Klhl25 (kelch-like family member 25) - Rat Genome Database

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Gene: Klhl25 (kelch-like family member 25) Rattus norvegicus
Analyze
Symbol: Klhl25
Name: kelch-like family member 25
RGD ID: 1310815
Description: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; regulation of fatty acid metabolic process; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of Cul3-RING ubiquitin ligase complex. Orthologous to human KLHL25 (kelch like family member 25); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ectoderm-neural cortex protein 2; ENC-2; kelch-like 25; kelch-like 25 (Drosophila); kelch-like protein 25; LOC293023; MGC116251; RGD1310815; similar to hypothetical protein FLJ12587
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81139,134,655 - 139,159,898 (+)NCBIGRCr8
mRatBN7.21129,724,894 - 129,750,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1129,722,026 - 129,750,227 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1137,630,051 - 137,655,206 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01144,800,323 - 144,825,478 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01137,689,819 - 137,714,976 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01137,333,880 - 137,359,107 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1137,333,881 - 137,359,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01138,322,710 - 138,355,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41131,540,949 - 131,566,141 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11131,636,985 - 131,638,938 (+)NCBI
Celera1121,829,642 - 121,854,834 (+)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:22578813  


Genomics

Comparative Map Data
Klhl25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81139,134,655 - 139,159,898 (+)NCBIGRCr8
mRatBN7.21129,724,894 - 129,750,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1129,722,026 - 129,750,227 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1137,630,051 - 137,655,206 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01144,800,323 - 144,825,478 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01137,689,819 - 137,714,976 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01137,333,880 - 137,359,107 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1137,333,881 - 137,359,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01138,322,710 - 138,355,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41131,540,949 - 131,566,141 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11131,636,985 - 131,638,938 (+)NCBI
Celera1121,829,642 - 121,854,834 (+)NCBICelera
Cytogenetic Map1q31NCBI
KLHL25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381585,759,326 - 85,794,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1585,759,326 - 85,794,925 (-)EnsemblGRCh38hg38GRCh38
GRCh371586,302,557 - 86,338,156 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361584,103,561 - 84,139,193 (-)NCBINCBI36Build 36hg18NCBI36
Celera1562,702,507 - 62,738,117 (-)NCBICelera
Cytogenetic Map15q25.3NCBI
HuRef1562,365,689 - 62,401,305 (-)NCBIHuRef
CHM1_11586,144,000 - 86,179,590 (-)NCBICHM1_1
T2T-CHM13v2.01583,511,457 - 83,547,035 (-)NCBIT2T-CHM13v2.0
Klhl25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39775,498,086 - 75,523,881 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl775,498,058 - 75,523,879 (+)EnsemblGRCm39 Ensembl
GRCm38775,848,338 - 75,874,133 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl775,848,310 - 75,874,131 (+)EnsemblGRCm38mm10GRCm38
MGSCv37782,993,224 - 83,019,016 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36775,721,910 - 75,741,004 (+)NCBIMGSCv36mm8
Celera773,298,548 - 73,327,582 (+)NCBICelera
Cytogenetic Map7D1NCBI
cM Map743.81NCBI
Klhl25
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541618,965,966 - 18,991,099 (+)NCBIChiLan1.0ChiLan1.0
KLHL25
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21675,302,695 - 75,340,844 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11579,007,350 - 79,045,503 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01564,448,130 - 64,486,254 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11583,661,360 - 83,671,886 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1583,670,090 - 83,671,859 (-)Ensemblpanpan1.1panPan2
KLHL25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1349,339,576 - 49,375,473 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl349,348,982 - 49,351,663 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha351,978,492 - 52,014,269 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0349,760,167 - 49,795,982 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl349,760,169 - 49,795,968 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1349,258,177 - 49,293,852 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0349,486,578 - 49,522,306 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0349,832,848 - 49,868,610 (-)NCBIUU_Cfam_GSD_1.0
Klhl25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640134,301,314 - 134,334,028 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648312,000,514 - 12,009,705 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648312,001,111 - 12,033,158 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL25
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl788,262,385 - 88,264,691 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1788,249,009 - 88,291,958 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2794,609,175 - 94,657,162 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL25
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1294,376,292 - 4,412,778 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl294,385,011 - 4,386,780 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605942,604,595 - 42,640,945 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl25
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476813,110,912 - 13,121,206 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476813,112,589 - 13,134,855 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:226
Count of miRNA genes:150
Interacting mature miRNAs:181
Transcripts:ENSRNOT00000014553
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132889797152403053Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760602142582180Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1111404407142582336Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429152404087Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
RH138666  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21129,749,880 - 129,750,031 (-)MAPPERmRatBN7.2
mRatBN7.21129,629,953 - 129,630,104 (+)MAPPERmRatBN7.2
Rnor_6.01137,333,991 - 137,334,141NCBIRnor6.0
Rnor_6.01137,325,570 - 137,325,720NCBIRnor6.0
Rnor_5.01138,329,910 - 138,330,060UniSTSRnor5.0
Rnor_5.01138,322,821 - 138,322,971UniSTSRnor5.0
RGSC_v3.41131,370,820 - 131,370,970UniSTSRGSC3.4
RGSC_v3.41131,565,880 - 131,566,030UniSTSRGSC3.4
Celera1121,854,573 - 121,854,723UniSTS
Celera1121,737,771 - 121,737,921UniSTS
RH 3.4 Map11032.0UniSTS
Cytogenetic Map1q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000014553   ⟹   ENSRNOP00000014553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1129,724,856 - 129,750,227 (+)Ensembl
Rnor_6.0 Ensembl1137,333,881 - 137,359,072 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097328   ⟹   ENSRNOP00000089869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1129,730,573 - 129,750,227 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111640   ⟹   ENSRNOP00000097538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1129,722,026 - 129,750,227 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112874   ⟹   ENSRNOP00000090402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1129,731,036 - 129,750,227 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112989   ⟹   ENSRNOP00000091951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1129,735,457 - 129,746,366 (+)Ensembl
RefSeq Acc Id: NM_001039006   ⟹   NP_001034095
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81139,134,706 - 139,159,898 (+)NCBI
mRatBN7.21129,724,950 - 129,750,142 (+)NCBI
Rnor_6.01137,333,880 - 137,359,072 (-)NCBI
Rnor_5.01138,322,710 - 138,355,032 (-)NCBI
RGSC_v3.41131,540,949 - 131,566,141 (+)RGD
Celera1121,829,642 - 121,854,834 (+)RGD
Sequence:
RefSeq Acc Id: XM_006229380   ⟹   XP_006229442
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81139,145,157 - 139,159,898 (+)NCBI
mRatBN7.21129,735,417 - 129,750,142 (+)NCBI
Rnor_6.01137,333,880 - 137,352,882 (-)NCBI
Rnor_5.01138,322,710 - 138,355,032 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759505   ⟹   XP_008757727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81139,134,655 - 139,159,898 (+)NCBI
mRatBN7.21129,724,894 - 129,750,142 (+)NCBI
Rnor_6.01137,333,880 - 137,359,107 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063284515   ⟹   XP_063140585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81139,138,627 - 139,159,898 (+)NCBI
RefSeq Acc Id: NP_001034095   ⟸   NM_001039006
- UniProtKB: Q4KLM4 (UniProtKB/Swiss-Prot),   A6JC16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229442   ⟸   XM_006229380
- Peptide Label: isoform X1
- UniProtKB: Q4KLM4 (UniProtKB/Swiss-Prot),   A6JC16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757727   ⟸   XM_008759505
- Peptide Label: isoform X1
- UniProtKB: Q4KLM4 (UniProtKB/Swiss-Prot),   A6JC16 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014553   ⟸   ENSRNOT00000014553
Ensembl Acc Id: ENSRNOP00000089869   ⟸   ENSRNOT00000097328
Ensembl Acc Id: ENSRNOP00000097538   ⟸   ENSRNOT00000111640
Ensembl Acc Id: ENSRNOP00000090402   ⟸   ENSRNOT00000112874
Ensembl Acc Id: ENSRNOP00000091951   ⟸   ENSRNOT00000112989
RefSeq Acc Id: XP_063140585   ⟸   XM_063284515
- Peptide Label: isoform X1
- UniProtKB: Q4KLM4 (UniProtKB/Swiss-Prot),   A6JC16 (UniProtKB/TrEMBL)
Protein Domains
BACK   BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KLM4-F1-model_v2 AlphaFold Q4KLM4 1-589 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690119
Promoter ID:EPDNEW_R644
Type:initiation region
Name:Klhl25_1
Description:kelch-like family member 25
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01137,359,091 - 137,359,151EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310815 AgrOrtholog
BioCyc Gene G2FUF-58861 BioCyc
Ensembl Genes ENSRNOG00000010959 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014553.5 UniProtKB/Swiss-Prot
  ENSRNOT00000097328.1 UniProtKB/Swiss-Prot
  ENSRNOT00000111640.1 UniProtKB/Swiss-Prot
  ENSRNOT00000112874.1 UniProtKB/Swiss-Prot
  ENSRNOT00000112989.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.420 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7461562 IMAGE-MGC_LOAD
InterPro BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KLHL25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:293023 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:116251 IMAGE-MGC_LOAD
NCBI Gene 293023 ENTREZGENE
PANTHER ACTIN-BINDING PROTEIN IPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KELCH PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klhl25 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010959 RatGTEx
SMART BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Kelch motif UniProtKB/TrEMBL
  POZ domain UniProtKB/TrEMBL
  SSF117281 UniProtKB/Swiss-Prot
  SSF54695 UniProtKB/Swiss-Prot
UniProt A6JC16 ENTREZGENE, UniProtKB/TrEMBL
  KLH25_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-27 Klhl25  kelch-like family member 25  Klhl25  kelch-like 25 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Klhl25  kelch-like 25 (Drosophila)  RGD1310815  similar to hypothetical protein FLJ12587  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1310815  similar to hypothetical protein FLJ12587  RGD1310815_predicted  similar to hypothetical protein FLJ12587 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310815_predicted  similar to hypothetical protein FLJ12587 (predicted)  LOC293023_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC293023_predicted  similar to hypothetical protein FLJ12587 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL