PCSK9 (proprotein convertase subtilisin/kexin type 9) - Rat Genome Database

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Gene: PCSK9 (proprotein convertase subtilisin/kexin type 9) Canis lupus familiaris
Analyze
Symbol: PCSK9
Name: proprotein convertase subtilisin/kexin type 9
RGD ID: 12338796
Description: ENCODES a protein that exhibits apolipoprotein binding (ortholog); apolipoprotein receptor binding (ortholog); low-density lipoprotein particle binding (ortholog); INVOLVED IN cellular response to insulin stimulus (ortholog); cellular response to starvation (ortholog); cholesterol homeostasis (ortholog); ASSOCIATED WITH autosomal recessive hypercholesterolemia (ortholog); classic citrullinemia (ortholog); coronary artery disease (ortholog); FOUND IN cell surface (ortholog); COPII-coated ER to Golgi transport vesicle (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1554,197,211 - 54,210,724 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha554,264,679 - 54,280,339 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0554,383,361 - 54,399,016 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1554,380,525 - 54,396,181 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0554,270,491 - 54,282,704 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0554,658,929 - 54,672,888 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References

Genomics

Comparative Map Data
PCSK9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1554,197,211 - 54,210,724 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha554,264,679 - 54,280,339 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0554,383,361 - 54,399,016 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1554,380,525 - 54,396,181 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0554,270,491 - 54,282,704 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0554,658,929 - 54,672,888 (-)NCBIUU_Cfam_GSD_1.0
PCSK9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38155,039,548 - 55,064,852 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl155,039,445 - 55,064,852 (+)EnsemblGRCh38hg38GRCh38
GRCh37155,505,221 - 55,530,525 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36155,277,808 - 55,303,111 (+)NCBINCBI36Build 36hg18NCBI36
Build 34155,217,240 - 55,242,544NCBI
Celera153,792,769 - 53,818,130 (+)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef153,618,200 - 53,643,557 (+)NCBIHuRef
CHM1_1155,621,314 - 55,646,685 (+)NCBICHM1_1
T2T-CHM13v2.0154,913,987 - 54,945,736 (+)NCBIT2T-CHM13v2.0
Pcsk9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394106,299,531 - 106,321,522 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4106,299,526 - 106,321,526 (-)EnsemblGRCm39 Ensembl
GRCm384106,442,334 - 106,464,325 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4106,442,329 - 106,464,329 (-)EnsemblGRCm38mm10GRCm38
MGSCv374106,114,939 - 106,136,930 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364105,940,274 - 105,974,961 (-)NCBIMGSCv36mm8
Celera4104,803,009 - 104,824,874 (-)NCBICelera
Cytogenetic Map4C7NCBI
cM Map449.67NCBI
Pcsk9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85126,440,102 - 126,462,507 (-)NCBIGRCr8
mRatBN7.25121,211,278 - 121,233,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5121,211,278 - 121,233,688 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5123,824,322 - 123,846,721 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05125,547,373 - 125,569,772 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05125,598,631 - 125,621,028 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05126,031,368 - 126,053,726 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5126,031,368 - 126,053,726 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05129,878,797 - 129,900,625 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45127,501,476 - 127,524,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15127,507,768 - 127,529,490 (-)NCBI
Celera5119,960,965 - 119,983,199 (-)NCBICelera
Cytogenetic Map5q34NCBI
Pcsk9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554644,425,435 - 4,439,842 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554644,424,583 - 4,439,805 (-)NCBIChiLan1.0ChiLan1.0
PCSK9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21171,754,941 - 171,787,297 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11170,895,635 - 170,927,961 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0154,323,036 - 54,355,397 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1155,911,016 - 55,943,404 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl155,911,016 - 55,936,456 (+)Ensemblpanpan1.1panPan2
Pcsk9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505869,116,048 - 69,144,955 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365226,272,507 - 6,299,917 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365226,271,339 - 6,300,202 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6157,388,372 - 157,409,551 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16157,388,370 - 157,409,620 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26145,451,983 - 145,473,336 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PCSK9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12077,893,574 - 77,921,076 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2077,893,590 - 77,918,613 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603339,376,139 - 39,401,572 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcsk9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248624,879,561 - 4,895,776 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248624,873,457 - 4,895,836 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PCSK9
220 total Variants

Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_038474427   ⟹   XP_038330355
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1554,380,525 - 54,396,181 (-)NCBI
RefSeq Acc Id: XM_038532074   ⟹   XP_038388002
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha554,264,679 - 54,280,339 (-)NCBI
RefSeq Acc Id: XM_038538811   ⟹   XP_038394739
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0554,658,929 - 54,672,888 (-)NCBI
RefSeq Acc Id: XM_038602902   ⟹   XP_038458830
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0554,270,491 - 54,282,704 (-)NCBI
RefSeq Acc Id: XM_038667514   ⟹   XP_038523442
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0554,383,361 - 54,399,016 (-)NCBI
RefSeq Acc Id: XP_038330355   ⟸   XM_038474427
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038458830   ⟸   XM_038602902
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038523442   ⟸   XM_038667514
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038388002   ⟸   XM_038532074
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038394739   ⟸   XM_038538811
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
NCBI Gene PCSK9 ENTREZGENE
VGNC ID VGNC:110601 ENTREZGENE