Paxip1 (PAX interacting protein 1)

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Gene: Paxip1 (PAX interacting protein 1) Rattus norvegicus

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Symbol:

Paxip1

Name:

PAX interacting protein 1

RGD ID:

1307547

Description:

Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; regulation of gene expression; and vasculogenesis. Predicted to act upstream of or within DNA damage response. Predicted to be part of MLL3/4 complex. Predicted to be active in nucleus. Orthologous to human PAXIP1 (PAX interacting protein 1); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; bisphenol A; flutamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC311944; PAX interacting (with transcription-activation domain) protein 1; PAX-interacting protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PAXIP1 (PAX interacting protein 1)	HGNC	Ensembl, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Mus musculus (house mouse):	Paxip1 (PAX interacting (with transcription-activation domain) protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Paxip1 (PAX interacting protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PAXIP1 (PAX interacting protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PAXIP1 (PAX interacting protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Paxip1 (PAX interacting protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PAXIP1 (PAX interacting protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PAXIP1 (PAX interacting protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Paxip1 (PAX interacting protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PAXIP1 (PAX interacting protein 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Paxip1 (PAX interacting (with transcription-activation domain) protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	paxip1 (PAX interacting (with transcription-activation domain) protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pis-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Ptip	Alliance	DIOPT (Hieranoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	paxip1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	8,258,930 - 8,310,490 (+)	NCBI		GRCr8
mRatBN7.2	4	7,525,132 - 7,576,659 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	7,525,004 - 7,576,548 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	12,535,163 - 12,586,700 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	8,349,408 - 8,400,945 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	6,695,594 - 6,747,133 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	3,956,931 - 4,008,326 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	3,959,640 - 4,008,326 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	3,996,608 - 4,047,988 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	2,790,532 - 2,839,246 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	2,717,068 - 2,839,242 (+)	NCBI
Celera	4	2,704,414 - 2,753,568 (-)	NCBI		Celera
Cytogenetic Map	4	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

holoprosencephaly 3 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-butoxyethanol (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

cadmium sulfate (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

doxorubicin (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

menadione (ISO)

methylseleninic acid (ISO)

N,N-diethyl-m-toluamide (EXP)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

permethrin (EXP)

piroxicam (ISO)

rotenone (EXP)

serpentine asbestos (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

topotecan (EXP)

trimellitic anhydride (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adipose tissue development (ISO)

biological_process (ND)

chorion development (ISO)

chromatin remodeling (ISO)

DNA damage response (ISO)

DNA damage response, signal transduction by p53 class mediator (ISO)

endothelial cell migration (ISO)

negative regulation of DNA-binding transcription factor activity (IEA,ISO)

positive regulation of isotype switching (ISO)

positive regulation of isotype switching to IgG isotypes (ISO)

positive regulation of protein ubiquitination (ISO)

positive regulation of transcription initiation by RNA polymerase II (IBA,ISO)

regulation of cell cycle G2/M phase transition (ISO)

response to ionizing radiation (ISO)

vasculogenesis (ISO)

Cellular Component

histone methyltransferase complex (ISO)

MLL3/4 complex (ISO)

nucleus (IBA,ISO)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Comprehensive gene review and curation	RGD comprehensive gene curation
6.	The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.	Shilatifard A Annu Rev Biochem. 2012;81:65-95. doi: 10.1146/annurev-biochem-051710-134100.

Additional References at PubMed

PMID:10908331	PMID:11940591	PMID:15456759	PMID:17178841	PMID:17500065	PMID:17690115	PMID:17925232	PMID:18353733	PMID:18710940	PMID:19124460	PMID:19583951	PMID:20671152
PMID:26744420

Genomics

Comparative Map Data

Paxip1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	8,258,930 - 8,310,490 (+)	NCBI		GRCr8
mRatBN7.2	4	7,525,132 - 7,576,659 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	7,525,004 - 7,576,548 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	12,535,163 - 12,586,700 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	8,349,408 - 8,400,945 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	6,695,594 - 6,747,133 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	3,956,931 - 4,008,326 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	3,959,640 - 4,008,326 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	3,996,608 - 4,047,988 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	2,790,532 - 2,839,246 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	2,717,068 - 2,839,242 (+)	NCBI
Celera	4	2,704,414 - 2,753,568 (-)	NCBI		Celera
Cytogenetic Map	4	q11	NCBI

PAXIP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	154,943,690 - 155,003,411 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	154,943,687 - 155,003,124 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	154,735,400 - 154,794,834 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	154,366,333 - 154,425,615 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	154,173,048 - 154,232,306	NCBI
Celera	7	149,152,557 - 149,211,836 (-)	NCBI		Celera
Cytogenetic Map	7	q36.2	NCBI
HuRef	7	148,468,426 - 148,527,705 (-)	NCBI		HuRef
CHM1_1	7	154,743,784 - 154,803,135 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	156,118,967 - 156,178,685 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	153,963,422 - 154,022,702 (-)	NCBI

Paxip1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	27,947,044 - 27,999,326 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	27,945,078 - 27,996,689 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	27,740,080 - 27,791,672 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	27,740,080 - 27,791,691 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	28,067,205 - 28,117,879 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	28,071,452 - 28,122,126 (-)	NCBI		MGSCv36	mm8
Celera	5	25,287,864 - 25,339,859 (-)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	13.23	NCBI

Paxip1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955491	8,177,422 - 8,219,766 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955491	8,177,422 - 8,219,764 (-)	NCBI	ChiLan1.0	ChiLan1.0

PAXIP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	191,372,868 - 191,432,198 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	43,383,480 - 43,442,465 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	146,546,658 - 146,605,912 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	158,274,193 - 158,329,139 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	158,276,798 - 158,330,911 (-)	Ensembl	panpan1.1		panPan2

PAXIP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	18,066,289 - 18,116,007 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	18,066,246 - 18,112,506 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	18,699,205 - 18,749,159 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	19,794,777 - 19,844,723 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	19,794,777 - 19,844,705 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	18,166,085 - 18,216,026 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	18,746,356 - 18,796,284 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	18,799,076 - 18,849,057 (-)	NCBI		UU_Cfam_GSD_1.0

Paxip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	3,415,214 - 3,463,432 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936527	9,440,036 - 9,484,245 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936527	9,440,129 - 9,488,215 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PAXIP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	3,066,848 - 3,111,240 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	3,066,853 - 3,111,239 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	3,227,951 - 3,250,496 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PAXIP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	123,095,968 - 123,156,157 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	123,095,966 - 123,155,800 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666072	19,215,604 - 19,275,681 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Paxip1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624800	2,653,732 - 2,707,161 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624800	2,653,381 - 2,709,261 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Paxip1
126 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	40
Count of miRNA genes:	39
Interacting mature miRNAs:	40
Transcripts:	ENSRNOT00000009439
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61408	Scl23	Serum cholesterol level QTL 23		0.0005	blood HDL phospholipid amount (VT:0010504)	serum high density lipoprotein phospholipid level (CMO:0001567)	4	1	27716890	Rat
2302371	Stl22	Serum triglyceride level QTL 22	5.15		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	57114705	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
9589046	Scfw2	Subcutaneous fat weight QTL 2	5.54	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	4	1	31934116	Rat
8552903	Pigfal2	Plasma insulin-like growth factor 1 level QTL 2	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	1	31934116	Rat
724557	Plsm1	Polydactyly-luxate syndrome (PLS) morphotypes QTL 1		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	4	1	27716890	Rat
9590100	Sffal4	Serum free fatty acids level QTL 4	7.36	0.05	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	4	1	31934116	Rat
61351	Bp33	Blood pressure QTL 33		0.0018	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	1	27716890	Rat
61415	Eae11	Experimental allergic encephalomyelitis QTL 11	2.9		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	4	1	39505420	Rat
1641905	Colcr1	Colorectal carcinoma resistance QTL 1	4.3	0.0003	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	4	1	29494328	Rat
1357341	Gluco5	Glucose level QTL 5	6.4		adipocyte free fatty acid secretion trait (VT:0010465)	absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)	4	1	33250345	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5214602	78882945	Rat
1357343	Gluco4	Glucose level QTL 4		0.00002	adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	4	1	33250345	Rat
1358201	Gluco12	Glucose level QTL12	1.6		adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake (CMO:0000870)	4	5218392	29593287	Rat
738021	Hcar13	Hepatocarcinoma resistance QTL 13	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	4	1	32584199	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	65958103	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5219178	56647776	Rat
61333	Gluco16	Glucose level QTL 16	4.3	0.00001	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	1	30372989	Rat
634323	Hc2	Hypercalciuria QTL 2	2.15		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	4	210796	45210796	Rat
9589097	Slep11	Serum leptin concentration QTL 11	5.09	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	4	1	31934116	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107844	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285937	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285938	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474057	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009439 ⟹ ENSRNOP00000009439

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	7,525,004 - 7,575,997 (+)	Ensembl
Rnor_6.0 Ensembl	4	3,959,640 - 4,008,326 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099077 ⟹ ENSRNOP00000081191

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	7,530,970 - 7,575,997 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104160 ⟹ ENSRNOP00000097277

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	7,525,128 - 7,576,548 (+)	Ensembl

RefSeq Acc Id:

NM_001107844 ⟹ NP_001101314

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	8,258,966 - 8,310,490 (+)	NCBI
mRatBN7.2	4	7,525,132 - 7,576,659 (+)	NCBI
Rnor_6.0	4	3,959,640 - 4,008,326 (+)	NCBI
Rnor_5.0	4	3,996,608 - 4,047,988 (+)	NCBI
RGSC_v3.4	4	2,790,532 - 2,839,246 (+)	RGD
Celera	4	2,704,414 - 2,753,568 (-)	RGD

Sequence:

show sequence

GTTATTCAGCTTCTTAAAGCTGGGAAAGCCAAGGAAGTCTCCTACAACGCTCTGGCCTCTCACA
TCATTTCGGAGGATGGTGACAACCCAGAGGTGGGAGAAGCCCGTGAGGTCTTTGACTTGCCCGT
TGTAAAGCCTTCCTGGGTGACTCTGTCCGTGCAATGTGGCACTCTCCTGCCAGTCAATGGTTTC
TCTCCAGAGTCCTGTCAGATTTTTTTTGGACTCACTGCCTGCCTTTCTCAGGTGTCGTCTGAAG
ACAGAAGTGCCCTGTGGGCCTTGGTTACGTTCCACGGGGGCAGCTGCCAGCTAAACCTTAACAA
GAAGTGCACACACCTGATTGTCCCAGAGCCGAAGGGGGAGAAGTACGAGCGTGCTGTCAAGAGA
ACAAGCATTAAGATTGTTACCCCTGACTGGGTCCTGGACTGTGTGTCTGAGAAGAGGAGGAAGG
ATGAAGCTTCTTACCATCCACGTCTGATCATCTATGAGGAGGAAGAGGAGGAGGAGGAGGAAGA
GGGAGACAACGAGGAGCAGGACTCTCAGAACGAGGGTAGCACTGACAAGTCCAGTGCAGCCAGC
TCTGCGGAGGCCTCCCCTGCTGACCAGCCGTGCTCTCCCAAGGCCAGGGCTGAGGTATCCAAAG
GGGAGTTGATGTTTGATGACTCTTCTGACTCATCCCCTGAAAAGCAGGAGCGCAGCTTGAACTG
GGCCCCCGCTGAAGCCCCGCCACTCAGCACAGCCCAGCACAGGCTGCCTCAGGGAAAAGGACCG
GGACTCATTAACCTGTGTGCCAATGTCCCACCTGTCCCAGGGGACATTCTGCCTCCTGACATGC
GGGGTAACTTGATGGCCGCTGGACAAAACCTCCAGAGTTCTGAGCGGCCGGAAATGTTAGGGAC
CTGGAGCCCAGCTGTCCGGACGTTGCGAAACATTACAAACAACGCTGATATCCAGCAAATCAGC
CGGCCATCCAATGTTGCACATATCTTACAATCCCTTTCAGCACCCACAAAAAACCTAGAGCAGC
AGGTGGCACATGTACAGCAGGGACACCCCAGTGCCAGTGCTGTGCTCTTTGGCCAGGCTAAAGG
TGCTCCTGAGACACACACGTTGCAGCAGCACCATCCTCCCCAGCAGCCTCAGCAGCAGCACCCA
GCCCTGCACCTCCAGCCCCAGATCATGCAGCTCCAGCAGCAACAGCAGCAGCAGCAGCAGCAGC
CCCAGCCTTACCCCCAGCCGCCATCACATCAGTTCCCACAGCAAGTCCATCAGCATCAGTTCTC
TCAGCAGCAGCTCCAGTTTCCACAGCAACCATTACACCCTCAGCAGCAGTTGCATCGCCCTCAA
CAGCAACTGCAGCCATTTCAGCAGCAGCATGCCCTGCAGCAGCAGCTCCATCAGTTGCAGCAGC
AACAGCTCCAGCAGCACCAGTTAGCACAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCA
GCACAACCTCCTCCAGCAGCAACAGCAGCAGCAGCTCCAGCGCTTGCACCAGCAGCAGCAGATG
CAGAATCAAGCAGCACACTTGAGCCAAACGTCCCAGGCACTACAACACCAGGTTCTACCCCAGC
AGCCCCTGCAGCTGCCCCTGCAGCCCCCACCTCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCA
GCAGCAGCAGCAGCAGCAGCAGCTTTTTGGACATGACCCAGCAGTGGAGATTCCAGAAGAAAGC
TTCTTGCTGGGCTGTGTGTTTGCCATTGCGGACTATCCCGAGCAGATGTCGGACAAGCAGCTGC
TGGCCACCTGGAAGAGGATAATCCAGGCACATGGTGGCACTGTGGACCCCACCTTCACTAGCCG
ATGCACACATCTACTCTGCGAGAGTCAAGTCAGCAGTATGTACGCACAGGCACTACGGGAGAGA
AAGCGGTGTGTCACTGCGCATTGGCTCAACACAGTGCTGAAGAAGAAGAAGCTGATGCCGCCTC
ATCGAGCCCTGCATTTCCCTGTGGCATTCCCACCCGGGGGCAAACCCTGTTCACAGCATATTAT
CTCTGTGACTGGATTTGTTGACAATGACAGAGATGACCTGAAGTTAATGGCATACCTGGCGGGT
GCCAAGTACACGGGGTACCTGTGCCGGAGCAACACAGTCCTCATCTGTAAAGAACCAAGCGGCT
TGAAGTACGAGAAGGCCAAAGAGTGGAGGATCCCGTGTGTGAATGCACAGTGGCTGGGGGACAT
TCTGCTGGGGAACTTCGAGGCCCTGCGGCAAGTCCAGTACAGCCGGTACACTGCCTTCAACCTG
CCGGACCCCTTCGTGCCCACTCCACACTTGGTCTTGAGTCTTCTAGATGCTTGGAGGACCCCAG
TGAAGGTGACTGCAGAGCTATTGATGAGTATAAGATTACCTCCTAAGCTGAAGCCGAATGAGGT
CGCCAACATCCAGCCTTCTAAAAGAGCCAGAATCGAAGACCTGCCTCCCCCCACTAAGAAGCTG
ACTCCGGAGCTGACGCCATACGTGCTCTTTACCGGGTTTGAGCCTGTTCAAGTTCAGCAGTACA
TTAAGAAGCTGTACATTCTTGGTGGGGAAGTTGCCGAGTCCACGAAGAAGTGTACTCACCTCAT
TGCCAGCAAGGTGACACGCACAGTGAAATTCCTGACGGCCATTTCTGTGGTGAAGCACATCGTG
ACTCCGGACTGGCTGGAGGAGTGCTTCAAGCGCCAGATGTTTATCGATGAGCAGAACTACATCC
TGCGAGATGCTGAGGCAGAAGTGCTCTTCTCTTTCAGTCTGGAGGAGTCCTTGAAGCGAGCCCA
CGTCTCTCCCCTCTTTAAGACAAAGTATTTTTACATCACCCCTGGCATCTGCCCAAGCCTTGCC
ACTATGAAGGCAATTGTGGAGTGTGCAGGGGGGAAGGTGTTAGCCAAGCAGCCGTCCTTTCGGA
AGCTCATGGAGCACAAGCAGAATAAGAGTCTGTCGGAGATAATTTTAATATCCTGTGAGAATGA
CCTGCACTTATGTCGAGAGTACTTTGCCAGGGGGATAGATGTTCACAATGCGGAGTTTGTTCTG
ACTGGAGTGCTCACACAGACACTGGACTACGAATCATATAAATTTAACTGATGGCCTCTTGGTG
CTGCTAGCCTGGAGCCTGGAGCACAAGGGCAGCTGCTGGCAGCGCAAACCAGGACTCCCTCCCT
GCAGAGGGCTTGTTTTCCAGCTCTGCCTTAGGGAGACATGAAATACTAACTGCATCGTGTTAAG
ATGTGTGACCTTATTCTAGGAAACATAAATTATGTTTGTATTATATGCCTAAGAGCCCACATTA
AGTCTTCTGATTAATTTGCCAGGTTTTTAATGTGTTTTCAGAAAGCTGTATGAAATTTCATCTA
CAAATAAAAATGATGTAAATAAAGACTTTGCTGTCTAAATTATGGATGTTAAAGATATGAGATG
TTTTGTACTTTGATTATTTTTATTTCTTACTTTTCTTTTATATTGATAACTTGCTCACATTTAA
ATAAATGTACTTTTGAACTTAGTAG

hide sequence

RefSeq Acc Id:

XM_063285937 ⟹ XP_063142007

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	8,258,930 - 8,310,490 (+)	NCBI

RefSeq Acc Id:

XM_063285938 ⟹ XP_063142008

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	8,258,930 - 8,310,490 (+)	NCBI

RefSeq Acc Id:

XM_063285939 ⟹ XP_063142009

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	8,259,253 - 8,310,490 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101314	(Get FASTA)	NCBI Sequence Viewer
	XP_063142007	(Get FASTA)	NCBI Sequence Viewer
	XP_063142008	(Get FASTA)	NCBI Sequence Viewer
	XP_063142009	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL86409	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009439.6
	ENSRNOP00000081191.1
	ENSRNOP00000097277.1

RefSeq Acc Id:

NP_001101314 ⟸ NM_001107844

- UniProtKB:

A0A8I5ZSF2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFDDSSDSSPEKQERSLNWAPAEAPPLSTAQHRLPQGKGPGLINLCANVPPVPGDILPPDMRGN
LMAAGQNLQSSERPEMLGTWSPAVRTLRNITNNADIQQISRPSNVAHILQSLSAPTKNLEQQVA
HVQQGHPSASAVLFGQAKGAPETHTLQQHHPPQQPQQQHPALHLQPQIMQLQQQQQQQQQQPQP
YPQPPSHQFPQQVHQHQFSQQQLQFPQQPLHPQQQLHRPQQQLQPFQQQHALQQQLHQLQQQQL
QQHQLAQLQQQQQQQQQQQHNLLQQQQQQQLQRLHQQQQMQNQAAHLSQTSQALQHQVLPQQPL
QLPLQPPPQQQQQQQQQQQQQQQQQQLFGHDPAVEIPEESFLLGCVFAIADYPEQMSDKQLLAT
WKRIIQAHGGTVDPTFTSRCTHLLCESQVSSMYAQALRERKRCVTAHWLNTVLKKKKLMPPHRA
LHFPVAFPPGGKPCSQHIISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKY
EKAKEWRIPCVNAQWLGDILLGNFEALRQVQYSRYTAFNLPDPFVPTPHLVLSLLDAWRTPVKV
TAELLMSIRLPPKLKPNEVANIQPSKRARIEDLPPPTKKLTPELTPYVLFTGFEPVQVQQYIKK
LYILGGEVAESTKKCTHLIASKVTRTVKFLTAISVVKHIVTPDWLEECFKRQMFIDEQNYILRD
AEAEVLFSFSLEESLKRAHVSPLFKTKYFYITPGICPSLATMKAIVECAGGKVLAKQPSFRKLM
EHKQNKSLSEIILISCENDLHLCREYFARGIDVHNAEFVLTGVLTQTLDYESYKFN

hide sequence

Ensembl Acc Id:

ENSRNOP00000009439 ⟸ ENSRNOT00000009439

Ensembl Acc Id:

ENSRNOP00000081191 ⟸ ENSRNOT00000099077

Ensembl Acc Id:

ENSRNOP00000097277 ⟸ ENSRNOT00000104160

RefSeq Acc Id:	XP_063142007 ⟸ XM_063285937
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZSF2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063142008 ⟸ XM_063285938
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5ZSF2 (UniProtKB/TrEMBL), D3ZSX6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063142009 ⟸ XM_063285939
- Peptide Label:	isoform X3
- UniProtKB:	A6KJK7 (UniProtKB/TrEMBL)

Protein Domains

BRCT

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZSX6-F1-model_v2	AlphaFold	D3ZSX6	1-824	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307547	AgrOrtholog
BioCyc Gene	G2FUF-46125	BioCyc
Ensembl Genes	ENSRNOG00000007131	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009439.6	UniProtKB/TrEMBL
	ENSRNOT00000099077.1	UniProtKB/TrEMBL
	ENSRNOT00000104160.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.10190	UniProtKB/TrEMBL
InterPro	BRCT	UniProtKB/TrEMBL
	BRCT_dom_sf	UniProtKB/TrEMBL
	DDR_Transcriptional_Reg	UniProtKB/TrEMBL
KEGG Report	rno:311944	UniProtKB/TrEMBL
NCBI Gene	311944	ENTREZGENE
PANTHER	PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN	UniProtKB/TrEMBL
	PAX-INTERACTING PROTEIN 1	UniProtKB/TrEMBL
Pfam	BRCT	UniProtKB/TrEMBL
	BRCT_2	UniProtKB/TrEMBL
	PTCB-BRCT	UniProtKB/TrEMBL
	RTT107_BRCT_5	UniProtKB/TrEMBL
PhenoGen	Paxip1	PhenoGen
PROSITE	BRCT	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000007131	RatGTEx
SMART	BRCT	UniProtKB/TrEMBL
Superfamily-SCOP	BRCT	UniProtKB/TrEMBL
UniProt	A0A8I5ZSF2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GMG2_RAT	UniProtKB/TrEMBL
	A6KJK7	ENTREZGENE, UniProtKB/TrEMBL
	D3ZSX6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-22	Paxip1	PAX interacting protein 1	Paxip1	PAX interacting (with transcription-activation domain) protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Paxip1	PAX interacting (with transcription-activation domain) protein 1	Paxip1_predicted	PAX interacting (with transcription-activation domain) protein 1 (predicted)	'predicted' is removed	2292626	APPROVED
2008-01-09	Paxip1_predicted	PAX interacting (with transcription-activation domain) protein 1 (predicted)	LOC681792	similar to Pax transcription activation domain interacting protein	Data merged from RGD:1591614	1643240	APPROVED
2006-11-20	LOC681792	similar to Pax transcription activation domain interacting protein			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-12	Paxip1_predicted	PAX interacting (with transcription-activation domain) protein 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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