Hr (HR lysine demethylase and nuclear receptor corepressor) - Rat Genome Database

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Gene: Hr (HR lysine demethylase and nuclear receptor corepressor) Heterocephalus glaber
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Symbol: Hr
Name: HR lysine demethylase and nuclear receptor corepressor
RGD ID: 18930052
Description: ENCODES a protein that exhibits histone deacetylase binding (ortholog); nuclear thyroid hormone receptor binding (ortholog); nuclear vitamin D receptor binding (ortholog); INVOLVED IN negative regulation of DNA-binding transcription factor activity (ortholog); negative regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH alopecia (ortholog); alopecia universalis (ortholog); atrichia with papular lesions (ortholog); FOUND IN histone deacetylase complex (ortholog); nuclear body (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hair growth associated; lysine-specific demethylase hairless; Protein hairless
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475817,699,400 - 17,715,482 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475817,699,357 - 17,719,188 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Hr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475817,699,400 - 17,715,482 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475817,699,357 - 17,719,188 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
HR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38822,114,419 - 22,131,052 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl822,114,419 - 22,133,384 (-)EnsemblGRCh38hg38GRCh38
GRCh37821,971,932 - 21,988,565 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,027,877 - 22,043,975 (-)NCBINCBI36Build 36hg18NCBI36
Build 34822,028,526 - 22,045,326NCBI
Celera820,934,236 - 20,950,880 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef820,514,477 - 20,541,503 (-)NCBIHuRef
CHM1_1822,173,616 - 22,190,245 (-)NCBICHM1_1
T2T-CHM13v2.0822,388,371 - 22,405,000 (-)NCBIT2T-CHM13v2.0
Hr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,789,644 - 70,810,988 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,789,652 - 70,810,988 (+)EnsemblGRCm39 Ensembl
GRCm381470,554,056 - 70,573,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,552,212 - 70,573,548 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,953,863 - 70,973,350 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361469,289,136 - 69,308,623 (+)NCBIMGSCv36mm8
Celera1468,095,776 - 68,115,052 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.32NCBI
Hr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81552,036,540 - 52,056,019 (+)NCBIGRCr8
mRatBN7.21545,626,835 - 45,646,313 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,626,835 - 45,646,313 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,744,700 - 49,764,175 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,856,205 - 50,875,680 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01547,715,507 - 47,734,986 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01552,241,801 - 52,261,276 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,241,801 - 52,261,276 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,967,613 - 55,984,797 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,957,053 - 50,972,842 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,972,821 - 50,988,623 (+)NCBI
Celera1545,305,217 - 45,324,692 (+)NCBICelera
Cytogenetic Map15p11NCBI
Hr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540345,605,510 - 45,624,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540345,605,870 - 45,624,386 (-)NCBIChiLan1.0ChiLan1.0
HR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2740,616,243 - 40,630,986 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1816,341,438 - 16,357,572 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0821,359,348 - 21,378,315 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1818,298,709 - 18,316,151 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,298,709 - 18,316,151 (-)Ensemblpanpan1.1panPan2
HR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12535,120,566 - 35,136,560 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2535,119,784 - 35,135,545 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2535,710,085 - 35,727,556 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02535,332,063 - 35,349,535 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2535,333,417 - 35,347,559 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12535,277,299 - 35,294,762 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02535,131,873 - 35,149,314 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02535,287,349 - 35,304,802 (+)NCBIUU_Cfam_GSD_1.0
Hr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494312,612,526 - 12,634,082 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365555,936,220 - 5,954,974 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365555,936,431 - 5,954,852 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl146,386,903 - 6,407,031 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1146,386,900 - 6,404,968 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2146,822,598 - 6,840,654 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1820,183,797 - 20,207,510 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl820,183,677 - 20,198,700 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605222,028,581 - 22,052,527 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000019584   ⟹   ENSHGLP00000019393
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475817,699,400 - 17,715,482 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000019585   ⟹   ENSHGLP00000019394
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475817,700,526 - 17,713,592 (-)Ensembl
RefSeq Acc Id: XM_013073466   ⟹   XP_012928920
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475817,699,357 - 17,717,694 (-)NCBI
RefSeq Acc Id: XM_013073468   ⟹   XP_012928922
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475817,699,357 - 17,719,188 (-)NCBI
RefSeq Acc Id: XM_013073469   ⟹   XP_012928923
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475817,699,357 - 17,719,188 (-)NCBI
RefSeq Acc Id: XM_013073470   ⟹   XP_012928924
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475817,699,357 - 17,719,188 (-)NCBI
RefSeq Acc Id: XM_021261230   ⟹   XP_021116889
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475817,699,357 - 17,719,188 (-)NCBI
RefSeq Acc Id: XM_021261231   ⟹   XP_021116890
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475817,699,357 - 17,719,188 (-)NCBI
RefSeq Acc Id: XM_021261232   ⟹   XP_021116891
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475817,699,357 - 17,719,188 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021116891   ⟸   XM_021261232
- Peptide Label: isoform X6
- UniProtKB: G5B9P7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012928924   ⟸   XM_013073470
- Peptide Label: isoform X4
- UniProtKB: A0A0P6J8Q4 (UniProtKB/TrEMBL),   G5B9P7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012928922   ⟸   XM_013073468
- Peptide Label: isoform X2
- UniProtKB: G5B9P7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012928923   ⟸   XM_013073469
- Peptide Label: isoform X3
- UniProtKB: G5B9P7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116890   ⟸   XM_021261231
- Peptide Label: isoform X5
- UniProtKB: G5B9P7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116889   ⟸   XM_021261230
- Peptide Label: isoform X1
- UniProtKB: G5B9P7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012928920   ⟸   XM_013073466
- Peptide Label: isoform X1
- UniProtKB: G5B9P7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000019393   ⟸   ENSHGLT00000019584
RefSeq Acc Id: ENSHGLP00000019394   ⟸   ENSHGLT00000019585


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000013891 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000019584 ENTREZGENE
  ENSHGLT00000019585 ENTREZGENE
Gene3D-CATH Cupin UniProtKB/TrEMBL
InterPro JHDM2-like UniProtKB/TrEMBL
  JmjC_dom UniProtKB/TrEMBL
NCBI Gene Hr ENTREZGENE
PANTHER LYSINE-SPECIFIC DEMETHYLASE HAIRLESS UniProtKB/TrEMBL
  PTHR12549 UniProtKB/TrEMBL
Pfam JmjC UniProtKB/TrEMBL
PROSITE JMJC UniProtKB/TrEMBL
SMART JmjC UniProtKB/TrEMBL
Superfamily-SCOP Clavaminate synthase-like UniProtKB/TrEMBL
UniProt A0A0P6J8Q4 ENTREZGENE, UniProtKB/TrEMBL
  G5B9P7 ENTREZGENE, UniProtKB/TrEMBL