PCSK9 (proprotein convertase subtilisin/kexin type 9) - Rat Genome Database

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Gene: PCSK9 (proprotein convertase subtilisin/kexin type 9) Homo sapiens
Symbol: PCSK9
Name: proprotein convertase subtilisin/kexin type 9
RGD ID: 731023
Description: Enables several functions, including lipoprotein particle receptor binding activity; serine-type endopeptidase activity; and sodium channel inhibitor activity. Involved in several processes, including cholesterol homeostasis; low-density lipoprotein particle receptor catabolic process; and regulation of receptor-mediated endocytosis. Located in several cellular components, including Golgi apparatus; endosome; and perinuclear region of cytoplasm. Part of PCSK9-AnxA2 complex and PCSK9-LDLR complex. Implicated in familial hypercholesterolemia and hypobetalipoproteinemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: convertase subtilisin/kexin type 9 preproprotein; FH3; FHCL3; HCHOLA3; LDLCQ1; NARC-1; NARC1; neural apoptosis regulated convertase 1; neural apoptosis-regulated convertase 1; PC9; proprotein convertase 9; subtilisin/kexin-like protease PC9
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl155,039,447 - 55,064,852 (+)EnsemblGRCh38hg38GRCh38
GRCh38155,039,548 - 55,064,852 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37155,505,221 - 55,530,525 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36155,277,808 - 55,303,111 (+)NCBINCBI36hg18NCBI36
Build 34155,217,240 - 55,242,544NCBI
Celera153,792,769 - 53,818,130 (+)NCBI
Cytogenetic Map1p32.3NCBI
HuRef153,618,200 - 53,643,557 (+)NCBIHuRef
CHM1_1155,621,314 - 55,646,685 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (ISO)
1-benzylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (ISO)
acetamide  (ISO)
acetohydrazide  (ISO)
Actein  (ISO)
aflatoxin B1  (EXP)
aldrin  (ISO)
amiodarone  (EXP)
arsenous acid  (EXP)
avobenzone  (EXP)
belinostat  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
butan-1-ol  (EXP)
caffeine  (ISO)
carbamazepine  (EXP)
carbon nanotube  (EXP,ISO)
chloroethene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP,ISO)
curcumin  (ISO)
cyclosporin A  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
diclofenac  (ISO)
dorsomorphin  (EXP)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
ezetimibe  (EXP)
fenofibrate  (EXP)
flusilazole  (ISO)
fluvastatin  (EXP)
Ganoderic acid A  (EXP)
gemcitabine  (EXP)
genistein  (ISO)
glafenine  (ISO)
glutathione  (ISO)
hydrazine  (ISO)
indometacin  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (EXP,ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
methylmercury chloride  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
O-methyleugenol  (EXP)
orphenadrine  (ISO)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (EXP)
pioglitazone  (EXP,ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (EXP)
resveratrol  (EXP)
rotenone  (ISO)
SB 431542  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP)
sulindac sulfide  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
troglitazone  (EXP)
valproic acid  (EXP,ISO)
Yessotoxin  (EXP)
zaragozic acid A  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
cellular response to insulin stimulus  (IEA,ISS)
cellular response to starvation  (IEA,ISS)
cholesterol homeostasis  (IEA,IMP,ISO)
cholesterol metabolic process  (IEA,ISO)
kidney development  (IEA,ISO,ISS)
lipid metabolic process  (IEA)
lipoprotein metabolic process  (IEA,ISO)
liver development  (IEA,ISO,ISS)
low-density lipoprotein particle receptor catabolic process  (IDA)
low-density lipoprotein receptor particle metabolic process  (IEA,ISO)
lysosomal transport  (IDA)
negative regulation of low-density lipoprotein particle clearance  (IDA)
negative regulation of low-density lipoprotein particle receptor binding  (IDA)
negative regulation of low-density lipoprotein receptor activity  (IDA)
negative regulation of receptor internalization  (IDA)
negative regulation of receptor recycling  (IDA)
negative regulation of receptor-mediated endocytosis involved in cholesterol transport  (IDA)
negative regulation of signaling receptor activity  (IEA)
negative regulation of sodium ion transmembrane transporter activity  (IDA)
neurogenesis  (IEA,ISO,ISS)
neuron differentiation  (IEA,ISS)
phospholipid metabolic process  (IEA,ISO)
positive regulation of low-density lipoprotein particle receptor catabolic process  (IDA)
positive regulation of neuron apoptotic process  (IEA,IMP)
positive regulation of receptor internalization  (IDA)
protein autoprocessing  (IDA,IEA,ISO)
protein processing  (IEA,ISO)
proteolysis  (IEA)
regulation of low-density lipoprotein particle receptor catabolic process  (IEA,ISO)
regulation of neuron apoptotic process  (IEA,ISS)
regulation of signaling receptor activity  (IDA)
steroid metabolic process  (IEA)
triglyceride metabolic process  (IEA,ISO)


Additional References at PubMed
PMID:10205269   PMID:12477932   PMID:12552133   PMID:14622975   PMID:14702039   PMID:14727156   PMID:15099351   PMID:15166014   PMID:15178557   PMID:15358785   PMID:15654334   PMID:15741654  
PMID:15893176   PMID:16159606   PMID:16183066   PMID:16211558   PMID:16224054   PMID:16314752   PMID:16344560   PMID:16407292   PMID:16465619   PMID:16571601   PMID:16875509   PMID:16909389  
PMID:16912035   PMID:16989838   PMID:17051583   PMID:17080197   PMID:17081983   PMID:17101087   PMID:17142622   PMID:17170371   PMID:17316651   PMID:17328821   PMID:17351764   PMID:17391637  
PMID:17435765   PMID:17449864   PMID:17452316   PMID:17461796   PMID:17495605   PMID:17502100   PMID:17537735   PMID:17539906   PMID:17550346   PMID:17599443   PMID:17645871   PMID:17702855  
PMID:17765244   PMID:17804797   PMID:17940607   PMID:17971861   PMID:18006936   PMID:18028451   PMID:18039650   PMID:18039658   PMID:18052825   PMID:18193043   PMID:18193044   PMID:18197702  
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PMID:19667110   PMID:19687008   PMID:19713274   PMID:19762784   PMID:19773416   PMID:19797716   PMID:19828345   PMID:19843101   PMID:19878649   PMID:19913121   PMID:19917273   PMID:19948975  
PMID:20006333   PMID:20031582   PMID:20031607   PMID:20145306   PMID:20163833   PMID:20167577   PMID:20172854   PMID:20186155   PMID:20236128   PMID:20308432   PMID:20333646   PMID:20400780  
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PMID:21378990   PMID:21497351   PMID:21502677   PMID:21539517   PMID:21596380   PMID:21619378   PMID:21692990   PMID:21763412   PMID:21771976   PMID:21805236   PMID:21805237   PMID:21813713  
PMID:21829380   PMID:21847580   PMID:21873635   PMID:21889145   PMID:21920719   PMID:22001517   PMID:22005270   PMID:22027821   PMID:22074827   PMID:22081141   PMID:22095935   PMID:22176652  
PMID:22207727   PMID:22286219   PMID:22288532   PMID:22300679   PMID:22331829   PMID:22375030   PMID:22417841   PMID:22460556   PMID:22493497   PMID:22544364   PMID:22580899   PMID:22611251  
PMID:22658674   PMID:22679642   PMID:22683120   PMID:22683370   PMID:22714699   PMID:22764087   PMID:22809551   PMID:22825241   PMID:22848640   PMID:22875854   PMID:22916037   PMID:23085658  
PMID:23105118   PMID:23106476   PMID:23135270   PMID:23283366   PMID:23300213   PMID:23308045   PMID:23329883   PMID:23333725   PMID:23380568   PMID:23380588   PMID:23400816   PMID:23422832  
PMID:23430252   PMID:23450051   PMID:23466067   PMID:23499248   PMID:23509406   PMID:23535506   PMID:23537802   PMID:23553812   PMID:23559630   PMID:23593297   PMID:23623011   PMID:23663650  
PMID:23669246   PMID:23675525   PMID:23726366   PMID:23743349   PMID:23775089   PMID:23788249   PMID:23817198   PMID:23925411   PMID:24097068   PMID:24103783   PMID:24122718   PMID:24134510  
PMID:24144304   PMID:24225950   PMID:24296664   PMID:24308640   PMID:24315769   PMID:24404629   PMID:24486405   PMID:24518357   PMID:24529132   PMID:24599757   PMID:24625727   PMID:24632287  
PMID:24659111   PMID:24685817   PMID:24721682   PMID:24769476   PMID:24776539   PMID:24793346   PMID:24801085   PMID:24808179   PMID:25014035   PMID:25062564   PMID:25070550   PMID:25110901  
PMID:25128757   PMID:25164566   PMID:25172631   PMID:25180781   PMID:25210046   PMID:25222343   PMID:25234562   PMID:25239117   PMID:25258384   PMID:25266949   PMID:25278291