Rnls (renalase, FAD-dependent amine oxidase) - Rat Genome Database

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Gene: Rnls (renalase, FAD-dependent amine oxidase) Rattus norvegicus
Analyze
Symbol: Rnls
Name: renalase, FAD-dependent amine oxidase
RGD ID: 1309804
Description: Predicted to enable several functions, including NADH binding activity; epinephrine binding activity; and monoamine oxidase activity. Involved in response to epinephrine; response to ischemia; and response to salt. Located in extracellular space. Biomarker of chronic kidney disease; congestive heart failure; glomerulosclerosis; and interstitial nephritis. Human ortholog(s) of this gene implicated in essential hypertension and hypertension. Orthologous to human RNLS (renalase, FAD dependent amine oxidase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-NAD(P)H oxidase/anomerase; LOC361751; MAO-C; monoamine oxidase-C; renalase; RGD1309804; similar to hypothetical protein FLJ11218
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21231,037,481 - 231,309,855 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,037,486 - 231,309,823 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1239,414,353 - 239,688,126 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01246,344,061 - 246,617,558 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01239,182,149 - 239,455,647 (-)NCBIRnor_WKY
Rnor_6.01251,828,285 - 252,101,963 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,828,290 - 252,100,759 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01259,052,388 - 259,324,901 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41237,364,578 - 237,639,800 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11237,528,600 - 237,803,823 (-)NCBI
Celera1228,151,441 - 228,423,443 (-)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Renalase gene polymorphisms in patients with type 2 diabetes, hypertension and stroke. Buraczynska M, etal., Neuromolecular Med. 2011 Dec;13(4):321-7. doi: 10.1007/s12017-011-8158-6. Epub 2011 Oct 2.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Renalase deficiency in heart failure model of rats--a potential mechanism underlying circulating norepinephrine accumulation. Gu R, etal., PLoS One. 2011 Jan 31;6(1):e14633. doi: 10.1371/journal.pone.0014633.
4. Lisinopril Protects Against the Adriamycin Nephropathy and Reverses the Renalase Reduction: Potential Role of Renalase in Adriamycin Nephropathy. Han P, etal., Kidney Blood Press Res. 2013 Sep 5;37(4-5):295-304.
5. Renalase protects against ischemic AKI. Lee HT, etal., J Am Soc Nephrol. 2013 Feb;24(3):445-55. doi: 10.1681/ASN.2012090943. Epub 2013 Feb 7.
6. Catecholamines regulate the activity, secretion, and synthesis of renalase. Li G, etal., Circulation. 2008 Mar 11;117(10):1277-82. doi: 10.1161/CIRCULATIONAHA.107.732032. Epub 2008 Feb 25.
7. Sodium-dependent modulation of systemic and urinary renalase expression and activity in the rat remnant kidney. Quelhas-Santos J, etal., J Hypertens. 2013 Mar;31(3):543-52; discussion 552-3. doi: 10.1097/HJH.0b013e32835d6e34.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Polymorphism of the renalase gene in end-stage renal disease patients affected by hypertension. Stec A, etal., Nephrol Dial Transplant. 2012 Nov;27(11):4162-6. doi: 10.1093/ndt/gfr293. Epub 2011 May 26.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Renalase deficiency aggravates ischemic myocardial damage. Wu Y, etal., Kidney Int. 2011 Apr;79(8):853-60. doi: 10.1038/ki.2010.488. Epub 2010 Dec 22.
14. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. Xu J, etal., J Clin Invest. 2005 May;115(5):1275-80. Epub 2005 Apr 7.
15. Renalase gene is a novel susceptibility gene for essential hypertension: a two-stage association study in northern Han Chinese population. Zhao Q, etal., J Mol Med (Berl). 2007 Aug;85(8):877-85. Epub 2007 Jan 10.
Additional References at PubMed
PMID:15489334   PMID:17565281   PMID:23863468   PMID:23964689   PMID:24113803   PMID:24366404   PMID:25531177   PMID:25781495   PMID:32053739  


Genomics

Comparative Map Data
Rnls
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21231,037,481 - 231,309,855 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,037,486 - 231,309,823 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1239,414,353 - 239,688,126 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01246,344,061 - 246,617,558 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01239,182,149 - 239,455,647 (-)NCBIRnor_WKY
Rnor_6.01251,828,285 - 252,101,963 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,828,290 - 252,100,759 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01259,052,388 - 259,324,901 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41237,364,578 - 237,639,800 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11237,528,600 - 237,803,823 (-)NCBI
Celera1228,151,441 - 228,423,443 (-)NCBICelera
Cytogenetic Map1q52NCBI
RNLS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381088,171,523 - 88,583,318 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1088,273,864 - 88,584,530 (-)EnsemblGRCh38hg38GRCh38
GRCh371090,033,619 - 90,343,075 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361090,023,601 - 90,332,988 (-)NCBINCBI36Build 36hg18NCBI36
Build 341090,023,600 - 90,332,988NCBI
Celera1083,780,492 - 84,089,897 (-)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1083,668,375 - 83,977,653 (-)NCBIHuRef
CHM1_11090,315,752 - 90,625,158 (-)NCBICHM1_1
T2T-CHM13v2.01089,157,945 - 89,467,392 (-)NCBIT2T-CHM13v2.0
Rnls
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391933,115,140 - 33,369,695 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1933,115,147 - 33,369,665 (-)EnsemblGRCm39 Ensembl
GRCm381933,137,740 - 33,392,295 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1933,137,747 - 33,392,295 (-)EnsemblGRCm38mm10GRCm38
MGSCv371933,212,234 - 33,466,785 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361933,203,744 - 33,458,836 (-)NCBIMGSCv36mm8
Celera1933,919,313 - 34,173,994 (-)NCBICelera
Cytogenetic Map19C1NCBI
Rnls
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554254,368,620 - 4,667,947 (+)NCBIChiLan1.0ChiLan1.0
RNLS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11088,502,588 - 88,809,439 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1088,503,683 - 88,808,990 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01084,996,999 - 85,304,240 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
RNLS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12638,137,662 - 38,413,666 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2638,083,371 - 38,414,033 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2637,955,732 - 38,233,014 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02639,670,571 - 40,000,185 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2639,702,516 - 40,000,302 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12637,574,898 - 37,840,447 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02637,159,099 - 37,435,881 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02638,428,192 - 38,705,871 (-)NCBIUU_Cfam_GSD_1.0
Rnls
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721377,744,737 - 78,131,700 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936735659,826 - 1,048,135 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNLS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14100,317,625 - 100,605,063 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114100,312,592 - 100,604,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214109,298,823 - 109,589,104 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RNLS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1981,725,115 - 82,029,361 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604842,407,027 - 42,707,316 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnls
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479114,542,625 - 14,873,393 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rnls
1179 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:198
Count of miRNA genes:142
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000028098
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1214537555238757011Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210702053240947965Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 15 15 15 9 8
Low 2 43 42 26 19 26 8 11 74 26 33 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028098   ⟹   ENSRNOP00000028098
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1231,037,486 - 231,309,823 (-)Ensembl
Rnor_6.0 Ensembl1251,828,290 - 252,100,759 (-)Ensembl
RefSeq Acc Id: NM_001014167   ⟹   NP_001014189
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21231,037,486 - 231,309,823 (-)NCBI
Rnor_6.01251,828,290 - 252,100,759 (-)NCBI
Rnor_5.01259,052,388 - 259,324,901 (-)NCBI
RGSC_v3.41237,364,578 - 237,639,800 (-)RGD
Celera1228,151,441 - 228,423,443 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231293   ⟹   XP_006231355
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21231,041,332 - 231,309,855 (-)NCBI
Rnor_6.01251,832,171 - 252,101,963 (-)NCBI
Rnor_5.01259,052,388 - 259,324,901 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231294   ⟹   XP_006231356
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21231,037,481 - 231,309,855 (-)NCBI
Rnor_6.01251,828,285 - 252,101,963 (-)NCBI
Rnor_5.01259,052,388 - 259,324,901 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760345   ⟹   XP_008758567
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21231,041,332 - 231,309,481 (-)NCBI
Rnor_6.01251,832,171 - 252,100,417 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039084508   ⟹   XP_038940436
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21231,104,157 - 231,309,852 (-)NCBI
RefSeq Acc Id: XM_039084510   ⟹   XP_038940438
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21231,250,422 - 231,309,847 (-)NCBI
RefSeq Acc Id: XR_005489056
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21231,073,594 - 231,309,853 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001014189   ⟸   NM_001014167
- Peptide Label: precursor
- UniProtKB: Q5U2W9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006231356   ⟸   XM_006231294
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006231355   ⟸   XM_006231293
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008758567   ⟸   XM_008760345
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000028098   ⟸   ENSRNOT00000028098
RefSeq Acc Id: XP_038940436   ⟸   XM_039084508
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038940438   ⟸   XM_039084510
- Peptide Label: isoform X4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2W9-F1-model_v2 AlphaFold Q5U2W9 1-315 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690860
Promoter ID:EPDNEW_R1385
Type:initiation region
Name:Rnls_1
Description:renalase, FAD-dependent amine oxidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01252,100,578 - 252,100,638EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309804 AgrOrtholog
BioCyc Gene G2FUF-55895 BioCyc
Ensembl Genes ENSRNOG00000020705 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000028098 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028098 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7134816 IMAGE-MGC_LOAD
InterPro Amino_oxidase UniProtKB/Swiss-Prot
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot
  RNLS UniProtKB/Swiss-Prot
KEGG Report rno:361751 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94458 IMAGE-MGC_LOAD
NCBI Gene 361751 ENTREZGENE
PANTHER PTHR23357 UniProtKB/Swiss-Prot
Pfam Amino_oxidase UniProtKB/Swiss-Prot
PhenoGen Rnls PhenoGen
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot
UniProt Q5U2W9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Rnls  renalase, FAD-dependent amine oxidase  RGD1309804  similar to hypothetical protein FLJ11218  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1309804  similar to hypothetical protein FLJ11218  RGD1309804_predicted  similar to hypothetical protein FLJ11218 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1309804_predicted  similar to hypothetical protein FLJ11218 (predicted)  LOC361751_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361751_predicted  similar to hypothetical protein FLJ11218 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL