGAGGGACGAGG
CGCCGCTCACTAGATAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_020930937	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000023174
	ENSSSCP00000023174.2
	ENSSSCP00025014366.1
	ENSSSCP00030037506.1
	ENSSSCP00035036770.1
	ENSSSCP00040006072.1
	ENSSSCP00045026428.1
	ENSSSCP00050003481.1
	ENSSSCP00055007168.1
	ENSSSCP00060036849.1
	ENSSSCP00065006013.1
	ENSSSCP00070028584.1

RefSeq Acc Id:

XP_020930937 ⟸ XM_021075278

- UniProtKB:

A0A4X1UJR8 (UniProtKB/TrEMBL), I3LGI0 (UniProtKB/TrEMBL), A0A8D0RKG7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MMERIRKEMILMERGLHSPTAGKRFSNLSDSAGNAVLEALENSQHPARLSPRLPSAPLHSALGD
LPAKGKFEIDTLFNLQHPGSESTVSSEIASAAEGRKKPGHYSEAAAEADMSSDVEVGCSALRSP
GGLGAAPLKENNGKGYAESGSAAGTTTSASGSGLGSLHGGGGSGGSGGGPALGGSGSGADQVRR
YRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMSWPH
PADPSFYTYMMTHAAATGSLPYPFHSHVPLHYYPHVGVTAAAAAAAASGAAAAASSPFATSIRP
LDTFRALSHPYSRPELLCSFRHPGLYQTPAAAAGLNSAASAAAAAAAAAAAASSAAAAGAPPSG
GSAPCSCLSCHSSQSAAAAAAAAAAALGSRGGGGGGGGGGGGAGAAGGSDFGCSAAAPRSESGF
LPYSAAVLSKTAVSPPDQRDEAPLTR

hide sequence

RefSeq Acc Id:

ENSSSCP00000023174 ⟸ ENSSSCT00000028295

Protein Domains

Homeobox

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000023146	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00025025529	UniProtKB/TrEMBL
	ENSSSCG00030058596	UniProtKB/TrEMBL
	ENSSSCG00035065367	UniProtKB/TrEMBL
	ENSSSCG00040011781	UniProtKB/TrEMBL
	ENSSSCG00045022281	UniProtKB/TrEMBL
	ENSSSCG00050006031	UniProtKB/TrEMBL
	ENSSSCG00055004601	UniProtKB/TrEMBL
	ENSSSCG00060062468	UniProtKB/TrEMBL
	ENSSSCG00065011114	UniProtKB/TrEMBL
	ENSSSCG00070017357	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000028295	ENTREZGENE
	ENSSSCT00000028295.3	UniProtKB/TrEMBL
	ENSSSCT00025034473.1	UniProtKB/TrEMBL
	ENSSSCT00030081758.1	UniProtKB/TrEMBL
	ENSSSCT00035088036.1	UniProtKB/TrEMBL
	ENSSSCT00040015453.1	UniProtKB/TrEMBL
	ENSSSCT00045038033.1	UniProtKB/TrEMBL
	ENSSSCT00050008188.1	UniProtKB/TrEMBL
	ENSSSCT00055009054.1	UniProtKB/TrEMBL
	ENSSSCT00060085184.1	UniProtKB/TrEMBL
	ENSSSCT00065014768.1	UniProtKB/TrEMBL
	ENSSSCT00070034225.1	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/TrEMBL
	Homeobox_metazoa	UniProtKB/TrEMBL
NCBI Gene	EVX2	ENTREZGENE
PANTHER	HOMEOBOX EVEN-SKIPPED HOMOLOG PROTEIN 2	UniProtKB/TrEMBL
	SEGMENTATION PROTEIN EVEN-SKIPPED	UniProtKB/TrEMBL
Pfam	Homeodomain	UniProtKB/TrEMBL
PRINTS	HOMEOBOX	UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
SMART	HOX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/TrEMBL
UniProt	A0A4X1UJR8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D0RKG7	ENTREZGENE, UniProtKB/TrEMBL
	I3LGI0	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:96290	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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