MACROD2 (mono-ADP ribosylhydrolase 2) - Rat Genome Database

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Gene: MACROD2 (mono-ADP ribosylhydrolase 2) Sus scrofa
Analyze
Symbol: MACROD2
Name: mono-ADP ribosylhydrolase 2
RGD ID: 14206789
Description: ENCODES a protein that exhibits ADP-ribosylglutamate hydrolase activity (inferred); deacetylase activity (inferred); hydrolase activity, acting on glycosyl bonds (inferred); INVOLVED IN response to bacterium (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH amenorrhea (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN nucleolus (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: MACRO domain containing 2; O-acetyl-ADP-ribose deacetylase MACROD2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1722,635,284 - 24,683,549 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11722,635,105 - 24,686,846 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21727,211,780 - 27,690,646 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleolus  (IEA)
nucleoplasm  (IBA,IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:30032202  


Genomics

Comparative Map Data
MACROD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1722,635,284 - 24,683,549 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11722,635,105 - 24,686,846 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21727,211,780 - 27,690,646 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MACROD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382013,995,516 - 16,053,197 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2013,995,369 - 16,053,197 (+)EnsemblGRCh38hg38GRCh38
GRCh372013,976,162 - 16,033,842 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362013,924,146 - 15,981,842 (+)NCBINCBI36Build 36hg18NCBI36
Build 342013,924,318 - 13,982,313NCBI
Celera2014,051,522 - 16,108,818 (+)NCBICelera
Cytogenetic Map20p12.1NCBI
HuRef2013,936,352 - 15,994,332 (+)NCBIHuRef
CHM1_12013,976,154 - 16,033,759 (+)NCBICHM1_1
T2T-CHM13v2.02014,044,768 - 16,102,640 (+)NCBIT2T-CHM13v2.0
Macrod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392140,237,223 - 142,234,886 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2140,237,229 - 142,234,886 (+)EnsemblGRCm39 Ensembl
GRCm382140,395,303 - 142,392,966 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2140,395,309 - 142,392,966 (+)EnsemblGRCm38mm10GRCm38
MGSCv372140,221,166 - 142,215,786 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362140,086,876 - 140,114,395 (+)NCBIMGSCv36mm8
Celera2141,585,472 - 143,579,729 (+)NCBICelera
Cytogenetic Map2F3- G1NCBI
cM Map269.2NCBI
Macrod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83148,173,821 - 150,191,077 (+)NCBIGRCr8
mRatBN7.23127,720,066 - 129,737,511 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3127,720,181 - 129,734,492 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.03135,729,839 - 136,422,082 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3134,413,170 - 134,441,540 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.03140,866,319 - 142,867,324 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43128,570,984 - 130,673,729 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3127,663,937 - 128,671,039 (+)NCBICelera
Cytogenetic Map3q41NCBI
Macrod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541523,398,776 - 25,226,450 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541523,398,409 - 25,239,184 (+)NCBIChiLan1.0ChiLan1.0
MACROD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22114,894,726 - 16,949,118 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12014,891,558 - 16,945,955 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02013,966,338 - 16,020,506 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12015,811,151 - 16,001,125 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2013,950,260 - 15,997,806 (+)Ensemblpanpan1.1panPan2
MACROD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1246,740,943 - 8,673,524 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl246,744,744 - 8,673,275 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha246,549,204 - 8,490,218 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0247,160,459 - 9,088,151 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl247,164,261 - 9,082,843 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1246,754,652 - 8,690,508 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0246,853,205 - 8,780,688 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0247,128,078 - 9,135,123 (-)NCBIUU_Cfam_GSD_1.0
Macrod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640155,484,882 - 157,435,824 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364853,919,525 - 5,859,251 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364853,917,060 - 5,859,527 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MACROD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1242,891,656 - 44,973,129 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660543,167,567 - 5,340,119 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Macrod2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474114,998,305 - 17,252,759 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474114,998,007 - 17,256,372 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MACROD2
55868 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10
Low 7 3 3 5 1 13 2 3 1
Below cutoff 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000025218   ⟹   ENSSSCP00000020311
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1722,635,284 - 24,683,549 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000032097   ⟹   ENSSSCP00000028197
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1722,635,284 - 24,683,549 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000089254   ⟹   ENSSSCP00000071057
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1722,635,284 - 24,683,549 (+)Ensembl
RefSeq Acc Id: XM_021077529   ⟹   XP_020933188
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11722,635,105 - 24,686,846 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021077530   ⟹   XP_020933189
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11722,635,105 - 24,677,199 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021077531   ⟹   XP_020933190
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11722,635,105 - 24,686,846 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021077532   ⟹   XP_020933191
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11722,635,105 - 24,686,846 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021077533   ⟹   XP_020933192
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11722,635,105 - 24,686,846 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020933188   ⟸   XM_021077529
- Peptide Label: isoform X1
- UniProtKB: I3LVP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020933191   ⟸   XM_021077532
- Peptide Label: isoform X3
- UniProtKB: A0A4X1UWP9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020933190   ⟸   XM_021077531
- Peptide Label: isoform X2
- UniProtKB: I3LVP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020933192   ⟸   XM_021077533
- Peptide Label: isoform X4
- UniProtKB: I3LVP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020933189   ⟸   XM_021077530
- Peptide Label: isoform X1
- UniProtKB: I3LVP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000020311   ⟸   ENSSSCT00000025218
RefSeq Acc Id: ENSSSCP00000071057   ⟸   ENSSSCT00000089254
RefSeq Acc Id: ENSSSCP00000028197   ⟸   ENSSSCT00000032097
Protein Domains
Macro


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000030112 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070019958 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000025218.4 UniProtKB/TrEMBL
  ENSSSCT00000032097 ENTREZGENE
  ENSSSCT00000032097.4 UniProtKB/TrEMBL
  ENSSSCT00000089254 ENTREZGENE
  ENSSSCT00000089254.2 UniProtKB/TrEMBL
  ENSSSCT00070039624.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.220.10 UniProtKB/TrEMBL
InterPro Macro_dom UniProtKB/TrEMBL
  Macro_dom-like UniProtKB/TrEMBL
NCBI Gene MACROD2 ENTREZGENE
PANTHER ADP-RIBOSE GLYCOHYDROLASE MACROD2 UniProtKB/TrEMBL
  GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED UniProtKB/TrEMBL
Pfam Macro UniProtKB/TrEMBL
PROSITE MACRO UniProtKB/TrEMBL
SMART A1pp UniProtKB/TrEMBL
Superfamily-SCOP SSF52949 UniProtKB/TrEMBL
UniProt A0A4X1UWP9 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2RHY2_PIG UniProtKB/TrEMBL
  I3L8F1_PIG UniProtKB/TrEMBL
  I3LVP4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:108725 ENTREZGENE