MACROD2 (mono-ADP ribosylhydrolase 2) - Rat Genome Database

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Gene: MACROD2 (mono-ADP ribosylhydrolase 2) Pan paniscus
Analyze
Symbol: MACROD2
Name: mono-ADP ribosylhydrolase 2
RGD ID: 11893688
Description: ENCODES a protein that exhibits ADP-ribosylglutamate hydrolase activity (inferred); deacetylase activity (inferred); hydrolase activity, acting on glycosyl bonds (inferred); INVOLVED IN response to bacterium (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH amenorrhea (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN nucleolus (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ADP-ribose glycohydrolase MACROD2; LOC100988863; LOC106634165; LOC106634172; MACRO domain containing 2; O-acetyl-ADP-ribose deacetylase MACROD2; O-acetyl-ADP-ribose deacetylase MACROD2-like; uncharacterized LOC106634172
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22114,894,726 - 16,949,118 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12014,891,558 - 16,945,955 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02013,966,338 - 16,020,506 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12015,811,151 - 16,001,125 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2013,950,260 - 15,997,806 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleolus  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
MACROD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22114,894,726 - 16,949,118 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12014,891,558 - 16,945,955 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02013,966,338 - 16,020,506 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12015,811,151 - 16,001,125 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2013,950,260 - 15,997,806 (+)Ensemblpanpan1.1panPan2
MACROD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382013,995,516 - 16,053,197 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2013,995,369 - 16,053,197 (+)EnsemblGRCh38hg38GRCh38
GRCh372013,976,162 - 16,033,842 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362013,924,146 - 15,981,842 (+)NCBINCBI36Build 36hg18NCBI36
Build 342013,924,318 - 13,982,313NCBI
Celera2014,051,522 - 16,108,818 (+)NCBICelera
Cytogenetic Map20p12.1NCBI
HuRef2013,936,352 - 15,994,332 (+)NCBIHuRef
CHM1_12013,976,154 - 16,033,759 (+)NCBICHM1_1
T2T-CHM13v2.02014,044,768 - 16,102,640 (+)NCBIT2T-CHM13v2.0
Macrod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392140,237,223 - 142,234,886 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2140,237,229 - 142,234,886 (+)EnsemblGRCm39 Ensembl
GRCm382140,395,303 - 142,392,966 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2140,395,309 - 142,392,966 (+)EnsemblGRCm38mm10GRCm38
MGSCv372140,221,166 - 142,215,786 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362140,086,876 - 140,114,395 (+)NCBIMGSCv36mm8
Celera2141,585,472 - 143,579,729 (+)NCBICelera
Cytogenetic Map2F3- G1NCBI
cM Map269.2NCBI
Macrod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83148,173,821 - 150,191,077 (+)NCBIGRCr8
mRatBN7.23127,720,066 - 129,737,511 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3127,720,181 - 129,734,492 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.03135,729,839 - 136,422,082 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3134,413,170 - 134,441,540 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.03140,866,319 - 142,867,324 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43128,570,984 - 130,673,729 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3127,663,937 - 128,671,039 (+)NCBICelera
Cytogenetic Map3q41NCBI
Macrod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541523,398,776 - 25,226,450 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541523,398,409 - 25,239,184 (+)NCBIChiLan1.0ChiLan1.0
MACROD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1246,740,943 - 8,673,524 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl246,744,744 - 8,673,275 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha246,549,204 - 8,490,218 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0247,160,459 - 9,088,151 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl247,164,261 - 9,082,843 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1246,754,652 - 8,690,508 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0246,853,205 - 8,780,688 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0247,128,078 - 9,135,123 (-)NCBIUU_Cfam_GSD_1.0
Macrod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640155,484,882 - 157,435,824 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364853,919,525 - 5,859,251 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364853,917,060 - 5,859,527 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MACROD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1722,635,284 - 24,683,549 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11722,635,105 - 24,686,846 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21727,211,780 - 27,690,646 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MACROD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1242,891,656 - 44,973,129 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660543,167,567 - 5,340,119 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Macrod2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474114,998,305 - 17,252,759 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474114,998,007 - 17,256,372 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000041045   ⟹   ENSPPAP00000018315
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2013,950,260 - 15,997,806 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000041048   ⟹   ENSPPAP00000018318
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2015,811,211 - 15,997,806 (+)Ensembl
RefSeq Acc Id: XM_034947082   ⟹   XP_034802973
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22114,894,729 - 16,949,118 (+)NCBI
NHGRI_mPanPan12014,891,562 - 16,945,955 (+)NCBI
Mhudiblu_PPA_v02013,966,341 - 16,018,920 (+)NCBI
RefSeq Acc Id: XM_034947083   ⟹   XP_034802974
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22114,894,729 - 16,949,118 (+)NCBI
NHGRI_mPanPan12014,891,560 - 16,945,955 (+)NCBI
Mhudiblu_PPA_v02013,966,338 - 16,018,920 (+)NCBI
RefSeq Acc Id: XM_034947084   ⟹   XP_034802975
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22114,894,728 - 16,949,118 (+)NCBI
NHGRI_mPanPan12014,891,559 - 16,945,955 (+)NCBI
Mhudiblu_PPA_v02013,966,338 - 16,020,506 (+)NCBI
RefSeq Acc Id: XM_055105080   ⟹   XP_054961055
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22114,894,729 - 16,949,118 (+)NCBI
NHGRI_mPanPan12014,891,561 - 16,945,955 (+)NCBI
RefSeq Acc Id: XM_055105081   ⟹   XP_054961056
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22114,894,728 - 16,949,118 (+)NCBI
NHGRI_mPanPan12014,891,559 - 16,945,955 (+)NCBI
RefSeq Acc Id: XM_055105082   ⟹   XP_054961057
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22114,894,728 - 16,949,118 (+)NCBI
NHGRI_mPanPan12014,891,559 - 16,945,955 (+)NCBI
RefSeq Acc Id: XM_055105083   ⟹   XP_054961058
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22114,894,727 - 16,949,118 (+)NCBI
NHGRI_mPanPan12014,891,558 - 16,945,955 (+)NCBI
RefSeq Acc Id: XM_055105084   ⟹   XP_054961059
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22114,894,726 - 16,949,118 (+)NCBI
NHGRI_mPanPan12014,891,558 - 16,945,955 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_034802975   ⟸   XM_034947084
- Peptide Label: isoform X8
- UniProtKB: A0A2R9ARC4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034802974   ⟸   XM_034947083
- Peptide Label: isoform X7
- UniProtKB: A0A2R9ARC4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034802973   ⟸   XM_034947082
- Peptide Label: isoform X6
- UniProtKB: A0A2R9ARC4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000018318   ⟸   ENSPPAT00000041048
RefSeq Acc Id: ENSPPAP00000018315   ⟸   ENSPPAT00000041045
RefSeq Acc Id: XP_054961058   ⟸   XM_055105083
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054961059   ⟸   XM_055105084
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054961056   ⟸   XM_055105081
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054961057   ⟸   XM_055105082
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054961055   ⟸   XM_055105080
- Peptide Label: isoform X1
Protein Domains
Macro


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000032282 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000041045.1 UniProtKB/TrEMBL
  ENSPPAT00000041048.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.220.10 UniProtKB/TrEMBL
InterPro Macro_dom UniProtKB/TrEMBL
  Macro_dom-like UniProtKB/TrEMBL
NCBI Gene LOC100988863 ENTREZGENE
PANTHER ADP-RIBOSE GLYCOHYDROLASE MACROD2 UniProtKB/TrEMBL
  GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED UniProtKB/TrEMBL
Pfam Macro UniProtKB/TrEMBL
PROSITE MACRO UniProtKB/TrEMBL
SMART A1pp UniProtKB/TrEMBL
Superfamily-SCOP SSF52949 UniProtKB/TrEMBL
UniProt A0A2R9AME4_PANPA UniProtKB/TrEMBL
  A0A2R9ARC4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-07-01 MACROD2  mono-ADP ribosylhydrolase 2  LOC100988863  O-acetyl-ADP-ribose deacetylase MACROD2  Symbol and/or name change 5135510 APPROVED
2020-06-11 LOC100988863  O-acetyl-ADP-ribose deacetylase MACROD2  LOC106634172  uncharacterized LOC106634172  Data merged from RGD:11942165 737654 PROVISIONAL
2020-06-11 LOC100988863  O-acetyl-ADP-ribose deacetylase MACROD2  LOC106634165  O-acetyl-ADP-ribose deacetylase MACROD2-like  Data merged from RGD:11975640 737654 PROVISIONAL