Kcnd3 (potassium voltage-gated channel subfamily D member 3) - Rat Genome Database

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Gene: Kcnd3 (potassium voltage-gated channel subfamily D member 3) Ictidomys tridecemlineatus
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Symbol: Kcnd3
Name: potassium voltage-gated channel subfamily D member 3
RGD ID: 12702989
Description: ENCODES a protein that exhibits A-type (transient outward) potassium channel activity (ortholog); monoatomic ion channel activity (ortholog); potassium channel activity (ortholog); INVOLVED IN cellular response to BMP stimulus (ortholog); potassium ion import across plasma membrane (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH atrial fibrillation (ortholog); Brugada syndrome (ortholog); Brugada syndrome 9 (ortholog); FOUND IN caveola (ortholog); dendrite (ortholog); GABA-ergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: potassium voltage-gated channel subfamily D member 3, transcript variant X1; potassium voltage-gated channel subfamily D member 3, transcript variant X2; potassium voltage-gated channel subfamily D member 3, transcript variant X3; potassium voltage-gated channel, Shal-related subfamily, member 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505816,850,374 - 17,059,824 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936690422,883 - 621,308 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936690417,907 - 627,025 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
excitatory synaptic transmission pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term potentiation  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Kcnd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505816,850,374 - 17,059,824 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936690422,883 - 621,308 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936690417,907 - 627,025 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCND3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381111,770,662 - 111,989,668 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1111,770,662 - 111,989,668 (-)EnsemblGRCh38hg38GRCh38
GRCh371112,313,284 - 112,532,290 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361112,119,977 - 112,333,300 (-)NCBINCBI36Build 36hg18NCBI36
Build 341112,030,495 - 112,243,819NCBI
Celera1110,565,074 - 110,778,378 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1110,189,856 - 110,403,378 (-)NCBIHuRef
CHM1_11112,433,439 - 112,646,758 (-)NCBICHM1_1
T2T-CHM13v2.01111,785,561 - 112,004,582 (-)NCBIT2T-CHM13v2.0
Kcnd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393105,359,206 - 105,581,318 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3105,359,646 - 105,581,318 (+)EnsemblGRCm39 Ensembl
GRCm383105,451,890 - 105,674,002 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3105,452,330 - 105,674,002 (+)EnsemblGRCm38mm10GRCm38
MGSCv373105,255,248 - 105,476,920 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363105,580,386 - 105,802,058 (+)NCBIMGSCv36mm8
Celera3107,640,899 - 107,862,899 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map346.32NCBI
Kcnd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82195,626,316 - 195,843,690 (+)NCBIGRCr8
mRatBN7.22192,937,950 - 193,155,345 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2192,937,950 - 193,155,345 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2200,532,308 - 200,749,767 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02198,418,563 - 198,635,769 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02193,235,506 - 193,452,721 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02207,923,775 - 208,140,727 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2207,923,775 - 208,140,727 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02227,345,052 - 227,561,680 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42200,709,778 - 200,924,575 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13128,828,320 - 128,840,436 (+)NCBI
Celera2185,602,165 - 185,617,489 (+)NCBICelera
Cytogenetic Map2q34NCBI
Kcnd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543515,227,615 - 15,431,190 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543515,227,386 - 15,431,136 (-)NCBIChiLan1.0ChiLan1.0
KCND3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21115,037,963 - 115,255,901 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11114,185,438 - 114,404,074 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01114,433,203 - 114,651,894 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11125,702,654 - 125,910,075 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1125,696,907 - 125,909,814 (+)Ensemblpanpan1.1panPan2
KCND3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11763,470,829 - 63,668,354 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1763,470,415 - 63,668,035 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1762,986,103 - 63,182,211 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01764,647,680 - 64,841,597 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1764,637,936 - 64,841,028 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11763,378,372 - 63,574,346 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01763,437,366 - 63,633,850 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01764,235,078 - 64,431,380 (+)NCBIUU_Cfam_GSD_1.0
KCND3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4108,246,237 - 108,621,510 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14108,394,687 - 108,621,514 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24118,542,614 - 118,763,673 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCND3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12021,618,365 - 21,833,443 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2021,625,147 - 21,833,186 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603836,641,070 - 36,861,725 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247727,484,632 - 7,693,329 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247727,482,462 - 7,694,316 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000001772   ⟹   ENSSTOP00000001580
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936690422,883 - 621,308 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000029244   ⟹   ENSSTOP00000018680
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936690422,883 - 621,308 (-)Ensembl
RefSeq Acc Id: XM_021734762   ⟹   XP_021590437
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505816,850,734 - 17,059,824 (+)NCBI
SpeTri2.0NW_004936690417,907 - 627,025 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021734763   ⟹   XP_021590438
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505816,853,421 - 17,059,824 (+)NCBI
SpeTri2.0NW_004936690417,907 - 624,796 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021734764   ⟹   XP_021590439
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505816,850,735 - 17,059,824 (+)NCBI
SpeTri2.0NW_004936690417,907 - 627,025 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040287394   ⟹   XP_040143328
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505816,850,374 - 17,059,824 (+)NCBI
RefSeq Acc Id: XM_040287395   ⟹   XP_040143329
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505816,851,574 - 17,059,824 (+)NCBI
RefSeq Acc Id: XP_021590439   ⟸   XM_021734764
- Peptide Label: isoform X2
- UniProtKB: I3LZ66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021590437   ⟸   XM_021734762
- Peptide Label: isoform X1
- UniProtKB: I3N2T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021590438   ⟸   XM_021734763
- Peptide Label: isoform X1
- UniProtKB: I3N2T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040143328   ⟸   XM_040287394
- Peptide Label: isoform X1
- UniProtKB: I3N2T4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040143329   ⟸   XM_040287395
- Peptide Label: isoform X1
- UniProtKB: I3N2T4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000001580   ⟸   ENSSTOT00000001772
Ensembl Acc Id: ENSSTOP00000018680   ⟸   ENSSTOT00000029244
Protein Domains
BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000001773 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000001772.3 UniProtKB/TrEMBL
  ENSSTOT00000029244.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv4 UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv4.3 UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv4_C UniProtKB/TrEMBL
  Shal-type_N UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
NCBI Gene Kcnd3 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 3 UniProtKB/TrEMBL
  PTHR11537 UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/TrEMBL
  DUF3399 UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
  Shal-type UniProtKB/TrEMBL
PRINTS KCHANNEL UniProtKB/TrEMBL
  KV43CHANNEL UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/TrEMBL
  SHALCHANNEL UniProtKB/TrEMBL
SMART BTB UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt I3LZ66 ENTREZGENE, UniProtKB/TrEMBL
  I3N2T4 ENTREZGENE, UniProtKB/TrEMBL