Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:bumetanide pharmacodynamics pathway
go back to main search page
Accession:PW:0002155 term browser browse the term
Definition:The pathway of bumetanide-target interaction and of the biochemical or physiological responses to drug. The drug blocks the luminal sodium-potassium-chloride symporter in the thick ascending limb of the loop of Henle. Bumetanide is used in the treatment of heart failure. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00088

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
bumetanide pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp1 aquaporin 1 (Colton blood group) ISO SMPDB SMP:00088 NCBI chrNW_004624783:164,615...177,317
Ensembl chrNW_004624783:164,609...177,766 		JBrowse link
G Aqp2 aquaporin 2 ISO SMPDB SMP:00088 NCBI chrNW_004624816:2,332,477...2,340,797
Ensembl chrNW_004624816:2,335,471...2,340,828 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) ISO SMPDB SMP:00088 NCBI chrNW_004624736:38,194,722...38,200,961
Ensembl chrNW_004624736:38,194,545...38,201,036 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 ISO SMPDB SMP:00088 NCBI chrNW_004624772:12,099,523...12,127,437
Ensembl chrNW_004624772:12,099,435...12,127,737 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 ISO SMPDB SMP:00088 NCBI chrNW_004624907:715,109...736,040
Ensembl chrNW_004624907:715,094...736,432 		JBrowse link
G Atp1a4 ATPase Na+/K+ transporting subunit alpha 4 ISO SMPDB SMP:00088 NCBI chrNW_004624794:1,068,056...1,108,303 JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 ISO SMPDB SMP:00088 NCBI chrNW_004624826:7,058,046...7,076,919
Ensembl chrNW_004624826:7,054,371...7,076,919 		JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 ISO SMPDB SMP:00088 NCBI chrNW_004624786:10,254,979...10,261,508
Ensembl chrNW_004624786:10,234,492...10,262,367 		JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 ISO SMPDB SMP:00088 NCBI chrNW_004624730:18,510,840...18,544,528
Ensembl chrNW_004624730:18,510,844...18,544,836 		JBrowse link
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 ISO SMPDB SMP:00088 NCBI chrNW_004624931:234,184...255,154
Ensembl chrNW_004624931:234,103...255,189 		JBrowse link
G Clcnka chloride voltage-gated channel Ka ISO SMPDB SMP:00088 NCBI chrNW_004624764:2,202,438...2,212,185
Ensembl chrNW_004624764:2,202,579...2,212,337 		JBrowse link
G Fxyd2 FXYD domain containing ion transport regulator 2 ISO SMPDB SMP:00088 NCBI chrNW_004624784:13,198,308...13,209,780
Ensembl chrNW_004624784:13,200,018...13,206,131 		JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha ISO SMPDB SMP:00088 NCBI chrNW_004624860:3,123,676...3,152,217
Ensembl chrNW_004624860:3,126,379...3,145,043 		JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta ISO SMPDB SMP:00088 NCBI chrNW_004624782:8,521,639...8,580,099
Ensembl chrNW_004624782:8,549,583...8,581,819 		JBrowse link
G Scnn1d sodium channel epithelial 1 subunit delta ISO SMPDB SMP:00088 NCBI chrNW_004624818:8,316,300...8,321,995 JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma ISO SMPDB SMP:00088 NCBI chrNW_004624782:8,424,192...8,452,686
Ensembl chrNW_004624782:8,424,270...8,452,824 		JBrowse link
G Slc12a1 solute carrier family 12 member 1 ISO SMPDB SMP:00088 NCBI chrNW_004624731:11,403,936...11,486,244
Ensembl chrNW_004624731:11,403,675...11,484,982 		JBrowse link
G Slc12a3 solute carrier family 12 member 3 ISO SMPDB SMP:00088 NCBI chrNW_004624746:29,087,867...29,132,793
Ensembl chrNW_004624746:29,098,254...29,132,752 		JBrowse link
G Slc12a6 solute carrier family 12 member 6 ISO SMPDB SMP:00088 NCBI chrNW_004624804:31,489...105,944
Ensembl chrNW_004624804:31,495...105,949 		JBrowse link
G Slc14a2 solute carrier family 14 member 2 ISO SMPDB SMP:00088 NCBI chrNW_004624778:8,943,209...9,379,942
Ensembl chrNW_004624778:9,330,064...9,379,942 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 ISO SMPDB SMP:00088 NCBI chrNW_004624736:9,246,348...9,325,671
Ensembl chrNW_004624736:9,246,262...9,325,485 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 ISO SMPDB SMP:00088 NCBI chrNW_004624855:2,623,595...2,661,739
Ensembl chrNW_004624855:2,623,547...2,659,742 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 ISO SMPDB SMP:00088 NCBI chrNW_004624926:1,363,322...1,368,768
Ensembl chrNW_004624926:1,363,431...1,368,534 		JBrowse link
G Slc38a4 solute carrier family 38 member 4 ISO SMPDB SMP:00088 NCBI chrNW_004624816:5,451,464...5,529,453
Ensembl chrNW_004624816:5,450,908...5,530,772 		JBrowse link
G Slc3a1 solute carrier family 3 member 1 ISO SMPDB SMP:00088 NCBI chrNW_004624738:25,762,064...25,802,407
Ensembl chrNW_004624738:25,768,573...25,802,716 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 ISO SMPDB SMP:00088 NCBI chrNW_004624926:1,301,866...1,314,598
Ensembl chrNW_004624926:1,301,584...1,315,707 		JBrowse link
G Slc6a20 solute carrier family 6 member 20 ISO SMPDB SMP:00088 NCBI chrNW_004624730:75,081,189...75,107,288
Ensembl chrNW_004624730:75,084,748...75,109,112 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 ISO SMPDB SMP:00088 NCBI chrNW_004624746:1,325,368...1,349,616 JBrowse link
G Slc7a6 solute carrier family 7 member 6 ISO SMPDB SMP:00088 NCBI chrNW_004624746:18,009,078...18,046,072
Ensembl chrNW_004624746:18,013,340...18,032,390 		JBrowse link
G Slc7a7 solute carrier family 7 member 7 ISO SMPDB SMP:00088 NCBI chrNW_004624820:9,692,057...9,757,251
Ensembl chrNW_004624820:9,708,482...9,757,251 		JBrowse link
G Slc7a8 solute carrier family 7 member 8 ISO SMPDB SMP:00088 NCBI chrNW_004624820:9,365,167...9,418,346
Ensembl chrNW_004624820:9,365,093...9,419,045 		JBrowse link
G Slc7a9 solute carrier family 7 member 9 ISO SMPDB SMP:00088 NCBI chrNW_004624794:7,761,511...7,792,473 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3917
    drug pathway 349
      cardiovascular system drug pathway 160
        diuretic drug pathway 32
          bumetanide drug pathway 32
            bumetanide pharmacodynamics pathway 32
paths to the root