Scart1 (scavenger receptor family member expressed on T-cells 1) - Rat Genome Database

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Gene: Scart1 (scavenger receptor family member expressed on T-cells 1) Rattus norvegicus
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Symbol: Scart1
Name: scavenger receptor family member expressed on T-cells 1
RGD ID: 1307378
Description: Predicted to be located in brush border; cytoplasm; and plasma membrane. Orthologous to human SCART1 (scavenger receptor family member expressed on T cells 1); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; testosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD163 molecule-like 1; Cd163l1; LOC293591; RGD1307378; scavenger receptor cysteine-rich domain-containing protein SCART1; similar to scavenger receptor cysteine-rich type 1 protein CD163c-alpha precursor
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81204,450,386 - 204,462,094 (+)NCBIGRCr8
mRatBN7.21195,020,750 - 195,031,807 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1195,020,750 - 195,031,807 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1203,377,169 - 203,388,200 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,506,684 - 210,517,711 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01203,180,523 - 203,191,550 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01212,695,735 - 212,706,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1212,695,735 - 212,706,790 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,609,867 - 219,621,118 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41200,046,057 - 200,057,112 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11200,197,882 - 200,343,277 (+)NCBI
Celera1192,693,576 - 192,704,631 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Scart1Ratamenorrhea  ISOSCART1 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary amenorrheaClinVarPMID:21681106

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Scart1Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SCART1 mRNACTDPMID:32741896
Scart1Rat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SCART1 mRNACTDPMID:32741896
Scart1Rat4,4'-sulfonyldiphenol affects methylationISOScart1 (Mus musculus)6480464bisphenol S affects the methylation of SCART1 exonCTDPMID:33297965
Scart1Rat4,4'-sulfonyldiphenol increases methylationISOSCART1 (Homo sapiens)6480464bisphenol S results in increased methylation of SCART1 geneCTDPMID:31601247
Scart1Rataflatoxin B1 decreases expressionISOSCART1 (Homo sapiens)6480464Aflatoxin B1 results in decreased expression of SCART1 mRNACTDPMID:32234424
Scart1Ratbenzo[a]pyrene affects methylationISOSCART1 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of SCART1 promoterCTDPMID:27901495
Scart1Ratbenzo[a]pyrene decreases expressionISOSCART1 (Homo sapiens)6480464Benzo(a)pyrene results in decreased expression of SCART1 mRNACTDPMID:32234424
Scart1Ratbisphenol A multiple interactionsISOSCART1 (Homo sapiens)6480464[bisphenol A co-treated with Fulvestrant] results in decreased methylation of SCART1 geneCTDPMID:31601247
Scart1Ratbisphenol A increases expressionISOScart1 (Mus musculus)6480464bisphenol A results in increased expression of SCART1 mRNACTDPMID:32156529
Scart1Ratfipronil multiple interactionsISOSCART1 (Homo sapiens)6480464[fipronil co-treated with DEET] results in decreased expression of SCART1 mRNACTDPMID:28991164
Scart1Ratfipronil decreases expressionISOSCART1 (Homo sapiens)6480464fipronil results in decreased expression of SCART1 mRNACTDPMID:28991164
Scart1Ratfulvestrant multiple interactionsISOSCART1 (Homo sapiens)6480464[bisphenol A co-treated with Fulvestrant] results in decreased methylation of SCART1 geneCTDPMID:31601247
Scart1RatN,N-diethyl-m-toluamide multiple interactionsISOSCART1 (Homo sapiens)6480464[fipronil co-treated with DEET] results in decreased expression of SCART1 mRNACTDPMID:28991164
Scart1RatN,N-diethyl-m-toluamide decreases expressionISOSCART1 (Homo sapiens)6480464DEET results in decreased expression of SCART1 mRNACTDPMID:28991164
Scart1RatN-Nitrosopyrrolidine decreases expressionISOSCART1 (Homo sapiens)6480464N-Nitrosopyrrolidine results in decreased expression of SCART1 mRNACTDPMID:32234424
Scart1RatO-methyleugenol decreases expressionISOSCART1 (Homo sapiens)6480464methyleugenol results in decreased expression of SCART1 mRNACTDPMID:32234424
Scart1Ratpermethrin increases expressionISOSCART1 (Homo sapiens)6480464Permethrin results in increased expression of SCART1 mRNACTDPMID:37047231
Scart1Rattestosterone multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SCART1 mRNACTDPMID:32741896
Scart1Rattriphenyl phosphate affects expressionISOSCART1 (Homo sapiens)6480464triphenyl phosphate affects the expression of SCART1 mRNACTDPMID:37042841
Scart1Ratvalproic acid increases methylationISOSCART1 (Homo sapiens)6480464Valproic Acid results in increased methylation of SCART1 geneCTDPMID:29154799

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Cellular Component

  


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:20381152   PMID:22795646  



Scart1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81204,450,386 - 204,462,094 (+)NCBIGRCr8
mRatBN7.21195,020,750 - 195,031,807 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1195,020,750 - 195,031,807 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1203,377,169 - 203,388,200 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,506,684 - 210,517,711 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01203,180,523 - 203,191,550 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01212,695,735 - 212,706,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1212,695,735 - 212,706,790 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,609,867 - 219,621,118 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41200,046,057 - 200,057,112 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11200,197,882 - 200,343,277 (+)NCBI
Celera1192,693,576 - 192,704,631 (+)NCBICelera
Cytogenetic Map1q41NCBI
SCART1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810133,453,945 - 133,469,760 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10133,453,928 - 133,523,558 (+)EnsemblGRCh38hg38GRCh38
GRCh3710135,267,449 - 135,283,264 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610135,117,422 - 135,131,943 (+)NCBINCBI36Build 36hg18NCBI36
Celera10128,235,313 - 128,249,827 (-)NCBICelera
Cytogenetic Map10q26.3NCBI
HuRef10128,812,764 - 128,827,262 (+)NCBIHuRef
CHM1_110135,549,071 - 135,563,582 (+)NCBICHM1_1
T2T-CHM13v2.010134,408,221 - 134,424,034 (+)NCBIT2T-CHM13v2.0
Scart1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397139,777,131 - 139,811,058 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7139,798,180 - 139,811,058 (+)EnsemblGRCm39 Ensembl
GRCm387140,197,218 - 140,231,145 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,218,267 - 140,231,145 (+)EnsemblGRCm38mm10GRCm38
MGSCv377147,404,166 - 147,417,044 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367140,069,587 - 140,082,465 (+)NCBIMGSCv36mm8
Celera7140,016,288 - 140,029,296 (+)NCBICelera
Cytogenetic Map7F4NCBI
cM Map785.26NCBI
LOC491694
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12841,012,407 - 41,021,862 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2841,105,804 - 41,118,032 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02841,688,859 - 41,701,099 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2841,689,958 - 41,699,740 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12841,169,910 - 41,182,219 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02841,158,805 - 41,171,129 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02841,561,537 - 41,573,854 (+)NCBIUU_Cfam_GSD_1.0
LOC100156553
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14141,445,314 - 141,457,631 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114141,444,260 - 141,455,965 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214153,627,205 - 153,637,809 (+)NCBISscrofa10.2Sscrofa10.2susScr3

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Variants in Scart1
83 total Variants

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:32
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000049269
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 90 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat

1 to 10 of 90 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 11 42 54 59 28 25 28 6 132 47 28 41 42 31



Ensembl Acc Id: ENSRNOT00000049269   ⟹   ENSRNOP00000045146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1195,020,750 - 195,031,807 (+)Ensembl
Rnor_6.0 Ensembl1212,695,735 - 212,706,790 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000054880   ⟹   ENSRNOP00000051764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1195,020,750 - 195,031,807 (+)Ensembl
RefSeq Acc Id: NM_001106312   ⟹   NP_001099782
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81204,450,386 - 204,461,441 (+)NCBI
mRatBN7.21195,020,750 - 195,031,807 (+)NCBI
Rnor_6.01212,695,735 - 212,706,790 (+)NCBI
Rnor_5.01219,609,867 - 219,621,118 (+)NCBI
RGSC_v3.41200,046,057 - 200,057,112 (+)RGD
Celera1192,693,576 - 192,704,631 (+)RGD
Sequence:
RefSeq Acc Id: XM_063286462   ⟹   XP_063142532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81204,450,386 - 204,462,094 (+)NCBI
Protein RefSeqs NP_001099782 (Get FASTA)   NCBI Sequence Viewer  
  XP_063142532 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11910 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045146
  ENSRNOP00000045146.3
  ENSRNOP00000051764.5
RefSeq Acc Id: NP_001099782   ⟸   NM_001106312
- Peptide Label: precursor
- UniProtKB: D4AEN2 (UniProtKB/TrEMBL),   A6HXH9 (UniProtKB/TrEMBL),   A6HXI0 (UniProtKB/TrEMBL),   D3ZR76 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045146   ⟸   ENSRNOT00000049269
Ensembl Acc Id: ENSRNOP00000051764   ⟸   ENSRNOT00000054880
RefSeq Acc Id: XP_063142532   ⟸   XM_063286462
- Peptide Label: isoform X1
- UniProtKB: A6HXH9 (UniProtKB/TrEMBL),   D4AEN2 (UniProtKB/TrEMBL),   A6HXI0 (UniProtKB/TrEMBL),   D3ZR76 (UniProtKB/TrEMBL)
SRCR

Name Modeler Protein Id AA Range Protein Structure
AF-D4AEN2-F1-model_v2 AlphaFold D4AEN2 1-995 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-57051 BioCyc
Ensembl Genes ENSRNOG00000018978 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049269 ENTREZGENE
  ENSRNOT00000049269.4 UniProtKB/TrEMBL
  ENSRNOT00000054880.6 UniProtKB/TrEMBL
Gene3D-CATH 3.10.250.10 UniProtKB/TrEMBL
InterPro SRCR-like_dom_sf UniProtKB/TrEMBL
  Srcr_rcpt UniProtKB/TrEMBL
KEGG Report rno:293591 UniProtKB/TrEMBL
NCBI Gene 293591 ENTREZGENE
PANTHER ANTIGEN WC1.1 UniProtKB/TrEMBL
  SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN SCART1 UniProtKB/TrEMBL
  SCAVENGER RECEPTOR DOMAIN-CONTAINING UniProtKB/TrEMBL
Pfam SRCR UniProtKB/TrEMBL
PhenoGen Scart1 PhenoGen
PRINTS SPERACTRCPTR UniProtKB/TrEMBL
PROSITE SRCR_1 UniProtKB/TrEMBL
  SRCR_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018978 RatGTEx
SMART SM00202 UniProtKB/TrEMBL
Superfamily-SCOP Srcr_receptor UniProtKB/TrEMBL
UniProt A6HXH9 ENTREZGENE, UniProtKB/TrEMBL
  A6HXI0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZR76 ENTREZGENE, UniProtKB/TrEMBL
  D4AEN2 ENTREZGENE, UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-18 Scart1  scavenger receptor family member expressed on T-cells 1  Cd163l1  CD163 molecule-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Cd163l1  CD163 molecule-like 1  LOC682108  similar to scavenger receptor cysteine-rich type 1 protein M160 precursor  Data merged from RGD:1586977 1643240 APPROVED
2008-03-07 Cd163l1  CD163 molecule-like 1  RGD1307378_predicted  similar to scavenger receptor cysteine-rich type 1 protein CD163c-alpha precursor (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC682108  similar to scavenger receptor cysteine-rich type 1 protein M160 precursor      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 RGD1307378_predicted  similar to scavenger receptor cysteine-rich type 1 protein CD163c-alpha precursor (predicted)  LOC293591_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC293591_predicted  similar to scavenger receptor cysteine-rich type 1 protein CD163c-alpha precursor (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL