Hr (HR lysine demethylase and nuclear receptor corepressor) - Rat Genome Database

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Gene: Hr (HR lysine demethylase and nuclear receptor corepressor) Ictidomys tridecemlineatus
Analyze
Symbol: Hr
Name: HR lysine demethylase and nuclear receptor corepressor
RGD ID: 12486025
Description: ENCODES a protein that exhibits histone deacetylase binding (ortholog); nuclear thyroid hormone receptor binding (ortholog); nuclear vitamin D receptor binding (ortholog); INVOLVED IN negative regulation of DNA-binding transcription factor activity (ortholog); ASSOCIATED WITH alopecia (ortholog); alopecia universalis (ortholog); atrichia with papular lesions (ortholog); FOUND IN histone deacetylase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hair growth associated; HR, lysine demethylase and nuclear receptor corepressor; HR, lysine demethylase and nuclear receptor corepressor, transcript variant X1; HR, lysine demethylase and nuclear receptor corepressor, transcript variant X2; lysine-specific demethylase hairless
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494312,612,526 - 12,634,082 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365555,936,220 - 5,954,974 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365555,936,431 - 5,954,852 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HrSquirrelalopecia  ISOHR (Homo sapiens)9068941alopecia universalis congenita and OMIM:203655 DNA:point_mutation:CDS:T3407A -> amino acid V1136DRGDPMID:9736769 and REF_RGD_ID:1599575
HrSquirrelfocal segmental glomerulosclerosis  ISOHr (Rattus norvegicus)9068941 RGDPMID:21325752 and REF_RGD_ID:150520024
HrSquirrelproteinuria  ISOHr (Rattus norvegicus)9068941 RGDPMID:21325752 and REF_RGD_ID:150520024
HrSquirrelSkin Abnormalities  ISOHR (Homo sapiens)9068941atrichia with papular lesions and OMIM:209500 DNA:deletion:exon:2147delCRGDPMID:9856480 and REF_RGD_ID:1599576
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HrSquirrelalopecia universalis  ISOHR (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11410842 more ...
HrSquirrelatrichia with papular lesions  ISOHR (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10205263 more ...
HrSquirrelCoffin-Siris syndrome 2  ISOHR (Homo sapiens)8554872ClinVar Annotator: match by term: COFFIN-SIRIS SYNDROME 2ClinVarPMID:21919222 more ...
HrSquirrelConotruncal Cardiac Defects  ISOHR (Homo sapiens)8554872ClinVar Annotator: match by term: Conotruncal heart malformationsClinVarPMID:28492532
HrSquirrelgenetic disease  ISOHR (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
HrSquirrelhypotrichosis 4  ISOHR (Homo sapiens)8554872ClinVar Annotator: match by term: Hypotrichosis 4ClinVarPMID:10777357 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HrSquirrelalopecia  ISOHR (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:16455232
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HrSquirrelalopecia universalis  ISOHR (Homo sapiens)7240710 OMIM 
HrSquirrelatrichia with papular lesions  ISOHR (Homo sapiens)7240710 OMIM 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HrSquirrelchromatin remodeling involved_inIEAGO:0032454150520179 GOCGO_REF:0000108
HrSquirreldemethylation involved_inIEAUniRule:UR001695797150520179 UniProtGO_REF:0000104
HrSquirrelnegative regulation of DNA-binding transcription factor activity  ISOHr (Rattus norvegicus)9068941 RGDPMID:11641275 and REF_RGD_ID:1599577
HrSquirrelnegative regulation of DNA-templated transcription acts_upstream_of_or_withinIEAUniProtKB:Q61645 and ensembl:ENSMUSP00000124816150520179 EnsemblGO_REF:0000107
HrSquirrelregulation of transcription by RNA polymerase II involved_inIEAPANTHER:PTN000284629150520179 TreeGrafterGO_REF:0000118

Cellular Component
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HrSquirrelchromatin located_inIEAPANTHER:PTN000284629150520179 TreeGrafterGO_REF:0000118
HrSquirrelhistone deacetylase complex  ISOHr (Rattus norvegicus)9068941matrix-associated deacetylase MAD bodiesRGDPMID:11641275 and REF_RGD_ID:1599577
HrSquirrelhistone deacetylase complex part_ofIEAPANTHER:PTN000284629150520179 TreeGrafterGO_REF:0000118
HrSquirrelhistone deacetylase complex part_ofIEAUniRule:UR001695797150520179 UniProtGO_REF:0000104
HrSquirrelnuclear body located_inIEAUniProtKB:Q61645 and ensembl:ENSMUSP00000124816150520179 EnsemblGO_REF:0000107
HrSquirrelnucleoplasm located_inIEAUniProtKB:O43593 and ensembl:ENSP00000370826150520179 EnsemblGO_REF:0000107
HrSquirrelnucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
HrSquirrelnucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
HrSquirrelnucleus located_inIEAUniRule:UR001695797150520179 UniProtGO_REF:0000104
1 to 9 of 9 rows

Molecular Function
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HrSquirrelchromatin DNA binding enablesIEAPANTHER:PTN000284629150520179 TreeGrafterGO_REF:0000118
HrSquirrelhistone deacetylase binding  ISOHr (Rattus norvegicus)9068941Hdac1 and Hdac3 and Hdac5RGDPMID:11641275 and REF_RGD_ID:1599577
HrSquirrelhistone H3K9 demethylase activity enablesIEAInterPro:IPR045109150520179 InterProGO_REF:0000002
HrSquirrelhistone H3K9 demethylase activity enablesIEAPANTHER:PTN000284629150520179 TreeGrafterGO_REF:0000118
HrSquirrelmetal ion binding enablesIEAUniRule:UR001695797150520179 UniProtGO_REF:0000104
HrSquirrelmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
HrSquirrelnuclear thyroid hormone receptor binding  ISOThra (Rattus norvegicus)9068941 RGDPMID:11641275 and REF_RGD_ID:1599577
HrSquirrelnuclear thyroid hormone receptor binding  ISOThrb (Rattus norvegicus)9068941 RGDPMID:11641275 and REF_RGD_ID:1599577
HrSquirrelnuclear vitamin D receptor binding  ISOVDR (Homo sapiens)9068941 RGDPMID:12847098 and REF_RGD_ID:1599578
HrSquirrelprotein binding enablesISOUniProtKB:A8MQ03 more ...9068941 PMID:32296183IntActPMID:32296183
HrSquirrelprotein binding enablesISOPR:O09106 more ...9068941 PMID:11641275MGIPMID:11641275
HrSquirrelprotein-containing complex binding  ISOVDR (Homo sapiens)9068941heterooligomerization and binds the vitamin D receptor-retinoid X receptor complexRGDPMID:12847098 and REF_RGD_ID:1599578
HrSquirreltranscription coregulator activity enablesIEAPANTHER:PTN000284629150520179 TreeGrafterGO_REF:0000118
HrSquirreltranscription corepressor activity  ISOHr (Rattus norvegicus)9068941 RGDPMID:11641275 and REF_RGD_ID:1599577
HrSquirreltranscription corepressor activity enablesIEAUniProtKB:Q61645 and ensembl:ENSMUSP00000124816150520179 EnsemblGO_REF:0000107
1 to 15 of 15 rows

PMID:30032202  



Hr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494312,612,526 - 12,634,082 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365555,936,220 - 5,954,974 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365555,936,431 - 5,954,852 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38822,114,419 - 22,131,052 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl822,114,419 - 22,133,384 (-)EnsemblGRCh38hg38GRCh38
GRCh37821,971,932 - 21,988,565 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,027,877 - 22,043,975 (-)NCBINCBI36Build 36hg18NCBI36
Build 34822,028,526 - 22,045,326NCBI
Celera820,934,236 - 20,950,880 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef820,514,477 - 20,541,503 (-)NCBIHuRef
CHM1_1822,173,616 - 22,190,245 (-)NCBICHM1_1
T2T-CHM13v2.0822,388,371 - 22,405,000 (-)NCBIT2T-CHM13v2.0
Hr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,789,644 - 70,810,988 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,789,652 - 70,810,988 (+)EnsemblGRCm39 Ensembl
GRCm381470,554,056 - 70,573,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,552,212 - 70,573,548 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,953,863 - 70,973,350 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361469,289,136 - 69,308,623 (+)NCBIMGSCv36mm8
Celera1468,095,776 - 68,115,052 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.32NCBI
Hr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81552,036,540 - 52,056,019 (+)NCBIGRCr8
mRatBN7.21545,626,835 - 45,646,313 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,626,835 - 45,646,313 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,744,700 - 49,764,175 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,856,205 - 50,875,680 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01547,715,507 - 47,734,986 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01552,241,801 - 52,261,276 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,241,801 - 52,261,276 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,967,613 - 55,984,797 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,957,053 - 50,972,842 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,972,821 - 50,988,623 (+)NCBI
Celera1545,305,217 - 45,324,692 (+)NCBICelera
Cytogenetic Map15p11NCBI
Hr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540345,605,510 - 45,624,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540345,605,870 - 45,624,386 (-)NCBIChiLan1.0ChiLan1.0
HR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2740,616,243 - 40,630,986 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1816,341,438 - 16,357,572 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0821,359,348 - 21,378,315 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1818,298,709 - 18,316,151 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,298,709 - 18,316,151 (-)Ensemblpanpan1.1panPan2
HR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12535,120,566 - 35,136,560 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2535,119,784 - 35,135,545 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2535,710,085 - 35,727,556 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02535,332,063 - 35,349,535 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2535,333,417 - 35,347,559 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12535,277,299 - 35,294,762 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02535,131,873 - 35,149,314 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02535,287,349 - 35,304,802 (+)NCBIUU_Cfam_GSD_1.0
HR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl146,386,903 - 6,407,031 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1146,386,900 - 6,404,968 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2146,822,598 - 6,840,654 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1820,183,797 - 20,207,510 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl820,183,677 - 20,198,700 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605222,028,581 - 22,052,527 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475817,699,400 - 17,715,482 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475817,699,357 - 17,719,188 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSSTOT00000016515   ⟹   ENSSTOP00000014779
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365555,936,220 - 5,954,974 (-)Ensembl
RefSeq Acc Id: XM_005329303   ⟹   XP_005329360
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494312,615,632 - 12,634,082 (+)NCBI
SpeTri2.0NW_0049365555,936,431 - 5,954,852 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013360343   ⟹   XP_013215797
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494312,615,632 - 12,634,082 (+)NCBI
SpeTri2.0NW_0049365555,936,431 - 5,954,852 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040293157   ⟹   XP_040149091
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494312,612,526 - 12,634,082 (+)NCBI
Protein RefSeqs XP_005329360 (Get FASTA)   NCBI Sequence Viewer  
  XP_013215797 (Get FASTA)   NCBI Sequence Viewer  
  XP_040149091 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000014779.2
GenBank Protein KAG3294415 (Get FASTA)   NCBI Sequence Viewer  
  KAG3294416 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005329360   ⟸   XM_005329303
- Peptide Label: isoform X2
- UniProtKB: I3MRP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013215797   ⟸   XM_013360343
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_040149091   ⟸   XM_040293157
- Peptide Label: isoform X1
Ensembl Acc Id: ENSSTOP00000014779   ⟸   ENSSTOT00000016515
JmjC



1 to 13 of 13 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSTOG00000016512 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000016515.3 UniProtKB/TrEMBL
Gene3D-CATH Cupin UniProtKB/TrEMBL
InterPro JHDM2-like UniProtKB/TrEMBL
  JmjC_dom UniProtKB/TrEMBL
NCBI Gene Hr ENTREZGENE
PANTHER LYSINE-SPECIFIC DEMETHYLASE HAIRLESS UniProtKB/TrEMBL
  PTHR12549 UniProtKB/TrEMBL
Pfam JmjC UniProtKB/TrEMBL
PROSITE JMJC UniProtKB/TrEMBL
SMART JmjC UniProtKB/TrEMBL
Superfamily-SCOP Clavaminate synthase-like UniProtKB/TrEMBL
UniProt I3MRP4 ENTREZGENE, UniProtKB/TrEMBL
1 to 13 of 13 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 Hr  HR lysine demethylase and nuclear receptor corepressor    HR, lysine demethylase and nuclear receptor corepressor  Symbol and/or name change 5135510 APPROVED