ATP4B (ATPase H+/K+ transporting subunit beta)

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Gene: ATP4B (ATPase H+/K+ transporting subunit beta) Pan paniscus

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Symbol:

ATP4B

Name:

ATPase H+/K+ transporting subunit beta

RGD ID:

11925348

Description:

ENCODES a protein that exhibits heterocyclic compound binding (ortholog); INVOLVED IN pH reduction (ortholog); potassium ion transmembrane transport (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; esomeprazole pharmacokinetics pathway; ASSOCIATED WITH atrophic gastritis (ortholog); autoimmune gastritis (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN potassium:proton exchanging ATPase complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ATPase H+/K+ transporting beta subunit; potassium-transporting ATPase subunit beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	115,160,113 - 115,170,521 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	113,851,442 - 113,861,871 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	94,796,689 - 94,807,210 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	113,848,121 - 113,859,054 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	113,848,126 - 113,859,054 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atrophic gastritis (ISO)

autoimmune gastritis (ISO)

Experimental Diabetes Mellitus (ISO)

factor X deficiency (ISO)

gastric mucosal hypertrophy (ISO)

obesity (ISO)

osteoporosis (ISO)

stomach cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell adhesion (IEA)

intracellular potassium ion homeostasis (IEA)

intracellular sodium ion homeostasis (IEA)

pH reduction (ISO)

potassium ion import across plasma membrane (IEA)

potassium ion transmembrane transport (ISO)

potassium ion transport (IEA)

proton transmembrane transport (IEA)

response to lipopolysaccharide (ISO)

sodium ion export across plasma membrane (IEA)

sodium ion transport (IEA)

Cellular Component

apical plasma membrane (IEA)

membrane (IEA)

potassium:proton exchanging ATPase complex (ISO)

sodium:potassium-exchanging ATPase complex (IEA)

Molecular Function

ATPase activator activity (IEA)

heterocyclic compound binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cimetidine pharmacodynamics pathway (ISO)

esomeprazole pharmacodynamics pathway (ISO)

esomeprazole pharmacokinetics pathway (ISO)

famotidine pharmacodynamics pathway (ISO)

lansoprazole pharmacodynamics pathway (ISO)

lansoprazole pharmacokinetics pathway (ISO)

nizatidine pharmacodynamics pathway (ISO)

omeprazole pharmacodynamics pathway (ISO)

omeprazole pharmacokinetics pathway (ISO)

pantoprazole pharmacodynamics pathway (ISO)

pantoprazole pharmacokinetics pathway (ISO)

pirenzepine pharmacodynamics pathway (ISO)

rabeprazole pharmacodynamics pathway (ISO)

rabeprazole pharmacokinetics pathway (ISO)

ranitidine pharmacodynamics pathway (ISO)

roxatidine acetate pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ATP4B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	115,160,113 - 115,170,521 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	113,851,442 - 113,861,871 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	94,796,689 - 94,807,210 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	113,848,121 - 113,859,054 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	113,848,126 - 113,859,054 (-)	Ensembl	panpan1.1		panPan2

ATP4B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	113,648,804 - 113,658,198 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	113,648,804 - 113,658,198 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	114,303,119 - 114,312,513 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	113,351,120 - 113,360,502 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	13	113,351,122 - 113,360,502	NCBI
Celera	13	95,130,374 - 95,139,808 (-)	NCBI		Celera
Cytogenetic Map	13	q34	NCBI
HuRef	13	94,742,367 - 94,751,761 (-)	NCBI		HuRef
CHM1_1	13	114,272,447 - 114,281,841 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	13	112,907,872 - 112,917,266 (-)	NCBI		T2T-CHM13v2.0

Atp4b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	13,436,209 - 13,446,778 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	13,436,205 - 13,446,825 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	13,386,209 - 13,396,778 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	13,386,205 - 13,396,825 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	13,386,209 - 13,396,778 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	13,386,186 - 13,396,755 (-)	NCBI		MGSCv36	mm8
Celera	8	13,554,643 - 13,565,216 (-)	NCBI		Celera
Cytogenetic Map	8	A1.1	NCBI
cM Map	8	5.89	NCBI

Atp4b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	82,846,329 - 82,855,242 (+)	NCBI		GRCr8
mRatBN7.2	16	76,144,150 - 76,153,063 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	76,144,150 - 76,153,063 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	81,424,745 - 81,433,658 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	84,877,703 - 84,886,616 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	80,126,502 - 80,135,394 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	81,136,218 - 81,145,131 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	81,136,218 - 81,145,131 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	80,624,778 - 80,633,691 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	81,000,154 - 81,009,067 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	81,000,418 - 81,009,332 (+)	NCBI
Celera	16	73,951,353 - 73,960,266 (+)	NCBI		Celera
RH 3.4 Map	16	743.6	RGD
Cytogenetic Map	16	q12.5	NCBI

Atp4b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955404	362,368 - 372,077 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955404	362,410 - 372,077 (+)	NCBI	ChiLan1.0	ChiLan1.0

ATP4B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	60,898,801 - 60,904,223 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	60,898,833 - 60,904,223 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	60,609,212 - 60,615,183 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	61,582,729 - 61,588,695 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	61,583,223 - 61,588,608 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	61,021,472 - 61,027,443 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	61,023,514 - 61,029,484 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	61,054,593 - 61,060,564 (-)	NCBI		UU_Cfam_GSD_1.0

Atp4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	195,778,134 - 195,783,608 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936472	168,750 - 173,968 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936472	168,745 - 173,996 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATP4B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	78,780,013 - 78,785,116 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	78,780,013 - 78,785,143 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	86,513,302 - 86,518,449 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ATP4B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	91,618,147 - 91,629,177 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	91,618,957 - 91,627,679 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666046	48,705,491 - 48,714,926 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Atp4b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624793	472,241 - 479,753 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624793	472,241 - 479,753 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003832110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000011480 ⟹ ENSPPAP00000002372

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	13	113,848,126 - 113,859,054 (-)	Ensembl

RefSeq Acc Id:

XM_003832110 ⟹ XP_003832158

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	14	115,160,113 - 115,170,521 (-)	NCBI
NHGRI_mPanPan1	13	113,851,442 - 113,861,871 (-)	NCBI
Mhudiblu_PPA_v0	13	94,796,689 - 94,807,210 (-)	NCBI
PanPan1.1	13	113,848,121 - 113,859,054 (-)	NCBI

Sequence:

show sequence

GGCGTAGAGGGTGCAGGGAGCAGACGGGAGGATCTCAGGCCAGGGACGATGGCGGCTCTGCAGG
AGAAGAAGACGTGTGGCCAGCGCATGGAGGAGTTCCAGCGTTACTGCTGGAACCCGGACACGGG
GCAGATGCTGGGCCGCACCCTGTCCCGGTGGGTGTGGATCAGCCTGTACTACGTGGCCTTCTAC
GTGGTGATGACTGGGCTCTTCGCCCTGTGCCTCTATGTGCTGATGCAGACAGTGGACCCGTACA
CACCGGACTACCAAGACCAGCTACGGTCACCAGGGGTAACCTTAAGGCCGGATGTTTACGGGGA
GAAAGGCCTGGAAATTGTCTACAACGTCTCTGATAACAGAACCTGGGCAGACCTCACACAGACT
CTCCACGCCTTCCTAGCAGGCTACTCTCCAGCAGCCCAGGAGGACAGCATCAACTGCACCTCCG
AGCAGTACTTCTTCCAGGAGAGTTTCCGCGCTCCCAACCACACCAAGTTCTCCTGCAAGTTCAC
GGCAGATATGCTGCAGAACTGCTCGGGCCTGGCGGATCCCAACTTCGGCTTTGAAGAAGGAAAG
CCATGTTTTATTATTAAAATGAACAGGATCGTCAAGTTCCTCCCCAGCAACGGCTCGGCCCCCA
GAGTGGACTGTGCCTTCCTGGACCAGCCCCGCGAGCTCGGCCAGCCGCTGCAGGTCGAGTACTA
CCCTCCCAACGGCACCTTCAGTCTGCACTACTTCCCTTATTACGGGAAGAAAGCCCAGCCCCAC
TACAGCAACCCCCTGGTGGCAGCGAAGCTCCTCAACATCCCCAGGAACGCTGAGGTCGCCATCG
TGTGCAAGGTCATGGCGGAGCACGTGACCTTCAACAATCCCCACGACCCGTATGAAGGGAAAGT
GGAGTTCAAACTCAAGATTGAGAAGTGAAACGGTTTGCGCAGGGGTCCTGGGCACGCCTGCGGG
GTTGCTCAAGGACACCCTCCTGGTTGGGCTTACCTTGCCCGTCAGTTCCCTGCCAAATCATCCC
CAAAGTGGTTTGGAGCAACGGTGTTGTCAGTGTGGGAACTCCAGAGAAGCGCCCACATCTGAAG
GGCCTGCTCGCGAGTATCAGTTCTTCCTTGTTGAATTCTTACAGTTTTTAGATGGAATTTGCTG
CTATAAGAATGTCCAGCTACCATGGGAACGCAAGGCAGCAACTCTCTAATTAACCAGGTCATAA
AAACGATTCGTCTTCTGTGTAGACATCACTTTCATACTATAATTTATTTTTCTACACTTCAATA
TGAACTGCCCCCCCACATTAATATAAAAACTACTAATGCACTGATATGAAACATGGCTTACACT
AATGACATTCTGAATTCTTGCTTTTAAAATTGCAATTCCTAAGTTGTAAACATAAAATATATTA
AAGTTACTCTTATTGTATGTTAAAAAAATCGTGTTTCCTGATATAGGAGAAAAATTAACTAAAA
ACCAAACGCTTCCTTAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003832158	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000002372.1

RefSeq Acc Id:

XP_003832158 ⟸ XM_003832110

- UniProtKB:

A0A2R8ZBW3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLYVLMQ
TVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGYSPAAQEDS
INCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFIIKMNRIVKFLPS
NGSAPRVDCAFLDQPRELGQPLQVEYYPPNGTFSLHYFPYYGKKAQPHYSNPLVAAKLLNIPRN
AEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIEK

hide sequence

Ensembl Acc Id:

ENSPPAP00000002372 ⟸ ENSPPAT00000011480

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000010621	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000011480.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.170	UniProtKB/TrEMBL
	2.60.40.1660	UniProtKB/TrEMBL
InterPro	Na/K_ATPase_sub_beta	UniProtKB/TrEMBL
	Na/K_ATPase_sub_beta_sf	UniProtKB/TrEMBL
KEGG Report	pps:100991047	UniProtKB/TrEMBL
NCBI Gene	ATP4B	ENTREZGENE
PANTHER	POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA	UniProtKB/TrEMBL
	PTHR11523	UniProtKB/TrEMBL
Pfam	Na_K-ATPase	UniProtKB/TrEMBL
PROSITE	ATPASE_NA_K_BETA_1	UniProtKB/TrEMBL
	ATPASE_NA_K_BETA_2	UniProtKB/TrEMBL
UniProt	A0A2R8ZBW3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-01	ATP4B	ATPase H+/K+ transporting subunit beta		ATPase H+/K+ transporting beta subunit	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB