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Gene: PCSK9 (proprotein convertase subtilisin/kexin type 9) Homo sapiens
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Symbol: PCSK9
Name: proprotein convertase subtilisin/kexin type 9
Description: Exhibits several functions, including lipoprotein particle receptor binding activity; molecular function regulator; and serine-type endopeptidase activity. Involved in several processes, including cholesterol homeostasis; low-density lipoprotein particle receptor catabolic process; and regulation of endocytosis. Localizes to several cellular components, including the PCSK9-AnxA2 complex; PCSK9-LDLR complex; and endosome. Implicated in hypobetalipoproteinemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: convertase subtilisin/kexin type 9 preproprotein; FH3; FHCL3; HCHOLA3; LDLCQ1; NARC-1; NARC1; neural apoptosis regulated convertase 1; neural apoptosis-regulated convertase 1; PC9; proprotein convertase 9; subtilisin/kexin-like protease PC9
Orthologs:
Mus musculus (house mouse) : Pcsk9 (proprotein convertase subtilisin/kexin type 9)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pcsk9 (proprotein convertase subtilisin/kexin type 9)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pcsk9 (proprotein convertase subtilisin/kexin type 9)
Pan paniscus (bonobo/pygmy chimpanzee) : PCSK9 (proprotein convertase subtilisin/kexin type 9)
Canis lupus familiaris (dog) : PCSK9 (proprotein convertase subtilisin/kexin type 9)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pcsk9 (proprotein convertase subtilisin/kexin type 9)
Sus scrofa (pig) : PCSK9 (proprotein convertase subtilisin/kexin type 9)
Chlorocebus sabaeus (green monkey) : PCSK9 (proprotein convertase subtilisin/kexin type 9)
Heterocephalus glaber (naked mole-rat) : Pcsk9 (proprotein convertase subtilisin/kexin type 9)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl155,039,447 - 55,064,852 (+)Ensembl
GRCh38 Ensembl155,039,548 - 55,064,852 (+)Ensembl
GRCh38155,039,548 - 55,064,853 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37155,505,149 - 55,530,526 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36155,277,808 - 55,303,111 (+)NCBINCBI36hg18NCBI36
Build 34155,217,240 - 55,242,544NCBI
Celera153,792,769 - 53,818,130 (+)NCBI
Cytogenetic Map1p32.3NCBI
HuRef153,618,200 - 53,643,557 (+)NCBIHuRef
CHM1_1155,621,314 - 55,646,685 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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