Macrod2 (mono-ADP ribosylhydrolase 2) - Rat Genome Database

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Gene: Macrod2 (mono-ADP ribosylhydrolase 2) Ictidomys tridecemlineatus
Analyze
Symbol: Macrod2
Name: mono-ADP ribosylhydrolase 2
RGD ID: 12495656
Description: ENCODES a protein that exhibits ADP-ribosylglutamate hydrolase activity (inferred); deacetylase activity (inferred); hydrolase activity, acting on glycosyl bonds (inferred); INVOLVED IN brain development (inferred); DNA damage response (inferred); peptidyl-glutamate ADP-deribosylation (inferred); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH amenorrhea (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN nucleolus (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ADP-ribose glycohydrolase MACROD2; MACRO domain containing 2; O-acetyl-ADP-ribose deacetylase MACROD2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640155,484,882 - 157,435,824 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364853,919,525 - 5,859,251 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364853,917,060 - 5,859,527 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Macrod2Squirrelamenorrhea  ISORGD:13479208554872ClinVar Annotator: match by term: AmenorrheaClinVarPMID:32870266
Macrod2Squirrelautism spectrum disorder  ISORGD:13479208554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:25741868|PMID:27569545
Macrod2Squirrelautistic disorder  ISORGD:13479208554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106|PMID:30208311
Macrod2Squirreldisorder of sexual development  ISORGD:13479208554872ClinVar Annotator: match by term: Disorder of sexual differentiationClinVar 
Macrod2SquirrelHigh Myopia  ISORGD:13479208554872ClinVar Annotator: match by term: High myopiaClinVar 
Macrod2Squirrelhypogonadotropic hypogonadism 21 with or without anosmia  ISORGD:13479208554872ClinVar Annotator: match by term: FLRT3-related condition | ClinVar Annotator: match by term: Hypogonadotropic hypogonadism more ...ClinVarPMID:23643382|PMID:25741868|PMID:28492532|PMID:30835274
Macrod2Squirrelschizophrenia  ISORGD:13479208554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106|PMID:30208311
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Macrod2SquirrelLiver Neoplasms  ISORGD:13479209068941CTD Direct Evidence: marker/mechanismCTDPMID:27064257
Macrod2Squirrelsubstance-related disorder  ISORGD:13479209068941CTD Direct Evidence: marker/mechanismCTDPMID:20098672


Biological Process
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Macrod2Squirrelbrain development involved_inIEAUniProtKB:Q3UYG8|ensembl:ENSMUSP00000105691150520179 EnsemblGO_REF:0000107
Macrod2SquirrelDNA damage response involved_inIEAUniProtKB:A1Z1Q3|ensembl:ENSP00000507484150520179 EnsemblGO_REF:0000107
Macrod2SquirrelDNA damage response involved_inIEAPANTHER:PTN001339578150520179 TreeGrafterGO_REF:0000118
Macrod2Squirrelpeptidyl-glutamate ADP-deribosylation involved_inIEAPANTHER:PTN001339578150520179 TreeGrafterGO_REF:0000118
Macrod2Squirrelpeptidyl-glutamate ADP-deribosylation involved_inIEAUniProtKB:A1Z1Q3|ensembl:ENSP00000507484150520179 EnsemblGO_REF:0000107
Macrod2Squirrelprotein de-ADP-ribosylation involved_inIEAUniProtKB:A1Z1Q3|ensembl:ENSP00000507484150520179 EnsemblGO_REF:0000107
Macrod2Squirrelpurine nucleoside metabolic process involved_inIEAUniProtKB:A1Z1Q3|ensembl:ENSP00000507484150520179 EnsemblGO_REF:0000107
Macrod2Squirrelpurine nucleoside metabolic process involved_inIEAPANTHER:PTN001339578150520179 TreeGrafterGO_REF:0000118
Macrod2Squirrelresponse to bacterium acts_upstream_of_or_withinIEAUniProtKB:Q3UYG8|ensembl:ENSMUSP00000105691150520179 EnsemblGO_REF:0000107
1 to 9 of 9 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Macrod2Squirrelnucleolus located_inIEAUniProtKB:A1Z1Q3|ensembl:ENSP00000507484150520179 EnsemblGO_REF:0000107
Macrod2Squirrelnucleoplasm located_inIEAUniProtKB:A1Z1Q3|ensembl:ENSP00000507484150520179 EnsemblGO_REF:0000107
Macrod2Squirrelnucleoplasm located_inIEAPANTHER:PTN001339578150520179 TreeGrafterGO_REF:0000118
Macrod2Squirrelnucleus located_inIEAUniProtKB:A1Z1Q3|ensembl:ENSP00000507484150520179 EnsemblGO_REF:0000107

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Macrod2SquirrelADP-ribosylglutamate hydrolase activity enablesIEAUniProtKB:A1Z1Q3|ensembl:ENSP00000507484150520179 EnsemblGO_REF:0000107
Macrod2SquirrelADP-ribosylglutamate hydrolase activity enablesIEAPANTHER:PTN001339578150520179 TreeGrafterGO_REF:0000118
Macrod2Squirreldeacetylase activity enablesIEAUniProtKB:A1Z1Q3|ensembl:ENSP00000507484150520179 EnsemblGO_REF:0000107
Macrod2Squirrelhydrolase activity, acting on glycosyl bonds enablesIEAUniProtKB:A1Z1Q3|ensembl:ENSP00000507484150520179 EnsemblGO_REF:0000107

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Macrod2SquirrelADP-ribosylation pathway, mono and poly-ribosylation  ISORGD:13479209068941 RGDPMID:26091342|REF_RGD_ID:11100038
PMID:30032202  



Macrod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640155,484,882 - 157,435,824 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364853,919,525 - 5,859,251 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364853,917,060 - 5,859,527 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MACROD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382013,995,516 - 16,053,197 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2013,995,369 - 16,053,197 (+)EnsemblGRCh38hg38GRCh38
GRCh372013,976,162 - 16,033,842 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362013,924,146 - 15,981,842 (+)NCBINCBI36Build 36hg18NCBI36
Build 342013,924,318 - 13,982,313NCBI
Celera2014,051,522 - 16,108,818 (+)NCBICelera
Cytogenetic Map20p12.1NCBI
HuRef2013,936,352 - 15,994,332 (+)NCBIHuRef
CHM1_12013,976,154 - 16,033,759 (+)NCBICHM1_1
T2T-CHM13v2.02014,044,768 - 16,102,640 (+)NCBIT2T-CHM13v2.0
Macrod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392140,237,223 - 142,234,886 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2140,237,229 - 142,234,886 (+)EnsemblGRCm39 Ensembl
GRCm382140,395,303 - 142,392,966 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2140,395,309 - 142,392,966 (+)EnsemblGRCm38mm10GRCm38
MGSCv372140,221,166 - 142,215,786 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362140,086,876 - 140,114,395 (+)NCBIMGSCv36mm8
Celera2141,585,472 - 143,579,729 (+)NCBICelera
Cytogenetic Map2F3- G1NCBI
cM Map269.2NCBI
Macrod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83148,173,821 - 150,191,077 (+)NCBIGRCr8
mRatBN7.23127,720,066 - 129,737,511 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3127,720,181 - 129,734,492 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.03135,729,839 - 136,422,082 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3134,413,170 - 134,441,540 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.03140,866,319 - 142,867,324 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43128,570,984 - 130,673,729 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3127,663,937 - 128,671,039 (+)NCBICelera
Cytogenetic Map3q41NCBI
Macrod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541523,398,776 - 25,226,450 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541523,398,409 - 25,239,184 (+)NCBIChiLan1.0ChiLan1.0
MACROD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22114,894,726 - 16,949,118 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12014,891,558 - 16,945,955 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02013,966,338 - 16,020,506 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12015,811,151 - 16,001,125 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2013,950,260 - 15,997,806 (+)Ensemblpanpan1.1panPan2
MACROD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1246,740,943 - 8,673,524 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl246,744,744 - 8,673,275 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha246,549,204 - 8,490,218 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0247,160,459 - 9,088,151 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl247,164,261 - 9,082,843 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1246,754,652 - 8,690,508 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0246,853,205 - 8,780,688 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0247,128,078 - 9,135,123 (-)NCBIUU_Cfam_GSD_1.0
MACROD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1722,635,284 - 24,683,549 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11722,635,105 - 24,686,846 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21727,211,780 - 27,690,646 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MACROD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1242,891,656 - 44,973,129 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660543,167,567 - 5,340,119 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Macrod2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474114,998,305 - 17,252,759 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474114,998,007 - 17,256,372 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSSTOT00000022616   ⟹   ENSSTOP00000018181
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364855,802,290 - 5,859,251 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000033656   ⟹   ENSSTOP00000029957
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364853,931,035 - 5,859,251 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000038328   ⟹   ENSSTOP00000030432
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364853,919,525 - 5,859,251 (-)Ensembl
RefSeq Acc Id: XM_005320463   ⟹   XP_005320520
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640155,484,882 - 157,428,160 (-)NCBI
SpeTri2.0NW_0049364853,917,060 - 5,859,526 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723257   ⟹   XP_021578932
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640155,484,882 - 157,428,162 (-)NCBI
SpeTri2.0NW_0049364853,917,060 - 5,859,527 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723258   ⟹   XP_021578933
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640155,484,882 - 157,428,160 (-)NCBI
SpeTri2.0NW_0049364853,917,060 - 5,859,526 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040275963   ⟹   XP_040131897
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640155,484,882 - 157,428,161 (-)NCBI
RefSeq Acc Id: XM_040275964   ⟹   XP_040131898
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640155,484,882 - 157,435,824 (-)NCBI
RefSeq Acc Id: XM_040275965   ⟹   XP_040131899
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640155,484,882 - 157,428,161 (-)NCBI
1 to 9 of 9 rows
Protein RefSeqs XP_005320520 (Get FASTA)   NCBI Sequence Viewer  
  XP_021578932 (Get FASTA)   NCBI Sequence Viewer  
  XP_021578933 (Get FASTA)   NCBI Sequence Viewer  
  XP_040131897 (Get FASTA)   NCBI Sequence Viewer  
  XP_040131898 (Get FASTA)   NCBI Sequence Viewer  
  XP_040131899 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000018181.2
  ENSSTOP00000029957.1
  ENSSTOP00000030432.1
1 to 9 of 9 rows
RefSeq Acc Id: XP_005320520   ⟸   XM_005320463
- Peptide Label: isoform X1
- UniProtKB: A0A287D8R4 (UniProtKB/TrEMBL),   A0A287DA42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021578932   ⟸   XM_021723257
- Peptide Label: isoform X2
- UniProtKB: A0A287DA42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021578933   ⟸   XM_021723258
- Peptide Label: isoform X4
- UniProtKB: A0A287DA42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040131898   ⟸   XM_040275964
- Peptide Label: isoform X5
- UniProtKB: A0A287DA42 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040131899   ⟸   XM_040275965
- Peptide Label: isoform X6
- UniProtKB: A0A287DA42 (UniProtKB/TrEMBL)
Macro



1 to 17 of 17 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSTOG00000034890 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000022616.2 UniProtKB/TrEMBL
  ENSSTOT00000033656.1 UniProtKB/TrEMBL
  ENSSTOT00000038328.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.220.10 UniProtKB/TrEMBL
InterPro Macro_dom UniProtKB/TrEMBL
  Macro_dom-like UniProtKB/TrEMBL
NCBI Gene Macrod2 ENTREZGENE
PANTHER ADP-RIBOSE GLYCOHYDROLASE MACROD2 UniProtKB/TrEMBL
  GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED UniProtKB/TrEMBL
Pfam Macro UniProtKB/TrEMBL
PROSITE MACRO UniProtKB/TrEMBL
SMART A1pp UniProtKB/TrEMBL
Superfamily-SCOP SSF52949 UniProtKB/TrEMBL
UniProt A0A287D8R4 ENTREZGENE, UniProtKB/TrEMBL
  A0A287DA42 ENTREZGENE, UniProtKB/TrEMBL
  I3N1D5_ICTTR UniProtKB/TrEMBL
1 to 17 of 17 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-15 Macrod2  mono-ADP ribosylhydrolase 2    MACRO domain containing 2  Symbol and/or name change 5135510 APPROVED