Rnls (renalase, FAD-dependent amine oxidase)

Gene: Rnls (renalase, FAD-dependent amine oxidase) Rattus norvegicus

Analyze

Symbol:

Rnls

Name:

renalase, FAD-dependent amine oxidase

RGD ID:

1309804

Description:

Predicted to enable several functions, including NADH binding activity; epinephrine binding activity; and monoamine oxidase activity. Involved in several processes, including response to epinephrine; response to ischemia; and response to salt. Located in extracellular space. Biomarker of chronic kidney disease; congestive heart failure; glomerulosclerosis; and interstitial nephritis. Human ortholog(s) of this gene implicated in essential hypertension and hypertension. Orthologous to human RNLS (renalase, FAD dependent amine oxidase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

alpha-NAD(P)H oxidase/anomerase; LOC361751; MAO-C; monoamine oxidase-C; renalase; RGD1309804; similar to hypothetical protein FLJ11218

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	240,450,702 - 240,723,472 (-)	NCBI		GRCr8
mRatBN7.2	1	231,037,481 - 231,309,855 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	231,037,486 - 231,309,823 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	239,414,353 - 239,688,126 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	246,344,061 - 246,617,558 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	239,182,149 - 239,455,647 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	251,828,285 - 252,101,963 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	251,828,290 - 252,100,759 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	259,052,388 - 259,324,901 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	237,364,578 - 237,639,800 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	237,528,600 - 237,803,823 (-)	NCBI
Celera	1	228,151,441 - 228,423,443 (-)	NCBI		Celera
Cytogenetic Map	1	q52	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autoimmune lymphoproliferative syndrome (ISO)

chronic kidney disease (IEP)

congestive heart failure (IEP)

end stage renal disease (ISO)

essential hypertension (ISO)

Familial Prostate Cancer (ISO)

glomerulosclerosis (IEP)

hypertension (ISO)

interstitial nephritis (IEP)

Kidney Reperfusion Injury (ISO)

Myocardial Reperfusion Injury (ISO)

PTEN hamartoma tumor syndrome (ISO)

Stroke (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

cantharidin (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

diuron (EXP)

dorsomorphin (ISO)

fulvestrant (ISO)

gentamycin (EXP)

glyphosate (EXP)

indometacin (ISO)

ketamine (EXP)

N,N-diethyl-m-toluamide (EXP)

nickel sulfate (ISO)

O-methyleugenol (ISO)

ozone (ISO)

permethrin (EXP)

pirinixic acid (ISO)

rotenone (EXP)

SB 431542 (ISO)

sodium fluoride (ISO)

sunitinib (ISO)

testosterone (ISO)

tetrachloroethene (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

tolcapone (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cardiac left ventricle morphogenesis (ISO)

dopamine metabolic process (ISO)

epinephrine metabolic process (ISO)

heart contraction (ISO)

negative regulation of blood pressure (ISO)

negative regulation of heart rate (ISO)

norepinephrine metabolic process (ISO)

phosphate ion homeostasis (ISO)

regulation of systemic arterial blood pressure (ISO)

response to catecholamine (IEP)

response to epinephrine (IEP)

response to ischemia (IEP)

response to norepinephrine (ISO)

response to salt (IDA)

Cellular Component

extracellular region (IBA,ISO)

extracellular space (IDA)

Molecular Function

epinephrine binding (ISO)

monoamine oxidase activity (ISO)

NADH binding (ISO)

oxidoreductase activity (ISO)

oxidoreductase activity, acting on NAD(P)H (IBA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Renalase gene polymorphisms in patients with type 2 diabetes, hypertension and stroke.	Buraczynska M, etal., Neuromolecular Med. 2011 Dec;13(4):321-7. doi: 10.1007/s12017-011-8158-6. Epub 2011 Oct 2.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Renalase deficiency in heart failure model of rats--a potential mechanism underlying circulating norepinephrine accumulation.	Gu R, etal., PLoS One. 2011 Jan 31;6(1):e14633. doi: 10.1371/journal.pone.0014633.
4.	Lisinopril Protects Against the Adriamycin Nephropathy and Reverses the Renalase Reduction: Potential Role of Renalase in Adriamycin Nephropathy.	Han P, etal., Kidney Blood Press Res. 2013 Sep 5;37(4-5):295-304.
5.	Renalase protects against ischemic AKI.	Lee HT, etal., J Am Soc Nephrol. 2013 Feb;24(3):445-55. doi: 10.1681/ASN.2012090943. Epub 2013 Feb 7.
6.	Catecholamines regulate the activity, secretion, and synthesis of renalase.	Li G, etal., Circulation. 2008 Mar 11;117(10):1277-82. doi: 10.1161/CIRCULATIONAHA.107.732032. Epub 2008 Feb 25.
7.	Sodium-dependent modulation of systemic and urinary renalase expression and activity in the rat remnant kidney.	Quelhas-Santos J, etal., J Hypertens. 2013 Mar;31(3):543-52; discussion 552-3. doi: 10.1097/HJH.0b013e32835d6e34.
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Polymorphism of the renalase gene in end-stage renal disease patients affected by hypertension.	Stec A, etal., Nephrol Dial Transplant. 2012 Nov;27(11):4162-6. doi: 10.1093/ndt/gfr293. Epub 2011 May 26.
12.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13.	Renalase deficiency aggravates ischemic myocardial damage.	Wu Y, etal., Kidney Int. 2011 Apr;79(8):853-60. doi: 10.1038/ki.2010.488. Epub 2010 Dec 22.
14.	Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure.	Xu J, etal., J Clin Invest. 2005 May;115(5):1275-80. Epub 2005 Apr 7.
15.	Renalase gene is a novel susceptibility gene for essential hypertension: a two-stage association study in northern Han Chinese population.	Zhao Q, etal., J Mol Med (Berl). 2007 Aug;85(8):877-85. Epub 2007 Jan 10.

Additional References at PubMed

PMID:15489334	PMID:17565281	PMID:23863468	PMID:23964689	PMID:24113803	PMID:24366404	PMID:25531177	PMID:25781495	PMID:32053739	PMID:37732586	PMID:38512760

Genomics

Comparative Map Data

Rnls
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	240,450,702 - 240,723,472 (-)	NCBI		GRCr8
mRatBN7.2	1	231,037,481 - 231,309,855 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	231,037,486 - 231,309,823 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	239,414,353 - 239,688,126 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	246,344,061 - 246,617,558 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	239,182,149 - 239,455,647 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	251,828,285 - 252,101,963 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	251,828,290 - 252,100,759 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	259,052,388 - 259,324,901 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	237,364,578 - 237,639,800 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	237,528,600 - 237,803,823 (-)	NCBI
Celera	1	228,151,441 - 228,423,443 (-)	NCBI		Celera
Cytogenetic Map	1	q52	NCBI

RNLS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	88,171,523 - 88,583,318 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	88,273,864 - 88,584,530 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	90,033,619 - 90,343,075 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	90,023,601 - 90,332,988 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	90,023,600 - 90,332,988	NCBI
Celera	10	83,780,492 - 84,089,897 (-)	NCBI		Celera
Cytogenetic Map	10	q23.31	NCBI
HuRef	10	83,668,375 - 83,977,653 (-)	NCBI		HuRef
CHM1_1	10	90,315,752 - 90,625,158 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	89,050,656 - 89,467,392 (-)	NCBI		T2T-CHM13v2.0

Rnls
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	33,115,140 - 33,369,695 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	33,115,147 - 33,369,665 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	33,137,740 - 33,392,295 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	33,137,747 - 33,392,295 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	33,212,234 - 33,466,785 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	33,203,744 - 33,458,836 (-)	NCBI		MGSCv36	mm8
Celera	19	33,919,313 - 34,173,994 (-)	NCBI		Celera
Cytogenetic Map	19	C1	NCBI
cM Map	19	29.08	NCBI

Rnls
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955425	4,368,620 - 4,667,947 (+)	NCBI	ChiLan1.0	ChiLan1.0

RNLS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	100,195,947 - 100,598,256 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	100,201,262 - 100,603,822 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	84,996,999 - 85,304,240 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	88,502,588 - 88,809,439 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	88,503,683 - 88,808,990 (-)	Ensembl	panpan1.1		panPan2

RNLS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	38,137,662 - 38,413,666 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	38,083,371 - 38,414,033 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	37,955,732 - 38,233,014 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	39,670,571 - 40,000,185 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	39,702,516 - 40,000,302 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	37,574,898 - 37,840,447 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	37,159,099 - 37,435,881 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	38,428,192 - 38,705,871 (-)	NCBI		UU_Cfam_GSD_1.0

Rnls
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	77,744,737 - 78,131,700 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936735	659,826 - 1,048,135 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RNLS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	100,317,625 - 100,605,063 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	100,312,592 - 100,604,953 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	109,298,823 - 109,589,104 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RNLS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	81,725,115 - 82,029,361 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666048	42,407,027 - 42,707,316 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rnls
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624791	14,542,625 - 14,873,393 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rnls
1239 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	198
Count of miRNA genes:	142
Interacting mature miRNAs:	152
Transcripts:	ENSRNOT00000028098
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	197814409	242814409	Rat
2302375	Bw83	Body weight QTL 83	4.87	0.0002	body mass (VT:0001259)	body weight (CMO:0000012)	1	197697768	242697768	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	201554356	246554356	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
61455	Niddm7	Non-insulin dependent diabetes mellitus QTL 7	5.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	214537555	238757011	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	216255568	260522016	Rat
1600392	Bw123	Body weight QTL 123		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	223201027	260522016	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	195804352	257091168	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	206081677	251081677	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	201554356	246554356	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
1300108	Rf8	Renal function QTL 8	3.75		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	1	228581588	259647894	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	183970203	243914901	Rat
734767	Niddm57	Non-insulin dependent diabetes mellitus QTL 57			body mass (VT:0001259)	body weight (CMO:0000012)	1	224054293	260122809	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	191019702	246062233	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	225126575	260522016	Rat
631843	Bw116	Body weight QTL 116	4.1	0.016	abdominal adipose amount (VT:1000220)	abdominal fat pad weight (CMO:0000088)	1	224054293	260122809	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	201554356	246554356	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	221264111	259647894	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
724538	Kidm1	Kidney mass QTL 1	3.2		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	213707201	252085212	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	201554356	246554356	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	197814409	242814409	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	193113876	238113876	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	224569538	260122809	Rat
734768	Niddm59	Non-insulin dependent diabetes mellitus QTL 59			body mass (VT:0001259)	body weight (CMO:0000012)	1	213843987	258843987	Rat
1358890	Bp259	Blood pressure QTL 259	3.06		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	210702053	260522016	Rat
724533	Rf51	Renal function QTL 51	5.3	0.0002	kidney plasma flow trait (VT:0005524)	renal plasma flow (CMO:0001914)	1	218753816	256448513	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	8e-07	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	196248093	241248093	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	197814409	242814409	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	199050459	259647894	Rat
1549910	Bw54	Body weight QTL 54		0.05	body mass (VT:0001259)	body weight (CMO:0000012)	1	214647894	259647894	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	214647894	259647894	Rat
1357399	Bw45	Body weight QTL 45	3.05		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	1	206329708	251329708	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	222363780	260522016	Rat
2316896	Gluco57	Glucose level QTL 57	7.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	228985440	245907899	Rat
1357404	Bw42	Body weight QTL 42	4.49	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	1	206329708	251329708	Rat
10053715	Scort24	Serum corticosterone level QTL 24	2.13	0.0088	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	221414816	260522016	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
1358916	Kidm22	Kidney mass QTL 22	3.32		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	210702053	240947965	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	185356336	231689108	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	178810256	240830002	Rat
61400	Niddm1	Non-insulin dependent diabetes mellitus QTL 1	11		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	218753689	245907899	Rat
10059587	Bw173	Body weight QTL 173	3.23	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	1	202069611	247069611	Rat
2292216	Bw80	Body weight QTL 80	3.23	0.0019	body mass (VT:0001259)	body weight (CMO:0000012)	1	213533809	243914901	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	243914901	Rat
10059590	Kidm44	Kidney mass QTL 44	3.42	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	191033875	236033875	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	197697768	238755659	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	196248093	241248093	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
2293700	Bmd27	Bone mineral density QTL 27	6.6	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	224054293	243747962	Rat
2293701	Bmd34	Bone mineral density QTL 34	8.3	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	1	224054293	243747962	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	183970203	243914901	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	197670404	242670404	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	203995416	244113296	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
1358191	Ept10	Estrogen-induced pituitary tumorigenesis QTL 10	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	192825253	243914732	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	216255568	260522016	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	201554356	246554356	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	218748008	257976495	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1		15	15		15				9	8
Low	2	43	42	26	19	26	8	11	74	26	33	11	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001014167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001399688	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006231294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084508	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005489056	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010055152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC123495	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC128595	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085833	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000028098 ⟹ ENSRNOP00000028098

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	231,037,486 - 231,309,823 (-)	Ensembl
Rnor_6.0 Ensembl	1	251,828,290 - 252,100,759 (-)	Ensembl

RefSeq Acc Id:

NM_001014167 ⟹ NP_001014189

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	240,450,702 - 240,723,043 (-)	NCBI
mRatBN7.2	1	231,037,481 - 231,309,825 (-)	NCBI
Rnor_6.0	1	251,828,290 - 252,100,759 (-)	NCBI
Rnor_5.0	1	259,052,388 - 259,324,901 (-)	NCBI
RGSC_v3.4	1	237,364,578 - 237,639,800 (-)	RGD
Celera	1	228,151,441 - 228,423,443 (-)	RGD

Sequence:

show sequence

GGGCTGATGGGATTGGGGCTCACCCTGTAGGCAAGCTGCTCTGTGGAGGCTGGGGCAGGCCCTT
CTCTGGGTTTGAGTCACCACTGCAGGGTTCCCCGCCCTCTCAGGAGCAGATGTCCCGCCCAGGG
CACGGCCCTGACCCTCGCGGGGACACGGTGGCTGAGTAGGCTAGCGCCTCTCTGAGCCTCTGCC
AGCGGCCTAGCTGAAGGCCCGCCGCCATGTTCCGGGTACTGGTGGTGGGCGCCGGGCTAACCGG
AAGTTTGTGTGCCGCGCTGCTGAGGAAGGAGATAACCGCTCCCCTGTACCTCGCCCTGTGGGAC
AAGGCTGGGGACATAGGGGGAAGAATGACTACTGCCAACAGTCCTCATAATCCCCGATGCACGG
CTGACTTGGGAGCTCAGTACATCACCTGTACTCCTCATTATGCCAAAAAGCACCAAAATTTTTA
TGAGGAGCTTTTAGCTCATGGGATTTTGGAGCCTCTGACGTCTCCCATTAAAGGAATGGAAGTG
AAGGAAGGAGAAAGCAACTTTGTGGCACCTCACGGCGTTTCTTCCATTATCAAGTACTACTTGA
AAGAATCAGGTGCTGAAGTCTTCCTCAGGCAGTGTGTGACTCAGATCAATCTAAGAGATAACAA
GTGGGAAGTCTCTGAGGACACCGGCTCCACCCAGCAGTTTGACCTTGTCATCCTTACCATGCCA
GCTCCTCAGATTCTGGGTCTTCAAGGTGACATTGTGAACTTAATTAGTGAACGCCAGAGGCAGC
AACTGGCATCTGTGAGCTACTCCTCTCGCTATGCTCTGGGCCTCTTTTATGAAGCAGGCATGAA
GATTGATGTCCCTTGGGCTGGCCAGTACATCACCAGTAATCCCTGCATACGCTTCATCTCCATT
GACAGTAAGAAGCGCAACACAGAGTCATCAGAATGTGGCCCATTGCTGGTGGTCCATACCACCG
TCCCATTTGGAGTCACACACTTGGAGCACAGTGAGGAGGATGTGCAGGAGTTAATCACCCAGCA
ACTGGAAACCATTCTGCCGGGCTTGCCGCCGCCAGTTGCTACCAAATGCTGGAAGTGGAGATAT
TCACAGGTTACAAACTCAGCTGCCAACAGTCCCGGCCAGATGACTCTTCATCTCAACCCTTTCC
TGATATACATCTGAAGTCATTGGACAGAAAATGTCTCGAACCTTTATGAACAATGGAATACTTA
TATCCTACAAGGGAGGGAAAAAACTTGTAAAGAGGGAGATGGGTTAGTAGTGGAATCATTCTTG
CAAGACATTCCTAAGATATTTCATAGCTGTTCATTCTAAGCATATTATTCTACAATTTTGTTAA
GATGTTCCAATGTGAGCAGAGACTCCATCCTCCTCAGAACCGAGATCATTGTCACCTCACTGTT
TCAGTCATGCTGAAGACCCCTGCTGCATTTGAACTTCCACCTGCTTCTTCCCCTTTCGAAGAAA
TAGCTAAGGAAGTCCATGTTCTAGTAGCTATTGGAAGGATGCTATAAAAGACTGCAGGGCAAAG
AAGTCCACCATTACCCCCTCAGGAAGATGGGAGTCAACCAAGCTTAAAACAGTGCTGGGGTGCA
CGTCTACTTCACAAGACCACACATTGCCACCGTATTTCCAAGTGAGGACTTTTATTAGTCAAGC
CAGGCAGGGAAAGCTGCTGTGTTTTGAAAGGAGCATATTCAAGTGAGAAACGGCTTGAGCAGTG
GGGTGATTTAATACTTGTTAGCTGATAAATATAGCCTTTGCCAGAATAAACCTTTATGATGCCC
GTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001399688 ⟹ NP_001386617

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	240,454,579 - 240,723,043 (-)	NCBI
mRatBN7.2	1	231,041,358 - 231,309,825 (-)	NCBI

RefSeq Acc Id:

XM_006231294 ⟹ XP_006231356

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	240,450,702 - 240,723,472 (-)	NCBI
mRatBN7.2	1	231,037,481 - 231,309,855 (-)	NCBI
Rnor_6.0	1	251,828,285 - 252,101,963 (-)	NCBI
Rnor_5.0	1	259,052,388 - 259,324,901 (-)	NCBI

Sequence:

show sequence

CTAGAAAGAAGTTTTCCAAGCAAAAGGGTCCCAAGAAACAAGCTGGAGTCACCATCCTAATATC
CAATAAAATACACATTCAACCAAAGTTAATTAAAATAGATGGGGAAGGACACTTCATACCCATC
AAAGGAAAAATTCACCAAGATCAAGTCTCAAACTTGTACATCTATGCCCTGGATGCAAGGGCAC
CCACATTCGTGAAAGAAACTTGACTAAAGCTCAAATACACATTGAACCTCATACAATAATAGTG
GGGGTCTTCAATACCCCACTTGCACCAATGGATAGGTCATTAAAATAAAAACTAAACAGAGACA
CAGTGAAAGTAACAGAAGTTTGGATCAAATGGATTTAACAGATATCTATAGAACATTTCATCCC
ACAACCAAAAAATAAATAAATAAATAAAACCCTGTTCTCATCACCTCATGGAACCTTCTCAAAA
ACTGACCATGTACTTGAACACAAAACAAGTTTCAACATACACAAGGAGATTGTTATAATCCCAT
GCATTCTATAAGATCCCCAGGGACTACAGCTGGACTTCAATAACAACAAAAGCAACAGAAAGCC
CACATACTCATGGAAACTGAACGACTCTCTAAAAATAATCTTTATGCATTCACTGCTTTTCCTA
TTCTTTGACTGCCATGCTTACACGTCTTCTTAGGGTTTTCCTCAACCTCTTAGATAAACAAAAA
CTGATCAAGCAAAAAGTTGATGATGGGAATTTTTGTCACCAGGAGACATTAAGCAAAACTTGAC
TTTTTTAAATGTTTTTATTATTGGCTACTATTGTCAAGGTTCCACGGCATTTTCCAGGTAATTA
TTTTTAGTGGCTCCCATTTTTCATTGCTTTTGTTGTTTTATTGAGAACTTCTCAGACAAAGTTG
AAGACGGCAATGGTGATGGCAGATTCGATTTCACAGAATATCCCTTGGTTCACAGTGAACCCAT
TTTTGACTCAGAAGTTAGCATTTGTGGCTAGAGTAAGTGATCCAAAATTTCCTGGTGACTCAAA
TGTCTGTATTCTACACAACTTTGGAAAGGATGTATTATTTTACACTTCAAAACCCCTGCCACCT
GAAGTGGCCTATAAAACCCCAGATGAACTCCAGTTGTGCCATTGCTGCTGTCTCCTCTCCTCAC
TTCAGTCATCCTCCTGAGGCCAGCTTGCTGTGACTTTCTGATTTTCCTCCAGGGGCTGATGGGA
TTGGGGCTCACCCTGTAGGCAAGCTGCTCTGTGGAGGCTGGGGCAGGCCCTTCTCTGGGTTTGA
GTCACCACTGCAGGGTTCCCCGCCCTCTCAGGAGCAGATGTCCCGCCCAGGGCACGGCCCTGAC
CCTCGCGGGGACACGGTGGCTGAGTAGGCTAGCGCCTCTCTGAGCCTCTGCCAGCGGCCTAGCT
GAAGGCCCGCCGCCATGTTCCGGGTACTGGTGGTGGGCGCCGGGCTAACCGGAAGTTTGTGTGC
CGCGCTGCTGAGGAAGGAGATAACCGCTCCCCTGTACCTCGCCCTGTGGGACAAGGCTGGGGAC
ATAGGGGGAAGAATGACTACTGCCAACAGTCCTCATAATCCCCGATGCACGGCTGACTTGGGAG
CTCAGTACATCACCTGTACTCCTCATTATGCCAAAAAGCACCAAAATTTTTATGAGGAGCTTTT
AGCTCATGGGATTTTGGAGCCTCTGACGTCTCCCATTAAAGGAATGGAAGTGAAGGAAGGAGAA
AGCAACTTTGTGGCACCTCACGGCGTTTCTTCCATTATCAAGTACTACTTGAAAGAATCAGGTG
CTGAAGTCTTCCTCAGGCAGTGTGTGACTCAGATCAATCTAAGAGATAACAAGTGGGAAGTCTC
TGAGGACACCGGCTCCACCCAGCAGTTTGACCTTGTCATCCTTACCATGCCAGCTCCTCAGATT
CTGGGTCTTCAAGGTGACATTGTGAACTTAATTAGTGAACGCCAGAGGCAGCAACTGGCATCTG
TGAGCTACTCCTCTCGCTATGCTCTGGGCCTCTTTTATGAAGCAGGCATGAAGATTGATGTCCC
TTGGGCTGGCCAGTACATCACCAGTAATCCCTGCATACGCTTCATCTCCATTGACAGTAAGAAG
CGCAACACAGAGTCATCAGAATGTGGCCCATTGCTGGTGGTCCATACCACCGTCCCATTTGGAG
TCACACACTTGGAGCACAGTGAGGAGGATGTGCAGGAGTTAATCACCCAGCAACTGGAAACCAT
TCTGCCGGGCTTGCCGCCGCCAGTTGCTACCAAATGCTGGAAGTGGAGATATTCACAGGTTACA
AACTCAGCTGCCAACAGTCCCGGCCAGATGACTCTTCATCTCAACCCTTTCCTGGTGTGTGGAG
GGGATGGATTCACTCACTCCAACTTCGATGGCTGCGTTGCCTCTGCCCTGAGTGTCGTGGAAGC
TTTAAAGAGTTATATTTAGTATATACATCTGAAGTCATTGGACAGAAAATGTCTCGAACCTTTA
TGAACAATGGAATACTTATATCCTACAAGGGAGGGAAAAAACTTGTAAAGAGGGAGATGGGTTA
GTAGTGGAATCATTCTTGCAAGACATTCCTAAGATATTTCATAGCTGTTCATTCTAAGCATATT
ATTCTACAATTTTGTTAAGATGTTCCAATGTGAGCAGAGACTCCATCCTCCTCAGAACCGAGAT
CATTGTCACCTCACTGTTTCAGTCATGCTGAAGACCCCTGCTGCATTTGAACTTCCACCTGCTT
CTTCCCCTTTCGAAGAAATAGCTAAGGAAGTCCATGTTCTAGTAGCTATTGGAAGGATGCTATA
AAAGACTGCAGGGCAAAGAAGTCCACCATTACCCCCTCAGGAAGATGGGAGTCAACCAAGCTTA
AAACAGTGCTGGGGTGCACGTCTACTTCACAAGACCACACATTGCCACCGTATTTCCAAGTGAG
GACTTTTATTAGTCAAGCCAGGCAGGGAAAGCTGCTGTGTTTTGAAAGGAGCATATTCAAGTGA
GAAACGGCTTGAGCAGTGGGGTGATTTAATACTTGTTAGCTGATAAATATAGCCTTTGCCAGAA
TAAACCTTTATGATGCCCGTTGAAAA

hide sequence

RefSeq Acc Id:

XM_039084508 ⟹ XP_038940436

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	240,518,466 - 240,723,472 (-)	NCBI
mRatBN7.2	1	231,104,157 - 231,309,852 (-)	NCBI

RefSeq Acc Id:

XR_005489056

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	240,486,808 - 240,723,472 (-)	NCBI
mRatBN7.2	1	231,073,594 - 231,309,853 (-)	NCBI

RefSeq Acc Id:

XR_010055152

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	240,454,746 - 240,723,472 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001014189	(Get FASTA)	NCBI Sequence Viewer
	NP_001386617	(Get FASTA)	NCBI Sequence Viewer
	XP_006231356	(Get FASTA)	NCBI Sequence Viewer
	XP_038940436	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85833	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000028098.5
GenBank Protein	Q5U2W9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001014189 ⟸ NM_001014167
- Peptide Label:	isoform 2 precursor
- UniProtKB:	Q5U2W9 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MFRVLVVGAGLTGSLCAALLRKEITAPLYLALWDKAGDIGGRMTTANSPHNPRCTADLGAQYIT CTPHYAKKHQNFYEELLAHGILEPLTSPIKGMEVKEGESNFVAPHGVSSIIKYYLKESGAEVFL RQCVTQINLRDNKWEVSEDTGSTQQFDLVILTMPAPQILGLQGDIVNLISERQRQQLASVSYSS RYALGLFYEAGMKIDVPWAGQYITSNPCIRFISIDSKKRNTESSECGPLLVVHTTVPFGVTHLE HSEEDVQELITQQLETILPGLPPPVATKCWKWRYSQVTNSAANSPGQMTLHLNPFLIYI hide sequence

RefSeq Acc Id:

XP_006231356 ⟸ XM_006231294

- Peptide Label:

isoform X1

- Sequence:

show sequence

MFRVLVVGAGLTGSLCAALLRKEITAPLYLALWDKAGDIGGRMTTANSPHNPRCTADLGAQYIT
CTPHYAKKHQNFYEELLAHGILEPLTSPIKGMEVKEGESNFVAPHGVSSIIKYYLKESGAEVFL
RQCVTQINLRDNKWEVSEDTGSTQQFDLVILTMPAPQILGLQGDIVNLISERQRQQLASVSYSS
RYALGLFYEAGMKIDVPWAGQYITSNPCIRFISIDSKKRNTESSECGPLLVVHTTVPFGVTHLE
HSEEDVQELITQQLETILPGLPPPVATKCWKWRYSQVTNSAANSPGQMTLHLNPFLVCGGDGFT
HSNFDGCVASALSVVEALKSYI

hide sequence

Ensembl Acc Id:

ENSRNOP00000028098 ⟸ ENSRNOT00000028098

RefSeq Acc Id:	XP_038940436 ⟸ XM_039084508
- Peptide Label:	isoform X2

RefSeq Acc Id:	NP_001386617 ⟸ NM_001399688
- Peptide Label:	isoform 1 precursor

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5U2W9-F1-model_v2	AlphaFold	Q5U2W9	1-315	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690860

Promoter ID:

EPDNEW_R1385

Type:

initiation region

Name:

Rnls_1

Description:

renalase, FAD-dependent amine oxidase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	252,100,578 - 252,100,638	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309804	AgrOrtholog
BioCyc Gene	G2FUF-55895	BioCyc
Ensembl Genes	ENSRNOG00000020705	Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000028098.6	UniProtKB/Swiss-Prot
Gene3D-CATH	3.50.50.60	UniProtKB/Swiss-Prot
	3.90.660.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7134816	IMAGE-MGC_LOAD
InterPro	Amino_oxidase	UniProtKB/Swiss-Prot
	FAD/NAD-bd_sf	UniProtKB/Swiss-Prot
	RNLS	UniProtKB/Swiss-Prot
KEGG Report	rno:361751	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94458	IMAGE-MGC_LOAD
NCBI Gene	361751	ENTREZGENE
PANTHER	PTHR23357	UniProtKB/Swiss-Prot
	RENALASE	UniProtKB/Swiss-Prot
Pfam	Amino_oxidase	UniProtKB/Swiss-Prot
	NAD_binding_8	UniProtKB/Swiss-Prot
PhenoGen	Rnls	PhenoGen
RatGTEx	ENSRNOG00000020705	RatGTEx
Superfamily-SCOP	SSF51905	UniProtKB/Swiss-Prot
UniProt	Q5U2W9	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-04-23	Rnls	renalase, FAD-dependent amine oxidase	RGD1309804	similar to hypothetical protein FLJ11218	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1309804	similar to hypothetical protein FLJ11218	RGD1309804_predicted	similar to hypothetical protein FLJ11218 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1309804_predicted	similar to hypothetical protein FLJ11218 (predicted)	LOC361751_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC361751_predicted	similar to hypothetical protein FLJ11218 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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