KCND3 (potassium voltage-gated channel subfamily D member 3) - Rat Genome Database

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Gene: KCND3 (potassium voltage-gated channel subfamily D member 3) Sus scrofa
Analyze
Symbol: KCND3
Name: potassium voltage-gated channel subfamily D member 3
RGD ID: 14114404
Description: ENCODES a protein that exhibits A-type (transient outward) potassium channel activity (ortholog); monoatomic ion channel activity (ortholog); potassium channel activity (ortholog); INVOLVED IN cellular response to BMP stimulus (ortholog); potassium ion import across plasma membrane (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH atrial fibrillation (ortholog); Brugada syndrome (ortholog); Brugada syndrome 9 (ortholog); FOUND IN caveola (ortholog); dendrite (ortholog); GABA-ergic synapse (ortholog); INTERACTS WITH zearalenone
Type: protein-coding
RefSeq Status: MODEL
Previously known as: potassium voltage-gated channel, Shal-related subfamily, member 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4108,246,237 - 108,621,510 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14108,394,687 - 108,621,514 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24118,542,614 - 118,763,673 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
excitatory synaptic transmission pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term potentiation  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCND3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4108,246,237 - 108,621,510 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14108,394,687 - 108,621,514 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24118,542,614 - 118,763,673 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCND3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381111,770,662 - 111,989,668 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1111,770,662 - 111,989,668 (-)EnsemblGRCh38hg38GRCh38
GRCh371112,313,284 - 112,532,290 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361112,119,977 - 112,333,300 (-)NCBINCBI36Build 36hg18NCBI36
Build 341112,030,495 - 112,243,819NCBI
Celera1110,565,074 - 110,778,378 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1110,189,856 - 110,403,378 (-)NCBIHuRef
CHM1_11112,433,439 - 112,646,758 (-)NCBICHM1_1
T2T-CHM13v2.01111,785,561 - 112,004,582 (-)NCBIT2T-CHM13v2.0
Kcnd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393105,359,206 - 105,581,318 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3105,359,646 - 105,581,318 (+)EnsemblGRCm39 Ensembl
GRCm383105,451,890 - 105,674,002 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3105,452,330 - 105,674,002 (+)EnsemblGRCm38mm10GRCm38
MGSCv373105,255,248 - 105,476,920 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363105,580,386 - 105,802,058 (+)NCBIMGSCv36mm8
Celera3107,640,899 - 107,862,899 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map346.32NCBI
Kcnd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82195,626,316 - 195,843,690 (+)NCBIGRCr8
mRatBN7.22192,937,950 - 193,155,345 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2192,937,950 - 193,155,345 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2200,532,308 - 200,749,767 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02198,418,563 - 198,635,769 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02193,235,506 - 193,452,721 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02207,923,775 - 208,140,727 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2207,923,775 - 208,140,727 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02227,345,052 - 227,561,680 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42200,709,778 - 200,924,575 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13128,828,320 - 128,840,436 (+)NCBI
Celera2185,602,165 - 185,617,489 (+)NCBICelera
Cytogenetic Map2q34NCBI
Kcnd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543515,227,615 - 15,431,190 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543515,227,386 - 15,431,136 (-)NCBIChiLan1.0ChiLan1.0
KCND3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21115,037,963 - 115,255,901 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11114,185,438 - 114,404,074 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01114,433,203 - 114,651,894 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11125,702,654 - 125,910,075 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1125,696,907 - 125,909,814 (+)Ensemblpanpan1.1panPan2
KCND3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11763,470,829 - 63,668,354 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1763,470,415 - 63,668,035 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1762,986,103 - 63,182,211 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01764,647,680 - 64,841,597 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1764,637,936 - 64,841,028 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11763,378,372 - 63,574,346 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01763,437,366 - 63,633,850 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01764,235,078 - 64,431,380 (+)NCBIUU_Cfam_GSD_1.0
Kcnd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505816,850,374 - 17,059,824 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936690422,883 - 621,308 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936690417,907 - 627,025 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCND3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12021,618,365 - 21,833,443 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2021,625,147 - 21,833,186 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603836,641,070 - 36,861,725 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247727,484,632 - 7,693,329 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247727,482,462 - 7,694,316 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KCND3
9963 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
9 2 23 3 1 10 7 23 3 6

Sequence


Ensembl Acc Id: ENSSSCT00000007428   ⟹   ENSSSCP00000007233
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4108,246,237 - 108,621,508 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000103955   ⟹   ENSSSCP00000076041
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4108,394,941 - 108,621,510 (+)Ensembl
RefSeq Acc Id: XM_001928519   ⟹   XP_001928554
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14108,394,687 - 108,621,514 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090024   ⟹   XP_020945683
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14108,394,687 - 108,621,514 (+)NCBI
Sequence:
RefSeq Acc Id: XP_001928554   ⟸   XM_001928519
- Peptide Label: isoform X1
- UniProtKB: A0A4X1T8H8 (UniProtKB/TrEMBL),   F1SBP4 (UniProtKB/TrEMBL),   A0A8D1LA13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945683   ⟸   XM_021090024
- Peptide Label: isoform X2
- UniProtKB: A0A4X1T8U5 (UniProtKB/TrEMBL),   A0A8W4FB14 (UniProtKB/TrEMBL),   A0A8D0XK54 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000007233   ⟸   ENSSSCT00000007428
Ensembl Acc Id: ENSSSCP00000076041   ⟸   ENSSSCT00000103955
Protein Domains
BTB   Ion transport   Potassium channel voltage dependent Kv4 C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000026680 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015009225 UniProtKB/TrEMBL
  ENSSSCG00030056281 UniProtKB/TrEMBL
  ENSSSCG00035041682 UniProtKB/TrEMBL
  ENSSSCG00040027560 UniProtKB/TrEMBL
  ENSSSCG00045037328 UniProtKB/TrEMBL
  ENSSSCG00060016262 UniProtKB/TrEMBL
  ENSSSCG00065043110 UniProtKB/TrEMBL
  ENSSSCG00070007349 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000007428 ENTREZGENE
  ENSSSCT00000007428.5 UniProtKB/TrEMBL
  ENSSSCT00000103955 ENTREZGENE
  ENSSSCT00000103955.1 UniProtKB/TrEMBL
  ENSSSCT00015012272.1 UniProtKB/TrEMBL
  ENSSSCT00015012375.1 UniProtKB/TrEMBL
  ENSSSCT00030078480.1 UniProtKB/TrEMBL
  ENSSSCT00030078515.1 UniProtKB/TrEMBL
  ENSSSCT00035055383.1 UniProtKB/TrEMBL
  ENSSSCT00035055390.1 UniProtKB/TrEMBL
  ENSSSCT00040037154.1 UniProtKB/TrEMBL
  ENSSSCT00040037308.1 UniProtKB/TrEMBL
  ENSSSCT00045064406.1 UniProtKB/TrEMBL
  ENSSSCT00045064436.1 UniProtKB/TrEMBL
  ENSSSCT00060021670.1 UniProtKB/TrEMBL
  ENSSSCT00060021679.1 UniProtKB/TrEMBL
  ENSSSCT00065058959.1 UniProtKB/TrEMBL
  ENSSSCT00065058964.1 UniProtKB/TrEMBL
  ENSSSCT00070014138.1 UniProtKB/TrEMBL
  ENSSSCT00070014141.1 UniProtKB/TrEMBL
  ENSSSCT00070014150.1 UniProtKB/TrEMBL
  ENSSSCT00070014157.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv4 UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv4.3 UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv4_C UniProtKB/TrEMBL
  Shal-type_N UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/TrEMBL
  VG_K_chnl UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100037946 UniProtKB/TrEMBL
NCBI Gene KCND3 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 3 UniProtKB/TrEMBL
  PTHR11537 UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/TrEMBL
  DUF3399 UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
  Shal-type UniProtKB/TrEMBL
PRINTS KCHANNEL UniProtKB/TrEMBL
  KV43CHANNEL UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/TrEMBL
  SHALCHANNEL UniProtKB/TrEMBL
SMART BTB UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A4X1T8H8 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T8U5 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T8V9_PIG UniProtKB/TrEMBL
  A0A8D0XK54 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1LA13 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FB14 ENTREZGENE
  A0S5T4_PIG UniProtKB/TrEMBL
  F1SBP4 ENTREZGENE
UniProt Secondary A0A8W4FB14 UniProtKB/TrEMBL
  F1SBP4 UniProtKB/TrEMBL
VGNC ID VGNC:98814 ENTREZGENE